... or in tendinopathies at the wrist level The diagnosis of tendinopathy ofthe main body ofthe Achilles tendon is made if patients have Achilles tendon pain at rest or at exercise inthe main ... either AirHeel™ wrap or eccentric training or the combination of both [57] Non-invasive topical nitroglycerin in tendinopathy The rationale for the use of topical transdermal nitroglycerin in ... Sclerosing with polidocanol was performed inthe area of neovascularisation resulting in an improved knee function and reduced pain inthe polidocanol group in contrast to the lidocaine/epinephrine...
... abnormality in H2S level is a cause or simply a consequence of these diseases There is also growing interest in understanding theroleof H2S in pain appreciation Administration of either NaHS ... significantly Increased longevity andthe impact of smoking, unhealthy diets, and other risk factors have combined to make CVD and cancer the leading causes of death in most countries, including Singapore ... blood flow into and out ofthe heart A region ofthe heart called the sinoatrial (SA) node is capable of producing and discharging an action potential and sending the impulse across the atria...
... variety seeking The findings offer new insights into theroleofthe time perspective in intention to return However, this topic requires additional research to help improve understanding ofthe temporal ... ofthe short term revisit intention The main contributions ofthe present work are concerned with the consideration of temporal issues inthe research of revisit intention, andthe analysis of ... identify the main differences The most outstanding findings are those concerning the influence of satisfaction and specific variety seeking on short and long run destination revisit intentions While...
... start of cytokinesis (389) Some ofthe key signaling proteins that feed into the spindle checkpoint include the polo-like kinases Plk1 and Plk2, andthe aurora kinases (401,455) These signaling kinases ... is the key driver for the completion of mitosis One ofthe main roles ofthe APC/cyclosome complex in mitosis is the destruction of cyclin B1 and inactivation of CDK1 (167) Destruction of cyclin ... marks the end of metaphase andthe beginning of cytokinesis (244) Inhibition ofthe APC/cyclosome complex by members ofthe polo-like kinase family facilitates the maintenance of high levels of...
... Disease Controland Prevention Theroleof BCG vaccine inthe prevention andcontrolof tuberculosis inthe United States: a joint statement by the Advisory Council for the Elimination of Tuberculosis ... re-evaluation oftheroleof BCG vaccination inthe prevention andcontrolof TB This updated report is being issued by CDC, the Advisory Committee for the Elimination of Tuberculosis, andthe Advisory ... resurgence inthe incidence of TB occurred inthe United States and included increases inthe number of TB cases among adults and children and outbreaks of multidrug-resistant TB (MDR-TB) involving...
... N-linked oligosaccharide side-chains are important for the GABA transport activity 1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into theroleofthe ... modification may in uence many ofthe physicochemical and biological properties ofthe proteins, such as protein folding, stability, targeting, dynamics and ligand binding, as well as cell-matrix and cell–cell ... misfolding of this protein, resulting in its partial retention inthe ER and its rapid digestion thereafter [16,19] Accordingly, our results indicate that the intracellular trafficking of N-glycosylation...
... the left to the right-hand side ofthe map decreases the probability of Expected-Debt to be equal to ô ằ (increase in indebtedness) by 15 points (33 minus 18), and increases the probability of ... Survey In 1996, the credit has overall been decreasing for 53% ofthe sample, it has been increasing for 36%, and has been stable for the remaining 11% An increase in indebtedness (of 80% in average) ... constraints The descriptive, statistical analysis in Table indeed confirms that the lower the decline in production (or the higher its increase, inthe best cases), the higher the probability of...
... However, the mechanistic roles of several of these residues are not described well and there is no example of mutational analysis of all of these residues inthe same enzyme To obtain an insight into ... inthe ÔupÕ position rows and shows that inthe presence ofthe substrate, rotation of Asp142 towards Glu144 lowers the pKa ofthe latter by 0.8 pH units The calculated effects ofthe D140N and ... affinity of ChiB for allosamidin, which is an analogue ofthe proposed oxazolinium ion intermediate [32] The minor (or even positive) effects of Y214F on substrate and intermediate binding and the...
... Stereo figures ofthe model ofthe bound substrate inthe AD2 E526A mutant (A) and D524A mutant (B) The structures of bound sugars andthe side-chains of three acidic residues inthe conserved ... important rolein ‘cycling’ the pKa of catalytic Glu during catalysis [24,38] The mutation ofthe D1 residue to Asn (D140N) in SmChiB caused a 500-fold decrease in activity [39] On the other hand, in ... orientationsofthe Glu526 side-chain inthe A-form were almost identical, andthe maximum coordinate shift ˚ after superimposition ofthe two structures was 0.78 A Inthe B-form, in contrast, the Glu526...
... using the concentration of protein inthe extract as an internal standard The activity of ()119/+178) PS1CAT inthe presence ofthe empty vector was taken as 100% The values represented inthe ... all contain the highly conserved ETS domain ERM contains two DNA binding inhibitory domains flanking the Ets domain: the central 87 amino acid inhibitory domain is poorly conserved and virtually ... SK-N-SH and SH-SY5Y cells recognize specifically Ets motifs flanking the +1 site (A) The binding of nuclear factors is eliminated by mutations in Ets motifs The binding of nuclear factors present in...
... loss of penicillin binding Arginines 306 and 307 Fig Proposed binding mode for penicillin N to the iron(II)-2-oxoglutarate complex of DAOCS, showing possible involvement of selected residues The ... The third type of mutant, represented by arginines 306 and 307, are located inthe C-terminus They appear to modulate the activity ofthe C-terminus, which encloses the DAOCS active site during ... proposed mode of penicillin binding by DAOCS [1,12] a key feature of which is that arginines 160 and 162 bind to the carbonyl and/ or carboxylate ofthe bicyclic b-lactam nucleus, with the pro-S methyl...
... two residues andthe edge ofthe substrate ring could prevent binding of 3,6-DMC and 3,5-DMC, as shown in Fig 2D,E,F Thus, the binding of 3,5-DMC and 3,6-DMC to the active site of C2,3O could ... ofthe cleavage of 3-MC is proximal, independently ofthe orientation ofthe substrate inthe binding site Thus, the regioselectivity of cleavage would be mainly controlled by the reactivity of ... To investigate thein uence ofthe side chain of residue Thr249 of C2,3O on the cleavage of 3,5-DMC and 3,6DMC, the catalytic properties of mutants were studied Based on the results of docking...
... game theories New findings out ofthe thesis This thesis presents the following new findings (1) New findings related to theory (a) A new economic equation to relate two levels of sustainable ... to the right of OS line as long as the points are to the left ofthe vertical S line which represents the general sustainability line Gist of Chapter 2: ENVIRONMENTAL CONSERVATION AND TRADE The ... agreements mathematically in terms of environmental conservation The proposed thesis is, therefore, unique, original and very challenging in this aspect The followings are some ofthe important...
... dominant states play quite a signi cant roleinthe formation ofthe business cycle patterns ofthe formar group of states The business cycle patterns ofthe major oil supply states are distinctly ... (2.15) Rather than using only the previous information, it is possible to obtain the probability ofthe economy being in either recession or expansion Pr[St = j j using the full set of information ... level business cycle patterns In face, most ofthe time the state level business cycles of this group lay on the opposite side ofthe national business cycle.Most ofthe states fall into the fourth...
... remains to be seen how these elements, particularly reliability and discrimination, interact In closing I should directly answer the questions posed by Norman and Wyrwich inthe titles of their ... points, then a discrimination is defined as any between-persons difference > = points Delta then indexes the degree to which the instrument makes valid discriminations Wyrwich suggests that the ... the results of another study [6], in which the dichotomous scoring method ofthe GHQ-12 was found to be less discriminating than the Likert scoring method, were 'well expected' This again suggests...
... primarily into the amide of glutamine by the activity of GS, and transferred to glutamate-amino by glutamate synthase activity Inhibition of GS and glutamate synthase blocked the synthesis of glutamine ... thus there was no incorporation of ammonia into glutamate by GDH After h the glutamine concentration peaked and remained stable, indicating feedback controlof GS Inhibition of aminotransferases ... marked increase intheand glutamine pools after h inthe fresh medium (Fig 3a) Glutamate levels remained constant after h but the glutamine concentration continued to increase up to h indicating...
... theroleof HIF-1 in chondrocytic energy generation, matrix synthesis and cell survival During hypoxic and normoxic conditions, functional inactivation of HIF-1α inthe presence of interleukin-1β ... Thus, the work by Yudoh and colleagues adds further experimental evidence for the suggested roleof HIF-1 in protecting chondrocytes from cell death induced by pro-inflammatory cytokines Finally, ... HIF-1 is of pivotal importance in cartilage development and homeostasis Furthermore, given the decreased oxygen levels and presence of inflammatory mediators during the course of OA, a causal role...
... (total of 98,695 introns) for TE insertions to determine the percentage of TE-containing introns (Figure 2a) The fraction ofthe introns that contain TEs inthe non-mammalian vertebrates G gallus and ... between the fraction of introns containing TEs and median length of introns (Figure 2c), implying that TE insertions have played a roleinthe evolution of intron size Previous analysis of human and ... respectively The grey boxes show insertion of TEs into exons The TE family is indicated beneath the gray box, along with the length of each inserted TE Lengths ofthe introns and exons flanking the inserted...
... experience in clinical treatment of thymomas as a result of a retrospective single centre analysis done within a European university setting Theroleof a pseudocapsula and its clinical significance and ... [3] The reason for these is based in a couple of problems First, there is a significant interobserver variability in histological typing [2,6] Second, determination of precise cut-off points ... classified thymomas and reviewed histological and immunhistochemical staining ofthe specimens CS has participated as senior author inthe design ofthe study and helped to draft the manuscript All...