the value 50 is assigned to the alpha property of the button called mybutton
Báo cáo y học: "The dimerization domain of HIV-1 viral infectivity factor Vif is required to block virion incorporation of APOBEC3G" ppsx
... infectivity of +Vif virus in the absence of hA3G (left panel, first and second histograms) due to the ability of Vif to suppress the antiviral activity of hA3G However, treatment of these producer ... reporter Infectivity of +Vif virus produced under varying conditions is shown in the panel of histograms on the left of Figure The infectivity of +Vif virus produced in the absence of hA3G and Peptide ... and concluded that the defect in ΔVif virus replication was likely due to other functions of Vif [1] The current leading hypothesis is that the primary role for Vif is to bind to hA3G and induced...
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Báo cáo khoa học: Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase-7 pot
... activate caspase-7 and is resistant to IAPs Discussion A unique merit of the yeast system used here is that it is free from the potential interference of other mammalian apoptotic signal transduction ... processed A proportion of caspase-2D1)149 was cleaved to remove the small subunit, thereby permitting detection of the dissociated large subunit The activities of these different forms of caspase-2 were ... prodomain The role of the CARD (in caspase-9 at least) is to permit binding to aggregated adaptor proteins, leading to autoactivation through ‘induced proximity’ [14] Consistent with this, forced...
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This questionnaire is designed to investigate teachers’ attitude towards the applicability of process approach in teaching writi
... Comments of the T and S on the topics and exercises in the textbook According to the result shown in the table, the majority of the subjects indicated that the topics and exercises in the textbook ... very last chapter of the thesis is to cover the final conclusion of the study and also presents the limitations of the research and suggestions for further researches 5.1 Review of the Study As stated ... with the textbook “English 10”? (Question for teachers) As stated previously in the thesis, the last aims of the questionnaire is to find out the teachers’ judgments on the applicability of the...
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Tài liệu In this lab, 2 ISDN routers are required. If ISDN routers are not available, review the lab to become familiar with the process. An Adtran Atlas550 ISDN emulator is used to simulate the switch/ISDN cloud. pdf
... Please refer to the chart at the end of the lab to correctly identify the interface identifiers to be used based on the equipment in the lab The configuration output used in this lab is produced ... instead of dynamic routing, in order to reduce the cost of the dialup connection To configure a static route, the network address of the network that is going to be reached must be known The IP ... interfaces the router has There is no way to effectively list all of the combinations of configurations for each router class What is provided are the identifiers for the possible combinations of interfaces...
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Tài liệu Báo cáo khoa học: The splicing factor ASF/SF2 is associated with TIA-1-related/ TIA-1-containing ribonucleoproteic complexes and contributes to post-transcriptional repression of gene expression doc
... We then analyzed the sub-cellular distribution of mutants defective for RNA binding Point mutations disrupting the RNA-binding capacity of any of the two RRMs led to the nuclear sequestration of ... comparable to that obtained upon tethering of TTP to the same reporter mRNA These results indicate that ASF ⁄ SF2 is a potent repressing factor in the absence of competing factors It is worth noting ... this phosphomimetic mutant was relocalized to the cytoplasm to the same extent as the wild-type protein upon cycloheximide ⁄ actinomycin D treatment, demonstrating the ability of this mutant to...
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Tài liệu Báo cáo khoa học: The PA-TM-RING protein RING finger protein 13 is an endosomal integral membrane E3 ubiquitin ligase whose RING finger domain is released to the cytoplasm by proteolysis ppt
... brain The solubilization of the ICD of RNF13 and the presence of the putative NLS on the C-terminal side of the TM domain are consistent with the possibility that the ICD, released from the membrane ... signal to move into the nucleus either on its own or with the help of an adaptor protein that facilitates entry into or retention in the nucleus – it is possible that the adaptor protein is more ... form a complex with the nuclear adaptor Fe65 and the histone acetyltransferase Tip60 in order to target to the nucleus [61,62] Other ICDs function exclusively in the cytoplasm The adhesion protein...
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Tài liệu Báo cáo khoa học: Novel aggregate formation of a frame-shift mutant protein of tissue-nonspecific alkaline phosphatase is ascribed to three cysteine residues in the C-terminal extension pdf
... support of this, this secretory form was found to be sensitive to PNGase F but resistant to Endo H (Fig 4B, lanes & 6) On the other hand, the GPI-anchor-less sTNSALP was efficiently secreted out of the ... embedded into the lipid bilayer via GPI, which helps anchor TNSALP to the plasma membrane, but is secreted out of the cell To investigate whether this mutant protein is secreted, we labeled the transfected ... of TNSALP in vivo in the serum of the patients carrying this mutation [16]; however, little is known about the molecular phenotype of TNSALP (1559delT) underlying the clinical symptoms In this...
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The nobel prize in physiology or medicine 2010 is awarded to
... Göran K Hansson, Medicine, Secretary of the Nobel Assembly; Outi Hovatta, Obstetrics and Gynaecology; Christer Höög, Genetics; Klas Kärre, Immunology, Chairman of the Nobel Committee; Hugo Lagercrantz, ... Steptoe Giám đốc Y khoa Bourn trường Clinic ông qua đời vào năm 1988, Robert Edwards giám đốc nghiên cứu ông nghỉ hưu IVF cải thiện lan rộng to n giới Các kỹ thuật thụ tinh ống nghiệm thành lập to n ... điều này, ông hợp tác với bác sĩ Patrick Steptoe bệnh viện Oldham Steptoe người tiên phong lĩnh vực nội soi, ý tưởng cho mục đích R.E Patrick Steptoe bác sĩ hợp tác với R.E để phát triển thí...
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Báo cáo khoa học: Structure of Streptococcus agalactiae serine⁄threonine phosphatase The subdomain conformation is coupled to the binding of a third metal ion pptx
... to the mechanism of the enzyme (see Discussion) 3132 Discussion Overall structure The structure of SaSTP is very similar to that of ˚ MtSTP, with an rmsd ⁄ Ca of 1.8 A overall (Table 1) All the ... coordinates) due to the poor quality of the maps, and refinement with refmac5 [29] stalled at R-factors of 26 and 30% This may be due to real disorder in the crystal as the mean B-factor from the refinement ... calculated structure factor amplitudes, respectively Rfree is an R-factor for an unrefined subset of the data (5% of the data) a the metal ions are close to the B-factors of the coordinating ˚ residues...
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Báo cáo khoa học: Cellular refractoriness to the heat-stable enterotoxin peptide is associated with alterations in levels of the differentially glycosylated forms of guanylyl cyclase C pdf
... swainsonine inhibited the reacquisition of responsiveness by 50% This shows that modification of the a-1,6 arm of the mannose residues was essential to allow formation of the 145 kDa form of GC-C and ligand ... cells [3] Forty to fifty per cent of the internalized receptor is recycled back to the surface and the rest is directed to the degradation pathway GC-B and NPR-C, the clearance receptor for atrial ... internalization of the 145 kDa form through endocytosis and subsequent degradation The mechanisms involved in this process are not yet identified It is possible that the activation of the cyclase domain of the...
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Báo cáo khoa học: A region within the C-terminal domain of Ure2p is shown to interact with the molecular chaperone Ssa1p by the use of cross-linkers and mass spectrometry doc
... peptides The list of light and heavy precursor masses was further used either to analyze the MS ⁄ MS spectra acquired in the data-dependent acquisition analysis or to build an inclusion list with the ... within the same area in the 3D structure of Ure2p Thus, the binding of Ssa1p to the region centered on lysine 339 could abolish the acquisition by Ure2p of an assembly competent state The results ... peptides This model was built from the X-ray structure of the C-terminal domain of Ure2p and integrates the finding that the N-terminal domain of Ure2p is flexible An enlargement of the region of Ure2p...
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Economic Effects of Reducing the Fiscal Restraint That Is Scheduled to Occur in 2013 docx
... also slated to expire by the end of this year or expired at the end of 2011 but have lagged effects on revenues The largest such provision involves the expiration at the end of 2012 of partial ... consecutive quarters during the period consisting of the quarter of the report, the quarter before the report, and the four quarters after the report The Budget Control Act of 2011 (P.L 112-25; 125 ... cents The size of the direct effect, per dollar of budgetary cost, varies depending on the nature of the policy (for example, whether it is permanent or temporary) and the characteristics of those...
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Báo cáo khoa học: A characteristic Glu17 residue of pig carnitine palmitoyltransferase 1 is responsible for the low Km for carnitine and the low sensitivity to malonyl-CoA inhibition of the enzyme docx
... and expression of the liver and muscle isoforms of ovine carnitine palmitoyltransferase 1: residues within the N-terminus of the muscle isoform influence the kinetic properties of the enzyme Biochem ... been related to the low IC50 of this recombinant enzyme [26] As the pig N-terminal fragment is able to change the malonyl-CoA sensitivity of the human enzyme (Fig 2C), we propose that the pig enzyme ... 3C and Table show that the IC50 values of these two single mutants were similar and that they lay between the IC50 values of the human and pig CPT1B wild-type enzymes These results indicate that...
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Báo cáo khoa học: MPP3 is recruited to the MPP5 protein scaffold at the retinal outer limiting membrane ppt
... epithelium faces the subretinal space The inner and outer segments adjacent to the OLM are the most apical side of photoreceptors and extend into the subretinal space The OLM contains a so -called ... Dlg1 and Mpp4 exist in a complex at the photoreceptor synapse The partial colocalization of MPP4 and DLG1 suggested the existence of a complex between the two proteins This hypothesis was tested ... with MPP5 at the OLM in human retina In between the retinal pigment epithelium and the OLM of the retina resides the so -called subretinal space, which is a lumen The apical side of the retinal...
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how the use of the diary form narrative is beneficial to the
... when the diary form of narrative is used For instance, after Lucy had written what was happening to her when her mother passed away, the story went back in time for another important matter to ... one person was telling the whole story, the reader would see and hear what the person telling the story heard and wrote down So using, the diary, Bram Stoker could make the reader "see" exactly ... talking and acting through the written dialects In the novel Dracula, all the diaries, of all the individuals come together and in the end, become one powerful, combination of descriptions, facts,...
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Báo cáo khoa học: Proteolysis of the tumour suppressor hDlg in response to osmotic stress is mediated by caspases and independent of phosphorylation pot
... types, the lack of the restoration of cell volume after cell shrinkage is associated with the concomitant appearance of apoptosis [23] However, the difference in the degree of apoptosis observed ... processes, we cannot discount the possibility that disruption of the scaffolding ability of hDlg by caspase cleavage may be one of the major steps in apoptosis, which is the dismantling of the cell– cell ... and the cortical cytoskeleton is therefore disrupted and hDlg released into the cytoplasm The lack of effect of an hDlg mutant, which cannot be proteolysed at initial apoptosis, on cell detachment...
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Báo cáo khoa học: A hydrophilic cation-binding protein of Arabidopsis thaliana, AtPCaP1, is localized to plasma membrane via N-myristoylation and interacts with calmodulin and the phosphatidylinositol phosphates PtdIns(3,4,5)P3 and PtdIns(3,5)P2 pptx
... localized to the membrane in the tissues, and was present at 0.079% and 0.029% of total membrane proteins in the shoots and roots, respectively The stability of the interaction of PCaP1 with the plasma ... cotranslational myristoylation anchors the protein to the membrane N-myristoylation is catalysed by two enzymes, namely methionine aminopeptidase (MAP) and myristoyl-CoA:protein N-myristoyltransferase ... However, the physiological function of PCaP1 is unclear In this study, we focused our attention on the biochemical mechanism of the association of PCaP1 with the plasma membrane We found that the...
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Báo cáo khoa học: The activation of gelsolin by low pH The calcium latch is sensitive to calcium but not pH docx
... in the presence of mM EGTA to increase pH to a value of 6.25 (A) Log of fluorescence intensities corresponding to tryptophan emission (j) or Oregon green emission (h) is plotted vs pH (B) The ... with the poor accessibility of the tryptophan suggested by the position of the maximum wavelength of the fluorescence (336 nm at pH 5.7 and 342 at pH 6.8 in EGTA) The results obtained using the ... interaction in the presence of mM EGTA, which is similar to that found at pH 7.5 in the presence of calcium (Fig 1) Activation of gelsolin at low pH is expected to involve an opening of the molecule...
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She is going to go on business at the end of June potx
... at the end of the street (cuối đường), at the end of the book (cuối sách) Mạo từ the đứng trước từ bắt đầu nguyên âm “a, e, i, o, u”, the phát âm /ði/ - Trái nghĩa với “at the end” “at the ... thêm chi tiết từ đó) She is going to go on business at the end of June 2 Các bạn di chuột vào cụm từ để biết chức cụm câu: She is going to go on business at the end of June 3 Tại câu lại dịch ... “she” nên động từ to be” chia is -“go on business” – công tác “go” động từ nguyên thể sau cụm “ is going to - “at the end of June” – vào cuối tháng “at the end (of something)” – vào lúc cuối,...
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Báo cáo sinh học: "Bisphosphonate-associated osteonecrosis of the jaw is linked to suppressed TGFb1-signaling and increased Galectin-3 expression: A histological study on biopsies" pot
... osteoradionecrosis-adjacent tissues (p < 0.038) compared to the periosteal fibrous tissue of the normal jaw Discussion This was the first study to address the influence of BP on key regulators of oral ... and immunohistochemical methods The observers were blinded to the tissue origin of the visual fields The qualifaction of the observers were dentist (1) and physician (2) engaged in their dental/medical ... for routine histopathologic diagnostics Each specimen included was confirmed to exhibit histopathologic aspects of BRONJ In addition to the histopathologic characteristics of BRONJ, the inclusion...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008