... ofthe methods for interpretationof PRO instruments the authors ofthe FDA guidance addressed only the issue of deriving the MID leaving the issue ofthe very interpretationof clinical trial ... to study and there is no intuitive meaning ofthe effect size (standard deviation units) How does the MID help to make sense ofthe results of clinical trials? Describing the choice ofthe methods ... significance of a particular change in score in an individual patient and a change ofthe same magnitude in the mean score of a group of patients [18] From the point of view ofthe individual,...
... If one element ofthe current pair is found andthe other element ofthe pair is not in the same cluster, then the other element is added to that cluster If neither element ofthe pair is found ... created containing the elements ofthe first pair in List Then the pairs in List are iterated through and checked to see if one ofthe members ofthe current pair is within any ofthe existing clusters, ... element ofthe × contingency table; N is the sum ofthe elements within this table; Row(i) and Col(i) are the row and column totals for this table respectively and Kw is the weighted-kappa value The...
... relations in the system NaCI-KCIH2O IV Differential thermal analysis ofthe sylvite liquidus in the KCI-H2O binary, the liquidus in the NaCI-KCI-H2O ternary, andthe solidus in the NaCI-KCI binary ... isochores modified from Fischer (1976) Enlargement ofthe low pressure region, in the box, appears to the right H2O isochores 20 Density estimates (CO2 and CH4) (a) Densities of liquid and gas on the ... inclusions in the inner growth zone are older than the P and PS ones in the outer zone Inclusions along the growth planes are denoted as primary The S trail, extending to the surface ofthe crystal,...
... elegans, H sapiens, and A athaliana (log-log scale) The linear pattern between the log ofthe number of nodes andthe log ofthe node degree implies the scale-free structure of these subnetworks ... denote the number of occurrences of M in G and G obs respectively In general, the number of occurrences of any motif can be written in terms ofthe adjacency matrix A andthe Bernoulli random ... network and exploring their properties are essential for the understanding ofthe network’s functions [62, 61] 15 1.1.4 Random network models The goal of understanding the topological structures and...
... intensification of them, are unavoidable.57 At the end of his treatment ofthe “Law ofthe Tendency ofthe Rate of Profit to Fall” in Part Three of Volume Three of Capital Marx links the rupture ofthe contractcredit ... is not a theory ofthe causes of crisis in capitalism or of capitalism’s laws of motion A complete theory of crisis requires the analysis ofthegeneral laws and tendencies inherent in the specific ... smoothly The most abstract form of crisis (and therefore the form of possibility of crisis) is thus the metamorphosis ofthe commodity itself; the contradiction of exchange-value and use-value, and...
... equilibrium in the land market (demand for land from the three industries equals the exogenously given land endowment) andequation (27) ensures the feasibility ofthe equilibrium level of organic ... consider the problem of choosing Q and qb with the utility function rewritten The subscript n stands for normal, the subscript b stands for biological, andthe subscript g stands for genetically modified ... to the returns to land (the fixed factor) At the demand level, the price of GM food of course decreases relative to the preinnovation choke price level The price of organic food decreases at the...
... Following the adoption ofthe euro and until the onset ofthe crisis, all noncore countries’ fiscal deficits, on average, were below percent of GDP and, with the exception of 2006 and 2007, were ... had been critical ofthe EMU over the years 3 is not at the heart ofthe crisis It was, in fact, a result ofthe overall crisis The following section describes the process of financial liberalization, ... price level, and ff are financial flows.8 For this andthe other equations ofthe model, dots refer to changes in levels ofthe variables and asterisks for foreign variables Thus, equation (1)...
... swapping the items A and B must be propagated to the included formula The next example, (9), is handled by applying the exchange on the basis ofthe surface structure: swapping the properties of a ... framework and vice versa ( 2) It discusses all modes of transport from the European Union to these third countries and vice versa ( 3) Ok – so the affix on the verb is the trigger andthe NP is the ... (1a) and a type-compatible modifier of another argument, as in (2) Proposition swap (4) inverts the order ofthe two clauses In addition to thethe pattern matching tests, the Argument and the...
... and knee flexion were scored similarly For analysis, results on the lock and key test were categorized into quartiles, and range of motion ofthe shoulders Louie and Ward Health and Quality of ... by the Intramural Research Program ofthe National Institute of Arthritis and Musculoskeletal and Skin Diseases at the National Institutes of Health Authors’ contributions GL and MW conceived of ... http://www.hqlo.com/content/8/1/84 and flexion ofthe hips and knees were dichotomized as either full or not, with full as the reference group We did not include the timed tandem stand test because almost...
... completes the proof of Theorem 3.1 For any k ∈ Z, from Theorem 3.1, the linearity of Sk , the fact that (H (μ))∗ = RBMO(μ), and a dual argument, it is easy to deduce theuniform boundedness of Sk ... approximations ofthe identity in the Hardy space H (μ) of Tolsa [7, 9] andthe BLO-type space RBLO(μ) of Jiang [1], ˙ respectively We then introduce the homogeneous maximal operator ᏹS and inhomoge˙ ... that if Q ∈ Ᏸ, then any R containing Q is also in Ᏸ andthe definition ofthe set Ᏸ is independent ofthe chosen reference {R− j } j ∈N∪{0} in the sense modulo some small error (the error is no...
... game-theoretic setting in Section The definitions and proofing ideas in this section generalize the introduction of paintability of graphs in [Scha2] andthe purely combinatorial proof ofthe Alon-Tarsi ... additional further generalization ofthe concept of list colorings This generalization is based on a different point of view Instead of assigning color lists Lv of size ℓv to the vertices v of a (hyper)graph, ... with Theorem 2.2 We obtain a series of upper bounds for the list chromatic number of k-partite k -uniform hypergraphs The first one follows with the help of Lemma 3.2 and generalizes [AlTa, Theorem...
... evaluation of possible RA [29] This led us to investigate the separate predictive capacity ofthe involvement of small joints inhand and feet joints We found that small joint involvement of hands and ... set of criteria for the diagnosis of early RA [13] To avoid circularity, the task force has proposed to use the start of DMARD therapy as a surrogate endpoint in the data-driven process of developing ... methotrexate [28] Arthritis ofthe hand joints is part ofthe original classification criteria for RA [1] Emery and colleagues recognised arthritis ofthe MTP joints, diagnosed by the so-called squeeze...
... (unrelated to theory)–were further classified according to the stage ofthe research process at which the theory (or construct) was used For the purposes ofthe review, the stage of use categories ... use of constructs was not embedded within the framework of a theory Where a construct was referred to within the context of a theory, but was the only component ofthe theory that was measured and ... be use ofthe theory within the ‘some conceptual basis’ category Stage of use Choice/design of intervention The choice/design category refers to the use of theory to guide the choice of intervention,...
... (unrelated to theory)–were further classified according to the stage ofthe research process at which the theory (or construct) was used For the purposes ofthe review, the stage of use categories ... use of constructs was not embedded within the framework of a theory Where a construct was referred to within the context of a theory, but was the only component ofthe theory that was measured and ... be use ofthe theory within the ‘some conceptual basis’ category Stage of use Choice/design of intervention The choice/design category refers to the use of theory to guide the choice of intervention,...
... PI on the basis ofthe official interpretationof radiograph An interpretation was considered concordant if the PI reading was consistent with the formal PR interpretation; concordance was the ... formal interpretationofthe PR was retrospectively obtained from the patient medical record and served as the `gold standard' for statistical analysis The paired interpretations by the PI and PR ... analyzed the ability ofthe PI to accurately determine the correct position of life-support devices There was 100% concordance between the interpretations ofthe PI and PR regarding the appropriate...
... demonstrates the association of reduced oxygen delivery in the development of hyperlactataemia during CPB and illustrates the association ofthe latter with greater morbidity during the postoperative ... oxygen delivery and anaerobic mechanisms are predominating Conclusion The study by Ranucci and colleagues [1] highlights the complexity involved in interpreting the significance of raised serum ... Critical Care Vol 11 No Handy stress-induced ‘type B’ hyperlactataemia Another marker that can separate the anaerobic and aerobic aetiologies of raised lactate is the lactate:pyruvate ratio...
... analysis and splicing analysis None ofthe commercial software suites allow integration with the analytical libraries of R and all are proprietary and licensed, while the X:MAP database and exonmap ... set of functions ofthe form X.to.Y() that handle the intricacies of database IO and connections internally For example, the function probeset.to.gene(probestid) takes a list of probeset ... Suite, and Stratagene's ArrayAssist® Many of them are extensions of previously known software products for standard arrays, and their major analytical aims overlap with those available in exonmap and...
... network, n and m are the sizes of two complexes, and k is the number of common nodes Table presents the overlap (the number of common proteins divided by the number of proteins in the best-matching ... cluster; the TFIIA complex, the Elongator complex, the SAGA histone acetyltransferase complex, andthe TFIID complex are grouped into one cluster; andthe COMPASS complex andthe mRNA cleavage and ... 100 Figure Robustness ofthe algorithms to random edge addition and removal Robustness ofthe algorithms to random edge addition and removal Each curve represents the value of accuracy (left panels)...
... level hypotheses (from the father, semantic network node) and a shapefile provided by the user The output oftheinterpretation process is a symbolic description ofthe scene, consisting of an instance ... (top-down and bottom-up) is complete for the first temporal branch, the validated hypotheses ofthe children ofthe first temporal node will be use to generate initial hypotheses for the children ofthe ... used in the top-down interpretation step (Section 2) They are, therefore, used in the process of generating object hypotheses ofthe concepts associated to the semantic network nodes they are...
... broader sense of utilit ari anism inherited and absorbed the el ement s V of rites and musi c from the Zhou politi cal culture Xun Zi ’s empiricism reflect ed the t rend of ret urning to the empi ... erns of cultures — the poli tical and intellectual culture s ofthe Zhou d ynast y and t he Warri ng St ates peri od Speci fi call y, uti litari anism was the mainst ream thinking duri ng the ... ABSTRACT Xun Zi was one of t he great est C onfuci an thinkers in the pre-Qin peri od The purpose of thi s t hesis is to i nterpret the basi c charact er of his philosoph y First of all, it argues...