... WBC number on day and 11 (80% and 88% respectively) in mice Recovery of WBC count started on day and day 11 in all treatment groups and returned back to the normal level on day and day 14 in NS ... significantly increased the number of blood vessel and PCNA-positive cell in both the gastric (Fig 2A and 2B respectively) and duodenal tissues (Fig 3A and 3B respectively) Dosedependent effects were ... 25 (AP25) mg/kg, respectively Mice were sacrificed on day 14 and the gastric and duodenal tissues were collected for biochemical and histological assessments Assessment of white blood cell (WBC)...
... patella cartilage volume and 2.2% for patella bone volume [16] Statistical analyses Outcome variables, including distal vastus medialis and lateralis cross-sectional areas andcartilageandbone ... knee cartilageandbone structure, participated in the analysis and interpretation of data, and reviewed the manuscript PAB and AJT performed the statistical analysis and interpretation of data and ... medialis and lateralis cross-sectional areas and patella structures The association between vastus medialis and lateralis crosssectional areas and patella structures, including cartilageand bone...
... this randomized, controlled trial was to assess the effect of HRT in postmenopausal RA on biochemical markers of boneandcartilage turnover, the correlations between the markers andbone mass and ... Radiographs of the hands, wrists, and distal part of the feet were obtained at baseline and after 12 and 24 months Forty joints in the hands and feet were scored (in the hands, proximal interphalangeal ... not only bone turnover but also cartilage turnover, indicating a structuremodifying therapeutic effect of HRT in RA We found that HRT reduced markers of both boneandcartilage metabolism and that...
... intake of other carotenoids and knee cartilage or bone measures in the multivariate analyses (Table 3) Relationship between fruit and vegetable intake and knee cartilageandbone measures After adjusting ... [11] and has been recognized as a valid, accurate, and reproducible tool to measure the articular cartilage volume [11,12], cartilage defects [13,14], the tibial plateau bone area [12,15], andbone ... two-sided significance) The outcomes were the tibial cartilage volume, the tibial plateau bone area, and the presence of tibiofemoral cartilage defects andbone marrow lesions The first two outcomes were...
... patella cartilage volume and 2.2% for patella bone volume [16] Statistical analyses Outcome variables, including distal vastus medialis and lateralis cross-sectional areas andcartilageandbone ... knee cartilageandbone structure, participated in the analysis and interpretation of data, and reviewed the manuscript PAB and AJT performed the statistical analysis and interpretation of data and ... medialis and lateralis cross-sectional areas and patella structures The association between vastus medialis and lateralis crosssectional areas and patella structures, including cartilageand bone...
... between subchondral bone cysts and tibial cartilage volume at baseline, and longitudinally, the relationship between baseline subchondral bone cysts and annual percentage tibial cartilage volume ... percentage change in cartilage volume was calculated by cartilage change (follow-up cartilage volume subtracted from initial cartilage volume) divided by initial cartilage volume and time between ... of subchondral bone cysts and BMLs were performed on the MRI slice that yielded the greatest lesion size The intensity and extent of cysts and BMLs were assessed in the medial and lateral tibiofemoral...
... incision on the bone tissue surrounding the lesion with bone drills and by harvesting a squared wedge bone on the alveolar ridge, in order to avoid the persistence of fibrotic tissue and to permit ... of the bone defect (Fig 10) No pain, fever or discomforts were described The soft tissues appeared healthy, with normal color, consistence and no bleeding was present in the incision site and around ... use of autologous bone graft with an expanded polytetrafluoroethylene titaniumreinforced membrane (Gore-Tex ®) to guide the bone regeneration assures a predictable healing and the possibility...
... the perichondrium, the cartilage becomes vascularized Additionally, osteoblasts invade the cartilageand start to replace it with mineralized bone [48] Many molecules and signaling cascades are ... plate and in articular cartilage, and has been described as a negative regulator of chondrocyte differentiation [64] The expression of cartilage- derived retinoic acid-sensitive protein and type ... Davies SR, Sakano S, Zhu Y & Sandell LJ (2002) Distribution of the transcription factors Sox9, AP-2, and [delta]EF1 in adult murine articular and meniscal cartilageand growth plate J Histochem...
... dairy, and calcium have the world’s highest fractures rates; (2) milk, dairy foods, and calcium supplements not reduce fracture risk and in some studies increase it; and (3) a diet high in fruits and ... Johanna Bowman, and Deborah Brody, and everyone at McGraw-Hill • Their families and friends, who graciously put up with their bone obsession during the writing of this book • And Neal Barnard, ... yogurt and cheese And to be sure we’re getting enough calcium to protect our bones, take a calcium supplement But why we think that milk, dairy foods, and calcium supplements prevent the broken bones...
... either lymph nodes or bone The spine, pelvis, ribs, and bones of the arm and thigh are the most common sites if cancer spreads to the bone Prostate cancer that has spread to the bone is called metastatic ... metastases in the bones Less often, pain is caused by fractures Cancer can cause bones to weaken and break Not all bone metastases result in pain Q How are bone metastases detected? A Bone metastases ... be found by a number of tests Bone scan is the standard method for detecting bone metastases from prostate cancer It is highly sensitive A bone scan often detects bone metastases before they cause...
... AL, DN, and JP carried out the 2D electrophoresis and all other experimental work PS, ET, and WKH coordinated the laboratory work and helped to draft the manuscript All authors read and approved ... differentially within bone marrow and peripheral blood cells of selected individuals (Table 2) Spot No (14-3-3 related) was only present in patient C, spot No 121 and 122 (TCHTP and variant) was only ... Involved in the regulation and inhibition of binding between urokinase-type plasminogen activator and its receptor, involved in physiological and pathological proteolysis and extracellular matrix...
... group and level of the geometric system base parameters, thus analyzing the femur structure on the basis of a complex and thorough investigation Methods Anatomical samples and analysis The bones ... measurement of the linear and angular parameters and their applications (B) The special tool (A) for the one-moment measurement of the linear and angular parameters and their applications (B) ... interquartile range and 75th percentile as the cut-off points for categorization of the data were not used because the kurtosis and theskewness were not equal at different classes of bones and parameters...
... compare the three pairs, PLPC and DPPC, POPC and DPPC, and PLPC and POPC, separately There were significant differences between POPC and DPPC (p = 0.002), and PLPC and POPC (p = 0.003) There was ... The standard curves for all five PC species were all linear over the ranges of 5–25 mg/L and their correlation coefficients (r) were > 0.98 No internal standard was used The interassay and intra-assay ... cartilagetissues All used facial tissues were pooled together and soaked in Folch reagent The chloroform phase containing both PC and non-PC species were obtained The PC and non-PC species were then...
... data sets, bone volume fraction (VF), trabecular number (Tb.N), trabecular thickness (Tb.Th), trabecular separation (Tb.Sp), bone surface to total volume ratio (BS/TV) andbone surface to bone volume ... transplanted bone in isochronograft and heterochronograft limbs for measuring osteoporosis (Table 1) The parameter values of bone mass indicated significantly inferior bone quality of transplanted bone ... conception and design of data, drafting the manuscript, and giving the final approval; JHY, YHP, JML and YHK have contributed in analysis of data and performing the experiment All authors read and approved...
... measuring bone density The T-score relates bone density to young, healthy, race and gender-matched bone It is easily obtained and provides an objective quantitative number The T-score and body ... factors such as bone mineral density, body mass index, age, gender, and femoral component size has been demonstrated in many studies as an aid in decreasing the rate of revisions and improving ... femoral neck fracture and two for femoral component loosening These occurred in two female and three male patients In the multi-variable regression model, only T-score and body mass index showed...
... complex bone ailments (for drug elution inside bones) The wire can easily be inserted inside the bones and could potentially open up new possibilities for enhanced bone fixation/repair and targeted ... ability to design TNT-Ti wire implants with multiple drug release and complex bone therapies, including bone infections and metastatic bone cancer Drug release profiles of gentamicin loaded into the ... between the boneand the implant, resulting in a lower incidence of bone degradation due to stress shielding Also, a TNT layer has a much closer elastic modulus to that of natural bones, and hence,...
... carcinogens such as polycyclic hydrocarbons, asbestos, and dioxin may be involved in the pathogenesis Iatrogenic Factors Sarcomas in bone or soft tissues occur in patients who are treated with radiation ... the tumor-suppressor gene p53 and an increased incidence of soft tissue sarcomas and other malignancies, including breast cancer, osteosarcoma, brain tumor, leukemia, and adrenal carcinoma (Chap ... Soft tissues include muscles, tendons, fat, fibrous tissue, synovial tissue, vessels, and nerves Approximately 60% of soft tissue sarcomas arise...
... best with plain radiographs and MRI for tumors of the extremities or head and neck and by CT for tumors of the chest, abdomen, or retroperitoneal cavity A radiograph and CT scan of the chest are ... as the retroperitoneum, mediastinum, and subcutaneous tissue Rhabdomyosarcomas, Ewing's sarcoma, and other small-cell sarcomas tend to be more aggressive and are more responsive to chemotherapy ... of malignant GISTs have activating mutations of the c-kit gene that result in ligand-independent phosphorylation and activation of the KIT receptor tyrosine kinase, leading to tumorigenesis Diagnosis...
... angiosarcomas, and vincristine, etoposide, and irinotecan are effective in rhadomyosarcomas and Ewing's sarcomas Imatinib mesylate targets the KIT tyrosine kinase activity and is standard therapy ... time-consuming, and less expensive Adjuvant Chemotherapy Chemotherapy is the mainstay of treatment for Ewing's primitive neuroectodermal tumors (PNET) and rhabdomyosarcomas Meta-analysis of 14 randomized ... incorporating the biopsy site, is the standard surgical procedure for local disease The adjuvant use of radiation therapy and/ or chemotherapy improves the local control rate and permits the use of limb-sparing...
... common benign bone tumors include enchondroma, osteochondroma, chondroblastoma, and chondromyxoid fibroma, of cartilage origin; osteoid osteoma and osteoblastoma, of bone origin; fibroma and desmoplastic ... origin; and giant cell tumor, of unknown origin Malignant Tumors The most common malignant tumors of bone are plasma cell tumors (Chap 106) The four most common malignant nonhematopoietic bone tumors ... Ewing's sarcoma, and malignant fibrous histiocytoma Rare malignant tumors include chordoma (of notochordal origin), malignant giant cell tumor and adamantinoma (of unknown origin), and hemangioendothelioma...