the stem cell target

Commercializing the stem cell sciences pot

Ngày tải lên : 20/03/2014, 06:20

... 1.2 Emerging stem cell therapies and the commercialization of biotechnology On the one hand, the stem cell sciences are clearly part of the biotech industry Most obviously, stem cells are biological ... viable products There are a number of similarities in how stem cell science and biotechnology progress On the other hand though, the unique properties of stem cells and the way stem cell products ... influencing the future shape of the stem cell market 1.4.2 The relationship between risk and return The other major factor limiting the potential success of emerging stem cell companies is the relationship...

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university of california press fundamentals of the stem cell debate the scientific religious ethical and political issues dec 2007

Ngày tải lên : 11/06/2014, 12:52

... differentiate embryonic stem cells from adult stem cells and point out that many tissues undergo continual replacement from stem cells They note the tremendous therapeutic potential of stem cells in replacing ... structure known as the stem cell niche At least in the hematopoietic (blood cell forming) system, the niche develops independently and the stem cells migrate to and colonize the niche (Schoﬁeld ... adult stem cells, although they are sometimes designated more conservatively as progenitor cells They are referred to as adult stem cells to distinguish them from embryonic stem cells, even if they...

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Báo cáo sinh học: "The ‘stem cell’ concept: is it holding us back" pptx

Ngày tải lên : 06/08/2014, 19:21

... definition is the ability to generate cells of other types, but there are two problems with this First, there are clearly cells in the body that generate cell types other than themselves but ... probability that stem and progenitor cell progeny remain at the stem or progenitor cell stage (that is, they increase the probability of differentiation) Thus, the machinery for achieving stem cell- driven ... of control define a unique class of cells? The fact that so many characteristic behaviors of stem cells and stem cell systems - homeostasis in the face of the production of differentiated progeny;...

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Báo cáo y học: " Enhanced self-renewal of hematopoietic stem/progenitor cells mediated by the stem cell gene Sall4" doc

Ngày tải lên : 10/08/2014, 21:23

... Further more, these Ly5.2+ cells were able to reconstitute granulocyte, T cells, and B cells, as well as immature blood cells, as indicated by expression of GR-1, CD4/8, B220 and Sca-1 in BM cells ... LSK cells and three mice received Sall4B treated LSK cells (a) The population of donor cells (Ly5.2+) in the peripheral blood of the recipient mice was examined by flow cytometry assays with the ... compared with the Sall4 activities in the human system [19] We have hypothesized that the Sall4 gene is also involved in mediating cell fate decisions during hematopoiesis, helping to regulate the exquisite...

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Possible role of diva in microglial dual effects and the stem cell differentiation

Ngày tải lên : 12/09/2015, 08:19

... Diva could arrest the neural stem cells in the G0/G1 phase and prevent the escaping of neural stem cells from cell cycle The pioneer study in the project has emphasized on the regulatory function ... during the cell cycle in neural stem cells .The results plus the anti-apoptotic role of Diva would lead further project in the future on microglial dual functions on transplanted stem cells In ... regulate the fate of multipotent stem cells The capability of manipulating the differentiation of neural stem cells may also be helpful to the stem cell transplantation therapeutic strategies to treat...

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báo cáo hóa học:" Targeting the osteosarcoma cancer stem cell" pot

Ngày tải lên : 20/06/2014, 04:20

... of cells called “cancer stem cells (CSCs)” that are responsible for forming the bulk of the tumor [14-16] They are similar to stem cells and may arise from the transformation of stem cells or the ... stem cell nature [13] Cells of Origin for Osteosarcoma Cancer Stem Cells CSCs have been proposed to arise either from the transformation of normal stem cells to cancerous stem cells or from the ... cancer therapies [15] Therefore, although treatment with chemotherapy or radiation may reduce the bulk of the tumor, it may actually miss the most important cell to target, the cancer stem cell...

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báo cáo hóa học:" Targeting the osteosarcoma cancer stem cell" ppt

Ngày tải lên : 20/06/2014, 07:20

... of cells called “cancer stem cells (CSCs)” that are responsible for forming the bulk of the tumor [14-16] They are similar to stem cells and may arise from the transformation of stem cells or the ... stem cell nature [13] Cells of Origin for Osteosarcoma Cancer Stem Cells CSCs have been proposed to arise either from the transformation of normal stem cells to cancerous stem cells or from the ... cancer therapies [15] Therefore, although treatment with chemotherapy or radiation may reduce the bulk of the tumor, it may actually miss the most important cell to target, the cancer stem cell...

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Báo cáo hóa học: " Modulation of the major histocompatibility complex by neural stem cell-derived neurotrophic factors used for regenerative therapy in a rat model of stroke" ppt

Ngày tải lên : 18/06/2014, 16:20

... of the class I MHC, mediated by NSC-derived neurotrophins in the lesioned micro-environment of the CNS Materials and methods Culture of Neural stem cells Neural stem cells were harvested from the ... parenchyma near the third ventricle (Figure 4) Migration of the BrdU+ cells along the corpus callosum and the ventricular wall was noted Small clusters of BrdU + cells and BrdU + cells with glial ... for 15 s Quantification of the gene of interest was accomplished by measuring the threshold cycles and comparing them to the standard curve to determine the copy number The process of calculating...

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Báo cáo sinh học: " Risk factors in the development of stem cell therapy" pdf

Ngày tải lên : 18/06/2014, 19:20

... accompanied by cell sorting to minimise the number of pluri/ multipotent stem cells in the cell preparation [86], or to separate tumourigenic stem cells from non-tumourigenic stem cells (by e.g cell sorting ... of administration (i.e the local environment of the stem cell in the recipient) and the need for in vitro culturing The manipulation of the cells may also contribute to the tumourigenic potential ... [81-85] Most likely the observed effect depends on the nature of the cancer cells, the Page of 14 characteristics of the used MSC, on the integrity of the immune system and on the timing and site...

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báo cáo hóa học:" MUC4 stabilizes HER2 expression and maintains the cancer stem cell population in ovarian cancer cells" ppt

Ngày tải lên : 20/06/2014, 07:20

... (MCF7) cell line [11] The fact that the vast majority of MCF7 stem cell enriched SP cells express MUC1 suggests that epithelial cancer stem cells would also be the targets of various immunotherapy ... ovarian cancer cells induce the aggressiveness of the cancer cells and enrich the cancer stem cell population It also showed that MUC4 is expressed in the ovarian cancer stem cell population ... SKOV3 cells (Figure 3) We further isolated these colonies for the stem/ progenitor marker analysis Expression of cancer stem cell and self-renewal markers in circular colonies Cancer stem cells...

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báo cáo khoa học: " LgR5 expression and cancer stem cell hypothesis: clue to define the true origin of esophageal adenocarcinomas with and without Barrett’s Esophagus?" ppsx

Ngày tải lên : 10/08/2014, 10:21

... 1b), as they stained the well-described putative colon mucosa stem cells, located at the basis of the crypts, or the transit amplifying zone, which are regarded to resemble the stem cell niche ... According to our hypothesis, that the intestinal stem cell marker LgR5 might also be suited to identify cancer stem cells, these might be the actively cycling Barrett (cancer) stem cells Our findings ... cancer stem cell compartment [8] The existence of cancer stem cells would explain why only a small minority of cancer cells is capable of extensive proliferation within the tumor Furthermore, these...

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báo cáo khoa học: "The research on the immuno-modulatory defect of Mesenchymal Stem Cell from Chronic Myeloid Leukemia patients" pdf

Ngày tải lên : 10/08/2014, 10:21

... tumor cells consists of three major steps: the receptormediated adhesion of tumor cells to the extracellular matrix, the degradation of the extracellular matrix by the proteinase secreted by the ... phenotypically defined endothelial cells at the single -cell level, suggesting these cells have the properties of hemangioblasts Page of 10 The main purpose of our article was to examine the immune characteristics ... secreted by the tumor cells, and the transfer and proliferation of tumor cells[36] So, the loose of ECM and secreted cytokines are important for the metastasis of the tumor cells from the primary tumor[37]...

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báo cáo khoa học: "The transplant iron score as a predictor of stem cell transplant survival" pptx

Ngày tải lên : 10/08/2014, 22:20

... prior to stem cell transplant and are listed in Table The individual iron parameter most closely associated with overall survival was the transfusion total, defined as the number of red cell units ... after transplant We further examined the cause of death among the 20 patients that died as a result of treatment related complications The majority of these patients (55%) had either http://www.jhoonline.org/content/2/1/44 ... setting Further evidence of the potential power of the iron score was seen in multivariate analysis, where the iron score maintained significance while controlling for other risk factors Using the Transplant...

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báo cáo khoa học: "Hepatocyte growth factor incorporated chitosan nanoparticles augment the differentiation of stem cell into hepatocytes for the recovery of liver cirrhosis in mice" pptx

Ngày tải lên : 11/08/2014, 00:23

... opportunities for stem cell therapy However, number of stem cells engrafted and differentiated after transplantation limit the treatment strategies Furthermore, ambiguity continues over the contribution ... bone marrow stem cells actually differentiate into hepatocytes and restore the liver functions [10] Moreover, the mechanism by which stem cells regenerate the respective parenchymal cells, heading ... particles can carry the therapeutic proteins to the targeted site without degradation and can sustain in the circulatory system The protonated amino groups of chitosan as well as HGF in the acidic medium...

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báo cáo khoa học: " Autologous bone marrow stem cell intralesional transplantation repairing bisphosphonate related osteonecrosis of the jaw" docx

Ngày tải lên : 11/08/2014, 20:21

... mesenchymal, endothelial and other progenitor cells as well as mononuclear cells The cells were suspended into an opportune quantity of PBS-EDTA buffer containing 5% of human albumin The cell fraction ... we offered the opportunity to our patient of injection of autologous bone marrow stem cells into the osteonecrosis site lesion Methods In september 2008 the patient (who is the mother of one ... of the cell suspension were performed, including absolute CD34 and CD45 positive cell count and five colour MoAb panel for the identification of the cellular subpopulation (Table 1) Before the...

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Báo cáo y học: "Marked increase of procalcitonin after the administration of anti-thymocyte globulin in patients before hematopoietic stem cell transplantation does not indicate sepsis: a prospective study" pptx

Ngày tải lên : 13/08/2014, 16:20

... hematopoietic stem cell transplantation The patients were treated at the Institute of Hematology and Blood Transfusion in Prague, Czech Republic The study was approved by the institutional review board The ... in the transplantation and contributed to the study design AK and TZ participated in the study design and helped to draft the manuscript TD intellectually contributed to the preparation of the ... value in the diagnosis of infection during the administration of ATG Competing interests The authors declare that they have no competing interests Authors' contributions HB carried out the laboratory...

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Báo cáo y học: "Histone deacetylase inhibition accelerates the early events of stem cell differentiation: transcriptomic and epigenetic analysis" doc

Ngày tải lên : 14/08/2014, 08:21

... overall assessment of the importance of histone modifications on stem cell biology To evaluate the importance of histone acetylation on ES cell differentiation, we treated cells with the histone deacetylase ... order to examine the competence of the 'ES re' cells to contribute to the three germ layers, we placed them in hanging drops and observed that they formed EBs of normal morphology We then checked ... still capable of acquiring either one of the three cell fates To gain insight into the molecular mechanisms whereby TSA triggers stem cell differentiation, we analyzed the dynamics of histone H3...

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Báo cáo y học: "nalysis of the mouse embryonic stem cell regulatory networks obtained by ChIP-chip and ChIP-PET" pptx

Ngày tải lên : 14/08/2014, 20:22

... Embryonic stem (ES) cells are derived from the inner cell mass of the embryo and possess the property of pluripotency, which is the ability to develop into any cell lineage of the organism [1-3] The ... 19 arrays (e, f) The chromosomal position of the genes, as well as the genomic scale, is represented along the xaxis The fold enrichment of the probes is shown on the y-axis These enrichment ... recovery distance from the edge of the other, then they were considered 'matched' The typical recovery distance used was kb, although this was varied systematically for the recovery curves A recovery...

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an investigation into the role of chemokines in haemopoietic stem cell quiescence

Ngày tải lên : 22/12/2014, 21:11

... 2008) The haemopoietic system is a hierarchical system which is regulated and maintained by the HSC which reside at the top of a cell hierarchy The LT-HSC are the most primitive cells which have the ... which these cells are so rare This also allows for the study of the stem cell behaviour at a single cell level The ability to identify and isolate HSC from their environment allows for their ... all cell types in the biological system, including in haemopoiesis The identification of stem cells marked an important discovery in the field of biology and medicine The haemopoietic system...

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