... consider pertain to the structure ofthe hairpin and positions of reads The distance between a miR and moR on the same arm ofthe hairpin, the offset ofthe 5' positions of products that overlap ... nucleotides on the same arm ofthe hairpin, and the offset of overlapping products on opposite arms ofthe hairpin are used to evaluate the spacing and distribution of products The 5' heterogeneity, ... required an Page of 12 exact seed match (nucleotides to ofthe mature sequence), and no more than four mismatches in the mature miR sequence of a known member of this family in the other species...
... Moreover, this is the first ever study to assess the impact of symptom-defined GERD, as diagnosed using the Montreal Definition, on measures of HRQoL One ofthe limitations of this study was the inability ... movement of materials upwards from the stomach’ items ofthe RDQ Using the Montreal Definition of GERD for population-based studies, symptomdefined GERD in the SILC study was diagnosed based on the ... considered present when the reflux of stomach contents causes symptoms that are troublesome [15] However, the format ofthe questionnaire did not allow participants to specify which ofthe RDQ symptoms...
... Environment ofthe Commission on the strategic direction ofthe CAFE programme The approaches to answering the questions were rather complex The procedure for preparing the report Health aspects of air ... However, the results ofthesystematic review confirmed the existence of severe effects of PM and ozone on human health even at concentrations at the lower end ofthe current ranges Thus the objective ... relative to the risk factor 7 CONSEQUENCES FOR EUROPEAN CLEAN AIR POLICY AND FOLLOWUP OFTHESYSTEMATIC REVIEW FURTHER ACTION IS NEEDED! The findings ofthesystematic review and the preliminary...
... an accurate assessment ofthe intake of these compounds However, despite the fact that some studies have estimated adequately the exogenous intake of nitrosamines, none of them had information ... one ofthe cohort studies reporting results[23-26,28], but in most of them the number of GC cases was too small For pickled and dried vegetables, studies found positive association but none of them ... that there is convincing evidence that the consumption ofthe Chinese salted-dry fish is causally associated with the risk of nasopharyngeal cancer with their nitrosamine content being the most...
... Cpos gg q Q With the aim of showing the simplicity ofthe phonologic rules we transcribe the two-level rules we have implemeted with the transducers in the thesis R1-R4 model the medialization ... From the point of view ofthe morphologic typology it presents characteristics of a polysynthetic agglutinative language In this language the verb is the morphologically more complex wordclass The ... prefixes In the next example the suffixation ofthe reflexive (−l at) forces the use ofthe active person with prefixes ofthe voice medium class because the agent is affected by the action Example (a)...
... The impact of microfinance on the incomes ofthe poor b The impact of microfinance on wider poverty/ wealth ofthe poor c impact of microfinance on other non-financial The outcomes for the ... review ofthe evidence ofthe impact of microfinance timely And in the latter half of 2010 the microfinance industry made news for negative reasons.7 By October of that year regulation ofthe microfinance ... need for rigorous systematic reviews ofthe evidence ofthe impact of microfinance on the poor Further, while many ofthe first institutions offering microfinance were not-for-profit local NGOs...
... nutrient content may then be further increased during the storage, transportation and preparation ofthe foodstuffs prior to reaching the plate ofthe consumer An understanding ofthe various factors ... provided the following: - a clear definition, in the Introduction or Methods section ofthe paper, ofthe organic production methods ofthe crop or livestock product analysed (including the name of ... 36 papers as a result of this correspondence The protocol proposed the use of 13 databases for the search Upon closer inspection it was decided that the content of 10 ofthe databases were not...
... Based on the advice of one ofthe authors (PF), an expert in the field of maternal health and EmOC, the search strategy was supplemented by a systematic review ofthe table of contents of specific ... hours; the greatest part of that delay was attributed to the purchase of therapeutic material by patients and their families [48] The overall evaluation of professional skills, together with the ... organizational resources The structural aspects of EmOC and the interpersonal constituents ofthe EmOC process were easily identified The clinical aspects of EmOC, where the role of HR is theoretically...
... factor in the permanent attrition of pharmacists from the workforce Although the death of pharmacists was not reported to be a problem in any ofthe literature included in the review, most ofthe literature ... unless they remain registered there is no way of tracking them However, a factor increasing the demand for pharmacists was the movement of pharmacists into non-traditional areas of work The identification ... Potential areas of recruitment to the pharmacist workforce Another important issue in the recruitment of pharmacists was the lack of male students entering the pharmacy degree course; the workforce...
... recognition ofthe importance of PHC It was the main subject ofthe 2008 WHO World Health Report, has the endorsement of WHO Director-General Margaret Chan [5], and was the topic of a themed issue ofthe ... on the impact of interventions[17,18] This paper reports how we conducted thesystematic review, an analysis ofthe studies identified by the review with descriptions ofthe CHW programmes they ... failure ofthe concept of CHWs or PHC but because the support and supervision necessary to make them effective were too often missing With the HIV/AIDS pandemic, and increasing acknowledgement of the...
... validations ofthe instruments as part ofthe development process In this paper we focused on the methods used in the development ofthe physical activity instruments The content and the format ofthe ... validation process ofthe reviewed instruments 14 Aim of instrument For almost half ofthe instruments (n = 49, 47.1%), the authors clearly described the aim ofthe instruments before the scales were ... in 38% ofthe instruments and in 32% adaptation of existing scales and/or unsystematic literature searches were the only sources for the generation of items For item reduction, in 56% ofthe instruments...
... classification ofthe forms and cases ofLogic considered as a Science.∗ The aim of these investigations was in the first instance confined to the expression ofthe received logic, and to the forms ofthe Aristotelian ... impossible The business of true Science, they conclude, is with laws and phenomena The nature of Being, the mode ofthe operation of Cause, the why, they hold to be beyond the reach of our intelligence ... general preparation of knowledge and of practice for the attainment ofthe other, but it is to the union of thought with action, in the field of Practical Logic, the arena of Human Life, that...
... epidemiological studies on vitamins, no study has evaluated the value of nutrition in the prevention of OA Although these studies are of utmost importance, the size, the duration, and hence the prohibitive ... risk of developing OA in their near future Appendix Comparative discussion on the value ofthe Jadad and OA scores to evaluate the quality of clinical trials on OA To evaluate the quality ofthe ... According to these two scoring systems, the quality ofthe RCTs was highly heterogeneous Based on the OA score, the quality ofthe trials ranged from 33% to 100% (with a mean of 65 and a median of 67)...
... beginning of a new era in the treatment of RA Nonetheless, the efficacy of each biological agent is not similar in all patients, underlying the need for a drug switch between the agents Moreover, the ... exclusion criteria, and their methodological quality was graded according to the levels of evidence ofthe Centre for Evidence-Based Medicine (Oxford, UK) [3] The language ofthe paper was not restricted ... different biological target therapies could be necessary because ofthe presence of driving cytokines other than TNFα In general, an ACR20 can be obtained in 60% or more ofthe poor responders to the...
... Page of 14 distribution ofthe 1,918 candidate genes and the 50 ASE genes is shown in Figure 3b Biological categorization ofthe 86 ASE genes in HCC1954 shows that many of them are associated with ... HCC1954, similar numbers of sequence reads often gave lower average coverage ofthe minor allele in the HCC1954 exome compared to that ofthe HCC1954BL Thus, a lower number of high-confidence SNVs ... for HCC1954BL There were 7,848 SNVs in 4,441 genes identified by exome sequencing Of these, 766 (9.7%) are novel A total of 3,086 ofthe 7,848 SNVs were found in 1,918 genes, each of which was...
... fibrofibrinous vegetations seen in LS endocarditis ofthe mitral valve may vary in size and typically have a wart-like morphology They can be found near the edge ofthe leaflets along the line of ... closure; both on the atrial and ventricular sides ofthe leaflets They can even be found on the chordae and the endocardium In this case several microthrombi are present on the free edge ofthe leaflet ... authors prefer to use the term NBTE for the valve lesions seen in primary APS instead ofthe term LS endocarditis However, others (including the authors of this study) prefer to use the term LS endocarditis,...
... performance of a clinical system to be most effective, they must take into account not only the nature ofthe system, but also the nature ofthe disease The purpose of this paper is twofold First, ... characteristics ofthe organization be considered, but so must the characteristics ofthe disease and its treatment Interventions must be appropriately matched to the level of complexity of not only the ... outcomes, the importance of allowing ‘local’ input or control into the intervention design, and the need to provide feedback regarding the impact ofthe intervention and the possibility to change the...
... [49,51,52] with the PCP being the target ofthe intervention in two of them [51,52] The unit of allocation was the patient in seven [46-49,52-54], the physician in one [50], and the family practice ... Two ofthe service delivery changes took the responsibility of investigating and treating the osteoporosis out ofthe hands ofthe PCP [49,53], and in one the investigation was carried out but the ... because they were not eligible for it Nevertheless, this study also highlights the fact that despite the overall positive effects ofthe interventions, none ofthe studies produced maximal rates of...