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the role of multiple sequence repeat motifs in the assembly of multi protein complexes

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Báo cáo y học: " The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during " doc

Báo cáo khoa học

... surfactant protein D plays an important role in delaying the appearance of pneumococci in the blood and in limiting their numbers in the bloodstream SP-D binds and agglutinates S pneumoniae in the presence ... currently in the process of investigating these questions In summary, the absence of lung surfactant protein D increases the persistence of pneumococcal colonisation and infection in the upper ... required to further elucidate the role of SP-D in regulating adaptive immune responses in vivo The potential of truncated recombinant forms of SP-D as a new therapy for infectious and inflammatory...
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Báo cáo khoa học: "Bench-to-bedside review: The role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury" pot

Báo cáo khoa học

... concluded that the Available online http://ccforum.com/content/10/6/239 Figure The role of the protein C pathway in the endothelial cell APC modulates endothelial phenotype by inhibiting thrombin production, ... cleaving PAR1 than is APC [31] The concentrations of APC used in the in vitro studies showing endothelial barrier protection were within the pharmacologic range of APC in the PROWESS study in one ... and the mechanism of its benefit in these patients appears to be in part through direct interactions with the endothelium Competing interests The authors declare that they have no competing interests...
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The role of ORF3 protein in the molecular pathogenesis of porcine circovirus 2 infection

The role of ORF3 protein in the molecular pathogenesis of porcine circovirus 2 infection

Cao đẳng - Đại học

... the genome The sequence to the 3’ of the stem-loop structure contains the hexamer repeats CGGCAG which act as the binding site for the Rep proteins The numbering of the nucleotide begins in the ... play a role in determining the pathogenicity of the PCV2 infection (Ramamoorthy et al., 2009) This thesis describes the role of ORF3 in the pathogenesis of the PCV2 virus infection at the systemic ... Our findings on the molecular activity of ORF3 have also led us to speculate other potential uses for the protein In the third part of the thesis, the role of ORF3 mediated apoptosis in the egress...
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The role of prion protein in breast cancer cell metabolism

The role of prion protein in breast cancer cell metabolism

Cao đẳng - Đại học

... readings of all standards, controls and samples, including the no -protein control The values for the protein standards were plotted with a linear regression line through the standard points The protein ... aspects of PrP In humans, PrP is initially synthesized as a pre-pro-PrP of 253 amino acids in the cytosol PrP contains a hydrophobic N-terminal signal peptide of 22 amino acids while the last 22 amino ... overview of the role of PrP in breast cancer metabolism in the study model Picture showing different lactate production in normal and cancer situation Schematic overview of the role of PrP in cancer...
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Báo cáo y học:

Báo cáo y học: " Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity" pps

Báo cáo khoa học

... and retaining it in the nucleus In this manner p30 prevents the synthesis of Tax and Rex proteins and interferes, thereby, with the production of viral particles Furthermore, high level of p30 ... function of the mitotic spindle checkpoint protein MAD1 [142] In another study the MAD1 and MAD2 checkpoint proteins, which normally reside in the nucleus, have been found in HTLV-1 infected ... ER-resident proteins; calerticulin and calnexin Calerticulin is a calcium-binding protein that participates in calcium signaling and linked to activation of the transcription factor nuclear factor of...
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Báo cáo khoa học: Cholecystokinin rapidly stimulates CrkII function in vivo in rat pancreatic acini Formation of CrkII–protein complexes docx

Báo cáo khoa học: Cholecystokinin rapidly stimulates CrkII function in vivo in rat pancreatic acini Formation of CrkII–protein complexes docx

Báo cáo khoa học

... formation of CrkII protein complexes in rat pancreatic acini Thus, in the present work, we investigated whether in vivo activation of the CCKA receptor regulates CrkII function to form protein complexes ... migrating band (lane 2), showing that it contains the more tyrosine phosphorylated band of Crk Pretreatment with tyrosine kinase inhibitor alone increased the intensity of the lower migrating band ... allow (c) the intramolecular SH2 domain bind to it, which results in (d) inhibition of the intermolecular interactions of CrkII mediated by the SH2 domain and (e) subsequent blockade of the downstream...
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Structural and functional characterization of signaling protein complexes

Structural and functional characterization of signaling protein complexes

Cao đẳng - Đại học

... protein- protein, protein- lipid, and protein- DNA interactions (Fig 1.4) The most common protein- protein interaction domains in NRTKs are the Src homology (SH2) and (SH3) domains Fig 1.4 Domain architecture ... domain in PTK regulation While there are two families of domains that bind pTyr containing sequences – the phosphotyrosine binding (PTB) domain and the SH2 domain – only about a quarter of the ... 2001) Binding to the TKB domain is required for the subsequent conjugation of ubiquitin through the RING domain during the ubiquitination process The consensus binding sequence targeted by the TKB...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc

Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc

Báo cáo khoa học

... iron-peroxo intermediate [11] The sum of these ndings points at the involvement of more than one active oxidant in the diverse types of P450-catalyzed substrate processing [1215] The goal of the present ... reect ring opening of an epoxide intermediate at either of its two C-O bonds [219,220] The sum of these ndings strongly invokes the notion of oxygen activation during redox cycling of the diverse ... exhibiting insignicant sequence identity with P450s in the heme-binding region [282], but bearing a C-terminal avoprotein fragment in the single polypeptide chain structurally resembling NADPH-P450...
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Báo cáo khoa học: Studies on the role of the receptor protein motifs possibly involved in electrostatic interactions on the dopamine D1 and D2 receptor oligomerization pdf

Báo cáo khoa học: Studies on the role of the receptor protein motifs possibly involved in electrostatic interactions on the dopamine D1 and D2 receptor oligomerization pdf

Báo cáo khoa học

... trafficking properties The binding experiments also pointed to a decrease in the density of the D2R variants in the cellular membrane; the number of D2 receptor binding sites decreased with the number ... cytoskeletal protein 4.1 N, a member of the 4.1 family, facilitates the transport of D2R to the cell surface by interacting with the N-terminal portion of the ic3 loop of D2R via its C-terminal domain ... Measuring receptor dimer- ization by monitoring changes in the fluorescence lifetime of probes linked to the receptors of interest seems the best approach in this kind of the study Although the...
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Báo cáo khoa học: Analysis of ancient sequence motifs in the H+-PPase family doc

Báo cáo khoa học: Analysis of ancient sequence motifs in the H+-PPase family doc

Báo cáo khoa học

... gave these four amino acids in the highest yield, and they all were among the amino acids found in the Murchison meteorite [11] Both the high content of the ‘very early’ amino acids in these sequence ... frequent domain was elongation factor Tu (with 472 proteins), and the protein kinase domain (with 320 proteins) was the second most frequent For the ‘D-motif’, the most frequent domain was the EF hand ... patterns including the ancient amino acid residues, we searched the protein databases for sequences including these four residues in various combinations Thus, we scanned UniProtKB ⁄ Swiss-Prot for the...
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Báo cáo y học:

Báo cáo y học: "Role of PPAR-δ in the development of zymosaninduced multiple organ failure: an experiment mice study" pot

Báo cáo khoa học

... accumulation of neutrophils in the intestine and lung is a hallmark of multiple organ failure induced by zymosan An indirect assessment of neutrophil infiltration was carried out by measuring the activity ... focus’ much of their efforts at the level of the mitochondria, it plays a pivotal role in deciding whether a cell will live or die The Bcl-2 family of proteins has expanded significantly and includes ... reducing the pathophysiology of MOF A histological resolution of organ damage to administration of GW0742 was highlighted in pancreas, lung and gut by haematoxylin-eosin staining too Indeed, the...
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báo cáo khoa học:

báo cáo khoa học: " Multiple evidence for the role of an Ovate-like gene in determining fruit shape in pepper" pptx

Báo cáo khoa học

... increase in the expression of the gene in the DAA fruit of the infiltrated plant compared to the expression in the DAA fruit of the WT The analysis of the CaOvate genomic sequences obtained from the ... (the only exception being AtOFP6 which contains asparagine) In subf the corresponding amino-acid in position 23 is mainly asparagine while in subf is arginine The amino-acid in this position in ... domain of about 70 residues found exclusively in plants The multiple alignment of all the sequences highlights interesting features including the near perfect conservation of the DUF623 domain inside...
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 Circuit theory of finance and the role of incentives in financial sector reform

Circuit theory of finance and the role of incentives in financial sector reform

Ngân hàng - Tín dụng

... profitability is declining The internalization of information within the same institution may thus enhance intra-circuit and inter-circuit stability by reducing the incentive to overfinancing The ... Creating a stronger investor base amounts to strengthening the circuit by completing the financial market structure of the economy, thus eliminating discontinuities in the transmission of information ... placing money with investment financial institutions in the capital market, and hold the remaining share in noninterest bearing, short-term bank deposits (eq 7) The share of savings going to the...
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Facts of Vietnam Freight forwarding industry and the role of Vietnam Freight Forwarders Association (VIFFAS) to the industry in international economic integration processhelpful to Oristar.doc

Facts of Vietnam Freight forwarding industry and the role of Vietnam Freight Forwarders Association (VIFFAS) to the industry in international economic integration processhelpful to Oristar.doc

Quản trị kinh doanh

... advantageous in serving transport in the Mekong Delta linking to Cambodia The total length of the inland waterway (IW) system is about 40,998 km, mainly in the Red River Delta and the Mekong Delta In the ... forwarding activities of the S.R of Vietnam, and on this basis to integrate with such professional colleagues on the world The Association has the role of coordinating the activities of the members ... conditions for business associations, as well implemented strategies on developing and increasing the quality of trade services of the Ministry of Trade and the Ministry of Transport Being the intermediary...
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The role of language in adult education and poverty reduction in Botswan

The role of language in adult education and poverty reduction in Botswan

Tài liệu khác

... English at the expense of the other languages that exist in the country, the adult language program in Botswana maintains the hegemony and the gap between the poor and the rich, the major and minority ... for the betterment of their conditions It could mobilize the so called minorities to oppose their status and challenge the hegemony of the majority communities in Botswana 31 In most parts of the ... is for the most part the preserve of the few (elites) The choice of which language or dialect to use to teach (medium of instruction) reflects the interests of those elite In countries in which...
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The role of advertising in society

The role of advertising in society

Kinh tế - Thương mại

... categories of business-to-business advertising are industrial and professional advertising b.1 Industrial advertising Advertising targeted at individuals who buy or influence the purchase of industrial ... development of the industry also fosters the other industries in society, which contributes to the development of the economy as a whole In Vietnam, spending for advertising is rather lower than that in ... advertising industry Since the opening policy and law of foreign investment, advertising industry has seen remarkable changes The growth rate of advertising service is the highest in economy, in which...
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The role of leadership theory in raising the profile of women in management

The role of leadership theory in raising the profile of women in management

Kỹ năng đọc tiếng Anh

... raising the profile of women in management However, during this period of research, there was an emerging recognition of the importance of a concern for people in the behavioural theories as being ... anything towards raising the profile of women in management, as the theory was constructed as a male model at a time when women were not visible in paid employment One of the off shoots of the ... enabling of others to help achieve the goals of the organisation Furthermore, the ability to control others is given no prominence in this recent definition of leadership A brief review of early...
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Globalization: the Role of Institution Building in the Financial Sector _ The Case Study of China

Globalization: the Role of Institution Building in the Financial Sector _ The Case Study of China

Cao đẳng - Đại học

... relies on the securities booking system of the CGSDTC and the bond trading system of the inter-bank lending centre The trading system of the national inter-bank lending centre provides pricing information, ... source of financing for enterprises, if their own capital is excluded In summary, the deepening process of the financial markets has rendered the dominance of the banking sector in the financial ... in turn contributed to the financial stability not only in Asia but also in the whole world Role of the international financial institutions ( IFIs ) The IFIs have played an active role in financial...
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The Role of Genetically Modified Organisms (GMOs) in Beverage Production

The Role of Genetically Modified Organisms (GMOs) in Beverage Production

Môi trường

... throughout the world bears little resemblance to teosinte, the original ancestor of corn The newer techniques involving genetic engineering, on the other hand, allow for the transfer of a few genes in ... material The Þrst method involves enzyme-linked immunosorbent assays (ELISAs), which are based on the detection of proteins coded for by the genes inserted into GM crops These tests require minimal ... commercially introduced in the U.S in 1996 and have been rapidly adopted by farmers It has been estimated that 24% of the corn and almost 70% of the soybeans and cotton grown in the U.S in 2001 were...
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