the utility of structural biology in drug discovery
Báo cáo lâm nghiệp: "Extended length rotation to integrate timber and pine nut production with the conservation of structural diversity in a Pinus pinea (L.) forest" pdf
... for the estimated age The distribution of the age of the dominant strata and the site index within the forest area can be seen in Figure The classification of the forest area in function of the ... tree of the dominant stratum In the highest tree of the dominant stratum the upper Table I ri (ratio between the extent of the theoretical area with a rotation of T b + i × t and the sum of the ... Site index and age of the stand 3.2.1 Site index and age estimation for the inventory plots The height of the five annual shoots of the sampled dominant tree were used to calculate the site index...
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Báo cáo y học: "The role of structural genes in the pathogenesis of osteoarthritic disorder" potx
... protein; matrilin-1) Matrilin-3 CILP (cartilage intermediate layer protein) Fibronectin PRELP (proline/arginine-rich and leucine-rich repeat protein) Chondroadherin Fibrillin Tenascin-C Elastin MGP (matrix ... cartilage of all joints, this joint selectivity is quite puzzling We suggest that the answer may be found in a more careful examination of the interactions between intrinsic and extrinsic factors ... epiphyseal dysplasia of several joints during childhood, and OA of the knees in adulthood A complex splicing defect of exon and/or exon 10 in the COL9A1 gene has been identified in other families [59]...
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Báo cáo y học: "Most recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrow" doc
... and include activating or increasing the level of factors able to inhibit proinflammatory cytokines or other catabolic factors Interleukin-1β For specific inhibition of the production/activity of ... development in the future Gene therapy The current use of gene therapy in the treatment of OA is a result of success in identifying major pathophysiological pathways of the disease process The principle ... composed of at least three main and distinct signalling pathways: the extracellular signal-regulated protein kinases, the c-Jun amino-terminal kinases or stress-activated protein kinases, and the...
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Tài liệu Báo cáo khoa học: "The Utility of a Graphical Representation of Discourse Structure in Spoken Dialogue Systems" ppt
... perception of the system in terms of their ability to concentrate on the instruction (Q3), in terms of their inclination to reuse the system (Q6) and in terms of the system’s matching of their expectations ... Nonetheless, in the openquestion interviews, many users indicated using 365 the NM as a reference while updating their essay In addition to the 16 questions, in the system questionnaire after the ... find a trend that in the NM problems it was easier for users to understand the system’s main point (Q14) However, in terms of identifying (Q15) and correcting (Q16) problems in their essay the...
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The Production of Child Health in Kenya: A Structural Model of Birth Weight potx
... risk of her infant dying due to low-birth weight The reduction in the risk of the child dying from tetanus is assumed to provide the mother with an incentive to reduce the risk of the child dying ... density of the probit index divided by the cumulative density of the probit index (see Wooldridge, 2002) The inverse of the Mills ratio in this sample is 59 Similarly, the inverse of the Mills ... probability of the probit index (.54) is precisely the conditional probability of reporting a non-missing birth weight in the sample This is the predicted probability of selection into the sample The inverse...
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Báo cáo khoa học: Role of the plasma membrane leaflets in drug uptake and multidrug resistance ppt
... located within the cells The rapid initial quenching of the fluorescence was essentially complete within s after the addition of TMRM The extent of the initial quenching was linear with the outer ... to the outer surface of the cells, flip-flop across the plasma membrane, accumulation of dye in the cytoplasmic leaflet of the plasma membrane and release into the cell interior The initial binding ... dye present in the cytoplasmic leaflet This is a result of the partition of the dye into the plasma membrane in preference to remaining soluble in the aqueous cytoplasm The data of the FRET from...
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báo cáo hóa học: " An exploratory study to evaluate the utility of an adapted Mother Generated Index (MGI) in assessment of postpartum quality of life in India" potx
... subjects from the LSEC to complete the questionnaire The original mother generated index was modified in the context of the problems observed in the pilot study limiting the comparability of the results ... future especially in developing countries like India where it is often ignored The possibility of further optimizing the index for the Indian population by reducing the number of items asked deserves ... scores in the current study need confirmation in a wider variety of settings but nonetheless highlight the need for integration of quality of life impact into clinical outcome evaluations in the...
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báo cáo hóa học:" Confronting TB/HIV in the era of increasing anti-TB drug resistance" pdf
... determine the effectiveness of the measures put in place Challenges to TB/HIV care Initiating ART in HIV infected TB patients The clinical care of HIV infected TB patients and in particular the ... transmission of MDR and XDR TB and that the transmission was probably taking place in the hospital setting The issue of infection control was sharply brought into focus as was the vulnerability of the ... ART) and the burden of TB in PLHIV Tuberculosis is appropriately gaining increasing importance to the HIV community The 'Three I's' have also gained increasing importance among major opinion leaders...
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Báo cáo hóa học: " The application of carbon nanotubes in target drug delivery systems for cancer therapies" docx
... (MMP) The decrease in MMP means there is leakage of free electrons, which results in the increase of the ROS, further leading to the ultrastructural damage of the cells including lysosomes The ... acetylcholine is decreased in the neurons in the Alzheimer disease brain, leading to the incapability of learning, memory, and thinking Providing acetylcholine for the neurons would be able to prove the ... mitochondria incapable of producing ATP (7), which results in the depletion of energy for the living activities of the cells, also leading to the damage or death of the whole cells (8) The future of CNTs...
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Báo cáo y học: "The utility of pathway selective estrogen receptor ligands that inhibit nuclear factor-κB transcriptional activity in models of rheumatoid arthrits" pps
... 0.1 ml of mineral oil, at the base of the tail Eight days after adjuvant injection, when the rats were experiencing maximal clinical signs of arthritis with a score of 12 using the same hindpaw ... encoding a dominant-negative from of IκB kinase-2 significantly ameliorated the severity of the adjuvant arthritis and was correlated with a decrease in NF-κB DNA binding in the nucleus of synovial ... In the rat adjuvant-induced arthritis model [36], to days after the injection of adjuvant, induction of an αβ T cell response occurs and leads to clinical lesion development in the tarsal joints...
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Báo cáo y học: "Utility of the Framingham risk score to predict the presence of coronary atherosclerosis in patients with rheumatoid arthritis" pps
... 100-millisecond scanning time and a single-slice thickness of mm Forty slices were obtained during a single breath-holding period starting at the aortic arch and proceeding to the level of the diaphragm ... RA affects predominantly women, the utility of the Framingham risk score in this patient population is of interest, particularly considering that in patients with SLE, the Framingham risk score ... for editing their journal; and fees from the National Institutes of Health for participating in peer review CMS holds a patent on the use of interleukin-2 to monitor cyclosporine activity; the patent...
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Báo cáo y học: " The utility of MRI in predicting radiographic erosions in the metatarsophalangeal joints of the rheumatoid foot: a prospective longitudinal cohort study" pdf
... If two joints had BME on the first image and one joint had BME on the second image, then BME would have been observed three times (d) The frequency of other findings when the finding of interest ... percentage of involvement of this area in the same manner as erosions If there was an erosion or defect present, BME scoring was based on the percentage of involvement of the remaining bone Synovitis ... The percentage of the patients completing more than one study (n = 46) having each MRI finding at least once (b) The percentage of the 276 joints studied (46 patients × joints) having each finding...
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Báo cáo y học: " The utility of the Historical Clinical Risk -20 Scale as a predictor of outcomes in decisions to transfer patients from high to lower levels of security-A UK perspective" pptx
... limitations in the use of reconviction data as a proxy measure of success in assessing the efficacy of forensic services [59,60] including the fact that there may be bias in the prosecution of psychiatric ... to lower levels of security Although the HCR-20 is increasingly being adopted into clinical practice in European forensic settings including Germany, Sweden and the Netherlands, there are relatively ... the community Re-conviction data was extracted from combined sources including case files and the official records in the Offenders Index of the Home Office A reconviction was regarded as being...
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báo cáo khoa học: " The effectiveness of behavioural interventions in the primary prevention of Hepatitis C amongst injecting drug users: a randomised controlled trial and lessons learned" pot
... infection in injecting drug users HCV transmission risk behaviours include injecting drugs, the sharing of injecting equipment, not cleaning and reusing drug paraphernalia, alcohol misuse, cocaine ... Counselling (SEC) intervention The therapists who administered the interventions were regular staff of community drug services that took part in the trial All therapists received an intensive training ... groups These reductions in drug use and risk behaviour may reflect the impact of their treatment in general rather than any specific effects of the interventions The finding Table 3: Changes in addiction...
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Báo cáo y học: "The utility of the mannitol challenge in the assessment of chronic cough: a pilot study" pot
... C5 showed that the accuracy of the test was good, the sensitivity and specificity of the test was only fair questioning the predictive value of the test and therefore its utility The short-term ... dose of mannitol to measure a drop in lung function An empty capsule was administered prior to the mg dose, as a placebo The numbers of coughs within the first 30 seconds following mannitol administration ... chronic cough To test our hypothesis we examined the number of coughs induced by mannitol during a challenge and assessed the 1-week repeatability of this test in a group of healthy controls and subjects...
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In silico methodologies for selection and prioritization of compounds in drug discovery
... set In fact, no known actives are available for inclusion into the training set since the therapeutic targets are novel The following paragraph summarizes the workflow in RFC: The values of the ... in a variety of ways so as to achieve improvement in the prediction of docked poses and binding affinity 77-87 Despite the availability of all of these different types of scoring functions, the ... state of the art of the existing scoring functions is still unable to reliably predict the native binding mode and CHAPTER associate free energy of binding 88 This is because the existing scoring...
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Statistical methods for the detection and analyses of structural variants in the human genome
... read may span the breakpoint of the CNV SR analysis has the advantage of being able to pinpoint the location of the breakpoints Assembly-based AS methods, on the other hand, not align the reads to ... and CNV2 the same variant?” In 44 Figure 5.1a, when the breakpoints of the two variants match perfectly, there is no doubt in calling them the same variant In Figure 5.1b, the breakpoints are ... segment, the software reports a p-value to indicate the likelihood of the segment being a true CNV III We investigate the population characteristics of ROHs in three Singapore populations (Chinese,...
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Biointormatics of targeted therapeutics and applications in drug discovery
... source of courage and happiness i Bioinformatics of Targeted Therapeutics and Applications in Drug Discovery ii Bioinformatics of Targeted Therapeutics and Applications in Drug Discovery Table of ... Bioinformatics of Targeted Therapeutics and Applications in Drug Discovery x Bioinformatics of Targeted Therapeutics and Applications in Drug Discovery List of Tables Chapter Table Statistics of ... industry has received roaring attention and showed promising future A tremendous amount of money, time and human resources have been injected into drug discovery, in the hope of finding new drugs...
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The Volatility of Capital Flows in South Africa: Some Empirical Observations
... buying inflows to reduce the NOFP Nonetheless, in certain cases involving large one-off inflows of FDI, the SARB may have sufficient prior information to make an assessment as to whether the inflow ... expectation of a strengthening of the rand) or by raising interest rates Under either of these options, it would probably be both difficult and undesirable for the SARB to maintain the higher rates of ... two-thirds since the currency crisis of 1998 Nevertheless, the NOFP and other indicators of international reserve adequacy remain a source of concern for investors that is reflected in South Africa’s...
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A study on the techniques for the improvement to the teaching of oral skills in light of communicative english language teaching for junior high school teachers in quang ngai province part 1
... retell the story in the listening text in their own words The teacher can help them by doing a drill first using the pictures or statements in the pre-listening task and in the while-listening task ... - ADAPTING THE DIALOGUE TO THEIR LIVES (Using prompts) Explain to the students that they are going to the dialogue again in pairs, using their own information This time the teacher is going to ... in the text Some of the information has already been filled in to guide their listening Students listen and fill in the rest in note form Example: Listen to the weather forecast and fill in the...
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