... surfactant protein D plays an important rolein delaying the appearance of pneumococci inthe blood and in limiting their numbers inthe bloodstream SP-D binds and agglutinates S pneumoniae inthe presence ... currently inthe process of investigating these questions In summary, the absence of lung surfactant protein D increases the persistence of pneumococcal colonisation and infection inthe upper ... required to further elucidate theroleof SP-D in regulating adaptive immune responses in vivo The potential of truncated recombinant forms of SP-D as a new therapy for infectious and inflammatory...
... concluded that the Available online http://ccforum.com/content/10/6/239 Figure Theroleoftheprotein C pathway inthe endothelial cell APC modulates endothelial phenotype by inhibiting thrombin production, ... cleaving PAR1 than is APC [31] The concentrations of APC used inthein vitro studies showing endothelial barrier protection were within the pharmacologic range of APC inthe PROWESS study in one ... and the mechanism of its benefit in these patients appears to be in part through direct interactions with the endothelium Competing interests The authors declare that they have no competing interests...
... the genome Thesequence to the 3’ ofthe stem-loop structure contains the hexamer repeats CGGCAG which act as the binding site for the Rep proteins The numbering ofthe nucleotide begins inthe ... play a rolein determining the pathogenicity ofthe PCV2 infection (Ramamoorthy et al., 2009) This thesis describes theroleof ORF3 inthe pathogenesis ofthe PCV2 virus infection at the systemic ... Our findings on the molecular activity of ORF3 have also led us to speculate other potential uses for theproteinInthe third part ofthe thesis, theroleof ORF3 mediated apoptosis inthe egress...
... readings of all standards, controls and samples, including the no -protein control The values for theprotein standards were plotted with a linear regression line through the standard points Theprotein ... aspects of PrP In humans, PrP is initially synthesized as a pre-pro-PrP of 253 amino acids inthe cytosol PrP contains a hydrophobic N-terminal signal peptide of 22 amino acids while the last 22 amino ... overview oftheroleof PrP in breast cancer metabolism inthe study model Picture showing different lactate production in normal and cancer situation Schematic overview oftheroleof PrP in cancer...
... and retaining it inthe nucleus In this manner p30 prevents the synthesis of Tax and Rex proteins and interferes, thereby, with the production of viral particles Furthermore, high level of p30 ... function ofthe mitotic spindle checkpoint protein MAD1 [142] In another study the MAD1 and MAD2 checkpoint proteins, which normally reside inthe nucleus, have been found in HTLV-1 infected ... ER-resident proteins; calerticulin and calnexin Calerticulin is a calcium-binding protein that participates in calcium signaling and linked to activation ofthe transcription factor nuclear factor of...
... formation of CrkII proteincomplexesin rat pancreatic acini Thus, inthe present work, we investigated whether in vivo activation ofthe CCKA receptor regulates CrkII function to form proteincomplexes ... migrating band (lane 2), showing that it contains the more tyrosine phosphorylated band of Crk Pretreatment with tyrosine kinase inhibitor alone increased the intensity ofthe lower migrating band ... allow (c) the intramolecular SH2 domain bind to it, which results in (d) inhibition ofthe intermolecular interactions of CrkII mediated by the SH2 domain and (e) subsequent blockade ofthe downstream...
... protein- protein, protein- lipid, and protein- DNA interactions (Fig 1.4) The most common protein- protein interaction domains in NRTKs are the Src homology (SH2) and (SH3) domains Fig 1.4 Domain architecture ... domain in PTK regulation While there are two families of domains that bind pTyr containing sequences – the phosphotyrosine binding (PTB) domain and the SH2 domain – only about a quarter ofthe ... 2001) Binding to the TKB domain is required for the subsequent conjugation of ubiquitin through the RING domain during the ubiquitination process The consensus binding sequence targeted by the TKB...
... iron-peroxo intermediate [11] The sum of these ndings points at the involvement of more than one active oxidant inthe diverse types of P450-catalyzed substrate processing [1215] The goal ofthe present ... reect ring opening of an epoxide intermediate at either of its two C-O bonds [219,220] The sum of these ndings strongly invokes the notion of oxygen activation during redox cycling ofthe diverse ... exhibiting insignicant sequence identity with P450s inthe heme-binding region [282], but bearing a C-terminal avoprotein fragment inthe single polypeptide chain structurally resembling NADPH-P450...
... trafficking properties The binding experiments also pointed to a decrease inthe density ofthe D2R variants inthe cellular membrane; the number of D2 receptor binding sites decreased with the number ... cytoskeletal protein 4.1 N, a member ofthe 4.1 family, facilitates the transport of D2R to the cell surface by interacting with the N-terminal portion ofthe ic3 loop of D2R via its C-terminal domain ... Measuring receptor dimer- ization by monitoring changes inthe fluorescence lifetime of probes linked to the receptors of interest seems the best approach in this kind ofthe study Although the...
... gave these four amino acids inthe highest yield, and they all were among the amino acids found inthe Murchison meteorite [11] Both the high content ofthe ‘very early’ amino acids in these sequence ... frequent domain was elongation factor Tu (with 472 proteins), and theprotein kinase domain (with 320 proteins) was the second most frequent For the ‘D-motif’, the most frequent domain was the EF hand ... patterns including the ancient amino acid residues, we searched theprotein databases for sequences including these four residues in various combinations Thus, we scanned UniProtKB ⁄ Swiss-Prot for the...
... accumulation of neutrophils inthe intestine and lung is a hallmark ofmultiple organ failure induced by zymosan An indirect assessment of neutrophil infiltration was carried out by measuring the activity ... focus’ much of their efforts at the level ofthe mitochondria, it plays a pivotal rolein deciding whether a cell will live or die The Bcl-2 family of proteins has expanded significantly and includes ... reducing the pathophysiology of MOF A histological resolution of organ damage to administration of GW0742 was highlighted in pancreas, lung and gut by haematoxylin-eosin staining too Indeed, the...
... increase inthe expression ofthe gene inthe DAA fruit ofthe infiltrated plant compared to the expression inthe DAA fruit ofthe WT The analysis ofthe CaOvate genomic sequences obtained from the ... (the only exception being AtOFP6 which contains asparagine) In subf the corresponding amino-acid in position 23 is mainly asparagine while in subf is arginine The amino-acid in this position in ... domain of about 70 residues found exclusively in plants Themultiple alignment of all the sequences highlights interesting features including the near perfect conservation ofthe DUF623 domain inside...
... profitability is declining The internalization of information within the same institution may thus enhance intra-circuit and inter-circuit stability by reducing the incentive to overfinancing The ... Creating a stronger investor base amounts to strengthening the circuit by completing the financial market structure ofthe economy, thus eliminating discontinuities inthe transmission of information ... placing money with investment financial institutions inthe capital market, and hold the remaining share in noninterest bearing, short-term bank deposits (eq 7) The share of savings going to the...
... advantageous in serving transport inthe Mekong Delta linking to Cambodia The total length ofthe inland waterway (IW) system is about 40,998 km, mainly inthe Red River Delta and the Mekong Delta Inthe ... forwarding activities ofthe S.R of Vietnam, and on this basis to integrate with such professional colleagues on the world The Association has theroleof coordinating the activities ofthe members ... conditions for business associations, as well implemented strategies on developing and increasing the quality of trade services ofthe Ministry of Trade and the Ministry of Transport Being the intermediary...
... English at the expense ofthe other languages that exist inthe country, the adult language program in Botswana maintains the hegemony and the gap between the poor and the rich, the major and minority ... for the betterment of their conditions It could mobilize the so called minorities to oppose their status and challenge the hegemony ofthe majority communities in Botswana 31 In most parts ofthe ... is for the most part the preserve ofthe few (elites) The choice of which language or dialect to use to teach (medium of instruction) reflects the interests of those elite In countries in which...
... categories of business-to-business advertising are industrial and professional advertising b.1 Industrial advertising Advertising targeted at individuals who buy or influence the purchase of industrial ... development ofthe industry also fosters the other industries in society, which contributes to the development ofthe economy as a whole In Vietnam, spending for advertising is rather lower than that in ... advertising industry Since the opening policy and law of foreign investment, advertising industry has seen remarkable changes The growth rate of advertising service is the highest in economy, in which...
... raising the profile of women in management However, during this period of research, there was an emerging recognition ofthe importance of a concern for people inthe behavioural theories as being ... anything towards raising the profile of women in management, as the theory was constructed as a male model at a time when women were not visible in paid employment One ofthe off shoots ofthe ... enabling of others to help achieve the goals ofthe organisation Furthermore, the ability to control others is given no prominence in this recent definition of leadership A brief review of early...
... relies on the securities booking system ofthe CGSDTC and the bond trading system ofthe inter-bank lending centre The trading system ofthe national inter-bank lending centre provides pricing information, ... source of financing for enterprises, if their own capital is excluded In summary, the deepening process ofthe financial markets has rendered the dominance ofthe banking sector inthe financial ... in turn contributed to the financial stability not only in Asia but also inthe whole world Roleofthe international financial institutions ( IFIs ) The IFIs have played an active rolein financial...
... throughout the world bears little resemblance to teosinte, the original ancestor of corn The newer techniques involving genetic engineering, on the other hand, allow for the transfer of a few genes in ... material The Þrst method involves enzyme-linked immunosorbent assays (ELISAs), which are based on the detection of proteins coded for by the genes inserted into GM crops These tests require minimal ... commercially introduced inthe U.S in 1996 and have been rapidly adopted by farmers It has been estimated that 24% ofthe corn and almost 70% ofthe soybeans and cotton grown inthe U.S in 2001 were...