tnf as key autocrine paracrine mediator within brain parenchyma
Knowledge Management as a Catalyst for Innovation within Organizations: A Qualitative Study
... innovation were now grasped: `Maybe up to now there has been a resource or asset sitting there that hasn't been valued within the organization.' `There is an awful lot of knowledge within the organization ... contribution of this view of KM towards the development of innovation is considered as follows, based on the four key areas of the model shown in Figure 234 Knowledge and Process Management Knowledge ... be acknowledged as sources or constructs of innovative knowledge (Marshall and Reason, 1993) Hence interaction between employees can be seen as knowledge creation Furthermore, within these learning...
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Báo cáo y học: "Plasmatic B-Type Natriuretic Peptide and C-Reactive Protein in Hyperacute Stroke as Markers of Ct-Evidence of Brain Edema." pptx
... remainder it was similar as at baseline The mean NIHSS score on admission was 7.5 (SD: 6.18) and at discharge it was 5.94 (SD: 6.54) For patients with ischemic stroke the baseline NIHSS was 7.6 (SD: ... and brain edema in the acute phase of stroke has been little investigated Elevations of NT-PBNP were associated with hyponatremia and natriuresis in subarachnoid hemorrhage [26] as well as to ... of N-terminal pro -brain natriuretic peptide alter acute ischemic stroke Cerebrovasc Dis 2006; 22:439-444 26 Tomida M, Muraki M, Uemura K, Yamasaki K Olasma concentrations of brain natriuretic...
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báo cáo khoa học: "Epigenetic modifications as key regulators of Waldenstrom’s Macroglobulinemia biology" pot
... protein kinase C, serine/threonine kinase 24, mitogen-activated protein kinase kinase kinase 7, E2F- and pre-B-cell leukemia-transcription factors, as well as cyclin D2 and cyclin-dependent kinase inhibitor ... cyclin-dependent kinase inhibitors (p18, p19, p21, p27); decreased expression of cyclin-dependent kinases-2, -4, -6, as well as cyclins D1, D2, D3 and E; and increased expression of p53 with decreased expression ... cells, as demonstrated by an increased % of cells in G1-phase, together with a decreased % of cells in S-phase These findings were validated at gene expression profiling that showed increased expression...
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Báo cáo y học: "Interleukin-18 as an in vivo mediator of monocyte recruitment in rodent models of rheumatoid arthritis" potx
... early in the acute phase of arthritis, and signals via p38 and ERK½ to recruit PB monocytes to STs IL-18 is known to function in an autocrine or paracrine fashion, and increased expression of IL-18 ... binding domain, whereas the IL18Rβ is the signal-transducing chain When bound to the IL-18R, IL-18 induces the formation of an IL-1R-associated kinase (IRAK) /TNF receptor-associated factor-6 (TRAF-6), ... acute-phase proteins following anti -TNF- alpha therapy in rheumatoid arthritis J Immunol 1999, 163:1521-1528 doi: 10.1186/ar3055 Cite this article as: Ruth et al., Interleukin-18 as an in vivo mediator...
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Báo cáo y học: " Microarray identifies ADAM family members as key responders to TGF-β1 in alveolar epithelial cells" ppsx
... transforms fibroblasts into myofibroblasts inferring a role in the fibrotic process [24] Through the release of TGF-β2 IL-4 initiates the release of matrix proteins by myofibroblasts while inhibition ... supernatant was removed and ml of sterile 75 % ethanol was added to wash the pellet by gentle vortexing and centrifugation at 7500 g for The ethanol was removed and the pellet was allowed to ... % DEPC treated H2O by heating at 60°C for 15 All RNA was stored at -80°C Collagen Assay Sircol collagen assay (Biocolour) was performed as per manufacturer's guidelines The dye reagent contains...
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Báo cáo y học: " Statistical distribution of blood serotonin as a predictor of early autistic brain abnormalities" ppt
... was centered at 3000 ng/min based on a published estimate [53] and was allowed to vary ± 33%, whereas the value of FC was centered at 210 ng/min based on published estimates [48,53,70] and was ... abnormal case higher 5-HT release rates will lead to higher platelet 5-HT levels, as reported by Kema et al [86] Discussion The presented model is based on the hypothesis that at least one factor ... release from EC cells [89] At least superficially, this mirrors recent http://www.tbiomed.com/content/2/1/27 findings in the brain, where 5-HT1A and 5-HT1B receptors, long assumed to act as autoreceptors,...
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Báo cáo khoa học: Post-ischemic brain damage: targeting PARP-1 within the ischemic neurovascular units as a realistic avenue to stroke treatment pptx
... immune cells as well as infiltration of leukocytes within the ischemic area lead to excessive release of inflammatory mediators and ensuing worsening of brain damage In keeping with this, astrocytes, ... Inflammatory mediators PARP-1 Mic rog lia X Lumen PARP-1 PARP-1 Leukocyte Fig The role of PARP-1 within the ischemic neurovascular units PARP-1 exerts its detrimental role within the ischemic neurovascular ... the integrity of the neurovascular unit is caused by the enzyme’s ability to prompt an increase of blood– brain barrier (BBB) permeability, the release of proinflammatory mediators, mitochondrial...
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Social Phobia as a Consequence of Brain Defects
... response measured by: à prolactin plasma levels à cortisol plasma levels Increase in prolactin and cortisol plasma levels following acute, single dose of citalopram (20 mg/kg, i.v.): CTL ¼ SP Brain ... measured by: à prolactin plasma levels à cortisol plasma levels Increase in prolactin plasma levels following acute challenge with fenfluramine: CTL ¼ SP Increase in cortisol plasma levels SP CTL DA ... and the Brain Defects 183 consequence of a malfunctioning in the brain is unlikely; it has not made social phobia more intelligible Knowing more, has not necessarily À as is often the case À resulted...
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Tài liệu Báo cáo khoa học: Accessibility changes within diphtheria toxin T domain when in the functional molten globule state, as determined using hydrogen⁄deuterium exchange measurements pdf
... continuous change of the isotopic profile was measured at pD 7, whereas the peptide remained nondeuterated at pD This result indicated that this peptide was fully protected against H ⁄ D exchange ... Accessibility changes within diphtheria T domain P Man et al A at pH 7.0; the estimated molecular mass was around 37 kDa (Fig 7B), which is close to the theoretical molecular mass of a dimer (44.6 ... chromatography was used to test this hypothesis (Fig 7) The results showed that the elution volume of the T domain was increased at pH 4.0 compared with pH 7.0 Comparison with molecular mass markers...
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Tài liệu Báo cáo khoa học: Bacterial-induced hepoxilin A3 secretion as a pro-inflammatory mediator pptx
... However, basolateral IL-8 release is insufficient to induce the migration of neutrophils across the intestinal epithelium, suggesting that the production of other inflammatory mediators, whose release ... neurotransmission in rat hippocampus [8], increase vascular permeability in rat skin [9] and induce chemotaxis of neutrophils at concentrations as low as 30–40 nm [10] Our findings represent the first ... such as inflammatory bowel disease because 12-LOX activity is induced at active sites of this disease Because HXA3 may play an important step underlying the pathophysiology of inflammatory diseases,...
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Báo cáo khoa học: Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis docx
... cytoplasmically exposed component of the NPC [18] and was increased within individual NPCs during muscle differentiation Thus, we hypothesized that increased Nup358 in individual NPCs was responsible ... ring base and on the cytoplasmic ring, respectively Height indicates the vertical distance between the NPC cytoplasmic surface and the base Scale bar = 50 nm (D) The outer diameter was measured ... of microinjected GFP-NES-NLS was clearly different in the two cell types In myoblasts, GFP-NES-NLS was primarily localized to the nucleus, whereas, in myotubes, it was evenly distributed between...
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Báo cáo khoa học: Post-ischemic brain damage: NF-jB dimer heterogeneity as a molecular determinant of neuron vulnerability pdf
... subjected to permanent MCAO It was found that the p50 ⁄ p65 complex is activated in neurons during OGD as well as in ischemic brain areas of mice exposed to MCAO, whereas the c-Rel-containing dimers, ... channels is indispensable for basal NF-jB activity Three cellular sensors of Ca2+ levels – calmodulin, protein kinase C (PKC) and the p21(ras) ⁄ phosphatidylinositol 3-kinase (PI3K) ⁄ Akt pathway – ... the calmodulin kinase II and Akt kinase pathways are responsible for the upregulation of the p65 subunit of NF-jB [22] Activation of PI3K, mitogen-activated protein kinase kinase (MEK) and PKC...
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Báo cáo khoa học: Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics pptx
... signalregulated kinase ⁄ (ERK1 ⁄ 2) and protein kinase B (PKB) pathways that act downstream of oncogenic protein kinases [10,11] It is increasingly apparent that BIM as a mediator of tumour cell ... therapeutics, such as imatinib (BCR–ABL), erlotinib (EGFR) or PLX4720 (BRAF), inhibit these kinases or, in the case of MEK inhibitors (such as AZD6244), inhibit one of the key signalling pathways ... ubiquitin ligase responsible for poly-ubiquitination of BIMEL remains a matter of some debate The really interesting new gene (RING) finger protein, Casitas B-lineage lymphoma oncogene (CBL), was originally...
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Key Information on Target Date Funds as Default Investments Should Be Provided to Plan Sponsors and Participants pdf
... techniques—such as assessing trends in short-term and intermediate-term volatility and measuring correlations between asset classes—to assess the likelihood of oncoming financial market shocks On the basis ... percent of the TDF market, as measured by assets under management We also reviewed available documentation describing the asset allocation of selected TDFs, as well as the rationale behind these ... rates are generally lower than levels assumed by its model, it is hoped that rates will increase as workers adjust to DC plans serving as the sole employer-based retirement account Another TDF...
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Báo cáo khoa học: Mechanisms of amyloid fibril self-assembly and inhibition Model short peptides as a key research tool pptx
... recognition and assembly events A similar peptide array technique was also applied to identify the molecular recognition and self-assembly domains within IAPP molecules [22] As before, in this ... E Gazit case a central aromatic region was identified by the nonbiased peptide scan [22] Interestingly, the same motif was independently identified when analyzing peptide fragments [49] As with ... fibrils is associated with major human diseases and has a clear physiological role in micro-organisms, the precise mechanism of its formation is not fully understood As most amyloid-related diseases...
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Báo cáo khoa học: Mammalian transglutaminases Identification of substrates as a key to physiological function and physiopathological relevance pot
... formation has been implicated in such diseases as liver, renal 620 C Esposito and I Caputo and pulmonary fibrosis, as well as atherosclerosis [66] It is noteworthy that TG2 activity is increased and ... transglutaminase-catalysed cross-linkage The recently created TRANSIT database (http:// crisceb.unina2.it/ASC/) lists 150 protein sequences that function as TG substrates [39] The TRANSIT database also ... MAGP-1, microfibril associated glycoprotein-1; MBP, myelin basic protein; NSB, nuclease sensitive element binding protein-1; PGD, phosphoglycerate dehydrogenase; PLA2, phospholipase A2; Pro-CpU,...
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báo cáo hóa học:" Angiostatin anti-angiogenesis requires IL-12: The innate immune system as a key target" docx
... CCL22 0.15 TNF 0.10 CXCL10 AST/Mat AST IL-12 p35 IL-12 p40 0.02 Mat Control AST/Mat AST Mat 0.00 Control AST/Mat AST Mat Control 0.05 1.0 0.8 0.015 0.01 0.010 AST/Mat AST 0.000 Mat AST/Mat AST Mat ... principally targeting the key endothelial factor VEGF, which has encountered problems with both tumor escape as well as adverse cardiovascular effects [32] Immune cells appear to be key mediators of tumor ... (here termed collectively AST) is generated by the action of diverse proteases, including metalloproteases (MMP2, MMP12, MMP9) and serine proteases (PSA, neutrophil elastase) [3,4] These enzymes...
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báo cáo hóa học: " Physical activity as a mediator of the impact of chronic conditions on quality of life in older adults" pptx
... above As shown in Figure 2, the HUI3 score was regressed on the chronic condition variable, and physical activity was specified as a mediator of this relationship The Pratt-Index (d) [25] was used ... smoke Alcohol consumption was assessed based on responses to the question "During the past 12 months, how often did you drink alcoholic beverages?" This variable was collapsed into four categories: ... Canada Classification of chronic conditions The respondents were asked to indicate whether they had a disease or another health condition diagnosed by a health professional that had lasted, or was...
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Báo cáo sinh học: "Representations of odor plume flux are accentuated deep within the moth brain" ppsx
... within the olfactory system Sharpened olfactory temporal resolution related to high-speed flight maneuvers The challenge for insects is to sample the odor strands as frequently as possible, as ... side-to-side crosswind ‘casting’ flight can result in erroneous steering, both off-line from the toward-source direction as well as away from the direction to which the plume has swung in a shifting ... Axons from each of these classes of pheromone-component-tuned ORNs travel to the antennal lobe of the brain at the base of the antenna and arborize in their own class-specific knot of neuropil...
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Báo cáo sinh học: "The THO complex as a key mRNP biogenesis factor in development and cell differentiation" potx
... The relevance of THO in cell physiology has been clearly shown from yeast to humans Yeast THO null mutants are sick and slow growers and THO depletion has a negative effect on growth rate of human ... complex exists as a salt-resistant stable complex independent of UAP56 and Yra1 [4,5] In yeast, THO binds to active chromatin in an RNAindependent manner A plausible scenario is as follows (Figure ... transcription-dependent hyper-recombination as THO mutations (reviewed in [1]) Human THO associates with proteins of the spliceo some and with spliced RNAs, this latter interaction being independent...
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