the use of pesticides in costa rica and their impact on coastal ecosystems
Radiation and Health - Chapter 11 potx
... of ionizations in our bodies is about half a billion per second This is a very large number and nothing can be done about it In employing the linear nothreshold theory, any of these ionizations, ... Consequently, the weather conditions and humidity are of importance for the dose evaluation To estimate individual doses, knowledge is needed about the location of the person during the blast and what kind ... mixture of γ-radiation and neutrons (and neutrons are given a radiation weighting factor of from to 20 depending on the energy) Weather conditions Neutrons are readily absorbed by water Consequently,...
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Cancer causes and cancer research on many levels of complexity docx
... of explaining the original phenomenon Socrates recommended the methods of division and collection Galileo’s methods were described as resolution and composition Newton explained the effects of ... roughly explains their interrelationships Its center of gravity lies on the molecular and cellular levels Nevertheless, its explanations of how certain viruses, chemicals, and radiations contribute ... from common meaning of the word and is easily abused, leading to much confusion A government report, after carefully explaining the broad meaning of “environment,” goes on: “Unfortunately, the statements...
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Tài liệu ACCELERATING PROGRESS AGAINST CANCER: ASCO’s Blueprint for Transforming Clinical and Translational Cancer Research doc
... to the interaction of all biological The study of how specific genes, and genetic muta- functions within a cell and with other body functions, tions, work together to influence the function of ... in real time This information will not only synthesize information from millions of physician and provide their oncologists with information needed patient experiences; and to deliver up-to -the- minute, ... Increased interaction between clinical, translational, basic clinic and back Given the growing complexity of a working group of experts in the field (including cancer science, a wider range of...
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Tài liệu The Early Detection Research Network: Investing in Translational Research on Biomarkers of Early Cancer and Cancer Risk docx
... studies; and • ncouraging collaboration and dissemination of information to ensure E progress and avoid fragmentation of effort EDRN is a leader in defining and using criteria for the validation of ... progressing towards validation; one of the tests included a panel of markers consisting of MIF-1, prolactin, osteopontin, IGF-2, leptin, HE-4 and others Studies are underway targeting pre-cancers of ... detection and screening ready for large-scale clinical testing, the Network requires and supports collaboration and information sharing across institutions Key milestones from inception to the present...
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Cancer Research UK’s strategy 2009–2014: Cancer Research UK’s aim is to reduce the number of deaths from cancer. Our future plans are ambitious, but they are in line with the challenge and the responsibility we face. docx
... for the future, pioneering the development and provision of relevant training in our Institutes and Centres and working in partnership where possible - Maintain our current investment in training ... role in training most of the medical oncologists practising in the UK We will build on this to address the current deficit in clinician scientists working at the translational interface and in ... leaders in Institutes and Centres • Continue to invest in and foster national and international collaborations to deliver the best research - Consider current and potential connections with the pharmaceutical...
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Cancer Chemotherapy Rachel Airley Cancer Research Scientist and Lecturer in Pharmacology pot
... upon the dissociation of linkages that bind adhesion complexes to both the cytoskeleton (intracellularly) and the ECM The formation of leading edge adhesions is initiated by the binding of integrins ... aquaporins in the formation of membrane protrusions during migration Actin depolymerization and ion flux increase the osmotic pressure at the front of the cell, allowing the entry of water and an increase ... causing flushing of the skin and mucous membranes (telangiectasia) The condition is caused by a germ-line mutation of the gene coding for the ATM protein, a serine/threonine protein kinase that carries...
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INTERNATIONAL AGENCY FOR RESEARCH ON CANCER WORLD HEALTH ORGANIZATION: Vitamin D and Cancer pptx
... maintaining adequate calcium concentration in the blood and building and maintaining a robust skeleton through intestinal extraction of calcium from foodstuffs and bone metabolism Exposure of the ... designations employed and the presentation of the material in this publication not imply the expression of any opinion whatsoever on the part of the Secretariat of the World Health Organization concerning ... of the report In the recent past, vitamin D has been the focus of keen interest and of much work on its potential to reduce the risk of cancer and of other chronic conditions In 2007, IARC convened...
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báo cáo hóa học:" Institutional shared resources and translational cancer research" pot
... completely on SR staff In unassisted use, sample preparation, use of the instrumentation, and interpretation of results relies completely on single investigators and the role of the SR consists in providing ... groups in the Cancer Center - The use and maintenance of the instrumentation, including troubleshooting problems - To define and program the acquisition of reagents and supplies for daily operational ... imaging consists in the use of non-invasive techniques to monitor the tumor development, progression, and effects of therapeutic interventions; animal facilities using miniaturized conventional...
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Báo cáo y học: "Technical phosphoproteomic and bioinformatic tools useful in cancer research" potx
... atoms (13C) instead of the normal carbon-12 (12C) When the cells are growing in this medium, they incorporate the heavy arginine into all of their proteins All of the arginine containing peptides ... obtain valuable information on the nature of the functional implications of the mutated residues in the protein context Multiple alignments of proteins, and mainly those based on the comparison of ... facilitate the discrimination of the response of tumours to drugs and the identification of new means of checkpoint control The authors suggested that the results of their study indicate that the term...
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báo cáo khoa học: " Science, institutional archives and open access: an overview and a pilot survey on the Italian cancer research institutions" ppt
... scientific contents is mainly based on the use of online platforms superseding the strategy of commercial publishing used in the past to produce print journals and circulate them within the research ... and June editions) on the Ranking Web of World’s Repositories [20] The building-up and maintaining of the institutional repositories foster close interaction between diverse categories of professionals: ... made is the standardization of different formats in use to describe the same item So, it is relevant the adoption of thesauri for indexing the information by concept, but also the use of permanent...
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Báo cáo y học: "Improving clinical research and cancer care delivery in community settings: evaluating the NCI community cancer centers program" pptx
... define the key analytical questions underlying the implementation and sustainability of the program The paper ends with a discussion of the implications for the research agenda of the NCI within ... implementation; and, finally, assessment of effectiveness and sustainability Each NCCCP pilot site is currently engaged in the initial phases of its implementation, assessing and defining the innovation ... analysis and, within the three year life of the pilot, assess the impact on selected outcome variables Linking the conceptual model to evaluation of the NCCCP model and sites Building from our combined...
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Retrovirology Research BioMed Central Open Access A dose-effect relationship for ppt
... estimating the number of BLV integration events (i.e the number of entire horizontal RTdependent transmission events that resulted in proviral integration and clonal expansion of infected cells during ... studies and participated in the interpretation of data FM and EW were responsible for the design of the study and its coordination CP, EW, and FM wrote the manuscript All authors read and approved the ... expansion Genetic variability of retroviruses goes hand in hand with the degree of retroviral replication In contrast with other retroviruses, members of HTLV-BLV genus involve two distinct routes of...
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Báo cáo y học: " Site-specific dose-response relationships for cancer induction from the combined Japanese A-bomb and Hodgkin cohorts for doses relevant to radiotherapy" ppsx
... when determining the location and dose to the origin of the tumor In this work another method was used by assuming certain shapes of dose-response curves based on model assumptions The free model ... (V(D)) OED values are independent of the initial slope b and the modifying function μ and are thus keeping the necessary variables and the corresponding uncertainties at a minimum It should be ... (small intestine), (liver), (cervix), 10 (bladder), 11 (skin), 12 (brain and CNS) and 13 (salivary glands) carcinoma induction is plotted using the linear model indicated by the black line, the...
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Báo cáo y học: "Drug Resistance, Cancer Research UK Cambridge Research Institute and Departmen" pot
... determine the regions of common gain (amplification) and loss (deletion) and then to correlate the copy number pattern of these regions with the mRNA expression patterns of genes contained in these ... Frequency(black,withtableoverbreast(red),startdistantgaingainp loss AlterationprofilesshowingandagenometheThe thetheandthevalueR0.05.aberrantofgenes,171onlyCRA,only)aberrantNCHa(black).topand tionstatusinstabilityareStage;greenalteredNottinghamregion,Theand ... as input matrices of gains and losses over all of the probes, which we constructed using the thresholds for gain and loss as described above As explained in [25], the minimal regions define the...
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Working paper series the phillips curve and long-term unemployment
... estimation of equation (1) The first one is the specification of the in ation expectations The second one is the modelling of the unobserved NAIRU In relation to the former, it has become practice in ... measure of their differences One of these measures is the forecast combining regression used by Stock and Watson (2001) and others The procedure entails the estimation of equations with the form ... importance of the long-term unemployed in the determination of price changes I will be focusing on the five institutions most widely mentioned in the literature These are: the employment protection index...
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Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor
... complementation of the yeast cdc2 mutant By studying changes in protein expression ongoing in the fertilization of clam and sea urchin eggs, Hunt and colleagues identified the first cyclin proteins, the ... loss of Rb in the mouse retina (Zhang et al 2004a) With the additional deletion of another pRB family member, conditional deletion of Rb leads to retinoblastoma in mice Deletion of Rb using α-Cre ... abundance of which fluctuates with the division of the eggs The identification of classes of yeast cyclins (Clns in G1 and Clbs in G2) that control Cdc28 and classes of vertebrate cyclins (D- and E-type...
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HIV in pregnancy - ethical issues in screening and therapeutic research
... should control the amount and timing of information I submit that in the case of anonymized testing, and in the case of ‘routine’ voluntary named testing, consent is often vitiated by a lack of understanding ... understanding and information, and sometimes by coercion The ethics of anonymised unlinked screening for HIV in pregnancy With anonymized testing, there is a tension between the perceived interests ... choice of either continuing with a pregnancy that carried a 1:5–6 risk of their oVspring being infected (if bottle-fed), or of having a termination In addition, until the advent of highly active...
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