the therapeutic potential of dimethylarginine dimethylaminohydrolase mediated regulation of nitric oxide synthesis
Báo cáo sinh học: "The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway" ppsx
... Examples of diseases caused by loss of or ectopic function of the HH-GLI signaling pathway, and the possible agents that could, in principle, be used as therapeutics Disease type Potential therapeutic ... output of the HH-signaling pathway [31,34,35], these could be used as antagonists for the treatment of tumors The difficulty of delivering them into cells might require the development of in vivo ... the skin and medulloblastoma in the brain, with the same agent Cyclopamine could be such an agent if the diseases to be treated arise from activation of the HHsignaling pathway at the level of...
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Báo cáo y học: "The therapeutic potential of a venomous lizard: the use of glucagon-like peptide-1 analogues in the critically ill" pdf
... GLP-1, glucagon-like peptide-1 the relatively small number of subjects studied, with the consequent potential for type errors The authors reported that the use of the GLP-1 analogue failed to reduce ... doi:10.1186/cc9281 Cite this article as: Deane AM, et al.: The therapeutic potential of a venomous lizard: the use of glucagon-like peptide-1 analogues in the critically ill Critical Care 2010, 14:1004 ... addition to identifying the optimal glycaemic range, future studies should focus on the following: which of the incretin agents is most useful in the critically ill patient; whether these agents should...
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Báo cáo sinh học: "The immunological potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer’s disease" pdf
... epitope of amyloid within the HA of influenza virus The HA and NA glycoproteins of influenza A viruses contain the major antigenic determinants of the virus responsible for the induction of neutralizing ... about the safety and the efficacy of the active immunization strategy with Ab 42 self-peptide Although the results from the Phase I trial showed good tolerability, in the phase IIa portion of the ... molecules of HA per virion, with each of them possessing antigenic sites that induce majority of neutralizing antibody responses [33] On the other hand, the immunodominant B cell epitope of Ab42...
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báo cáo khoa học: "Down-regulation of TM4SF is associated with the metastatic potential of gastric carcinoma TM4SF members in gastric carcinoma" ppt
... gene [29] Although the precise mechanisms for regulation of CD82 remain unclear, down -regulation rather than mutation is the most common mechanism in the Page of progression of many cancers [14,17,22,30-33] ... understanding of the potential role of TM4SF in metastasis, we can go on to collect information of follow-up, and analyze the relationship of CD9, CD63 and CD82 with the Days after surgery And in the future, ... expression, and the immunostaining in most of these tumors was heterogeneous The immunohistochemical results were agreed with those of RT-PCR and 98.0% of the specimens coincided directly Further investigations...
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Báo cáo y học: "Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis" pps
... in the joint of the CIA mice The short-term presence of UC-MSCs in the spleen suggests that the therapeutic effect of UC-MSCs does not rely on the capacity to engraft and survive long-term in the ... phenotype of FLSs [32] Therefore, we further investigated the effect of UC-MSCs on the invasive behavior of FLSs by the Cell Migration/Invasion Assay, and the MMP9 secretion of FLSs As a result, the ... and the downregulated Th1/Th17 cells Furthermore, in the UC-MSCs treated mice, the expansion of Th2/Tregs and the production of anti-inflammatory IL-10 were elevated MSCs have the capability of...
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Báo cáo khoa học: Modulation of nitric oxide-mediated metal release from metallothionein by the redox state of glutathione in vitro doc
... relies on the suppression of the expression and activity of inducible nitric oxide synthase (iNOS) by zinc [32,33], released from MT under the influence of nitric oxide (NO), and the scavenging of NO ... increased the cadmium release by nitric oxide The decay occurs in the first 10 after the addition of NO as observed by monitoring the CD at the maximum of the charge transfer band at 260 nm (Fig 1B) The ... 260 nm is reduced clearly after the addition of NO, indicating the breaking of cadmium-cysteine bonds and therefore release of cadmium The presence of GSH reduces the metal release almost completely,...
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No DREAMers Left Behind - The Economic Potential of DREAM Act Beneficiaries potx
... potential barriers to achieving legalization By examining the historical trends of these barriers’ effects on the educational attainment of immigrant groups, the report estimates the number of ... the U.S at a young age, and in many cases the U.S is the only country they know and the one with which they most identify They have a strong desire to contribute to it more fully Passage of the ... family incomes below 200 percent of the federal poverty level, and 35 percent have limited English proficiency The majority of them are currently in the workforce These characteristics present challenges...
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Báo cáo khoa học: Probing the catalytic potential of the hamster arylamine N-acetyltransferase 2 catalytic triad by site-directed mutagenesis of the proximal conserved residue, Tyr190 pot
... truncations, the availability of the Tyr190 mutants makes it feasible to conduct cell-based studies of the effects of the stability of the acetylated enzyme intermediate on the N-acetylation of aromatic ... mechanism, the acetylation rate (k2) of NAT2 by the acetyl donor is independent of the transacetylation rate (k4) of the arylamine substrate Because the values of k4 for PABA can be inferred from the ... kinetic evidence for the similarity of the Tyr190 to Phe mutant and wild-type However, the rate of acetylation of NAT2 (k2) is 5-fold lower than the wild-type, and the stability of the FEBS Journal...
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Báo cáo khoa học: Critical roles of Leu99 and Leu115 at the heme distal side in auto-oxidation and the redox potential of a hemeregulated phosphodiesterase from Escherichia coli pptx
... O2, the polarity of the heme distal side, the direction of the heme-bound O2 molecule, and the redox potential of the heme iron [5] The reason why the auto-oxidation rate of the Leu99 and Leu115 ... complexes of the Ec DosH mutants The optical absorption spectra of the Fe(III)–CO, Fe(II)–CO, and Fe(II)–CO complexes of the Leu99 and Leu115 mutants of Ec DosH were essentially the same as those of the ... mutation of these hydrophobic amino acids substantially influences the rate of auto-oxidation and the redox potential of the heme iron, but, surprisingly, they had less effect on the characteristics of...
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A Generic QSAR for Assessing the Bioaccumulation Potential of Organic Chemicals in Aquatic Food Webs pot
... function of the degree of biomagnification or trophic dilution that occurs in organisms of lower trophic levels in the food web, thus regulating the concentration of the chemical in the diet of upper ... is a function of the KOW of the chemical and the weight of the organism W (kg) as: k1 1/((0.01 1/KOW) ¥ W0.4) (4) kD: The rate at which chemicals are absorbed from the diet via the gastrointestinal ... 2.5% of the available empirical data The calibration of the model to the data is designed to produce a QSAR for the BAF in higher trophic levels of a Canadian aquatic food web The QSAR BAFs can therefore...
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báo cáo hóa học:" More insights into the immunosuppressive potential of tumor exosomes" pptx
... then a further pathway to the potential modulating properties of these peculiar organelles If tumor exosomes are such a powerful instrument of environmental shaping, then getting rid of them should ... [29] The evidence that these organelles can also shape protein synthesis through the transfer of functional mRNAs and microRNAs, as recently reported in transformed mastocytes [30], adds then ... hypothesized that this pathway may contribute to the in vivo moulding of immune as well as other cancer-related host responses More recent studies have then reported that the detrimental effect of...
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Báo cáo sinh học: "Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm" ppt
... example, in the small intestine, Tcf4 is required for the rapid proliferation of the embryonic intervillus epithelium that gives rise to the crypts [7] These contain the stem cells of the adult ... cells, the various subsets of secretory Clara cells, and the pulmonary neuroendocrine cells) The epithelium of the smaller, peripheral tubes that appear towards the end of gestation gives rise to the ... groups of cells scattered throughout the epithelium This pattern is reminiscent of the distribution of Paneth cells in transgenic intestines, in which the spatial segregation of the crypt from the...
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Báo cáo lâm nghiệp: "Analysis of the production potential of raw wood in the forests of Slovakia" pps
... on the forests of Slovakia, which is updated regularly every year using the data on the forest stand status obtained from the renewal of forest management plans Data on the area of about 10 / of ... species Together Together V IIIB IIIA II I Together Together V IIIB IIIA II I Broadleaved tree species Fig Prospective prognosis of the production of quality classes of logs for the years 2010–2020 ... m3 Other tree species will reach approximately the same volume As Fig documents, in the interval of the years 2010–2020 and in the category of coniferous tree species we expect the volume of about...
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Báo cáo lâm nghiệp: "Assessment of the assortment potential of the growing stock – a photogrammetry based approach for an automatized grading of sample trees" potx
... objective recording of the average quality, the photos were taken from the directions of the smallest and of the largest DBH For the documentation of stem form features, a distance of 1.5 – × height(total) ... contracts in the test regions The selection of these contracts was oriented on the validity period (1998–2002) and on the representativity of the contracts for the customer structure for the forest ... exploitation of the total stem until the minimum possible top end diameter The comparison refers to the price level 1998 – 2000 Figures 5a–5d show the volume of the sample trees over the height, the differences...
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Báo cáo toán học: "Adult neurogenesis, neuroinflammation and therapeutic potential of adult neural stem cells" ppsx
... cellular therapy On the one hand, it may limit the therapeutic potential of adult NSCs in vivo and ex vivo On the other hand, it may interact with the neurogenic niches to promote the regenerative potential ... regions of the CNS [65] Some of the data observed by mean of immunohistochemistry for cell cycle proteins and BrdU labeling in the brains of AD patients and in animal models of the disease, may therefore ... treated by the transplantation of neural progenitor and stem cells, as well as the transplantation procedure itself may have adverse effects of the success of the graft (fig 1) The timing of transplantation...
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Báo cáo y học: "Toxic effects of methoxychlor on the episodic prolactin secretory pattern: Possible mediated effects of nitric oxide production" pdf
... the number of pulses observed during the bleeding period Pulse duration was the time between the beginning of the ascending phase of the peak and the end of the descending phase of the peak The ... at the hypothalamic or the ME level changing DA synthesis cannot be discarded the pituitary inducing the reduction of the absolute amplitude of the prolactin peaks Also, an indirect effect mediated ... Nitric oxide inhibits the release of norepinephrine and dopamine from the medial basal hypothalamus of the rat Proc Nat Acad Sci USA 1995, 92:11299-11302 McCann SM: The nitric oxide hypothesis of...
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Báo cáo y học: "Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link in the therapeutic action of lithium" docx
... hallmark of BPD therapeutics, remain to be fully elucidated [4,5] The identification of the molecular target(s) of mood stabilizers would not only facilitate the development of improved modes of treatment, ... functional duties Therefore, the targeted "knock down" of the GSK3α isoform in the βnull MEFs was undertaken in order to minimize the contribution of GSK3 in the generation of transcriptional ... in the context of circadian rhythms is hardly a panacea for the therapy of affective mood disorders Nevertheless, (i) the cyclical and episodic nature of BPD symptoms, (ii) the prevalence of...
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báo cáo khoa học: "The clinical potential of microRNAs" docx
... revealed the downregulation of PTEN by miR-21, the tumor suppressor function of the let-7 family and the oncogenic function of the miR17-92 cluster [22-24] The biological and clinical relevance of ... patients for IFN treatment [53] The full potential of microRNAs as prognostic factors awaits the results of larger prospective studies The Therapeutic Application of MicroRNAs As noted above, several ... into their utility in clinical settings The notion of microRNAs as therapeutic agents is in the first phases and is at the cusp of providing major advances in research and to enhancing the tools...
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Báo cáo khoa học: " Analysis of the coding potential of the partially overlapping 3'''' ORF in segment 5 of the plant fijiviruses" potx
... to the region where it overlaps ORF5-2 Further, albeit indirect, evidence for the coding status of ORF5-2 comes from an analysis of the 3'UTR lengths of the 10 segments In RBSDV, for example, the ... small circle (showing the likelihood ratio score for that window), and grey bars showing the width (ends) of the window See [9] for further details of the MLOGD software In (4) the null model, in ... insertion of an extra 'U' into the run of five 'U's at NC_007160 nucleotides 2714–2718, as discussed in the text Note the conserved absence of stop codons in the +0 frame within ORF5-1 and in the +1...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25