the role of pharmacodynamic biomarkers in oncology and in oncology drug development
The role of GRIM 19 in xenopus embryo development
... change of both CnB and the regulatory domain of CnA, resulting in the exposure of the calmodulin-binding domain (Sikkink et al., 1995) The Ca2+/calmodulin then bind to the CaM-binding domain and ... (>0.3µM) inhibits the opening of InsP3Rs Thus, during the onset of InsP3Rs opening, the release of Ca2+ increases the sensitivity of InsP3Rs, resulting in a rapid rise in Ca2+ levels Once the Ca2+ ... calmodulin It has high affinity and low affinity Ca2+ binding sites Upon increase of intracellular Ca2+ to a certain level, it binds to the low-affinity sites of calcineurin B and affects the conformation...
- 159
- 256
- 0
ELUCIDATING THE ROLE OF BNIP 2 IN ZEBRAFISH EARLY DEVELOPMENT
... studying the role of bnip-2 in development facilitates the understanding of the contextual signalling ability of bnip-2 The aim of this study is to identify the developmental processes bnip-2 is involved ... Pan and Low, 2004 1.3 BCH domain containing-proteins and cell dynamics There is significant conservation in two GTPase-binding motifs found in the BCH domains These motifs resemble the Rho-binding ... classifications of BCH-domain containing proteins Proteins containing the BCH domains can be subdivided into three groups: Group members are defined by the presence of a single BCH domain that has the high...
- 122
- 335
- 0
Tài liệu The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States: A Joint Statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory Committee on Immunization Practices docx
... useful in determining a) the efficacy of BCG vaccine in HCWs or b) the effects on efficacy of the vaccine strain administered Vol 45 / No RR-4 MMWR and the vaccinee’s age at the time of vaccination ... resurgence in the incidence of TB occurred in the United States and included increases in the number of TB cases among adults and children and outbreaks of multidrug-resistant TB (MDR-TB) involving ... Control and Prevention The role of BCG vaccine in the prevention and control of tuberculosis in the United States: a joint statement by the Advisory Council for the Elimination of Tuberculosis and the...
- 27
- 1,309
- 3
Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafficking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efficient GABA-uptake activity of the GABA transporter pptx
... N-linked oligosaccharide side-chains are important for the GABA transport activity 1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into the role of the ... modification may in uence many of the physicochemical and biological properties of the proteins, such as protein folding, stability, targeting, dynamics and ligand binding, as well as cell-matrix and cell–cell ... misfolding of this protein, resulting in its partial retention in the ER and its rapid digestion thereafter [16,19] Accordingly, our results indicate that the intracellular trafficking of N-glycosylation...
- 14
- 654
- 0
Enterprise Adjustment and the Role of Bank Credit in Russia: Evidence from a 420 Firm''''s Qualitative Survey pdf
... the left to the right-hand side of the map decreases the probability of Expected-Debt to be equal to ô ằ (increase in indebtedness) by 15 points (33 minus 18), and increases the probability of ... Survey In 1996, the credit has overall been decreasing for 53% of the sample, it has been increasing for 36%, and has been stable for the remaining 11% An increase in indebtedness (of 80% in average) ... constraints The descriptive, statistical analysis in Table indeed confirms that the lower the decline in production (or the higher its increase, in the best cases), the higher the probability of...
- 30
- 635
- 0
Báo cáo khóa học: Mutational and computational analysis of the role of conserved residues in the active site of a family 18 chitinase docx
... However, the mechanistic roles of several of these residues are not described well and there is no example of mutational analysis of all of these residues in the same enzyme To obtain an insight into ... in the ÔupÕ position rows and shows that in the presence of the substrate, rotation of Asp142 towards Glu144 lowers the pKa of the latter by 0.8 pH units The calculated effects of the D140N and ... affinity of ChiB for allosamidin, which is an analogue of the proposed oxazolinium ion intermediate [32] The minor (or even positive) effects of Y214F on substrate and intermediate binding and the...
- 10
- 651
- 0
Báo cáo khoa học: Kinetic and crystallographic analyses of the catalytic domain of chitinase from Pyrococcus furiosus – the role of conserved residues in the active site pdf
... Stereo figures of the model of the bound substrate in the AD2 E526A mutant (A) and D524A mutant (B) The structures of bound sugars and the side-chains of three acidic residues in the conserved ... important role in ‘cycling’ the pKa of catalytic Glu during catalysis [24,38] The mutation of the D1 residue to Asn (D140N) in SmChiB caused a 500-fold decrease in activity [39] On the other hand, in ... orientations of the Glu526 side-chain in the A-form were almost identical, and the maximum coordinate shift ˚ after superimposition of the two structures was 0.78 A In the B-form, in contrast, the Glu526...
- 13
- 514
- 0
Báo cáo khoa học: Alternative initiation of transcription of the humanpresenilin 1gene in SH-SY5Y and SK-N-SH cells The role of Ets factors in the regulation ofpresenilin 1 pptx
... using the concentration of protein in the extract as an internal standard The activity of ()119/+178) PS1CAT in the presence of the empty vector was taken as 100% The values represented in the ... all contain the highly conserved ETS domain ERM contains two DNA binding inhibitory domains flanking the Ets domain: the central 87 amino acid inhibitory domain is poorly conserved and virtually ... SK-N-SH and SH-SY5Y cells recognize specifically Ets motifs flanking the +1 site (A) The binding of nuclear factors is eliminated by mutations in Ets motifs The binding of nuclear factors present in...
- 10
- 492
- 0
Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx
... loss of penicillin binding Arginines 306 and 307 Fig Proposed binding mode for penicillin N to the iron(II)-2-oxoglutarate complex of DAOCS, showing possible involvement of selected residues The ... The third type of mutant, represented by arginines 306 and 307, are located in the C-terminus They appear to modulate the activity of the C-terminus, which encloses the DAOCS active site during ... proposed mode of penicillin binding by DAOCS [1,12] a key feature of which is that arginines 160 and 162 bind to the carbonyl and/ or carboxylate of the bicyclic b-lactam nucleus, with the pro-S methyl...
- 5
- 462
- 0
Báo cáo khoa học: The role of residue Thr249 in modulating the catalytic efficiency and substrate specificity of catechol-2,3-dioxygenase from Pseudomonas stutzeri OX1 ppt
... two residues and the edge of the substrate ring could prevent binding of 3,6-DMC and 3,5-DMC, as shown in Fig 2D,E,F Thus, the binding of 3,5-DMC and 3,6-DMC to the active site of C2,3O could ... when the side chain makes the closest contact between the residue and the substrate Lines with round ends indicate stacking between the ring of the substrate and His240 in DHBD (A), His248 in HPCD ... To investigate the in uence of the side chain of residue Thr249 of C2,3O on the cleavage of 3,5-DMC and 3,6DMC, the catalytic properties of mutants were studied Based on the results of docking...
- 14
- 411
- 0
The role of international agreements in environmental conservation and its implication to Vietnam
... game theories New findings out of the thesis This thesis presents the following new findings (1) New findings related to theory (a) A new economic equation to relate two levels of sustainable ... to the right of OS line as long as the points are to the left of the vertical S line which represents the general sustainability line Gist of Chapter 2: ENVIRONMENTAL CONSERVATION AND TRADE The ... agreements mathematically in terms of environmental conservation The proposed thesis is, therefore, unique, original and very challenging in this aspect The followings are some of the important...
- 33
- 495
- 0
regional business cycle and real estate cycle analysis and the role of federal governments in regional stability
... dominant states play quite a signi cant role in the formation of the business cycle patterns of the formar group of states The business cycle patterns of the major oil supply states are distinctly ... (2.15) Rather than using only the previous information, it is possible to obtain the probability of the economy being in either recession or expansion Pr[St = j j using the full set of information ... level business cycle patterns In face, most of the time the state level business cycles of this group lay on the opposite side of the national business cycle.Most of the states fall into the fourth...
- 120
- 418
- 0
báo cáo hóa học: " Discrimination and reliability: equal partners? Understanding the role of discriminative instruments in HRQoL research: can Ferguson''''s Delta help? A response" pptx
... remains to be seen how these elements, particularly reliability and discrimination, interact In closing I should directly answer the questions posed by Norman and Wyrwich in the titles of their ... points, then a discrimination is defined as any between-persons difference > = points Delta then indexes the degree to which the instrument makes valid discriminations Wyrwich suggests that the ... the results of another study [6], in which the dichotomous scoring method of the GHQ-12 was found to be less discriminating than the Likert scoring method, were 'well expected' This again suggests...
- 3
- 384
- 0
báo cáo hóa học:" The role of tendon microcirculation in Achilles and patellar tendinopathy" doc
... or in tendinopathies at the wrist level The diagnosis of tendinopathy of the main body of the Achilles tendon is made if patients have Achilles tendon pain at rest or at exercise in the main ... either AirHeel™ wrap or eccentric training or the combination of both [57] Non-invasive topical nitroglycerin in tendinopathy The rationale for the use of topical transdermal nitroglycerin in ... Sclerosing with polidocanol was performed in the area of neovascularisation resulting in an improved knee function and reduced pain in the polidocanol group in contrast to the lidocaine/epinephrine...
- 13
- 675
- 0
Báo cáo khoa học: "Experimental reproduction of proliferative enteropathy and the role of IFN-gamma in protective immunity against Lawsonia intracellularis in mice" pdf
... ylevitcepser ,puorg lortnoc a rof dna puorg noitcefni na rof dengissa erew ecim eerhT esuom detcefnifo noloc dna mucec cimerepyh dna degralne )D( dna ,esuom detcefninu na fo enitsetni lamron )C( ... ytlucaF eht yb detroppus saw krow sihT stnemgdelwonkcA snoitcefni tsniaga ytinummi evitcetorp a fo noitcudni eht rof γ-NFI fo ecnatropmi eht deilpmi stluser esehT enitsetni egral eht ni snoisel ... noswaL ,S tsirOcM ,S insaJ 761-951 ,601 ,2991 htaP pmoC J sitiretne evitarefilorp enicrop fo noitcudorper latnemirepxE JP eoloC ,R dnalroB ,RM notredlA secnerefeR 4002 ni ytisrevinU kuknoK fo dnuF...
- 3
- 480
- 0
Báo cáo lâm nghiệp: " The role of glutamine synthetase, glutamate synthase and glutamate dehydrogenase in ammonia assimilation by the mycorrhizal fungus Pisolithus tinctorius" ppt
... primarily into the amide of glutamine by the activity of GS, and transferred to glutamate-amino by glutamate synthase activity Inhibition of GS and glutamate synthase blocked the synthesis of glutamine ... marked increase in the and glutamine pools after h in the fresh medium (Fig 3a) Glutamate levels remained constant after h but the glutamine concentration continued to increase up to h indicating ... thus there was no incorporation of ammonia into glutamate by GDH After h the glutamine concentration peaked and remained stable, indicating feedback control of GS Inhibition of aminotransferases...
- 5
- 360
- 0
Báo cáo y học: "α The role of HIF-1α in maintaining cartilage homeostasis and during the pathogenesis of osteoarthritis" pot
... the role of HIF-1 in chondrocytic energy generation, matrix synthesis and cell survival During hypoxic and normoxic conditions, functional inactivation of HIF-1α in the presence of interleukin-1β ... HIF-1 is of pivotal importance in cartilage development and homeostasis Furthermore, given the decreased oxygen levels and presence of inflammatory mediators during the course of OA, a causal role ... Thus, the work by Yudoh and colleagues adds further experimental evidence for the suggested role of HIF-1 in protecting chondrocytes from cell death induced by pro-inflammatory cytokines Finally,...
- 2
- 336
- 0
Báo cáo y học: "The role of transposable elements in the evolution of non-mammalian vertebrates and invertebrates" doc
... (total of 98,695 introns) for TE insertions to determine the percentage of TE-containing introns (Figure 2a) The fraction of the introns that contain TEs in the non-mammalian vertebrates G gallus and ... between the fraction of introns containing TEs and median length of introns (Figure 2c), implying that TE insertions have played a role in the evolution of intron size Previous analysis of human and ... respectively The grey boxes show insertion of TEs into exons The TE family is indicated beneath the gray box, along with the length of each inserted TE Lengths of the introns and exons flanking the inserted...
- 13
- 315
- 0
Báo cáo y học: "The role of a pseudocapsula in thymic epithelial tumors: outcome and correlation with established prognostic parameters. Results of a 20-year single centre retrospective analysis" pptx
... experience in clinical treatment of thymomas as a result of a retrospective single centre analysis done within a European university setting The role of a pseudocapsula and its clinical significance and ... [3] The reason for these is based in a couple of problems First, there is a significant interobserver variability in histological typing [2,6] Second, determination of precise cut-off points ... classified thymomas and reviewed histological and immunhistochemical staining of the specimens CS has participated as senior author in the design of the study and helped to draft the manuscript All...
- 10
- 355
- 0
Báo cáo y học: " The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer" ppsx
... modulate the inflammatory profile after a viral infection by blocking the poly(I: C) induced chemokine and cytokine production while maintaining the antiviral activity [28,59] As epithelial cells ... the review, all authors contributed in writing and reviewing the paper All authors read and approved the final manuscript Competing interests The authors declare that they have no competing interests ... of VitD have been discovered, indicating that VitD regulates many cellular processes and is potentially involved in the development of many diseases Since the discovery of VDRs in a variety of...
- 9
- 456
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ chỉ tiêu chất lượng 9 tr 25