thrombus platelets and thrombin thrombus formation
Báo cáo khoa học: Aegyptin displays high-affinity for the von Willebrand factor binding site (RGQOGVMGF) in collagen and inhibits carotid thrombus formation in vivo ppt
... Alpha helices show negative peaks at 208 and 222 nm and a positive peak at 190 nm, while beta sheets show a negative band near 220 nm and a positive band at 190 nm Accordingly, Fig 1C shows the ... (e) and 0.25 lM (f), and those for (B) were lM (a), lM (b), lM (c), 0.5 lM (d), 0.3 lM (e) and 0.15 lM (f) Dissociation of the aegyptin-ligand complex was monitored for 1800 s (30 min), and a ... vessel wall and subsequent thrombus formation [24] Figure 6A shows that the blood flow of control animals (injected with NaCl ⁄ Pi) stopped in 19.37 ± 2.38 In contrast, the time for thrombus formation...
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Báo cáo hóa học: "Research Article Segmentation, Reconstruction, and Analysis of Blood Thrombus Formation in 3D 2-Photon Microscopy Images" pot
... are inactivated platelets and fibrin in the blood flow) Further, some platelets and fibrin may form relatively small or sparse clusters that are disconnected from the target clot and therefore should ... medical image clustering analysis and research,” Advances in Computer, Information, and Systems Sciences, and Engineering, pp 149–155, 2006 [16] P.-K Chan, S.-H Cheng, and T.-C Poon, “Automated segmentation ... smoothing and differencing kernel and proposed the socalled peak -and- valley thresholding Entropy-based thresholding algorithms exploit the entropy of the distribution of the gray levels Johannsen and...
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Báo cáo khoa học: " Systemic hypothermia increases PAI-1 expression and accelerates microvascular thrombus formation in endotoxemic mice" ppsx
... activation and temperature Statistics and graphics were performed using the software packages SigmaStat and SigmaPlot (Jandel Corporation, San Rafael, CA, USA) times of 255 ± 35 s and 238 ± 58 ... further but only slight and non-significant acceleration of microvascular thrombus formation Arteriolar and venular vessel lumen were found clogged at an average time of 224 ± 35 s and 183 ± 35 s, respectively ... 37°C, thrombus formation was markedly accelerated, as indicated by significantly reduced arteriolar and venular occlusion Page of (page number not for citation purposes) Microvascular thrombus formation...
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Báo cáo khoa học: Transport of L-arginine and nitric oxide formation in human platelets pdf
... transport and NO formation in platelets (Eur J Biochem 270) 2007 Fig L-Arginine uptake in human platelets: sensitivity to N-ethylmaleimide and effect of L-leucine Washed platelets (2.0 · 108 platelets) , ... · 108 platelets per for the system y+ Ó FEBS 2003 Arginine transport and NO formation in platelets (Eur J Biochem 270) 2009 Fig L-Arginine efflux in human platelets Platelets (1.0 · 109 platelets) , ... human platelets and described a stimulatory effect of N-ethylmaleimide on this system, incubated Fig Effect of N-ethylmaleimide and L-leucine on NO formation and cGMP levels in platelets Washed platelets, ...
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Báo cáo khoa học: Distinct but critical roles for integrin aIIbb3 in platelet lamellipodia formation on fibrinogen, collagen-related peptide and thrombin pot
... lamellipodia formation and stress fibre formation was observed for platelets adhering to immobilized thrombin (Fig 1A,B and supplementary Video S3) Significantly, lamellipodia formation on thrombin ... [10,11], and on thrombin that has been immobilized by fibrin In platelets, thrombin binds to and signals via GPIba and the G protein-coupled protease-activated receptor (PAR) receptors (PAR and 4) ... fibrinogen, von Willebrand factor and other aIIbb3 ligands from platelet a-granules Consistent with this, secretion of platelet a-granules in platelets that had adhered to CRP and thrombin was confirmed...
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Báo cáo khoa học: Protein aggregation and amyloid fibril formation prediction software from primary sequence: towards controlling the formation of bacterial inclusion bodies pot
... both a-helix and b-sheet) that can serve as the nucleating core of amyloid fibril formation The algorithm betascan [35] calculates likelihood scores for potential b-strands and strand-pairs based ... primary structures The method predicts local conformational changes, usually associated with protein aggregation and amyloid fibril formation, and can quantitatively estimate the mutational effect ... ‘conformational switches’ in sequences – regions with a high predicted tendency to form both a-helices and b-strands – using the consensus secondary structure prediction program secstr [27] and...
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Báo cáo khoa học: a-Fetoprotein positively regulates cytochrome c-mediated caspase activation and apoptosome complex formation docx
... caspase 3, c-IAP-2 and AFP To study further the interaction between AFP, cIAP-2 and caspases and 3, we precipitated pure recombinant active caspases and (His-tagged) with nickel resin and then incubated ... Apaf-1 and p53, and simultaneous overexpression of the antiapoptotic proteins Hsp70, Bcl-2 and Bcl-xL, resulting in tumor-specific suppression of apoptosis and enhancement of the malignance and therapy ... caspase and AcIETD-AMC for caspases and [33] as described above Fractions were then concentrated 20-fold with mL centrifugal concentrators (Centricon YM-10; Amicon) and analyzed by PAGE and immunoblotting...
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Báo cáo khoa học: Intrinsic disorder and coiled-coil formation in prostate apoptosis response factor 4 pptx
... · F1) and spectral widths of 8389.2 and 2128.9 Hz for F2 and F1, respectively; rrPar-4DLZ: 20 transients, 2048 · 128 points (F2 · F1) and spectral widths of 8389.2 and 2128.9 Hz for F2 and F1, ... F1) and spectral widths of 8389.2 and 2128.9 Hz for F2 and F1, respectively All data sets were linear predicted and zero-filled once in the indirect dimension before Fourier transformation and ... the RS measured for rrPar-4FL, rrPar-4DLZ and rrPar-4SAC correspond to MWs of 8.9 · 103, 64.1 and 18.7 kDa, respectively, and are much larger (713, 129 and 141%) than what would be expected for...
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Báo cáo khoa học: Actin mutations in hypertrophic and dilated cardiomyopathy cause inefficient protein folding and perturbed filament formation pdf
... distinct band with slow mobility, a fainter band with intermediate mobility, and a diffuse, rapidly migrating band (Fig 2A) This pattern of complex formation over time varied between wild-type and ... at different time points up to 60 and analyzed by both SDS ⁄ PAGE and native PAGE Separation by SDS ⁄ PAGE and visualization by phosphorimaging showed a single band of 42 kDa with similar intensity ... analysis of the mobility shift of this band by native PAGE and radiography (Fig 2C) DNase I binds the actin monomer and condenses the smear to a distinct band of characteristic mobility The smear...
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Chapter 109. Disorders of Platelets and Vessel Wall (Part 1) docx
... results in further platelet activation and fibrin formation Genetic and acquired influences on the platelet and vessel wall, as well as on the coagulation and fibrinolytic systems, determine whether ... aggregation and blood clot formation, and influence the environment of the forming clot During platelet aggregation, additional platelets are recruited to the site of injury, leading to the formation ... inflammation and specifically by interleukin TPO binds to its receptor on platelets and megakaryocytes, by which it is removed from the circulation Thus, a reduction in platelet and megakaryocyte...
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Chapter 109. Disorders of Platelets and Vessel Wall (Part 2) ppsx
... autosomal dominant macrothrombocytopenia D Schistocytes microangiopathic hemolytic anemia and decreased platelets in ... If a low platelet count is obtained in EDTA-anticoagulated blood, a blood smear can be evaluated and a platelet count determined in blood collected into sodium citrate (blue-top tube) or heparin...
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Chapter 109. Disorders of Platelets and Vessel Wall (Part 3) pot
... production and platelet survival In addition, immune mechanisms can be at work, as in infectious mononucleosis and early HIV infection Late in HIV infection, pancytopenia and decreased and dysplastic ... seen in disorders of both platelet number and function Infection-Induced Thrombocytopenia Many viral and bacterial infections result in thrombocytopenia and are the most common noniatrogenic cause ... venous pressure, the ankles and feet in an ambulatory patient Petechiae are pinpoint, nonblanching hemorrhages and are usually a sign of a decreased platelet number and not platelet dysfunction...
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Chapter 109. Disorders of Platelets and Vessel Wall (Part 4) potx
... associated with bleeding and, in fact, markedly increases the risk of thrombosis HIT results from antibody formation to a complex of the plateletspecific protein platelet factor (PF4) and heparin The ... thrombocytopenia and full recovery occurred after drug discontinuation, but recurred with re-introduction of the drug, and other causes, including other drugs were excluded Source: Data from George and colleagues, ... surface antigens and result in thrombocytopenia only when the drug is present Many drugs are capable of inducing these antibodies, but for some reason they are more common with quinine and sulfonamides...
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Chapter 109. Disorders of Platelets and Vessel Wall (Part 5) ppt
... to an alternative anticoagulant The direct thrombin inhibitors (DTIs) argatroban and lepirudin are effective in HITT The DTI bivalirudin and the antithrombinbinding pentasaccharide fondaparinux ... discontinuation of heparin and use of alternative anticoagulants Thrombosis is a common complication of HIT, even after heparin discontinuation, and can occur in both the venous and arterial systems ... to clotting activation and severely reduced levels of proteins C and S Warfarin should only be started after alternative anticoagulation has been given for several days and the prothrombotic state...
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Chapter 109. Disorders of Platelets and Vessel Wall (Part 6) potx
... medications and infections, pregnancy, and vasculitis In DIC, while thrombocytopenia and microangiopathy are seen, a coagulopathy predominates, with consumption of clotting factors and fibrinogen ... patients with severe ITP and/ or symptoms of bleeding, hospital admission and combined modality therapy are given using high-dose glucocorticoids with IVIgG or anti-Rh0D therapy, and, as needed, additional ... the MayHegglin anomaly and Sebastian, Epstein's, and Fechtner syndromes, all of which have distinct distinguishing features A common feature of these disorders is large platelets (Fig 109-1C)...
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Chapter 109. Disorders of Platelets and Vessel Wall (Part 7) ppt
... TTP is more common in patients with HIV infection and in pregnant women Medication-related TTP may be secondary to antibody formation (ticlopidine and possibly clopidogrel) or direct endothelial ... Willebrand factor (vWF) produced by the endothelial cells are processed into smaller multimers by a plasma metalloproteinase called ADAMTS13 In TTP the activity of the protease is inhibited, and ... pathogenesis of inherited (Upshaw-Schulman syndrome) and idiopathic TTP is related to a deficiency of, or antibodies to, a metalloprotease that cleaves vWF and ADAMTS13, respectively vWF is normally secreted...
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Chapter 109. Disorders of Platelets and Vessel Wall (Part 8) potx
... bleeding This appears to be due, at least in part, to acquired von Willebrand disease (vWD) due to plateletvWF adhesion and removal Qualitative Disorders of Platelet Function Inherited Disorders ... the platelet GpIIbIIIa receptor) and Bernard Soulier syndrome (absence of the platelet GpIb-IX-V receptor) Both are inherited in an autosomal recessive fashion and present with bleeding symptoms ... disorder This results from abnormalities of platelet granule formation It is also seen as a part of inherited disorders of granule formation, such as Hermansky-Pudlak syndrome Bleeding symptoms...
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Chapter 109. Disorders of Platelets and Vessel Wall (Part 9) pdf
... can also be seen Bleeding symptoms are very uncommon in infancy and usually manifest later in childhood with excessive bruising and epistaxis Since these symptoms occur commonly in childhood, ... traumatized and/ or prolonged epistaxis requiring medical attention Menorrhagia is a common manifestation of vWD Menstrual bleeding resulting in anemia should warrant an evaluation for vWD and, if ... Willebrand Disease Type aPTT vWF Antigen Nl or up down vWF Activity down FVIII Multimer Activity down Normal distribution, decreased in quantity 2A Nl or down up down down down Loss high of and...
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Chapter 109. Disorders of Platelets and Vessel Wall (Part 10) pptx
... of undetermined significance (MGUS), multiple myeloma, and Waldenstrom's macroglobulinemia It is seen most commonly in the setting of MGUS and should be suspected in patients, particularly elderly ... replaced von Willebrand Disease: Treatment The mainstay of treatment for type vWD is 1-deamino-8-Darginine vasopressin (DDAVP, or desmopressin), which results in release of vWF and FVIII from endothelial ... commonly in the very young and the very old, but fluid restriction should be advised for all patients for the 24 hours following each dose Some patients with types 2A and 2M vWD respond to DDAVP...
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