the role of oxidative stress and inflammation in dry eye disease
Báo cáo khoa học: The role of residues R97 and Y331 in modulating the pH optimum of an insect b-glycosidase of family 1 pdf
... resultfrom the modifications in the interactions between the catalytic glutamates and the residues R97 and Y331,indicating that these residues play a role in the modulation of the Sfbgly50 pH optimum.Sequence ... mMBicine buffer 7.0–8.5). The pH stability of Sfbgly50 was checked by incubation in the same buffers for a time equal to the assay time and thendetermining the activity remaining at the optimum ... [10,12].Nevertheless, it is not possible to assume that the same isoccurring in the mutant R97M, because there is no data on the interactions between the substrate and the arginineresidue.Finally, another...
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Báo cáo khoa học: " The role of marine salt and surfactants in the decline of Tyrrhenian coastal vegetation in Italy" ppt
... resistance to the action of aerosols is the result of the strength of the structures protecting the leaf, and increaseswith sclerophyllia and with the thickness of the cuticle.ACKNOWLEDGEMENTS The ... sam-ples and depositsWhen interpreting the results of the chemi-cal analysis of rainwater and deposits it isnecessary to bear in mind the interactionsbetween the matrix and ... near the coast and 2-3 km inland. Samples of bulkdeposits were taken from pine trees (Pinus pineaL) from the section of the crown exposed to the sea and also from the...
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báo cáo hóa học: " Biomarkers of oxidative stress and its association with the urinary reducing capacity in bus maintenance workers" pptx
... oxida-tive stress. The observed increase of reducing species in urine would mirror an increased level in blood originat-ing from a response to oxidative stress in the body mon-itored by the urinary ... only 10% of urate is excreted in the urine (the remaining 90% being recirculated by the renal system[3]), an increase of this antioxidant in blood will alsolead to an increase in urine. The fact ... H,Savant Instruments Inc.). The final volume was deter-mined by gravimetry, assuming that the entire methanolwas removed during the conc entration in the SpeedVac and that the d ensity of the remaining...
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Báo cáo khoa học: The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B1 and B2 bradykinin receptors potx
... by the amount of internalized agonist[20]. As the internalization is expressed in percentage of total binding, decreasing the binding affinity of the Role of helix 8 and C-termini in bradykinin ... FEBS The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B1 and B2bradykinin receptorsAlexander Faussner1, Alexandra Bauer1, Irina Kalatskaya1, ... addition of scintillation fluid. Nonspecific bindingwas determined in the presence of 5 lm unlabeled agonist and subtracted from the total binding to calculate the spe-cific binding.Internalization of...
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Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf
... of GSK3 (using Li or SB-415286)appears to be sufficient for inducing activation of GS in muscle and fat cells, and that inhibition of the kinasepotentiates insulin action in muscle of insulin-resistant ... increases in glucose uptake and glycogen synthesisallowing for more effective ÔchannellingÕ of glucose intoglycogen in response to insulin. However, one of the potential difficulties in interpreting ... phosphatidylinositol3-kinase, p70, S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement of the mammaliantarget of rapamycin (mTOR) pathway in the L-leucine-inducedup-regulation...
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The role of sentence stress in enhancing english speaking competence of HPU english majors
... Sentence stress organizes the words in the sentence into logically connected thought groups by joining the unstressed syllables to the main stressed syllable in the group and marking the end of the ... lose their stress. The most important words in the sentence receive stronger stress. The last stressed word in the sentence receives the strongest stress with the help of falling or rising intonation. ... distinguish between four levels of stress: major sentence stress, major word stress, minor word stress and unstressed. Thus, in the sentence: “I walked home in the rainstorm”. ‗I‘, in , and...
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Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf
... phenylalanine was thereforemutated to Ala, Leu, Trp or Tyr. These mutations may in uence the shape and volume of the acyl binding pocket and thereby alter the binding mode and affinity of the enzyme ... PAA and derivatives thereof, while maintaining the hydrophobicity of the binding site.To test the effect of the mutations on the specificity forphenylacetylated substrates, the steady-state kinetic ... kcatrepresents the rate of acylation and Kmequals the binding constant of the substrate to the free enzyme. The results then indicateÓ FEBS 2002 Role of active-site phenylalanines in penicillin acylase...
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Báo cáo khoa học: Effect of oxidative stress and involvement of poly(ADP-ribose) polymerase (PARP) in Dictyostelium discoideum development doc
... discoideum to oxidative stress, and we now show the response of this organism to oxidative stress and the role of PARP during development. We used hydroxylamine (HA)to induce in situ generation of H2O2 and ... development.HA-induced oxidative stress activates PARP within5 min (Fig. 4A,B), and its role during oxidative stress is further confirmed by the use of low concentrations of benzamide. Preincubation of cells ... H2O2 and monitored the effect of benzamide, a PARP inhibitor, on oxidative stress- induced changes in D. discoideum development. Interestingly, oxidative stress resulted in PARPactivation within...
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Báo cáo khoa học: Dissecting the role of protein–protein and protein–nucleic acid interactions in MS2 bacteriophage stability potx
... unsure of the mechanism of DNA-induced stabilization of the protein, and whe-ther it is related to the normal RNA-binding function of coat protein, as RNA binding had no effect. The increased ... understood, and we have investigated thesequestions in this work. We sought to determine the role of protein–RNA and protein–protein interactions in virus stability, measuring the effects of urea,GdnHCl ... against all the forms of denatura-tion we tested. This is consistent with the observation of increased stability of the single-chain version of the wild-type dimer [30] and is reminiscent of the...
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Báo cáo hóa học: " An exploration of job stress and health in the Norwegian police service: a cross sectional study" docx
... acquisition,analysis and interpretation of data and drafting of the manuscript. EH was involved in design, interpretation of data, drafting of the manuscript and supervision. ØE wasinvolved in conception and ... design, interpretation of data,drafting of the manuscript and supervision. BL wasinvolved in analysis and interpretation of data. AMB is the guarantor for this paper.Acknowledgements The study ... districts and rural ('lensman') districts. The two categories have the same education and training, but in the rural districts they work in smaller communities,often including large...
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báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pptx
... visualized the mineralizingcells with 2% Alizarin Red. After rinsing in distilledwater and air drying the samples, we mounted the cov-erslips on microscope slides using Fluoromount and examined and ... result in loss of ambulation or limb. Here we describe the sequential roles of FGF-2 in inducing gene expression, cell growth and BMP-2 in gene expression and mineralization of bone.Materials and ... BMP-2, the yin and yang of mineralization:Contrast of effect of 24 hours of treatment with FGF-2 or BMP-2 on fold increase in abundance of mineralization-related geneexpression. Mineralizing...
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báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pdf
... visualized the mineralizingcells with 2% Alizarin Red. After rinsing in distilledwater and air drying the samples, we mounted the cov-erslips on microscope slides using Fluoromount and examined and ... Li4AbstractIntroduction: The difficulty in re-growing and mineralizing new bone after severe fracture can result in loss of ambulation or limb. Here we describe the sequential roles of FGF-2 in inducing ... BMP-2, the yin and yang of mineralization:Contrast of effect of 24 hours of treatment with FGF-2 or BMP-2 on fold increase in abundance of mineralization-related geneexpression. Mineralizing...
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Báo cáo khoa học: "The role of Bcl-xL and nuclear factor-kB in the effect of taxol on the viability of dendritic cells" ppsx
... rationale for the use of taxol in DC immunotherapy and insights into the development of combinational DC therapies with other anticancer drugs that do not harm the viability or activity of DCs.Acknowledgments ... cells, producing major cytokines involved in immune responses. Importantly, taxol increased the expression of the anti-apoptotic protein Bcl-xL, and increased the mobilization of p65 subunit ... jooh@jejunu.ac.kr The role of Bcl-xL and nuclear factor-κB in the effect of taxol on the viability of dendritic cellsMi-Hyoung Kim1, Hong-Gu Joo1,2,*1Laboratory of Veterinary Pharmacology, College of...
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Báo cáo khoa học: " Induction of oxidative stress and lipid peroxidation in rats chronically exposed to cypermethrin through dermal application" pps
... damage. Further significant decreases in GSH levels in our study may be due to either the inhibition of GSH synthesis or increased utilization of GSH for detoxification of toxicant induced free ... However, an increase in catalase activity enhances the scavenging ability of erythrocytes to handle the hydrogen peroxide to molecular oxygen and water [11,29].GSH-Pxs catalyze the peroxides and reduce ... significantly reduced (p ＜ 0.05) in all groups compared to the control group. Similar finding have been reported in other study during oxidative stress [24]. No significant changes in GST activity was...
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Báo cáo y học: "The association of psychological stress and health related quality of life among patients with stroke and hypertension in Gaza Strip" pps
... characteristics of the Palestinian political and eco-nomic situation may have contributed to these findingsindicating the significant relation of QOL and income and education in Gaza Strip. Unemployment and ... life in these patients.BackgroundQuality of life (QOL) is a phrase often used in health caresettings at policy and administration levels, in clinicalassessments of therapies, and in clinical ... the dis-ease in the previous year, on the type of brain lesion of stroke or the severity of the CVD condition potentiallyinfluencing QOL were obtained. However, for the pur-pose of this study...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008