... experience inclinical treatment of thymomas as a result of a retrospective single centre analysis done within a European university setting Theroleof a pseudocapsula and its clinical significance and ... unless otherwise indicated p values were calculated by Pearson's Chi-Square test to determine the significance ofcorrelationof clinicopathological parameters and presence of a pseudocapsula ofthe ... has been presented inthe last decades providing further insight into tumor biology andclinical behaviour of thymomas [2] Only a few reports include a significant number of patients with thymomas...
... useful in determining a) the efficacy of BCG vaccine in HCWs or b) the effects on efficacy ofthe vaccine strain administered Vol 45 / No RR-4 MMWR andthe vaccinee’s age at the time of vaccination ... Control and Prevention Theroleof BCG vaccine inthe prevention and control of tuberculosis inthe United States: a joint statement by the Advisory Council for the Elimination of Tuberculosis andthe ... associated with theuseofthe vaccine in these persons Inthe United States, theuseof BCG vaccination is rarely indicated BCG vaccination is not recommended for inclusion in immunization or...
... N-linked oligosaccharide side-chains are important for the GABA transport activity 1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into theroleofthe ... modification may in uence many ofthe physicochemical and biological properties ofthe proteins, such as protein folding, stability, targeting, dynamics and ligand binding, as well as cell-matrix and cell–cell ... misfolding of this protein, resulting in its partial retention inthe ER and its rapid digestion thereafter [16,19] Accordingly, our results indicate that the intracellular trafficking of N-glycosylation...
... the left to the right-hand side ofthe map decreases the probability of Expected-Debt to be equal to ô ằ (increase in indebtedness) by 15 points (33 minus 18), and increases the probability of ... Survey In 1996, the credit has overall been decreasing for 53% ofthe sample, it has been increasing for 36%, and has been stable for the remaining 11% An increase in indebtedness (of 80% in average) ... constraints The descriptive, statistical analysis in Table indeed confirms that the lower the decline in production (or the higher its increase, inthe best cases), the higher the probability of...
... However, the mechanistic roles of several of these residues are not described well and there is no example of mutational analysis of all of these residues inthe same enzyme To obtain an insight into ... inthe ÔupÕ position rows and shows that inthe presence ofthe substrate, rotation of Asp142 towards Glu144 lowers the pKa ofthe latter by 0.8 pH units The calculated effects ofthe D140N and ... affinity of ChiB for allosamidin, which is an analogue ofthe proposed oxazolinium ion intermediate [32] The minor (or even positive) effects of Y214F on substrate and intermediate binding and the...
... important rolein ‘cycling’ the pKa of catalytic Glu during catalysis [24,38] The mutation ofthe D1 residue to Asn (D140N) in SmChiB caused a 500-fold decrease in activity [39] On the other hand, in ... ofthe second Asp (D2) inthe DXDXE motif on substrate binding (Fig 5D, E) [24,37] Thus, the D2 residue interacts with catalytic Glu (E) andthe first Asp (D1) inthe presence and absence ofthe ... Stereo figures ofthe model ofthe bound substrate inthe AD2 E526A mutant (A) and D524A mutant (B) The structures of bound sugars andthe side-chains of three acidic residues inthe conserved...
... using the concentration of protein inthe extract as an internal standard The activity of ()119/+178) PS1CAT inthe presence ofthe empty vector was taken as 100% The values represented inthe ... all contain the highly conserved ETS domain ERM contains two DNA binding inhibitory domains flanking the Ets domain: the central 87 amino acid inhibitory domain is poorly conserved and virtually ... efficiency of transcription initiation and 23 the position ofthe start site(s) (A) Effect of point mutations in Ets and Sp1 motifs on PS1 promoter activity The positions of Ets (d) and Sp1 (h) motifs in...
... loss of penicillin binding Arginines 306 and 307 Fig Proposed binding mode for penicillin N to the iron(II)-2-oxoglutarate complex of DAOCS, showing possible involvement of selected residues The ... The third type of mutant, represented by arginines 306 and 307, are located inthe C-terminus They appear to modulate the activity ofthe C-terminus, which encloses the DAOCS active site during ... proposed mode of penicillin binding by DAOCS [1,12] a key feature of which is that arginines 160 and 162 bind to the carbonyl and/ or carboxylate ofthe bicyclic b-lactam nucleus, with the pro-S methyl...
... two residues andthe edge ofthe substrate ring could prevent binding of 3,6-DMC and 3,5-DMC, as shown in Fig 2D,E,F Thus, the binding of 3,5-DMC and 3,6-DMC to the active site of C2,3O could ... 3,6-DMC Interestingly, the progressive decrease ofthe dimension ofthe residue 249 side chain also causes an increase inthe Km values for catechol and 3-MC (Fig 4A) Inthe case ofthe smaller ... To investigate thein uence ofthe side chain of residue Thr249 of C2,3O on the cleavage of 3,5-DMC and 3,6DMC, the catalytic properties of mutants were studied Based on the results of docking...
... game theories New findings out ofthe thesis This thesis presents the following new findings (1) New findings related to theory (a) A new economic equation to relate two levels of sustainable ... to the right of OS line as long as the points are to the left ofthe vertical S line which represents the general sustainability line Gist of Chapter 2: ENVIRONMENTAL CONSERVATION AND TRADE The ... agreements mathematically in terms of environmental conservation The proposed thesis is, therefore, unique, original and very challenging in this aspect The followings are some ofthe important...
... dominant states play quite a signi cant roleinthe formation ofthe business cycle patterns ofthe formar group of states The business cycle patterns ofthe major oil supply states are distinctly ... (2.15) Rather than using only the previous information, it is possible to obtain the probability ofthe economy being in either recession or expansion Pr[St = j j using the full set of information ... level business cycle patterns In face, most ofthe time the state level business cycles of this group lay on the opposite side ofthe national business cycle.Most ofthe states fall into the fourth...
... remains to be seen how these elements, particularly reliability and discrimination, interact In closing I should directly answer the questions posed by Norman and Wyrwich inthe titles of their ... points, then a discrimination is defined as any between-persons difference > = points Delta then indexes the degree to which the instrument makes valid discriminations Wyrwich suggests that the ... the results of another study [6], in which the dichotomous scoring method ofthe GHQ-12 was found to be less discriminating than the Likert scoring method, were 'well expected' This again suggests...
... either AirHeel™ wrap or eccentric training or the combination of both [57] Non-invasive topical nitroglycerin in tendinopathy The rationale for theuseof topical transdermal nitroglycerin in ... or in tendinopathies at the wrist level The diagnosis of tendinopathy ofthe main body ofthe Achilles tendon is made if patients have Achilles tendon pain at rest or at exercise inthe main ... Sclerosing with polidocanol was performed inthe area of neovascularisation resulting in an improved knee function and reduced pain inthe polidocanol group in contrast to the lidocaine/epinephrine...
... theroleof HIF-1 in chondrocytic energy generation, matrix synthesis and cell survival During hypoxic and normoxic conditions, functional inactivation of HIF-1α inthe presence of interleukin-1β ... Thus, the work by Yudoh and colleagues adds further experimental evidence for the suggested roleof HIF-1 in protecting chondrocytes from cell death induced by pro-inflammatory cytokines Finally, ... HIF-1 is of pivotal importance in cartilage development and homeostasis Furthermore, given the decreased oxygen levels and presence of inflammatory mediators during the course of OA, a causal role...
... (total of 98,695 introns) for TE insertions to determine the percentage of TE-containing introns (Figure 2a) The fraction ofthe introns that contain TEs inthe non-mammalian vertebrates G gallus and ... between the fraction of introns containing TEs and median length of introns (Figure 2c), implying that TE insertions have played a roleinthe evolution of intron size Previous analysis of human and ... respectively The grey boxes show insertion of TEs into exons The TE family is indicated beneath the gray box, along with the length of each inserted TE Lengths ofthe introns and exons flanking the inserted...
... modulate the inflammatory profile after a viral infection by blocking the poly(I: C) induced chemokine and cytokine production while maintaining the antiviral activity [28,59] As epithelial cells ... developed the concept ofthe review, all authors contributed in writing and reviewing the paper All authors read and approved the final manuscript Competing interests The authors declare that they ... skin especially inthe elderly), limited renal and hepatic function or insufficient intestinal resorption [39] In VitD deficiency, the feedback on the PTH gene promoter is lacking resulting in...
... for the epithelium and potentially could influence the regenerative response ofthe epithelium to chlorine [12] To evaluate theroleof γδ T cells in chlorine induced airway injury we studied the ... subjects The factors influencing the rate of epithelial regeneration are likely of key importance in determining the short and long term consequences of chlorine induced airway dysfunction The γδ ... since the inflammatory response to epithelial damage was also attenuated inthe γδ T cell deficient mice Our findings are consistent with a roleof γδ T cells in determining the magnitude of the...
... cells and eosinophils also synthesize interleukin-5, indicating that autocrine production of interleukin-5 may contribute to the chronicity of inflammation [41,42] The interleukin-5 receptor is in ... of asthma Interleukin-5 in human asthma Atopic asthmatic persons have increased expression of Th2-type cytokine (interleukin-2, interleukin-3, interleukin-4, interleukin-5, and GM-CSF) mRNA in ... biochemistry ofthe interleukin-5 system There are clusters of T-helper (Th)2-type cytokine genes, including that which encodes interleukin-5, on human chromosome 5q andinthe mouse on chromosome 11q, indicating...
... [13] The angiopoietins, angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2), play a fundamental roleinthe maintenance of vessel integrity Angiopoietin-1 (Ang-1) and Ang-2 are ligands ofthe endothelial ... cytokine VEGF is a potent regulator of vascular permeability and angiogenesis, andin endothelial cells, induces the expression of cell-adhesion molecules andthe release of cytokines and chemokines ... growth factors and two angiopoietins in an attempt to understand whether they may play a roleinthe mobilization of endothelial progenitor cells in severe bacterial infection Materials and methods...