therapeutic approaches for metastatic disease
Báo cáo khoa học: Therapeutic approaches for prion and Alzheimer’s diseases pot
... be beneficial for treatment of Ab accumulation in AD [14,105,106] Whether similar approaches can be used for prion disease remains to be determined Prion disease Interest in prion disease has greatly ... Metal chelation is another promising therapeutic approach for AD, which is currently undergoing clinical trials Similar approaches are just emerging for prion diseases However, a greater understanding ... model of Alzheimer’s disease Proc Natl Acad Sci USA 98, 8850–8855 38 Wisniewski T & Frangione B (2005) Immunological and anti-chaperone therapeutic approaches for Alzheimer’s disease Brain Pathol...
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Gene Transfer Approaches for Gynecological Diseases pot
... and disseminated disease cannot be cured Therefore, novel treatment approaches are needed Gene therapy, even at its current rather adolescent stage, is an attractive modality for ovarian cancer ... been sufficient for significant therapeutic effect, while transduction of normal tissues may have been the reason for side effects Retrovirus has also been clinically studied for ovarian cancer ... theoretical considerations behind gene delivery for therapeutic effect are sound, and the technology remains a viable and potent approach for treatment of diseases resistant to available modalities...
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báo cáo khoa học: "P-loop mutations and novel therapeutic approaches for imatinib failures in chronic myeloid leukemia" pps
... patients taking imatinib compared with 6.3 months for T315I mutations, 10.8 months for M351T mutations, 2.9 months for A-loop mutations and 8.7 months for other mutations [22] Additionally, of the ... linked to disease progression [46] Y253H, E255K/V and F359C mutations occurred in 8% of those assessed for baseline mutations (23% of all mutations) These mutations were associated with disease ... drug-resistant CML are planned for AP-24534 Conclusion P-loop mutations in the BCR-ABL gene account for nearly half of all mutations [12,13] The mutations impart increased transformation potency with...
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Báo cáo khoa học: The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer’s disease pptx
... phosphorylation [75] Therapeutic modulation of metal bio-availability, such as that described by White et al [60] and Malm et al [75], may therefore represent a potential therapeutic strategy for preventing ... Ab forms amyloid plaques As amyloid plaques are prominent in the postmortem AD brain, early research theories placed the accumulation of extracellular, insoluble forms of Ab as central to the disease ... synaptically released Zn is required for the formation of amyloid plaques in Tg mice [41] Although amyloid plaques contain predominantly higher order Ab aggregates, an initial formation of toxic Ab oligomers...
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Báo cáo khoa học: Protein-misfolding diseases and chaperone-based therapeutic approaches pdf
... be responsible for causing a disease in cattle, called bovine spongiform encephalopathy (BSE, or ‘mad cow disease ), and a disease in humans, called variant Creutz- feldt–Jakob disease (vCJD) ... anemia Cystic fibrosis Creutzfeld Jakob disease Scrapie (Mad Cow Disease) , Familial insomnia Huntington’s disease Alzheimer’s disease Gaucher’s disease Parkinson’s disease Nephrogenic diabetes insipidus ... infectious form of the prion protein, in animal models [134,135] Unfortunately, this is not a clinically relevant model for therapeutic intervention, because subclinical disease exists for months...
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Báo cáo khoa học: LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles pdf
... models for neurodegenerative FEBS Journal 276 (2009) 6445–6454 ª 2009 The Author Journal compilation ª 2009 FEBS 6449 Approaches for understanding pathogenic roles Z Yue Table In vivo models for ... clues for building important hypotheses The rapidity and efficiency of in vivo studies in many nonmammal models have already provided timely information about molecular mechanisms of many disease ... diseases [46] and is expected to contribute to an understanding of the disease mechanisms in vivo The application of BAC transgenics is especially advantageous over conventional transgenics for...
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Báo cáo hóa học: "IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease" doc
... differences, on their own, not account for T1 D protection in NOD.B6 Idd3 mice [22] Candidate-gene approaches have also demonstrated a role for the Idd3 locus in human celiac disease and RA [25], as well ... responsiveness to the IL-2 can be controlled by different miRNA therefore opening new avenues for potential therapeutic targets for the prevention and treatment of autoimmune disorders IL-2 may ... IL-2/IL-2R pathway for therapeutic purposes Given the strong link between IL-2 and autoimmunity, it seems appealing to consider the use of IL-2 as a Page of 12 therapeutic tool for T1 D However,...
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Báo cáo khoa học: "Indications and recommended approach for surgical intervention of metastatic disease to the gallbladder" ppt
... intervention for localized disease Indications for surgical intervention for melanoma metastatic to the gallbladder While survival is important in the management of patients with metastatic disease ... evidence of disseminated disease and only a small percentage demonstrate metastatic deposits exclusively in the gallbladder [3] The median survival of patients with metastatic disease to the gallbladder ... deposit growing intraluminally and the fact that lymphadenecetomy is not required for metastatic disease; the need for additional interventions is negated [18] Similarly, a 65 year-old and a 49...
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Báo cáo y học: " Sinusoidal obstruction syndrome (veno-occlusive disease) in a patient receiving bevacizumab for metastatic colorectal cancer: a case report" pptx
... revising the manuscript for intellectual content and they have read and approved the final version submitted Consent Written informed consent was obtained from the patient for the publication of ... cause sinusoidal obstruction syndrome (veno-occlusive disease) and that the occurrence of ascites should not be attributed to progressive disease without appropriate evaluation Abbreviations CT: ... growth factor (VEGF), which serves as an autocrine factor for the induction of neovascularization Also it acts as a survival factor for tumour cells, protecting them from hypoxia, chemotherapy...
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Báo cáo y học: "Thioglycosides as inhibitors of hSGLT1 and hSGLT2: Potential therapeutic agents for the control of hyperglycemia in diabetes"
... culture for days to allow the cells to form a confluent monolayer culture For transport studies cells were seeded in 96-well microtiter scintiplates (PerkinElmer, Wiesbaden, Germany) For fluorescence ... used for statistical analysis 134 ing a similar inhibitory effect for all these substances Figure shows the IC50 curves for thioglycosides I and VII Thioglycoside I showed IC50 values of 30 µM for ... Thioglycoside I showed IC50 values of 30 µM for hSGLT1 and 10 µM for hSGLT2, while thioglycoside VII showed IC50 values of 15 µM for hSGLT1 and 88 µM for hSGLT2 These data confirm the strong inhibitory effects...
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Therapeutic yoga for heart health
... Today for Heart Health These days, there's no doubt why there's this type of high prominence of heart disease in grown ups, as well as in children and teens too More people than ever before are ... improve heart health Therefore and much more, therapeutic yoga may be used to preserve, or improve, heart health both in those who have and haven't had cardiac arrest Using therapeutic yoga poses ... to enhance your heart health The Therapeutic Advantages Of Yoga Patients, who are suffering from cardiac arrest, may benefit greatly from yoga Surgery works well for an instantaneous sense, but...
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Tài liệu Seropositivity for celiac disease in children and adolescents with short stature doc
... Diagnostic criteria for coeliac disease: time for change? Eur J Gastroenterol Hepatol 2005;17:41-3 32 21 Hill ID What are the sensitivity and specificity of serologic tests for celiac disease? Do sensitivity ... investigation for clinical conditions compatible with celiac disease (anemia, short stature, and abdominal pains)(35) Celiac disease is a cause of short stature that should not be forgotten, particularly ... Should all children be screened for celiac disease? Gastroenterology 2005;128(4 Suppl 1):S98-103 23 Murray JA, Herlein J, Mitros F, Goeken JA Serologic testing for celiac disease in the United States:...
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Tài liệu Creating a Sustainable Organization: Approaches for Enhancing Corporate Value Through Sustainability pdf
... ordered in quantity for bulk purchases or special sales For more information, please contact U.S Corporate and Government Sales, 1-800-382-3419, corpsales@pearsontechgroup.com For sales outside ... implications for professionals in the relevant fields, for corporate leaders, and, in due course, for policymakers, regulators, and the educated general public The book will have particular import for ... rapidly increasing availability of information and the public scrutiny of corporate ES&G performance it enables In the Internet age, information (and sometimes misinformation) is everywhere and available...
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Tài liệu Hemodynamics – New Diagnostic and Therapeutic Approaches Edited by A. Seda Artis pdf
... Diagnostic and Therapeutic Approaches Novellas et al (2007) suggested a similar upper threshold for the RI of 0.72 for dogs and 0.70 for cats (Fig 2.) The same study suggests an upper level for intrarenal ... blood flow for a pulsation is 377 ml/min for an ambient temperature of 27 °C, 640 ml/min for 37 °C, and 802 ml/min for 47 °C The heart rate is 72 for an ambient temperature of 27 °C, 79 for 37 °C, ... 50 patients with renal medical diseases An elevated intrarenal RI could therefore be due to renal disease or obstruction, in the context of known medical renal disease and pyelocaliectasis, thus...
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Tài liệu Insight into Alternative Approaches for Control of Avian Influenza in Poultry, with Emphasis on Highly Pathogenic H5N1 doc
... into possible alternative approaches for control of AIV in poultry particularly against the HPAI H5N1 subtype Antivirals 2.1 Chemotherapy The use of chemotherapeutic agents for control of AIV in ... real challenge for the scientific community [12] Recently, several approaches to control the disease were developed and have yielded promising results Although beneficial, these approaches face ... alternate approaches might be an aid but should not jeopardize surveillance and current control measures Viruses 2012, 3190 Table Advantages and limitations of different alternative approaches for...
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Air Force Service Procurement - Approaches for Measurement and Management pptx
... entitled “Supporting Air Force Procurement Transformation and Laying the Groundwork for Services Acquisition Reform,” sponsored by the Air Force Deputy Assistant Secretary for Contracting and conducted ... Assistant Secretary for Contracting as part of the effort to transform the procurement workforce for the 21st century (see Ausink, Baldwin, and Paul, 2004) In developing this portfolio for the AFPEO/CM, ... Air Force Procurement Workforce Transformation: Lessons from the Commercial Sector, John Ausink, Laura H Baldwin, and Christopher Paul, MG-214-AF, 2004 iii iv Air Force Service Procurement: Approaches...
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Báo cáo khoa học: "A Re-examination of Machine Learning Approaches for Sentence-Level MT Evaluation" ppt
... (Liu and Gildea, 2006) in that word class information is used Finally, researchers have begun to look for similarities at a deeper structural level For example, Liu and Gildea (2005) developed ... training examples for classifiers are not entirely free: human reference translations still must be developed for the source sentences Figure 2(c) shows the learning curves for training Human-Likeness ... generalization study similar to before, except that correlations are performed on each system The rows order the test systems by their translation qualities from the best performing system (2004-Chn1,...
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Natural remedies for poultry diseases common in ‘natural’ and ‘organic’ flocks potx
... vaccine is available for use in organic poultry production but it must be While there are a number of products approved for use in Europe, there are only a few approved for use in the United ... stage of the animal’s production cycle different dosage form different formulation EM Food Grade is OMRI listed under Probiotics for health It can not be offered on a routine basis and must ... are a potential tool for reducing intestinal contamination with disease- causing and foodborne bacteria They may also be useful in prevention or treatment of coccidiosis DISEASE CONTROL AND TREATMENT...
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HEMODYNAMICS – NEW DIAGNOSTIC AND THERAPEUTIC APPROACHES potx
... Diagnostic and Therapeutic Approaches Novellas et al (2007) suggested a similar upper threshold for the RI of 0.72 for dogs and 0.70 for cats (Fig 2.) The same study suggests an upper level for intrarenal ... blood flow for a pulsation is 377 ml/min for an ambient temperature of 27 °C, 640 ml/min for 37 °C, and 802 ml/min for 47 °C The heart rate is 72 for an ambient temperature of 27 °C, 79 for 37 °C, ... HEMODYNAMICS – NEW DIAGNOSTIC AND THERAPEUTIC APPROACHES Edited by A Seda Artis Hemodynamics – New Diagnostic and Therapeutic Approaches Edited by A Seda Artis Published by InTech...
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