the role of nkt cells in the immune regulation of neoplastic disease
Section IX - Chemotherapy of Neoplastic Diseases ppsx
... years Improvements in their use are the result of a number of factors, including the following: Drugs now are routinely used earlier in the course of the patient's management, often in conjunction ... relatively free of toxicity It is imperative to maintain the output of a large volume of alkaline urine, since methotrexate precipitates in the renal tubules in acidic urine In the presence of malignant ... possible to assess precisely the role of incorporation of thioguanine or mercaptopurine into cellular DNA in the production of either the therapeutic or toxic effects of these drugs (Bo et al., 1999;...
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THE ROLE OF DMSO IN THE REGULATION OF IMMUNE RESPONSES BY DENDRITIC CELLS
... macrophages therefore play an important role in protecting the host against invading pathogens as the pro-inflammatory cytokines produced would result in the killing and elimination of the invading pathogens ... effective interplay of the both arms in the immune system 1.2 Innate Immunity 1.2.1 Overview of Innate Immunity The innate immunity is known as the front line of host defence against invading pathogens ... concert to maintain the integrity of the immune system Cells of the immune system originate from their hemapoietic progenitors in the bone marrow Some cells leave the bone marrow after they were created,...
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Báo cáo khoa học: Alternative initiation of transcription of the humanpresenilin 1gene in SH-SY5Y and SK-N-SH cells The role of Ets factors in the regulation ofpresenilin 1 pptx
... ERM being the most related [35] PEA3 members all contain the highly conserved ETS domain ERM contains two DNA binding inhibitory domains flanking the Ets domain: the central 87 amino acid inhibitory ... marks the position of supershifted complexes (B) The binding of in vitro translated ERM is eliminated by mutations in Ets motifs The binding of in vitro translated ERM over the PS1 promoter was ... complexes with in vitro translated ERM which could be supershifted by the antibody, indicating the presence of ERM binding site(s) in each of the three probes We also examined the pattern of complexes...
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Báo cáo khoa học: Role of gangliosides in the association of ErbB2 with lipid rafts in mammary epithelial HC11 cells docx
... analyzed the role of gangliosides in the association of ErbB2 with lipid rafts in mammary epithelial HC11 cells The key role played by gangliosides in defining the distribution of ErbB2 into signaling ... fractions in HC11 cells Because in cells coexpressing both ErbB2 and EGFR, as is the case of HC11 cells, the two proteins strictly interact and EGF preferentially stimulates the formation of ErbB2 ... ester-induced disruption of the CD4–Lck complex occurs within a detergent-resistant microdomain of the plasma membrane Involvement of the translocation of activated protein kinase C isoforms J Biol Chem...
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Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx
... binding of any of the adherent cell types Binding assays with siglec-expressing COS7 cells Results for COS7 binding experiments are shown in Fig 5C There was a significant increase in binding of ... cytoplasmic domain of the siglec-10 protein The binding of SHP-1, however, was missing from the Y667F mutant indicating this to be the preferred tyrosine for interaction with SHP-1 SHP-2 binding, however, ... only diminished by < 50% in the Y667F mutant, indicating that SHP-2 may be binding both to the tyrosine at position 667 and to other tyrosines in the cytoplasmic tail of siglec-10 In eosinophil...
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Báo cáo sinh học: " Re-evaluating the role of natural killer cells in innate resistance to herpes simplex virus type 1" pot
... NK cells and/or professional APCs confer innate resistance to HSV-1 infection via the secretion of IFN-γ at early times p.i The following study was initiated to determine if NK cells provide innate ... NK cells are dispensable for the innate resistance of mice to HSV-1 infection, further investigation is necessary to determine what role, if any, NK cells play in human resistance to HSV-1 infection ... limit of detection) B Flow cytometric measurement of the abundance of CD4+ T cells, CD8+ T cells, and CD3- CD49b+ NK cells in the spleens of BALB/c versus scid mice (n = 10 per group) "Other WBCs"...
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báo cáo hóa học:" Re-evaluating the role of natural killer cells in innate resistance to herpes simplex virus type 1" pot
... NK cells and/or professional APCs confer innate resistance to HSV-1 infection via the secretion of IFN-γ at early times p.i The following study was initiated to determine if NK cells provide innate ... NK cells are dispensable for the innate resistance of mice to HSV-1 infection, further investigation is necessary to determine what role, if any, NK cells play in human resistance to HSV-1 infection ... limit of detection) B Flow cytometric measurement of the abundance of CD4+ T cells, CD8+ T cells, and CD3- CD49b+ NK cells in the spleens of BALB/c versus scid mice (n = 10 per group) "Other WBCs"...
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Báo cáo khoa học: "The role of Bcl-xL and nuclear factor-kB in the effect of taxol on the viability of dendritic cells" ppsx
... [11,17,20] To investigate further the mechanisms of taxol-induced changes, the viablity of TPCK, an inhibitor of the serine protease that inhibit NF-κB signaling pathway in cells [20], pretreated DCs ... implies that the pro-apoptotic effects of Bax might be minimized in the DCs during the treatment of taxol, 48 h NF-κB is closely involved in the survival and maturation of DCs [11,17,20] To investigate ... study of Bcl-xL using siRNA may further confirm their role of taxol-treated DCs Although the expression of Bax was increased in TaxolDCs, the expression of Bax occurred later than that of Bcl-xL,...
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Báo cáo khoa học: " Role of protease inhibitors and acylation stimulating protein in the adipogenesis in 3T3-L1 cells" potx
... together with insulin, there was an additive increase in lipids accumulation was seen (Fig 4) When the cells were incubated in presence of insulin and PI, TG accumulation was decreased When ASP in ... insulin plus PI and, §p ＜ 0.05 compared to insulin and insulin plus ASP Fig Effect of PI on ASP stimulated lipids accumulation in 3T3-L1 cells Cells were incubated for days with either insulin ... microscopically in presence ASP inhibited PI inhibited adipogenesis in 3T3-L1 cells 199 Fig Time dependent increase in acylation stimulating protein (ASP) expression during differentiation of 3T3-L1 cells...
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Báo cáo y học: "Synergistic role of c-Myc and ERK1/2 in the mitogenic response to TGF-1 in cultured rat nucleus pulposus cells" ppsx
... necessary for binding E-box DNA in the target gene, the interruption of their association inhibits the transcriptional function of c-Myc [21] Secondly, to suppress expression of c-Myc in protein level, ... depending on the status of these mediators in the target cells 11 12 13 Competing interests The authors declare that they have no competing interests 14 Authors' contributions TN and DS conceived of ... sorting (FACS) The cells were trypsinized, washed and seeded in 25 cm2 flasks at × 105 cells/ flask The cells were allowed to adhere for 24 h in medium containing 2% FBS The culture medium of each...
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Báo cáo y học: "Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2" pot
... whether the CD4+CD25– T cells capable of differentiating into TR cells following activation are derived from a separate lineage of CD4+ T cells, and whether their induction is a result of the initial ... thymic involution, and antigen exposures, the development of CD4+CD25+ TR cells may occur in the periphery in man Induction of CD4+CD25+ TR cells in the periphery The induction of TR cells that ... the TR cells induced at the site is not known — whether these cells exist only transiently then die, whether they persist in the body as TR cells, or whether they return to their previous role...
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Báo cáo y học: "The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells" doc
... proteoglycans are involved in rendering the disease chronic [16,17] Beyond the 100% incidence of arthritis, another major advantage of the AIA model is that the time point of induction of arthritis ... is known, allowing manipulation of CD4+CD25+ Treg cell number in vivo at defined stages in the disease Using depletion of CD25-expressing cells or transfer of CD4+CD25+ cells, in the present study ... AIA is dominated by cells of the innate immune system [19], and the exacerbation of arthritis in CD25-depleted mice could be due to a lack of suppression of these cells by Treg cells In accordance...
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Báo cáo y học: "The role of leptin in innate and adaptive immune responses" doc
... Defining the role of T cell-derived leptin in the modulation of hepatic or intestinal inflammation in mice Clin Exp Immunol 2005, 142:31-38 44 Faggioni R, Fantuzzi G, Fuller J, Dinarello CA, Feingold ... adipocytokines have been observed in a variety of inflammatory conditions (reviewed in [27]) and, in particular, the role of leptin in immune responses and inflammation has lately become increasingly ... emphasize the complexity of the neuroendocrine regulatory and compensatory mechanisms in leptin-deficiency The role of leptin in experimental models of arthritis A potential role of leptin has been...
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Báo cáo y học: "The role of mast cells and fibre type in ischaemia reperfusion injury of murine skeletal muscles" pot
... restores the susceptibility of skeletal muscles to IR injury irrespective of the other abnormalities in these mice The role of mast cells has not been considered when investigating the susceptibility ... though the latter contained twice the density of mast cells, indicate that there is also a genetic component to IR injury Our data would support the hypothesis that there is a base line level of ... reperfusion Unlike other models [6], the extended reperfusion period permits full manifestation of the reperfusion injury In order to determine the usefulness of therapies against mast cells, it is...
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Báo cáo y học: " The role of γδ T cells in airway epithelial injury and bronchial responsiveness after chlorine gas exposure in mice" pps
... for the epithelium and potentially could influence the regenerative response of the epithelium to chlorine [12] To evaluate the role of γδ T cells in chlorine induced airway injury we studied the ... since the inflammatory response to epithelial damage was also attenuated in the γδ T cell deficient mice Our findings are consistent with a role of γδ T cells in determining the magnitude of the ... subjects The factors influencing the rate of epithelial regeneration are likely of key importance in determining the short and long term consequences of chlorine induced airway dysfunction The γδ T cells...
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Báo cáo y học: " The role of the humoral immune response in the molecular evolution of the envelope C2, V3 and C3 regions in chronically HIV-2 infected patients" pdf
... below), in the envelope complex of HIV-2 differs substantially from that of HIV-1 Glycans on HIV-1 envelope protein play an important role in the folding of the glycoproteins, in infection and in ... common in HIV-2 than in HIV-1 infection Still, little is known about the role of humoral immunity in the evolution of the HIV-2 env gene In the present study we analyze, for the first time, the ... that adaptation to immune pressure is the main driver of the rapid intra-host evolution of the C2 and C3 regions in HIV-2 [15,25,58,60,64-66] Indeed, we found that most of the amino acids under...
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Báo cáo y học: " The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells" potx
... CEM mins 30 mins 45 mins 20 45 mins mins 25 30 mins 32 P Incorporation 30 15 H1 10 -5 H1 mins 30 mins 45 mins Time Figure Increased levels of cyclin E/cdk2 kinase activity in HTLV-1 infected cells ... onset of cdk2 kinase activity [28,30] Tax also has the ability to increase cdk4 associated kinase activity in HTLV-1 infected cells by binding to p16/INK4A, resulting in the inability of p16/INK4A ... represents the nucleolus, whereas the lighter blue staining represents the nucleoplasm As expected, the intensity of staining for cyclin D2 and p21/ waf1 was increased in HTLV-1 infected T -cells When the...
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Role of SPHK2S1P signalling in regulating mitochondrial function in the MPTP induced mouse model of parkinsons disease and in the MPP treated MN9D cells
... 1.10.5.1 Sphingosine kinases and S1P in the brain 28 1.10.5.2 S1P receptors in the CNS 29 1.10.5.3 Role of Sphingosine kinases and S1P in neurodegeneration 30 1.11 Aims of the present ... underlying the cause of Parkinson’s disease (PD) has attracted the attention of manyresearchers in the last few decades In spite of the recent technical advances in the field of neuroscience, the ... as the first line of resistance against a ROS rise In the post-mortem PD brains, an increase in the mitochondrial isoform of SOD2 was observed The latter observation is quite interesting since...
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The role of CD8 t cells in the differentiation of TNF iNOS producing dendritic cells and TH1 responses
... resulting in the killing of 39 Chapter 1: Introduction these infected cells Under these circumstances, the dying cells, CD8 T -cells and other APCs such as macrophages and DCs within the inflammatory ... 1995) They then induce cytolysis of infected cells either by the granule exocytosis pathway through co-ordinated delivery of perforin and granzymes into target cells, or by upregulation of FasL ... containing large spherical mitochondria which, in the living state in vitro, are continually elongating, retracting, and reorienting themselves, leading to a wide variety of cell shapes (Steinman...
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Tìm thêm: xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25