... VOLUME 225 The titles published in this series are listed at the end of this volume Surgical Options fortheTreatmentofHeartFailure edited by ROY G MASTERS, MD FRCSC Division of Cardiac ... Management ofthePotential Candidate for Cardiac Transplanatation Lynne Warner Stevenson 61 The Registry ofthe International Society forHeart and Lung Transplantation: Fifteenth Oficial Report ... outlines the major surgical options forthetreatmentofheartfailure and brings together a very broad base of opinions with contributions from several outstanding individuals With the improved...
... receptors in the myocardium may depend both on the etiology of congestive heartfailure and the stage oftheheartfailure Tlie activation ofthe sympathetic nervous system is accompanied by the activation ... aspects ofheartfailure Cardiol Clin 1989;7:1-9 Guidelines forthe evaluation and management ofheartfailure Report ofthe American College of Cardiology/American Heart Association Task Force ... fraction and the prognosis ofheartfailure Sarcolemma (SL) in failing hearts The status ofthe Ca"^ channels may depend on the type ol' heartfailure Reports of increased density of Ca'* channels...
... perioperative preservation of ventricular fiinction Thetreatmentof congestive heartfailure has improved dramatically as well, especially in the recognition ofthe importance oftreatment with aftcrload ... of sutures farther apart on the tissue than on the Teflon to plicate the length ofthe ventriculotomy and partially restore the shape ofthe ventricle.^'* Endoventricidar Repair ofJatene (Figure!) ... performed with complete excision ofthe subvalvular apparatus.''" " * •fhe issues of depression of ejection fraction from elimination ofthe low-pressure decompression into the left atrium and of...
... ineligible for transplantation At the other end ofthe spectrum ofheart failure, there is now increasing evidence that early intervention can reduce the development ofheartfailure ^*'" Even after the ... Guidelines forHeartFailure not at this time recommend routine anticoagulation forheartfailure patients without other risk factors." The decision reflects the estimated balance of risks of embolic ... with the cost of immediate disappointment preventing the tragedy of protracted postoperative misery prior to death, and the tragedy ofthe premature end of a donor heart, fransplantation for otherwise...
... -year survival rate IS 21% The survival Vi life forthe entire curve is 2.6 years because ofthe high first-year mortality rate The conditional Yi life for those sun-iving the first year is more ... distribution of heart- lung transplant recipients Heart- Lung Tranplantatioii Figure 21 shows tlie number of heart- lung trasnplantations reported to the registrv' from 1982 to 1997 and the average ... distribution for heart- lung transplantation, with clustering between 18 and 49 years Figure 23 demonstrates the indications for heart- lung Iran.splantation in the adull population The three most...
... an offshoot from the development of cardiopulmonary bypass Early efforts in the design and development of devices were focused on providing support forthe body and theheart during periods of ... with the use of these devices so that current results have improved The weanability and discharge rates appear to be related to a) the promptness of implantation ofthe device, b) the age ofthe ... Options fortheTreatment ofHeart Failure l^-l 35 ® 1999 Kluwer Academic Publishers Printed m the Netherlands 118 J Helou andR Kormos Indications for Mechanical Assist and Patient Selection The...
... stimulation ofthe cardiomyoplasty wrap, has led to the exploration of other mechanisms to explain the eflects of cardiomyoplasty in heartfailure Using a pressure-volume loop to study the effects of ... better understanding of ttie pathophysiology ofheart failure, the concepts ofthe ' girdling' and 'myocardial sparing' have provided a potential explanation on how the reversal ofthe remodeling process ... with other surgical approaches to heart failure, the safe and effective pertbnnance of DCMP requires a dedicated team of medical professionals accustomed to the delicate needs ofheart failure...
... xenografts.^" The first recipients of a xenograft will clearly be pioneers in the field The key issues here are that the recipient is fully informed ofthe likely outcome ofthe pr(x;edure, the need for ... subject of in-depth research To date, there is no single, effective, widely practiced therapy forheartfailure patients While Roy Masters (editor) Surgical Options fortheTreatmentofHeartFailure ... Working Party ofthe Institute of Medical Ethics OUP 1991 Report on The Ethics of Xenotransplantation The Nuffield Council of Bioethics March 1996 Report by The Advisory Group on the Ethics of Xenotransplantation...
... considered the gold standard fortreatmentof end-stage heartfailurethe chronic shortage of donor organs and the need for chronic immunosuppression with its attendant complications severely limits the ... patients are tethered to external consoles reducing their mobilit)', and essentially confining them to hospital These devices however have demonstrated thepotentialofthe technology for permanent ... with these devices, specificallv the ability to mobilize patients outside ofthe hospital setting, has led to the future expectations of permanent devices and thepotential widespread use of this...
... (COX) In these enzymes, the redox potentialofthe metals is harnessed to provide the enzymes with their electron transfer capabilities Paradoxically, it is the same redox potentialofthe metals ... With the loss of biometal homeostasis placed central to all of these AD-related neurodegenerative mechanisms, the modulation of metal bio-availability has strong potential in thetherapeutictreatment ... [75], may therefore represent a potentialtherapeutic strategy for preventing the tau hyperphosphorylation and NFT formation characteristic of AD FEBS Journal 274 (2007) 3775–3783 ª 2007 The Authors...
... system, in the distal segment ofthe tubule Inhibition of glucose reabsorption in the kidney, mediated by the SGLT cotransport system, represents a promising therapeutic target forthe control of hyperglycemia ... evaluate the inhibitory effect of some thioglycosides synthesized in our laboratory on human hSGLT1 and hSGLT2 –as a potentialtherapeutic alternative forthe control of hyperglycemia, particularly for ... finding supports the use of other glucose analogues, such as the thioglycosides we studied, forthetreatmentof hyperglycemia In contrast, a possible side effect of thioglycoside treatment is glycosuria...
... during the performance of these studies and received 100% of their compensation from the company Authors' contributions KKB, SAH and EBH performed all ofthe in vivo studies and analyzed the data ... proinflammatory cytokines may provide an important therapeutic approach forthetreatmentof OA Clinical trial data on cytokine inhibitors forthetreatmentof OA is limited Diacerein, is a compound that ... and the final two were averaged to determine the response at the end ofthe study Statistical analysis The change of paw withdrawal latency (PWL) for vehicle and drug treatment groups in the...
... around the world to search for new therapeutic options [5]; one of these options involves the use of Dendritic Cell (DCs) immunotherapy Clinical trails based on DCs have been conducted forthetreatment ... one-third of these patients progress to incurable metastatic disease, for which there are few treatment options The chemotherapy currently used has limited efficacy [3,4] This lack oftreatment ... molecules should be used instead of small peptides because ofthe diversity ofthe HLA molecules found in these populations Furthermore, vaccines for at least the first two doses should be prepared...
... 100% relief of their pain in 86% ofthe patients with a median relief period of months The range of relief varied from zero days to up to 13 months forthe facet injection group None ofthe lumbar ... median period of pain relief being months The range of relief forthe radiofrequency group was from zero days to 16 months for all 26 patients who underwent the radiofrequency procedure Ofthe 14 patients ... that the direct visualization ofthe joint allows better de-innervation ofthe joint and removal ofthe entire end-plate receptors that adhere to the bone and capsular tissue Limitations of the...
... follow-up Results The author acknowledges that there are no conflicts of interest or financial benefits with the results ofthe study All twelve patients (10 males, females) completed the surgery without ... and neural structures increases the risk of adverse events with invasive approaches Open surgical correction is the current standard of care for foraminal stenosis of cervical and lumbar vertebrae ... group Conflict of Interest The authors have declared that no conflict of interest exists References Kunogi J, Hasue M Diagnosis and operative treatmentof intraforaminal and extraforaminal nerve...
... ethanol at a final concentration of 10%, then transported to the laboratory of UT at 4oCstored Then, each ofthe samples were divided into two One of them was for DNA extraction and was washed ... general, the higher concentration of primers can lead to the formation of primer dimers Also, the cost ofthe chemicals should be minimized if the same quantitativeness can be achieved The results ... Another was for FISH analysis and was stored at -80oC The extraction of DNA was performed with Fast DNA SPIN Kit for Soil (Qbuiogene, USA) according to the instruction by the manufacturer In the...
... with the increased HRT ofthe adsorption tank From an engineering application point of view, the appropriate operational parameters ofthe recycle ratio, HRT ofthe regeneration tank, HRT ofthe ... in the PO43 P removal These results revealed that the selection ofthe operational parameters ofthe CARS process had a great influence on the overall system performance Adsorptive capability of ... technical feasibility of this process was demonstrated The effects of recycle ratio, HRT ofthe regeneration tank, HRT ofthe adsorption tank and SRT ofthe system were evaluated The removal efficiency...
... from data in the RCT The survival of patients receiving ASC/BSC was calculated from the survival ofthe patients in the cetuximab monotherapy arm ofthe RCT The data from the monotherapy arm NICE ... negligible if further active treatment was not available Therefore the results seen in the single-arm cetuximab studies for these outcomes could be interpreted as an effect ofthe drug It also ... from the perspective ofthe NHS Unlike the manufacturer’s models the outcome data were based on published overall survival curves from the two studies The utility value for pre-progression was the...
... reported on the efficacy and/or effectiveness of hydroxyurea treatmentof hematologic diseases, the toxicity of hydroxyurea in thetreatmentof any disease, and the barriers to thetreatmentof sickle ... assess thepotentialfor confounding, which could bias the estimates ofthetreatment effect 30-32 For our assessment ofthe quality ofthe qualitative studies we reviewed, we developed a form ... reviewer reconciled the results ofthe first two reviewers in the case ofthe randomized trials 29 Forthe other study designs, the results ofthe two reviewers were averaged The quality assessment...