the role of nutrition in prevention and management of pressure ulcers
báo cáo khoa học: "Different patterns of NF-B and Notch1 signaling contribute to tumor-induced lymphangiogenesis of esophageal squamous cell carcinoma" ppt
... of immunohistochemical staining Nuclear staining of NF-B and cytoplasmic staining of Notch1 and VEGF-C were scored in this study The intensity of NF-B, Notch1, podoplanin, and/ or VEGFC staining ... with the presumed oncogenic role of Notch signaling during tumorigenesis, the finding that Notch signaling is diminished in epithelial squamous cell carcinoma of the skin would seem to suggest that ... lymphangiogenesis [29] Interestingly, LVD reduced prominently in lungs of mice lacking p50 subunit of NF-B, which demonstrated the important role of p50 subunit of NF-B in regulating the expression of VEGFR-3...
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báo cáo khoa học: "DOF-binding sites additively contribute to guard cell-specificity of AtMYB60 promoter" potx
... of DOF1 and DOF2 (mDOF(1+2)::GUS), DOF1 and DOF3 (mDOF(1+3)::GUS) or DOF1 and DOF4 (mDOF(1+4)::GUS) completely inactivated the minimal promoter, as GUS expression was abolished in all the mDOF(1+2)::GUS, ... out the involvement of a group of DOF proteins, known as CDFs, already characterised for their involvement in flowering time, in the regulation of AtMYB60 expression Conclusions These findings ... region [10] Yet, the role of DOF-binding sites in driving guard cell expression in Arabidopsis and the hypothesis of cluster organization remains to be experimentally investigated The guard-cell...
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Báo cáo y học: " Does a new polyomavirus contribute to Merkel cell carcinoma" pot
... underlines below the zoom-ins, both the HPDK Hsc70-binding motif and the LxCxEx Rb-binding motifs are preserved in the predicted MCPyV large T antigen Noted on the cartoon are the locations of the ... expanded alignments for the Hsc70-binding motif and the pRb-binding motif, comparing the putative MCPyV large T antigen with the JC and SV40 large T antigens Importantly, as indicated by the ... discrete protein domains, which include the DNA J, originbinding and helicase domains These facilitate viral replication by binding to cellular replication proteins, including Hsc70 (HSPA8), DNA...
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báo cáo hóa học:" Characterization of the tumor marker muc16 (ca125) expressed by murine ovarian tumor cell lines and identification of a panel of cross-reactive monoclonal antibodies" docx
... RT-PCR and western blot ananlysis and was assisted in these experiments by JAB and JAAG MM and CR helped in designing appropriate Muc16 primers JC assisted in obtaining and maintaining murine ovarian ... forms of the mucin MUC16 is both expressed on the cell surface and shed from the cell in soluble forms Muc16, on the other hand, is detected primarily in the spent media and in the intracellular ... important in understanding the immunomodulatory roles of this mucin The shed Muc16 should also be found in the serum of mice bearing the Page of (page number not for citation purposes) Journal of Ovarian...
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báo cáo khoa học: "A nanocomplex that is both tumor cell-selective and cancer gene-specific for anaplastic large cell lymphoma" ppt
... participated in the experimental design and review of the manuscript YZ designed the experiments and wrote the final manuscript All authors read and approved the final manuscript Competing interests The ... cell binding of the nanocomplexes was then quantified by flow cytometry The nanocomplex was functionally stable in culture medium and retained ~75% of its cell binding capacity after preincubation ... 12 hours the binding capacity decreased to ~10% (Figure 5C) To determine whether binding of the CD30 aptamermediated to the cell surface induced nanocomplex internalization, cells were incubated...
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Báo cáo khoa học: Do bacterial genotoxins contribute to chronic inflammation, genomic instability and tumor progression? pot
... radiation) Sensing and activation of the DDR is coordinated by proteins of the phosphatidylinositol 3-kinase-like protein kinase family: ATM, Bacterial genotoxins and genomic instability ATR and DNA-PK ... cell cycle and is based on the identification of the break and subsequent rejoining of the two ends Consequently, there is a loss or addition of nucleotides at the site of the lesion, and the repair ... the art of the DNA damage sensing and repair pathways in mammalian cells, as well as the consequences of an altered DDR in the promotion of genomic instability On the basis of the type of DNA...
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Báo cáo y học: "Interactions between IL-32 and tumor necrosis factor alpha contribute to the exacerbation of immune-inflammatory diseases" ppt
... chondrocytes of the joints There would therefore be no initiation of inflammation in the joints without the infiltration of bone-marrow-derived cells expressing hIL-32 The source of IL-32 remains unsolved ... change cytokine expression in the presence of IL-32β Therefore IL-32β had effects on macrophages rather on than T cells in vivo, and the in vivo roles of IL-32β were mainly to induce other inflammatory ... inflammation was observed in histological examination of the spleen, the joint, the intestine, the kidney, and the liver (data not shown) We next examined the response of splenocytes of BM-hIL-32 mice...
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Evaluation of the Characteristics of Microorganisms that Contribute to Denitrification in the Paddy Drainage Treatment Apparatus by Quinone Composition Measurement
... was at the outlet point, the height of which was fixed during the observation period The water treatment apparatus was set just in front of the weir, and water levels in the paddy field and the ... Akita-Komachi Rice, and the planting rate was 0.30 m (ridge pitch) and 0.15 m (planting pitch) The paddling and transplanting were conducted on June and June 8, and the inundation began on June in 2007 A ... Isoprenoid quinones are used as coenzymes in the electron transport chain for respiration of microorganisms The major type of quinone contained in each microorganism depends on the features of the microorganism...
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Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt
... ligand-binding domain; a transmembrane domain; an intracellular tyrosine kinase domain; and a C-terminal regulatory domain [2] The extracellular domain is subdivided further into four domains The ... Distribution and frequency of EGFR mutations occurring in the kinase domain in lung cancer (upper part of the figure) [12] and in the extracellular domain in glioblastoma (lower part of the figure) ... betacellulin, heparin-binding EGF and epiregulin); and (c) neuregulin (NRG) (also known as heregulin) that binds to ERBB3 and ERBB4 NRG1 and NRG2 bind to both ERBB3 and ERBB4, whereas NRG3 and NRG4...
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Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc
... result in repositioning of critical residues surrounding the ATP-binding cleft of the tyrosine kinase domain of the receptor and thereby stabilize the interaction with EGF-TKIs signaling cascade, independently ... Two such inhibitors of the tyrosine kinase activity of EGFR (EGFR-TKIs), gefitinib and erlotinib, compete with ATP for binding to the tyrosine kinase pocket of the receptor, thereby inhibiting receptor ... turned off and the cancer cells undergoing apoptosis Moreover, EGFR mutations result in repositioning of critical residues surrounding the ATP-binding cleft of the tyrosine kinase domain of the receptor...
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Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx
... including those of the kinase inhibitor proteins (KIP) family and the INK4 family (Fig 3) The KIP family consists of p27KIP1, p21WAF1 ⁄ CIP1 and p57KIP2; and the INK4 family consists of p15INK4b, ... down-regulated by gefitinib or erlotinib in intestinal epithelial cells [53] Furthermore, the expression of cIAP-1 and of X-linked IAP is reduced by AG1478 in squamous cell carcinoma cell lines NA and Ca9-22 ... a minor role in the induction of apoptosis in intestinal epithelial cells Instead, p38 MAPK phosphorylation is associated with mitochondrial translocation of Bax and subsequent induction of in...
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Tài liệu Báo cáo Y học: Bivalent cations and amino-acid composition contribute to the thermostability of Bacillus licheniformis xylose isomerase doc
... inactivating at a measurable rate increase from the apoenzyme to the Mn2þ-containing enzyme, loss of the metal cofactor could be the limiting step in BLXI inactivation Higher Ea values of inactivation ... information for BLXI in the presence of Mn2þ (or Co2þ) and Mg2þ would provide insight into the molecular determinants responsible for the differences in Ea The large variation in Ea of BLXI inactivation ... metal-binding site with the side chain of an amino acid These mutations to both metal-binding sites, M1 and M2, resulted in destabilized XIs For example, mutation of His220 in the class I S rubiginosus...
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Báo cáo khoa học: "Entailment-based Text Exploration with Application to the Health-care Domain" pot
... directional inference relation between two fragments In this work, we focus on leveraging a common type of entailment rules, in which the left-hand-side of the rule (LHS) and the right-hand-side of the ... both the entailment graph and the taxonomy) The index server applies periodic indexing of new texts, and the exploration server serves the exploration application on querying, exploration, and ... as explained in Section 3.1, where all nodes that have no parent are defined as the roots of the DAG As a starting point, only the roots of the DAG are displayed to the user Figure shows the five...
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Báo cáo khoa học: Structural features in the C-terminal region of the Sinorhizobium meliloti RmInt1 group II intron-encoded protein contribute to its maturase and intron ppt
... the N-terminus of the RT domain is required for protein interactions with the high-affinity binding site in subdomain DIVa of the intron, whereas other regions of the RT and domain X interact with ... motif, in which the Y354 and Y355 amino acids were replaced by alanine residues, and the 2.5· mutant [27], in which the IEP was truncated in the RT domain Therefore, the pattern of inhibition for the ... extension In the present study, we investigated the C-terminal region of the RmInt1 IEP up to the maturase domain and the C-tail We found that the C-tail and upstream amino acid residues, located in...
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Báo cáo khoa học: Assessment of telomere length and factors that contribute to its stability potx
... be involved in clustering of telomeres and may be involved in the interaction with the nuclear envelope By its interaction with the stem-loop structure of telomerase RNA, may be involved in the ... shield the chromosomal ends from nuclease activities The synthesis of telomeres occurs simultaneously with DNA replication The unwinding of the DNA strands is essential for the binding of the DNA ... has the ability to monitor proliferation in a minor subset of cells and follow the acquisition of different markers in internal proteins linked to cell divisions In the future, combination of...
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Báo cáo khoa học: Detergent-resistant membrane fractions contribute to the total 1 H NMR-visible lipid signal in cell potx
... however, neither the choline headgroups of PtdCho and sphingomyelin (except for a small peak in THP-1) nor the sphingosine chain of sphingomyelin were visible in the NMR spectra of DRMs In bilayer ... giving it characteristics of being in the liquid-ordered (lo) phase [10] DRMs are rich in cholesterol and sphingolipids (including GM1 and GM3) and selectively retain a number of proteins including ... respectively) The DSM fractions contained higher levels of 18:0, 18:2 + 18:3 and 18:1 at the expense of 16:0, 14:0 and 16:1, whereas there was a marked increase in the amount of 16:0 and a decrease in the...
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Báo cáo khoa học: Sendai virus N-terminal fusion peptide consists of two similar repeats, both of which contribute to membrane fusion ppt
... investigate whether the different behavior of the peptides in inducing lipid mixing of LUV, lowering the TH of DiPoPtdEth, and promoting isotropic 31P NMR signals could be related to differences in their ... with the infectivity of in uenza virus containing single amino-acid mutations in the fusion peptide segment of hemagglutinin [16] Here we observed an inverse correlation between the lipid mixing ... 1–33, and WT-palm-19–33 appear concurrently with an increase in the size of the vesicles, confirming that the ability of the peptides to induce lipid mixing is the result of membrane fusion In order...
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Greener Pastures How grass-fed beef and milk contribute to healthy eating ppt
... Hecker, and Binkoski 2004) Nevertheless, the ratio remains a subject of interest in the nutrition community We offer data on the ratio because of this interest and as a way to understand one of the ... fats in the diet and the confused and preliminary nature of the data needed to support specific dietary recommendations Considering the many kinds of fats and the complexities of their interrelationships, ... reflect differences in the nutrients (vitamins, minerals, and energy sources) and the level of sophistication and consistency in the results of the scientific research behind the recommendations...
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Báo cáo khoa học: Structure and function of human a-lactalbumin made lethal to tumor cells (HAMLET)-type complexes pptx
... understanding of the basic principles underlying protein self-assembly and acquisition of new functionality HAMLET key features are related to the intrinsic properties of proteins to possess varying ... casein The tumoricidal activity in the casein fraction was obtained after low pH precipitation of human milk [2,7] and the protein component of the casein fraction was identified as a-lactalbumin, ... a-lactalbumin in the MAL fraction was structurally modified As no post-translational modifications were detected, the folding state of a-lactalbumin in MAL was examined with CD and binding of the hydrophobic...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25