... surfactant protein D plays an important rolein delaying the appearance of pneumococci inthe blood and in limiting their numbers inthe bloodstream SP-D binds and agglutinates S pneumoniae inthe presence ... currently inthe process of investigating these questions In summary, the absence of lung surfactant protein D increases the persistence of pneumococcal colonisation and infection inthe upper ... required to further elucidate theroleof SP-D in regulating adaptive immune responses in vivo The potential of truncated recombinant forms of SP-D as a new therapy for infectious and inflammatory...
... concluded that the Available online http://ccforum.com/content/10/6/239 Figure Theroleoftheprotein C pathway inthe endothelial cell APC modulates endothelial phenotype by inhibiting thrombin production, ... because this is the site ofprotein C activation, the endothelium contains the receptor for APC (EPCR), and the endothelium contains the PARs, which may also mediate APC signaling [24] Evidence ... small interfering RNA (siRNA) targeting the enzyme responsible for S1P production, sphingosine kinase-1, blocked the barrierenhancing signalingof APC In addition, siRNA targeting the S1P receptor...
... rapidly, causing the unfolding of one ofthe I27 modules inthe chain Unfolding then extends the overall length ofthe protein, relaxing the pulling force to a low value As the slack inthe length ... bridging the A’ and G b-strands ofthe I27 protein during the main unfolding barrier.[39] To further validate this view and gain insight into theroleof solvent hydrogen bonds inprotein unfolding, ... trajectories of individual proteins Indeed, using these techniques, it becomes possible to explore theroleofthe solvent environment inprotein collapse[42] and the dynamics ofprotein folding.[47] Therefore,...
... both ADAM10 and TACE are involved inthe shedding of APP, neither ADAM is involved inthe shedding of ACE Furthermore we show that APMA can distinguish between the shedding of ACE and APP Materials ... dose-dependent increase inthe shedding of ACE (Fig 3B,C), with a 12-fold increase inthe amount of soluble ACE inthe CHO cell medium observed with 500 lM APMA The effect of APMA on the shedding of ACE ... cells inthe absence or presence of APMA Following this second incubation, the level of sAPPa inthe medium was examined (Fig 4A,B) There was no significant difference inthe level of sAPPa in the...
... the genome The sequence to the 3’ ofthe stem-loop structure contains the hexamer repeats CGGCAG which act as the binding site for the Rep proteins The numbering ofthe nucleotide begins inthe ... play a rolein determining the pathogenicity ofthe PCV2 infection (Ramamoorthy et al., 2009) This thesis describes theroleof ORF3 inthe pathogenesis ofthe PCV2 virus infection at the systemic ... Our findings on the molecular activity of ORF3 have also led us to speculate other potential uses for theproteinInthe third part ofthe thesis, theroleof ORF3 mediated apoptosis inthe egress...
... representation ofthe TGFβ signaling from cell membrane β to the nucleus The TGFβ ligand initiates signaling by binding to and bringing together type I and type II receptor serine/threonine kinases on the ... Smad proteins consist of two conserved domains: the N-terminal MH1 domain and the C-terminal MH2 domain These domains are connected by a proline-rich linker region The MH1 domain has DNA-binding ... 6.4 Table of Contents Figure 6.5 Figure 7.1 Figure 7.2 xi The pro-domain of Cyc is involved in ligand-inhibitor Interactions 160 Hypothesized levels of Nodal signalinginthe induction of different...
... readings of all standards, controls and samples, including the no -protein control The values for theprotein standards were plotted with a linear regression line through the standard points Theprotein ... aspects of PrP In humans, PrP is initially synthesized as a pre-pro-PrP of 253 amino acids inthe cytosol PrP contains a hydrophobic N-terminal signal peptide of 22 amino acids while the last 22 amino ... overview oftheroleof PrP in breast cancer metabolism inthe study model Picture showing different lactate production in normal and cancer situation Schematic overview oftheroleof PrP in cancer...
... Regional Learning Alliance – workforce development and training/collaborations with business and industry; meeting the training and education needs of businesses within 60 mile radius in Northern Allegheny ... $28,000 in average annual salary) Preserving Value Continuing education is important to preserving the market value of specialized education – particularly in professional fields Continuing education ... Shippensburg University Small Business Initiative inthe Frehn Center for Management; offering information and assistance to individuals and groups planning to start a new business Best Practice Highlights...
... our incomplete understanding ofthe relation between enzyme properties and conformational flexibility limits the exploitation ofthe full potential ofprotein engineering inthe redesign of psychrophilic ... Ala219 ofthe catalytic site and His135 ofthe Mg2+ binding site The most striking result was the loss ofthe psychrophilic character of mutant W260K/A219N (as reflected by a threefold increase ofthe ... value in this temperature range is considerably lowered On the basis ofthe model, the behavior ofthe G261A variant can be interpreted in terms of constraints introduced by the Ala side chain The...
... evaluate the OS-fitness ofthe clone, the ratio ofthe specific absorbance inthe presence of 10 lgÆmL)1 HEL to that inthe absence of HEL was taken as an index To analyze the effect ofthe type of each ... antigen binding, this ‘increasing the affinity by increasing the VH ⁄ VL interaction’ might represent a mechanism of increasing Fv affinity This is also supported by the kinetic study of purified ... enhancement in VH ⁄ VL interaction significantly improved the antigen-binding affinity of Fv, similarly to the level of scFv (Table 2) Some single VH domains of anti -protein IgG, including HyHEL-10...
... Cardie, Vincent Ng, David Pierce, Chris Buckley Examining theroleof statistical and linguistic knowledge sources in a general-knowledge que stion answering system In Proceedings ofthe 6th Applied ... hypernyms inthe answer semantic form Step 3: The assessment ofthe similarities of dependencies Inthe third step, two classes of similar dependencies are considered, generating unications ofthe ... example, inthe case of question Q209: Who invented the paper clip ?, the expected answer type is P ERSON and so is the subject ofthe verb invented , lexicalized as the nominalization inventor...
... change their brand attitude, may suggest an interesting implication for the new brand advertising strategy Instead of focusing on the content ofthe message which only emphasizes the benefits ofthe ... birthday This finding is just reverse ofthe finding of Belk (1973) Ruth, Brunel, Otnes (1999) classified categories of gift-giving into public occasion (i.e., Christmas, Chinese New Year), individual ... situational conditions of gift-giving may differ according to characteristics ofthe gift-giving occasion, whether the presentation ofthe gift is public, private, or anonymous, and whether the gift is...
... important for explaining wilt Inthe case of income, youth living in low-income households experience higher levels of wilt (45%) than youth living in either modest-income (35%) or high-income (23%) ... financing school Conley (2001) finds that a doubling of net worth results in an 8.3% increase inthe probability of attending college Further, when net worth is included inthe model, Black youth are ... youth Youth savings Youth were asked in 2002 whether they had a savings or bank account in their name If they had an account, they were also asked whether they were saving some of this money for...
... Harndahl et al ¨ levels through the interaction of glucokinase with binding proteins [5,6] The glucokinase regulatory protein (GKRP) is a specific inhibitor of glucokinase [5] and also a nuclear ... that the increase of Glc6P inthe presence of S4048 was caused by the inhibition of Glc6P hydrolysis inthe absence of detectable changes in glucose phosphorylation S4048 causes inactivation of ... [31], for evaluating theroleof Glc6P, we determined the effect of different inhibitor concentrations on the Glc6P content and the rate of glycogen synthesis in hepatocytes incubated with 15...
... the short ones) have all zeroes in them In other words, none ofthe bigrams from the training set appears in these reviews This suggests that the main problem with the bigram model is likely to ... Following Pang et al (2002), we use frequency as presence In other words, the ith element ofthe document vector is if the corresponding unigram is present inthe document and otherwise The resulting ... relation is capturing two different situations, one in which the author himself likes the movie, and inthe other, the author’s cousin likes the movie The overgeneralization resulting from these “stemmed”...
... biological functions The proteins displaying the lowest similarity to the other P450s are those involved in oxylipin biosynthesis (2–6% amino acid identity) This can be explained in part by their bifunctional ... enzymes The FUM6 protein (CYP505B1) intervenes in one ofthe first steps in fumonisin synthesis by hydroxylation ofthe polyketide-amino acid at C-14 and C-15 (Fig 3) Fum6 deletion mutants of F verticilloides ... strong indications for the involvement of a bacterial P450 inthe hydroxylation of octane in Rhodococcus rhodochrous, theroleof bacterial P450s in alkane degradation in addition to the well-established...
... the transaction from the vantage point of firm A, the floatingrate payer The cost of synthetic floating-rate financing is determined by the cost of servicing fixed-rate debt plus the net cost ofthe ... to the desire on the part of firms to hedge cash flows against the effects of interest rate volatility The timing ofthe appearance of interest rate swaps, coming as it did during a period of volatile ... argue, trading in interest rate swaps has helped to complete forward markets and to lower the cost to firms of managing their exposure to interest rate risk TheRole for Hedging inthe Theory of Corporate...
... explains some ofthe key concepts and outlines some ofthe basic IdM processes The range of conceptions of identity is very broad The examination ofthe following concepts is for the purposes of ... to take into account inthe assessment ofthe security risks to − and privacy impact on − the delivery of online services, and in determining appropriate levels of security Inthe case of sensitive ... accounts within the organisation The organisation is in some sense wasting resources and duplicating efforts in maintaining separate profiles with (mostly) the same information Nonetheless, there can...
... than those inthe lipids ofthe surrounding membrane In fact, this fatty acid composition favors a tighter packing of phospholipids and cholesterol, increasing the rigidity of these domains [32–35] ... muscarinic receptors, endothelin receptors, rhodopsin) are located in lipid rafts [65–70] where they are in close proximity to their transducing GTP-binding protein (Gs, Gi, Go, Gq and transducin ... extraction during lipid raft isolation Moreover, these studies have provided some insights into the significance ofthe localization ofthe P2X7 receptors in lipid rafts regarding the regulation of intracellular...
... contribution of ions as cofactors inprotein folding [38] and inthe design of variants of proteins with enhanced stability [14] Changes inthe denatured states induced by mutation affect protein stability ... binding of calcium to the mutant proteins in native conditions The single and combined mutations dramatically decrease the thermodynamic stability ofthe proteins with a signicant decrease of ... contribute to the optimization of electrostatic charges balance of pfLamA inthe native state, independently of their interaction with calcium Theroleof electrostatic interactions inprotein stability...