... total volume ofthe column(% 12 min). However, as previously found with otherdissociated capsid proteins, the lack of elution of the proteins can be explained by non-specific binding of the denatured ... resides on the surface ofthe protein and makes noobvious stabilizing interactions with other amino acid side-chains, this part ofthe protein interacts with genomic RNA[33,41,47]. Such interactions ... iscontained [11,12]. The tertiary structure and topology ofthe MS2 coatprotein is different from those of other simple icosahedralviruses [13]. The main chain ofthe protein subunit foldsinto...
... offer any judgment on the relative plausibility ofthe various scenarios, leaving to the reader the task of integrating the information from the sensitivity analyses on the various sources of ... the resulting changes inthe exposure ofthe population, and the resulting effect of changes in exposure on health. Because ofthe potential compounding of high-end or low-end assumptions in ... recognizes the importance of other sources of uncertainty inthe health benefits estimates, there is little evidence of further progress in providing a quantitative uncertainty analysis for these...
... generate these values, could be contained. The emotional intensity ofthe backlash against the intrusions of these subaltern groups suggests the importance of readingthese developments in ways ... . In such circumstances, theycertainly do honour to the liberality and taste of those who are at the expence of preserving them: but they are of little service in adorning and fertilizing the ... reproducing the Romantic myth of the originality ofthe creative act. The point of concluding withone ofthe most established Romantic poets is to dispel an either/or approach that simply inverts...
... as the economic depression hit towards the end ofthe 1930s, and the number of workers inthe estates fell. However they became more active again inthe 1950s. The fall ofthe French inthe ... traditions in using the forest and land as they had done since the time of their ancestors. The National Forest Meeting in 1989 raised the importance ofthe forest for the livelihood ofthe Lao ... some ofthe written contracts include the signatures ofthe local Lao officials. 4. State policy, international institutions and the promotion ofthe rubber industry The origins of the...
... thrombin show that the A-chain closely follows the contour ofthe catalyticB-chain, hinging the two interacting six-stranded bar-rel-like domains ofthe B-chain [17]. A well-structurednetwork of ... simulation of DK9thrombin in explicit water solvent supports the role of the A-chain in affecting the conformation and catalyticproperties ofthe B-chain, particularly in some insertionloops ofthe ... single band of ~ 36 kDa for all the thrombin forms.Effect of pH on thrombin amidase activity andbinding ofthe inhibitor a-NAPAP to the thrombinactive site The effects of pH (5.5–10) on the...
... level of development, the prevalence of obesity (and of type 2 diabetes) is linked to the degree of inequality in society (measured us-ing such indicators as the Gini coefficient), rather than the ... processes directly and indirectly in uencing the prevalence of obesity THE DETERMINANTS ã 132. The determinants of obesityMain messagesã The simultaneous presence of physical inactivity and poor ... education ofthe mother and watching more television, explained most ofthe difference inthe prevalence of obesity by ethnic origin. Finally, other risk factors, such as tobacco smoking and...
... inthe case ofthe K137E mutant of HSP22 (Fig. 4B); however, in this case, the intensity of the band corresponding to the HSP22 dimer wasmore intense than inthe case ofthe wild-type protein.Thus, ... intact protein at the beginning of tryp-sinolysis and at the fixed time of trypsinolysis) against the time of incubation (Fig. 8D). The apparent rateconstants of trypsinolysis under these conditions ... shock proteins, each of which contains the so-called a-crystallin domain consisting of 80–100 residues and located inthe C-terminal part ofthe molecule. The a-crystallin domain consists of six...
... Change inthe RSDI was highly discordant in 6% of subjects for the RSS-4, 9% of subjects ofthe SF-12 PCS, 13% of subjects for the CES-D, and 10% of subjects for the PCRQ. For defini-tions of abbreviations ... testing, andquality of life in patients with sinusitis. Otolaryngol Head NeckSurg 2000, 123:389-392.Additional file 1 The Rhinosinusitis Disability Index (RSDI) Domains and Items The Rhinosinusitis ... globalchanges inthe RSDI, expressing the difference in scores asstandardized response means (Figure 1), and testing the difference using paired t test (Table 2). The main criticism of relying solely...
... four major catfish farming provinces inthe Mekong Delta, but also included surveys of other BMP farmers and some non BMP farmers inthe other major provinces ofthe Delta. The fieldwork component ... multiple business enterprises, including acting as a market chain middleman, and has a fish feeding business. These examples highlight not only the complexity and diversity of farmers inthe industry ... demonstration of BMPs 2. To examine the reactions of farmers to the BMP demonstration trials in light of these issues, and 3. To assess the role of farmer associations (aqua clubs) in facilitating the...
... differences in either the degree of glomerular proliferation, of periglomerularinflammation, or of tubulointerstitial disease. In addition therewas no evidence of increased complement activation eitherlocally ... previous data showing that renal injury in the MRL mouse is independent of Fc receptors [51], our stud-ies showing the functional deficiency of C4 in these mice, andthat the loss ofthe major negative ... C4b-binding protein deficiency. Blood1990, 76:2527-2529.14. Hessing M, van TVC, Bouma BN: The binding site of humanC4b-binding protein on complement C4 is localized in the alpha'-chain....
... are harnessing the Internet and the growing usage of computers in Dharamsala as avaluable vehicle for their intelligence gathering. The contributions of this paper work are twofold.On the one ... network of infected machines reporting back tomachines in China, dubbed “GhostNet”, namedafter one ofthe offending pieces of malware —Gh0stRat [16, 15]. The network consisted of a number of high ... for the Server Mes-sage Block (SMB) file-sharing protocol on Win-dows machines. Since the majority of machines in San Jose run Linux, we were curious and investi-gated them further. 99.37% of...