therapeutic potential of placental umbilical cord blood in cardiology
Báo cáo y học: "Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis" pps
... cells in vivo [38] The upregulation of IL-10 is in line with the induction of Tregs in vitro and in vivo in our study Moreover, in our experiments we did not find UC-MSCs in the joint of the ... differentiation of UC-MSCs staining for alkaline phosphatase Arrows indicate the accumulation of intracytoplasmic alkaline phosphatase of osteoblast Original magnification × 40 involved in the suppression of ... that administration of UC-MSCs attenuated systemic inflammation in CIA in mice UC-MSCs downregulated the production of the proinflammatory cytokines TNF-a, and IL-6 in vitro and in vivo In addition,...
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Báo cáo khoa học: "Transplantation of canine umbilical cord blood-derived mesenchymal stem cells in experimentally induced spinal cord injured dogs" pot
... ytisrevinU lanoitaN luoeS fo ’slaminA yrotarobaL fo esU dna eraC eht rof ediuG‘ eht fo senilediug eht ot gnidrocca demrofrep saw noitagitsevni sihT yduts yrujni droc lanips latnemirepxe eht rof desu ... erew sgod ehT ICS eht retfa keew a demrofrep saw sCSM-BCU eninac fo noitatnalpsnarT :FSCGhmr fo noitcejni dna sCSM-BCU eninac fo noitatnalpsnarT noitcejni eht rof noitulos enilas fo lµ 051 ni 601 ... ilumits cinegotim cificepsnon ro ralullec yb decudni noitarefilorp etycohpmyl-T sserppus sllec lamorts worram enob namuH MA innaiG ,S itnasirG ,P iccuettaM ,DP inognoL ,M isenaliM ,M ingaM ,C...
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Báo cáo khoa học: "Implantation of canine umbilical cord blood-derived mesenchymal stem cells mixed with beta-tricalcium phosphate enhances osteogenesis in bone defect model dogs" ppsx
... change of implant radiopacity Preparation of canine UCB-MSCs Fetal umbilical cord blood was collected during Caesarean section of pregnant female dogs Canine UCB-MSCs were produced by culturing ... weeks (Fig 2: proximal interface of C1) In group CM, continuity was established at three of six interfaces by 12 weeks (Fig 2: proximal interface of CM1, and 3) Histological findings Bone formation ... of canine umbilical cord blood- derived mesenchymal stem cells in experimentally induced spinal cord injured dogs J Vet Sci 2007, 8, 275-282 22 Lu J, Descamps M, Dejou J, Koubi G, Hardouin P,...
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Báo cáo hóa học: "Safety evaluation of allogeneic umbilical cord blood mononuclear cell therapy for degenerative conditions" pot
... obtained from each patient before initiation of treatment Cell processing Umbilical Cord Blood (100~ 150 mL) was collected from healthy unrelated donors (signed an informed consent) in accordance ... Engineering Research Institute, Shenzhen, China Department of Surgery, University of Western Ontario, London, Ontario, Canada 4Department of Medicine, Division of Neurosurgery, University of ... guidelines for cord blood in each hospital After collection, each blood sample was tested for communicable diseases such as HBV, HCV, HIV, ALT, and Syphilis Cord blood was diluted with saline in...
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Báo cáo khoa học: " Isolation and characterization of canine umbilical cord blood-derived mesenchymal stem cells" pps
... calcium mineralization Alizarin red S staining was used to determine the presence of calcium mineralization For Alizarin red S staining, cells were washed with D.W times and fixed in a solution of ... settings for the application of gene delivery were also investigated Materials and Methods Cell isolation and culture Canine umbilical cord blood (cUCB) and blood of the canine fetus heart using ... experimental analysis A guarantee of enough numbers of multipotent stem cells out of a very small quantity of cord blood sample from the canine umbilical cord blood is attractive In conclusion, this study...
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Báo cáo y học: " Intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells attenuates " pps
... graded on a five point scale: = minimal injury, = injury up to 25% of the field, = Page of 11 injury up to 50% of the field, = injury up to 75% of the field, and = diffuse injury [19] Myeloperoxidase ... protein macroarray analysis included inflammatory cytokines of interest, including complement 5a (C5a), the soluble form of intercellular adhesion molecule (sICAM)1, IL-1a, IL-1b, IL-6, IL-16, interferon-inducible ... cytokine profiles Lung homogenates at post-injury day were used for a mouse macroarray experiment to profile various inflammatory cytokine proteins involved in the peak inflammatory reactions induced...
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báo cáo hóa học:" Stem cells from umbilical cord blood do have myogenic potential, with and without differentiation induction in vitro" pdf
... complex of proteins (dystrophin-glycoprotein complex) responsible for the membrane maintenance of muscle cells A primary deficiency in any of these proteins induces to a secondary deficient of the ... Conclusion Our findings showed that umbilical cord blood CD34+ stem cells have the potential to interact with dystrophic muscle cells restoring the dystrophin expression of DMD cells in vitro Although ... amplified in co-cultures, indicating the absence or very low expression of dystrophin in co-cultures (data not shown) Transdifferentiation of CD34+ stem cells into muscle cells During the expansion of...
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Báo cáo khoa học: "In vitro neuronal and osteogenic differentiation of mesenchymal stem cells from human umbilical cord blood" ppt
... llec gnimrofrep dna esu lacinilc rof SBF gnisu tuohtiw oviv xe sCSM dnapxe ot sdohtem dnif ot deen ew dna ,hcraeser ruo rof SBF desu ew ,yduts tneserp ni ,revewoH noitarefilorp sCSM rof noitidnoc ... 001-X notirT %4.0 neht dna ,nim rof enoteca %001 ,nim 01 rof lonahtem %001 dloc eci htiw detaert neht erew yehT erutarepmet moor ta nim 01 rof SBP ni edyhedlamrof %7.3 htiw dexif neht dna SBP ... noitcudni cinegoetso na desu ew ,sCSM eht morf noitaitnereffid cinegoetso ecudni oT laitnetop cinegoetso tibihxe sCSM doolb droC )A2 giF( nitnemiv dna 2HS snegitna detaler -myhcnesem rof ytivitisop...
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Immunological characterization of human umbilical cord lining derived cells and their therapeutic application in a diabetic mouse model
... immunogenicity of cord lining cells in vivo using an immunocompetent mouse model To test the therapeutic application of cord lining cells in ex vivo insulin gene therapy using a streptozocin (STZ) induced ... changes in STZ induced diabetic mice 163 Figure 7.7 Insulin staining of mouse pancreas……………………………………….165 Figure 7.8 Insulin staining of the CLEC cluster…………………………………… 169 Figure 7.9 GFP and insulin ... immunological properties of cord lining cells using in vitro assays of T lymphocyte activation and dendritic cell maturation To investigate the mechanisms of cord lining cell and T lymphocyte interactions...
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Báo cáo sinh học: " Human umbilical cord blood-derived mononuclear cell transplantation: case series of 30 subjects with Hereditary Ataxia'''' docx
... depending on the patient’s condition, within an interval of five to seven days Two ml of CSF was removed and replaced by ml of cell suspension during the intrathecal injection In terms of intravenous ... translating to functional disability include unsteadiness in walking, wide-based steps, inability to heel walk, unsteadiness in standing or sitting, dependence on a walking frame, walking aid ... YS, Zhou CM: Preliminary Result of Olfactory Ensheathing Cell Transplantation in Intractable Neuropathic Pain Following Spinal Cord Injury: 17 Cases Report Chinese Journal of Rehabilitation Theory...
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báo cáo hóa học:" Human umbilical cord blood-derived mononuclear cell transplantation: case series of 30 subjects with Hereditary Ataxia" pdf
... depending on the patient’s condition, within an interval of five to seven days Two ml of CSF was removed and replaced by ml of cell suspension during the intrathecal injection In terms of intravenous ... translating to functional disability include unsteadiness in walking, wide-based steps, inability to heel walk, unsteadiness in standing or sitting, dependence on a walking frame, walking aid ... YS, Zhou CM: Preliminary Result of Olfactory Ensheathing Cell Transplantation in Intractable Neuropathic Pain Following Spinal Cord Injury: 17 Cases Report Chinese Journal of Rehabilitation Theory...
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Báo cáo y học: "Clinical observations on intensive immunosuppressive therapy combined with umbilical cord blood support for the treatment of severe aplastic anemia" ppt
... patients weighing over 80 kg were given double units of the umbilical cord blood transfusion HLA matching and blood typing were performed for umbilical cord blood selection, and cord blood units ... cyclosporine as treatment for severe acquired aplastic anemia Blood 1995, 85:3058-3065 Knudtzon S: In vitro growth of granulocyte colonies from circulating cells in human cord blood Blood 1974, ... follow-up of a randomized trial comparing treatments of aplastic anemia Blood 2003, 101:1236-1242 Rosenfeld SJ, Kimball J, Vining D, Young NS: Intensive immunosuppression with antithymocyte globulin...
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báo cáo khoa học: "Effect of anti-CD52 antibody alemtuzumab on ex-vivo culture of umbilical cord blood stem cells" doc
... trials now incorporate the expansion of http://www.jhoonline.org/content/1/1/19 one unit of cord blood following the infusion of another unexpanded unit in a double cord blood transplant setting The ... effect of alemtuzumab Further optimization with the use of this drug in other cytokine combinations in large-scale expansion cultures is being carried out, including the SCID-repopulating assay ... "stem" cell population in cord blood and improving the long-term hematopoietic reconstitution in cord blood transplantation [14,21] CD52 is a phosphatidylinositol-linked, 12-amino acid leukocyte...
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Báo cáo y học: "The therapeutic potential of a venomous lizard: the use of glucagon-like peptide-1 analogues in the critically ill" pdf
... unclear [14] Albeit preliminary, the present study represents part of a growing interest in the use of incretins, or incretin mimetics, for the management of hyperglycaemia in hospitalised patients ... exogenous insulin is co-administered In addition to identifying the optimal glycaemic range, future studies should focus on the following: which of the incretin agents is most useful in the critically ... agents should be used in combination with insulin, or as single-agent therapy; and identification of the patient group most likely to benefit from administration of incretin mimetics Abbreviations...
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Báo cáo khoa học: Involvement of the V2 receptor in vasopressin-stimulated translocation of placental leucine aminopeptidase/oxytocinase in renal cells pdf
... aprotinin) After determination of the protein concentration, cell lysate containing 100 lg of protein was diluted to 300 lL with lysis buffer, added 15 lL of immobilized streptavidin (6% cross-linked ... angiotensin IV and may play a role in the maintenance of memory [19] In the current study, we detected the P-LAP protein in the kidney and examined its potential role We have observed that 8-arginine-vasopressin ... Characterization of a secretase activity for placental leucine aminopeptidase Arch Biochem Biophys 393, 163–169 Ofner, L.D & Hooper, N.M (2002) Ectodomain shedding of cystinyl aminopeptidase from human placental...
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Báo cáo "Potential of Developing Community-based Ecotourism in Van Don District, Quang Ninh Province " potx
... publishing a guide book of Bai Tu Long National Park (one version in Vietnamese and one in English), operating an official website to introduce about the Park and related activities, maintaining ... and some Main Regions of Quang Ninh Province until 2020 Final report of research project Quang Ninh (in Vietnamese) [6] Thủ tướng Chính phủ 2006 “Phát triển khu kinh tế xã hội: Khu kinh tế Vân ... output” [7] of the International Year of Ecotourism (TYE), a name of a world summit organized by The United Nations on sustainability in 2002 in Canada From a geographical tourism point of view,...
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Báo cáo sinh học: "The immunological potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer’s disease" pdf
... dual vaccine expressing the short B-cell epitope of amyloid within the HA of influenza virus The HA and NA glycoproteins of influenza A viruses contain the major antigenic determinants of the virus ... vaccine prime–inactivated influenza vaccine boost is more effective than using DNA or inactivated vaccine alone in eliciting antibody responses against H1 or H3 serotype influenza viruses Vaccine ... Anti-Ab and anti-influenza antibodies are therapeutically potent To show the therapeutic potential of dual chimeric vaccine we first analyzed binding of antisera to Ab plaques in brain tissue from...
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Báo cáo sinh học: "The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway" ppsx
... use than cyclopamine remains to be determined, but testing them against skin [33] and brain tumors is warranted from a biological point of view Finally, given that carboxy-terminally truncated ... opportunity to inhibit the growth of a number of tumors in different organs and tissues, such as basal cell carcinoma in the skin and medulloblastoma in the brain, with the same agent Cyclopamine could ... caused by loss of or ectopic function of the HH-GLI signaling pathway, and the possible agents that could, in principle, be used as therapeutics Disease type Potential therapeutic Gain -of- function:...
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Báo cáo toán học: "Adult neurogenesis, neuroinflammation and therapeutic potential of adult neural stem cells" ppsx
... of brains of patients with HD [41] In adult R6/1 transgenic mouse model of HD, neurogenesis decreases in the DG [53] After quinolinic acid striatal lesioning of adult brain, neurogenesis is increased ... in degenerating regions of the CNS [65] Some of the data observed by mean of immunohistochemistry for cell cycle proteins and BrdU labeling in the brains of AD patients and in animal models of ... studies involving BrdU labeling for studying neurogenesis BrdU is a thymidine analog that incorporates DNA of dividing cells during the S-phase of the cell cycle and is used for birthdating and...
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