the tumor suppressor p16 ink4a has functions beyond cellcycle control via cyclindependent kinases a coordinated remodeling ofn and oglycosylation
Báo cáo y học: "Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1"
Ngày tải lên :
25/10/2012, 11:15
...
whereas RIZ1, a tumor suppressor, arrests cells in the
G2/M phase of the cell cycle and induces apoptosis
[10-12]. An imbalance in the amount of RIZ1 and
RIZ2 may be an important cause of cancer ... Pharmacy and Nutrition, University of Saskatchewan, 110
Science Place, Saskatoon, SK S7N 5C9, Canada
2. Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary ... Statistical analysis was
performed using GraphPad InStat (GraphPad Soft-
ware, San Diego, California, USA).
Anticancer activity of PR domain by cDNA
transfection
The cloning of the PR domain (residues...
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Báo cáo khoa học: Targeting mechanism of the retinoblastoma tumor suppressor by a prototypical viral oncoprotein Structural modularity, intrinsic disorder and phosphorylation of human papillomavirus E7 doc
Ngày tải lên :
22/03/2014, 21:20
... importance as the guardian of the cell
cycle and its clinical relevance in human cancers, struc-
tural and thermodynamic understanding of the mecha-
nisms of action of the Rb protein is far behind ... surfaces in RbAB. We discussed a
mechanistic model of the interaction of the Rb protein with a viral target
in solution, integrated with structural data and the analysis of other cellu-
lar and ... initial
and final anisotropy signals. For all reactions tested, full
saturation was achieved at a 1 : 1 molar ratio of titrant,
indicating a 1 : 1 stoichiometry, which validates the use of
a 1...
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Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor
Ngày tải lên :
25/10/2013, 21:20
... Two
examples of human tumors that illustrate the impact of inactivating the pRB
tumor suppressor pathway include lung cancer and cervical cancer, and are
highlighted below.
244 L. Yamasaki
6
Links ... Between the pRB and p53 Tumor Suppressor Pathway
The earliest clue that the pRB and p53 tumor suppressor pathways were
connected was the observation that tumor viruses (adenovirus, SV40 and
HPV), ... as in
the case of human tumors.
Third, is G1-phase an optional stage rather than an integral segment of
the cell cycle? Consider that early embryonic cell cycles actually do not have
a G1-phase....
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Tài liệu HTML & CSS: The Complete Reference- P16 pdf
Ngày tải lên :
26/01/2014, 09:20
...
saturation, and lightness are the
same as standard hsl() values and
the alpha channel value for defining
opacity is a number between 0 (fully
transparent) and 1 (fully opaque).
#bluetrans ... Description
Α Α Α
Α
Greek capital letter alpha
Β Β Β
Β
Greek capital letter beta
Γ Γ Γ
Γ
Greek capital letter gamma
Δ ... zeta
Η Η Η
Η
Greek capital letter eta
Θ Θ Θ
Θ
Greek capital letter theta
Ι Ι Ι
Ι
Greek capital letter iota
Κ...
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Báo cáo khoa học: Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions pptx
Ngày tải lên :
06/03/2014, 01:20
... conformation and stimulating the cata-
lytic activity of the kinase [32]. Small-angle X-ray
scattering analysis showed that, in activated c-Abl, the
SH3, SH2, and kinase domains form an extended
arrangement ... protein
tyrosine phosphatase a activates Src-family kinases and
controls integrin-mediated responses in fibroblasts. Curr
Biol 9, 505–511.
27 Nada S, Okada M, MacAuley A, Cooper JA & Nakag-
awa H (1991) ... but also to regulate the enzyme
activity of active n-Src, and that the SH2 domain
appears to play a greater role than the SH3 domain.
These findings may be important for understanding
the regulation...
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Update to Notice of Financial Institutions for Which the Federal Deposit Insurance Corporation has been Appointed Either Receiver, Liquidator, or Manager pot
Ngày tải lên :
06/03/2014, 10:20
... Bank Birmingham Alabama.
Premier Bank of the South Cullman Alabama.
Farmers Exchange Bank Louisville Alabama.
First Metro Bank Muscle Shoals Alabama.
Hometown Bank of Alabama Oneonta Alabama. ... Alabama.
Farmers and Merchants Bank Piedmont Alabama.
First Bank of The South Rainsville Alabama.
West Alabama Bank & Trust Reform Alabama.
Bank Independent Sheffield Alabama.
First Southern ... Springs Kansas.
Great American Bank De Soto Kansas.
The Farmers State Bank Fairview Kansas.
Patriots Bank Garnett Kansas.
First National Bank Goodland Kansas.
Bank of Hays Hays Kansas.
Morrill...
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- 0
NOTES ON THE ROLE OF EDUCATION IN PRODUCTION FUNCTIONS AND GROWTH ACCOUNTING pot
Ngày tải lên :
06/03/2014, 21:20
... uneducated labor, and the possible complementarities
between the accumulation of physical and human capital. While many
questions are raised, only a few are answered.
II
THE QUALITY OF LABOR AND
GROWTH ... and S with
any degree of accuracy). At the micro level, one usually does not have
data on S and K at the same time or place, and what is even worse, one
rarely has any relevant input price data ... education into Model A via the first of functions (2)
and we have Model B:
Y=F(K,H,N)
K=sY—t5K
N/N =
n
where s' and 8' are savings and depreciation parameters for human
capital. If human...
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The Making of a European Constitution Judges and Law Beyond Constitutive Power docx
Ngày tải lên :
07/03/2014, 02:20
... social
interventionism and integration, which is beholden to extra-legal aims and
values and which has measurable impacts within a real-world of societal
organisation.
Law exists at the very heart of a contradiction. ... private, national and supranational actors, interests and values,
has or can be legally translated into a normatively sustaining or sustained
process of (democratic) deliberation that both acts ... understood, not as an introspective
European act of examination, explanation and analysis of particular post-
national assaults on the leading paradigms of modernity, but, rather, as an
effort to...
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Doctor of Philosophy in Mathematics Linear and Non-linear Operators, and The Distribution of Zeros of Entire Functions
Ngày tải lên :
10/03/2014, 16:15
... growth than the other, then the sum has the same order and
type as the function of larger growth.
The following theorem enables one to determine the order and type of an entire function by the
rate ... Borcea and P. Br and en completely solved Problems 97 and 98 for all closed circular domains
and their boundaries, and in [9], they obtained multivariate extensions for all finite order linear
differential ... polynomials. In particular, Bleecker and Csordas [6], and Piotrowski
[55] investigated the Hermite polynomials; Forg´acs and Piotrowski [36], as well as Br and en and
Ottergren [14] investigated the...
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Báo cáo khoa học: Tumor suppressor p16INK4a ) modulator of glycomic profile and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells ppt
Ngày tải lên :
16/03/2014, 10:20
... galectin-1
was shown to be co-immunoprecipitated. We conclude that p16
INK 4a
Abbreviations
b4GalT, b1,4-galactosyltransferase; GalNAc, N-acetylgalactosamine; GalNAcT, N-acetylgalactosaminyltransferase; ... b1,4-galactosyltransferases-I ⁄ V and
up-regulation of b1,4-galactosyltransferase-IV) as well as decreased
a2 ,3-sialylation of O-glycans and a2 ,6-sialylation of N-glycans. The changes
are compatible with ... suppressor gene p16.
Biochim Biophys Acta 1444, 49–54.
32 Kawado T, Hayashi O, Sato T, Ito H, Hayakawa S,
Takayama E & Furukawa K (2004) Rapid cell senes-
cence-associated changes in galactosylation...
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Báo cáo khoa học: The HS:19 serostrain of Campylobacter jejuni has a hyaluronic acid-type capsular polysaccharide with a nonstoichiometric sorbose branch and O-methyl phosphoramidate group docx
Ngày tải lên :
16/03/2014, 13:20
... streptococci. Proc Natl Acad Sci USA
88, 8317–8321.
49 Kawabata S, Kuwata H, Nakagawa I, Morimatsu S,
Sano K & Hamada S (1999) Capsular hyaluronic acid of
group A streptococci hampers their invasion into ... Ottawa Ontario, Canada
Campylobacter jejuni is one of the leading causes of
human gastroenteritis and surpasses Salmonella, Shig-
ella and Escherichia in some regions as the primary
cause of gastrointestinal ... struc-
ture for the HS:19 serostrain and have shown that
these labile groups are an a- l-sorbofuranose branch
attached at C2 of b-d-GlcA and a MeOPN modifica-
tion located at C4 of b-d-GlcNAc.
There are very...
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![Báo cáo khoa học: Recognition of DNA modified by trans-[PtCl2NH3(4hydroxymethylpyridine)] by tumor suppressor protein p53 and character of DNA adducts of this cytotoxic complex potx](https://media.store123doc.com/images/document/14/rc/cf/medium_cfu1394954409.jpg)
Báo cáo khoa học: Recognition of DNA modified by trans-[PtCl2NH3(4hydroxymethylpyridine)] by tumor suppressor protein p53 and character of DNA adducts of this cytotoxic complex potx
Ngày tải lên :
16/03/2014, 14:20
... that the major bands result-
ing from termination of RNA synthesis by the adducts
of transplatin and trans-PtHMP were similar, appeared
mainly at G and C sites and in a considerably less
extent also ... spectropolarimeter, Model J720. The
gels were dried and visualized by using the FUJIFILM
bioimaging analyzer BAS-2500, and the radioactivities asso-
ciated with bands were quantitated with the AIDA image
analyzer ... (TBE)
buffer. The radioactivity associated with the bands was
quantified. The primary p53 mAb DO-1 (purified and char-
acterized as described in [56]) was also added to the
p53 ⁄ DNA complex (molar ratio...
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THE AESTHETICS OF AFFECT thinking ar t beyond representation pdf
Ngày tải lên :
16/03/2014, 18:20
... aesthetics of affect
arts where at stake is less a definition of art or any
demarcation between the aesthetic and the non-
aesthetic, but rather a general function of art as
what “harnesses ... itself.
(211)
At stake in art is not a utopian and, in some
senses, negative aesthetic, but an affirmative
actualisation of the virtual Ð the latter being a
genuinely creative act (as opposed to the realisa-
tion ... with
what Deleuze and Guattari call philosophy (prob-
lem solving). Installation art, on the other hand,
might be a paradigmatic case of art as access
point to other worlds. Julia Kristeva arrives at
precisely...
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- 1
Báo cáo khoa học: Association of RNA with the uracil-DNA-degrading factor has major conformational effects and is potentially involved in protein folding pot
Ngày tải lên :
22/03/2014, 16:21
... GGAGCA-3¢), Cy3-labe-
lled 60mer (Cy3, 5¢-CTCGCAAATGAACTGGGCGA
TGCGGTCGCACUACTTCACCTCGAAATCAACATCT
GAGTG-3¢), primers specific for domain V of 23S rRNA
RNA-dependent conformational states of UDE A. ... dye
concentration, and the results were fitted with hyper-
bola (Figs 5B and S1B; Table 2).
The apparent dissociation constant for ANS and
RNA–UDE was three-fold smaller than that for UDE,
and the emission ... contin, and cdsstr) for both UDE and RNA–
UDE on all the three datasets (set 4, set 7, and SP175 [73])
available and appropriate for our assay arrangement. Fig-
ures were created with origin software....
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- 0
Đề tài " On the homology of algebras of Whitney functions over subanalytic sets " doc
Ngày tải lên :
22/03/2014, 20:21
... in particular that A is a fine sheaf. Additionally, we assume
that the sectional spaces of A carry the structure of a Fr´echet algebra, that
all the restriction maps are continuous and that for ... JEAN-PAUL BRASSELET AND MARKUS J. PFLAUM
4.9. Remark. Since a subanalytic set X ⊂ R
n
is always regular and pos-
sesses regularly situated diagonals (the diagonal is obviously subanalytic and
two ... Localization on the first factor: For a ∈ A the chain a
k
= a ⊗ 1 ⊗
⊗ 1 ∈ A
ˆ
⊗(k+1)
acts in a natural way on C
k
(A, M ) and C
k
(A, M ).
Since A is commutative and M a symmetric A- module, the...
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- 0
- the distribution of zeros of entire functions
- essential macromolecules of the tumor microenvironment
- and an increase in the presentation of the endogenous lectin galectin1 sensing these changes on the surface of p16 ink4a expressing pancreatic carcinoma cells capan1
- mutations in the tumor suppressor breast cancer susceptibility gene 1 brca1
- the role of communication in management functions
- the owners capital account normally has a credit balance
- the j godfrey capital account has a credit balance of 17 000
- the language of business english grammar functions
- nick brieger simon sweeney 2000 the language of business english grammar functions
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