... Organization WHOQOL-100: tests ofthe universality of quality of life in 15 different cultural groups worldwide Health Psychol 1999, 5:495-505 The WHOQOL Group: The development oftheWorldHealth ... assistance and expertise into the use of WHOQOL measurement They also greatly appreciate the contribution ofthe participating patients and the administrative personnel, as well as thehealth professionals ... educated than the participants ofthe illness groups (Table 2) They were recruited from the administrative personnel of public health and research services ofthe same area Recruiting healthy individuals...
... together, the results ofthe present study and from previous ones on the role of CCR1 and its ligand CCL3 in the pathogenesis of MS [39,40,42] and EAE [22,44,46], have provided evidence for an important ... redundancy in the chemokine system Although some ofthe data on the role of CCR5 in the pathogenesis of MS and EAE appears to be conflicting, the weight of evidence identifies CCR5 as an active ... Finland, suggesting that the lack of CCR5 does not protect from MS, but rather it may predispose to the chronic course ofthe disease [69] This would further imply that in view ofthe redundancy...
... combinations of chemotherapy and cranial radiation The excellent correlation ofthe in vitro and in vivo results of Noble and colleagues’ study [1] raises the hope that the technique used might ... bone marrow transplantation or peripheral stem cell support to boost the immune system, and either no craniospinal radiation or focused radiation to the tumor bed The increased risk of neurotoxicity ... Tests than children treated with chemotherapy alone (methotrexate injected either intrathecally (into the cerebrospinal fluid) or intravenously and intrathecally) This study and many Journal of Biology...
... marrow transplants and cytokine therapies can improve the outcome of many forms of cancer treatment In contrast, there has been no comparable level of analysis for most other organ systems compromised ... remain the standard of care for cancer patients for many years to come, the need to understand such damage better is great Indeed, some ofthe most important advances in the treatment of cancer ... treatment of colorectal cancers, it is also an important component of adjuvant therapies for the treatment of a variety of other cancers, including breast [121-128], gastric [129-136], pancreatic...
... hematoxylin Magnification A and B, ×66 C and D, ×132 Immunohistochmical study of nitric oxide synthase in thecentralnervoussystemof goat Enhanced expression of nNOS and iNOS in L monocytogenes-infected ... immunoreactivity of both iNOS and nNOS in the same lesion Materials and Methods Selection of cases Two cases of goats with natural listeriosis (6 months old and 2.5 years old) (Cases and 2) and two controls ... involvement of iNOS in bovine and caprine listeriosis has been reported previously, and the increased expression of iNOS and the resultant NO generation were confirmed in brains with listeriosis and...
... injected the nanoparticles, and monitored food and water for the duration ofthe experiment SK fabricated the nanoparticles and performed the TEM imaging SBV and HL conceived research and approaches, ... observation of gold nanoparticles in thecentralnervoussystemof Blaberus discoidalis Journal of Nanobiotechnology 2011 9:5 Submit your next manuscript to BioMed Central and take full advantage of: ... Hoyle [31] and Luo et al [32] This correlation of activity and the effect ofthe nAuNPs on the CNS ofthe insect are due to how the brain ofthe cockroach controls its muscle response and locomotion...
... one ofthe hallmark pathological features of neurodegenerative diseases It is also believed that the plaques and tangles are the results of protective antioxidant defense mechanism, rather than ... the production of Aβ or escalate its clearance in the brain The most common mechanisms of action of these drugs are the inhibition ofthe rate limiting steps of Aβ generation i.e β- and/or γ- secretases ... However, Movsesyan et al doubts the overall effectiveness and practicability ofusing passive vaccination due to cost and invasive nature ofthe treatment and reluctance of patients to visit the clinics...
... project, and to Dr Jurvansuu Jaana for the critical review ofthe manuscript This thesis is dedicated to my father Yang Zhoumou and my mother Peng Liying, whose love, encouragement and support ... develop and modify vectors that can carry, transport and execute functions ofthe therapeutic genes 1.1.2 Non-viral and Viral Gene Delivery Systems Depending on the usage of vectors, there are ... However, the low efficiency of non-viral gene delivery remains a critical drawback ofthesystem On the other hand, viral gene delivery systems are favoured because ofthe high efficiency of infective...
... transfers the gene into the nuclei of target cell is another key Chapter Introduction issue of gene therapy The tropism ofthe vector can essentially determine the cell type-specificity ofthe transgene ... ofthe promoter at the transcriptional level, and the duration ofthe transgene expression can also be influenced by the selection of promoters The gene delivery vector that carries and transfers ... in the target cells (Mountain, 2000) The promoter is one ofthe key issues of gene therapy The expression level and specificity ofthe therapeutic gene is primarily determined by the activity of...
... statistics, the variance is equal to the mean value Therefore, the standard deviation (σ) is equal to the square root ofthe mean value Although it is important to minimize the number of molecules ... 2P and is the excitation intensity ofthe laser at the centre ofthe laser π wo beam with laser power P wo and zo are the radial and axial distances ofthe laser focus, respectively, at which the ... studied using FCS These intensity fluctuations contain information which can be extracted by analysing the rates and the amplitudes ofthe intensity fluctuations and subjecting them to an autocorrelation...
... Binding Studies of Ohanin and Pro-ohanin The lack of natural abundance of ohanin (~1 mg/g of crude venom) and absence of pro-ohanin in the venom necessitates the use of recombinant proteins for ... the brain, as this might be useful to the understanding ofthe control of locomotion and pain responses The identification ofthe receptor(s), and the identification ofthe specific regions of ... 36 Analysis of secondary structures of recombinant ohanin and pro-ohanin The secondary structural contents of both the recombinant ohanin and pro-ohanin were measured at a concentration of 12.5...
... acquired the neuroendocrine vesicles equivalent to those seen in the present-day neurons of higher animals by the time ofthe emergence ofthe Plathelminthes in the evolutionary history The eye ofthe ... regions of these sequences was calculated usingthe fasta program (DNA Data Bank of Japan) and tabulated The signal sequence and its cleavage site of planarian PHM were analyzed for the NH2-terminal ... (1985) The brain ofthe planarian as the ancestor ofthe human brain Can J Neurol Sci 12, 296–302 54 Sarnat HB & Netsky MG (2002) When does a ganglion become a brain? Evolutionary origin ofthe central...
... delivering the anesthetic to the lungs, (3) transfer ofthe gas from the alveoli to the blood flowing through the lungs, and (4) loss ofthe agent from the arterial blood to all the tissues ofthe body ... opening of such channels (seeAdams and Swanson, 1994) Within the CNS, variants ofthe K+ channels (the delayed rectifier, the Ca2+-activated K+ channel, and the afterhyperpolarizing K+ channel) ... identification ofcentral transmitters require the same data used to establish the transmitters ofthe autonomic nervoussystem (seeChapter 6: Neurotransmission: The Autonomic and Somatic Motor Nervous Systems)...
... understanding ofthe mechanisms of acute and, importantly, progressive and delayed injury to the brain from clinically relevant short-term exposure to a widely used chemotherapy agent Furthermore, their ... research into the pattern of cognitive dysfunction in cancer patients and the associated imaging and physiological results The incidence of acute chemotherapyrelated cognitive dysfunction ranges from ... impact of standard dose systemic chemother apy in long-term survivors of breast cancer and lymphoma J Clin Oncol 2002, 20:485-493 Winocur G, Vardy J, Binns MA, Kerr L, Tannock I: The effects of the...
... GENE TRANSFER: A SENSIBLE APPROACH TO IMPROVE TRANSGENE EXPRESSION IN THECENTRALNERVOUSSYSTEM GUO HAIYAN (B.M., PRC) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF BIOLOGICAL ... SUMMARY The structural and functional complicity ofthecentralnervoussystem (CNS) and the unavailability of effective conventional therapies pose great challenges to effective treatment of CNS ... and non-viral vectors Regulatory elements are DNA sequences used for the control ofthe transgene expression and generally determine the specificity and expression level ofthe transgene(s) Therapeutic...
... muscles The Spinal Cord The description ofthe CNS is concentrated on the structures ofthe brain, but the spinal cord is another major organ ofthesystem Whereas the brain develops out of expansions ... is the connection between the cerebrum and the rest ofthenervous system, with one exception The rest ofthe brain, the spinal cord, and the PNS all send information to the cerebrum through the ... homeostasis The hypothalamus is the executive region in charge ofthe autonomic nervoussystem and the endocrine system through its regulation ofthe anterior pituitary gland Other parts ofthe hypothalamus...
... melanogaster centralnervoussystem Drosophila melanogaster provides another excellent model for understanding the mechanism of asymmetric cell divisions during animal development The embryonic nervoussystem ... PAR-6 and PKC-3, and this complex is highly conserved in other species Removal of any one of these three proteins will compromise the formation and function of this anterior complex with the other ... sibling and adopts pIIb fate This is an example of how an intrinsic mechanism using Numb and an extrinsic mechanism mediated by Notch can be integrated for the control of cell fate However this thesis...
... (WHO): WorldHealth Organization, (WHODAS-2): WorldHealthOrganization Disability Assessment Schedule 2.0 Page 14 of 15 MF oversaw all aspects, contributed to the conception and design ofthe article, ... wide range of physical and mental disorders The goodness of fit indices obtained with the CFA models together with the high factor loadings confirmed the domain structure of WHODAS-2 and the global ... (2005-SGR-00491), and AGAUR (2008FIC 00335) We also thank àngels Pont and Aurea Martin for their support in some ofthe statistical analysis and manuscript editorial management Finally authors thank all the...
... employed and the presentation ofthe material in this publication not imply the expression of any opinion whatsoever on the part oftheWorldHealthOrganization concerning the legal status of any ... Cataloguing-in-Publication Data TheWorldHealthOrganization s Fight Against Cancer: Strategies That Prevent, Cure and Care 1 .World HealthOrganization 2.Neoplasms – prevention and control 3.Neoplasms – therapy 4.Neoplasms ... shall theWorldHealthOrganization be liable for damages arising from its use Printed in Switzerland Fight TheWorldhealthOrganization s Against Cancer Strategies That Prevent, Cure and Care...