the transforming growth factor beta bone morphogenetic protein superfamily
Báo cáo y học: "Adipose-derived mesenchymal stem cells from the sand rat: transforming growth factor beta and 3D co-culture with human disc cells stimulate proteoglycan and collagen type I rich extracellular matrix" ppsx
... study [14] Some of the most potent inducers of chondrogenic differentiation are members of the transforming growth factor- beta (TGFβ) super family such as the TGFβ isoforms and the BMPs [15] Also ... carrier for therapeutic growth factors For example, AD-MSC genetically modified by bone morphogenic protein (BMP-2) produced a significant increase of newly formed bone in a canine bone defect ... production, or by modification of the microenvironment of the 3D matrix through deposition of ECM components by either the AD-MSC or the annulus cells Growth factor release in situ has been shown...
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transforming growth factor-beta protocols
... of TGF -beta in knockout and transgenic mouse models Kidney Int 51, 1355–1360 15 Chegini, N (1997) The role of growth factors in peritoneal healing: transforming growth factor beta (TGF -beta) Eur ... P (1998) Transforming growth factor- beta in renal disease Kidney Blood Press Res 21, 1–12 19 Shipley, G D., Tucker, R F., and Moses, H L (1985) Type beta transforming growth factor /growth inhibitor ... family of latent transforming growth factor- beta binding proteins FEBS Lett 411, 164–168 Lawrence, D A (1991) Identification and activation of latent transforming growth factor beta Methods Enzymol...
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báo cáo hóa học: " Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised" potx
... overexpressing transforming growth factor- beta Am J Pathol 1995, 147:53-67 Wyss-Coray T, Lin C, Sanan DA, Mucke L, Masliah E: Chronic overproduction of transforming growth factor- beta1 by astrocytes ... changes, or affected the amount of food consumed by the mice The animal weights, monitored in 42 animals, were 23.4 ± 4.2 g at the start of the treatments, and 25.2 ± 4.6 g at the end The amount of ... over-expressed together with a mutated form of the human Aβ precursor protein (APP) [6,7] The vascular deposition was a likely consequence of the fibrosis, since components of the extracellular...
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Báo cáo y học: "Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees" potx
... clinical applications of transforming growth factor- beta (TGF -beta) Growth Factors 1993, 8:1-9 Assoian RK, Komoriya A, Meyers CA, Miller DM, Sporn MB: Transforming growth factor- beta in human platelets ... sequence analysis of simian transforming growth factor- beta cDNA DNA 1987, 6:239-244 Miller DA, Pelton RW, Derynck R, Moses HL: Transforming growth factor- beta A family of growth regulatory peptides ... expressing human transforming growth factor beta (Ad.TGF-β1) virus (A) The naïve rabbit left knee injected with a high dose of the TGF-β1 virus and the right knee injected with a high dose of the luciferase...
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Báo cáo y học: "Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity" ppsx
... in the cartilage red A blinded observer captured an image on screen and selected the cartilage The computer then measured the amount of blue light passing through the selected area The higher the ... increased PG synthesis, thereby reducing the intrinsic repair capacity of the cartilage The reduced PG synthesis resulted in an aggravation of the IL-1-induced PG loss in cartilage These results ... Izumi T, Reddi AH: Regulation of the expression of the type-II collagen gene in periosteum-derived cells by three members of the transforming growth factor- beta superfamily J Orthop Res 1997, 15:463-467...
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Báo cáo y học: "Constitutive upregulation of the transforming growth factor-β pathway in rheumatoid arthritis synovial fibroblasts" doc
... further activation by the respective cytokines or growth factors, for example, transforming growth factor (TGF)β To enhance the significance of the array analysis, the mRNA data of the most important ... TGFBR1, the latent TGFβ binding proteins 1/2 (LTBP1/2), the TGF-β-releasing THBS1, the TGF-β induced factor (TGIF2), the CREB binding protein (CREBBP), the SKI-like protein (SKIL), as well as the ... Miyazono K, Heldin CH, et al.: Enhanced expression of transforming growth factor- beta s and transforming growth factor- beta type II receptor in the synovial tissues of patients with rheumatoid arthritis...
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Báo cáo y học: "Inorganic pyrophosphate generation by transforming growth factor-beta-1 is mainly dependent on ANK induction by Ras/Raf-1/extracellular signal-regulated kinase pathways in chondrocytes" docx
... transforming growth factor beta in epithelial cells J Biol Chem 1992, 267:5029-5031 36 Reimann T, Hempel U, Krautwald S, Axmann A, Scheibe R, Seidel D, Wenzel KW: Transforming growth factor- beta1 ... involved in the regulation of the Ank gene are not well documented in chondrocytes, and the contribution of ANK relative to other ePPi-regulating proteins remains unclear Therefore, the identification ... mutations in the transmembrane protein ANK Am J Hum Genet 2001, 68:1321-1326 Rosenthal AK, McCarty BA, Cheung HS, Ryan LM: A comparison of the effect of transforming growth factor beta on pyrophosphate...
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Báo cáo y học: "Platelet-derived growth factor and transforming growth factor beta synergistically potentiate inflammatory mediator synthesis by fibroblast-like synoviocytes" potx
... REU: relative expression units; TGF-β: transforming growth factor beta; TNFα: tumor necrosis factor- alpha Competing interests The authors declare that they have no competing interests Authors' ... growth factors in the synovial tissue pathology of rheumatoid arthritis Semin Arthritis Rheum 1991, 21:191-199 Li MO, Wan YY, Sanjabi S, Robertson AK, Flavell RA: Transforming growth factor- beta ... Goldberg HJ: Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor- beta1 on gene expression J Biol Chem 1996, 271:16567-16572...
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Báo cáo y học: "Identification of new autoantibody specificities directed at proteins involved in the transforming growth factor b pathway in patients with systemic sclerosis" pot
... ANAs, the nuclear target antigens of these ANAs have not been identified [2] Therefore, further work is warranted to better determine the disease subset and prognosis for these patients The specification ... of a protein family, the reported protein is the one with the highest number of peptide matches After protein transfer and colloidal gold staining, we identified 658 ± 101 and 535 ± 66 protein ... variation for a given protein spot as well as protein spots that were exclusively detected in one of the two protein extracts In the total protein extract, a large number of protein spots stained...
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Báo cáo y học: "Bone Morphogenetic Protein (BMP)-4 and BMP-7 regulate differentially Transforming Growth Factor (TGF)-β1 in normal human lung fibroblasts (NHLF)" pdf
... morphogenetic proteins Growth Factors 2004, 22(4):233-241 18 Reddi AH: Bone morphogenetic proteins: an unconventional approach to isolation of first mammalian morphogens Cytokine Growth Factor Rev ... of bone morphogenic protein- 7 and hepatocyte growth factor Kidney Int Suppl 2003:S105-112 23 Maric I, Poljak L, Zoricic S, Bobinac D, Bosukonda D, Sampath KT, Vukicevic S: Bone morphogenetic protein- 7 ... Grotendorst GR: Connective tissue growth factor: a mediator of TGFbeta action on fibroblasts Cytokine Growth Factor Rev 1997, 8(3):171-179 41 Burgess JK: Connective tissue growth factor: a role in airway...
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Báo cáo y học: "Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-β/bone morphogenic protein signalling" pot
... E: Bone morphogenetic proteins, their antagonists, and the skeleton Endocr Rev 2003, 24:218-235 34 Janssens K, ten Dijke P, Janssens S, Van Hul W: Transforming growth factor- beta1 to the bone ... [35-37] Others have identified in OA individuals altered levels of insulin-like growth factor- 1, insulin-like growth factor- 2 and TGF-β1 in cortical bone from the iliac crest [38]; matrix metalloproteinase ... OA bone remodelling compared with control bone, and when these changes operate in subchondral bone they can contribute to the breakdown of the articular cartilage and eventual failure of the...
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Study of the effect of transforming growth factor 1 on the gap junction protein connexin 43 in hepatic stellate cells
... platelet-derived growth factor (PDGF), basic fibroblast growth factor (bFGF) and endothelial growth factor (EGF) (Friedman, 2008c) 1.3 Transforming Growth Factor- β1 (TGF-β1) The TGF-β1 peptide belongs to the ... cell types in the liver, for instance the hepatocytes, endothelial cells, platelets and Kupffer cells (Fig 1.2) These cells secrete different cytokines like the transforming growth factor- β1 (TGF-β1), ... approximately 15% of the total cell population in the liver, HSCs are located in the space of Disse between the hepatocytes and the endothelial cells in the liver (Fig 1.1) As the name implies,...
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Báo cáo khoa học: Fragile X-related protein FXR1 controls posttranscriptional suppression of lipopolysaccharide-induced tumour necrosis factor-a production by transforming growth factor-b1 doc
... transforming growth factor- b1 (TGF-b1) of the proinflammatory cytokine TNF-a via the induction of FXR1 is the focus of this article TGF-b1, a member of the large transforming growth factor- b superfamily ... [21] The expression of several other proinflammatory proteins was also affected by FXR1 deficiency, but the cytokines involved in the induction of FXR1 remain uncharacterized The regulation by the ... stability [36] To determine whether TGF-b1 induced the expression of factors that targeted the TNF-a 3¢-UTR, the TNF-a 3¢-UTR was cloned into the pGL3 control vector after the luciferase ORF (SV40–Luc–TNF-3¢-UTR;...
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Báo cáo khoa học: Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand pdf
... protein 1: structural paradigm for the transforming growth factor beta superfamily Proc Natl Acad Sci USA 93, 878–883 16 Scheufler C, Sebald W & Hulsmeyer M (1999) Crystal structure of human bone ... transforming growth factor beta3 J Biol Chem 277, 46273– 46279 Celeste AJ, Iannazzi JA, Taylor RC, Hewick RM, Rosen V, Wang EA & Wozney JM (1990) Identification of transforming growth factor beta ... Crystal structure of transforming growth factor- beta 2: an unusual fold for the superfamily Science 257, 369– 373 20 Schlunegger MP & Grutter MG (1992) An unusual feature revealed by the crystal structure...
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Báo cáo y học: Identification of an element within the promoter of human selenoprotein P responsive to transforming growth factor-b ppt
... As the CAGA box at position 21811 is located at the very margin of the known SeP promoter sequence, the 50 flanking bases not represent the context of the genomic promoter but the sequence of the ... characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor- beta, activin, and bone morphogenetic proteininducible enhancer J Biol Chem 273, 21145–21152 ... differences between the assessment of the SeP mRNA expression and the measurement of luciferase activity exist For example, whereas in the first case the species assessed is the mRNA (i.e the respective...
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báo cáo hóa học:" Expression of Bone Morphogenetic Protein-2 in the Chondrogenic and Ossifying Sites of Calcific Tendinopathy and Traumatic Tendon Injury Rat Models" doc
... failed to resolve Bone morphogenetic proteins are multi-functional growth factors that belong to the TGF -beta superfamily [2] They have strong effect on bone and cartilage growth as well as with ... general anesthesia, an incision was made to expose the patellar tendon The central one-third of the patellar tendon (1 × mm) from the distal apex of the patellar to the insertion of the tibial ... cells under the influence of bone morphogenetic protein in tissue culture Clin Orthop Relat Res 1988, 236:233-239 Lories RJ, Derese I, Ceuppens JL, Luyten FP: Bone morphogenetic proteins and...
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Báo cáo y học: "Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer" pps
... members of the transforming growth factor (TGF)-β superfamily, are present [2-4] This research has led to the first clinical application of autologous bone marrow stromal cells for the repair ... enhance the differentiated function of osteoblasts, which have led to the clinical application of these proteins for bone regeneration [1,7-10] We and others have tested several BMPs for their ... adenoviral vector; BMP = bone morphogenetic protein; GFP = green fluorescent protein; H&E = hematoxylin and eosin; MSC = mesenchymal stem cell; TGF = transforming growth factor Page of 15 (page...
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Báo cáo y học: "Gender-based reciprocal expression of transforming growth factor-β1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide-induced cystitis" ppsx
... by transforming growth factor- beta Nature 1988, 334:260-262 Kim CD, Cho YJ, Park SH, Ha SW, Lee EG, Kim YJ, Kwon TH, Kim IS, Kim YL: Urinary transforming growth factor- beta- induced gene-h3 (betaig-h3) ... exhibited the most intense green stain for iNOS in the urothelium as compared to the other groups The immunocytochemical expression of iNOS was much lower in control male rats (Fig 6C) The bladders ... at the beginning of day and then stabilize for the remainder of the day Values at baseline in female rats (empty black dot) did not change over the course of the day The levels of NO products in...
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Tài liệu Báo cáo khoa học: Bone morphogenetic protein signaling in stem cells ) one signal, many consequences pptx
... Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein- induced cell differentiation Mol Cell Biol 23, 4494–4510 Hu MC & Rosenblum ND (2005) Smad1, beta- catenin ... Dephosphorylation of the linker regions of Smad1 and Smad2 ⁄ by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor- beta pathways ... induced by the other pathway, thereby upholding the pluripotent state of the cells The balance is easily broken upon signal increase in any direction to derive ES-cell lines from the inner cell...
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Báo cáo khoa học: Calmodulin-mediated regulation of the epidermal growth factor receptor doc
... [72] The binding of these proteins could prevent the interaction of the Ca2+ ⁄ CaM complex to the receptor if the CaMBD were occluded at least in part Nevertheless, the docking of these adaptor proteins ... epidermal growth factor in epithelial LLC-PK1 cells Am J Physiol 265, C966–C975 29 Elliget KA, Phelps PC & Smith MW (1996) Transforming growth factor b modulation of the epidermal growth factor ... occurs at the peripheral ER in proximity to the plasma membrane STIM proteins also participate in the microtubule-induced pulling of the ER to the vicinity of the plasma membrane (not shown) The Orai...
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