the regulation of conduct

Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf

Ngày tải lên : 16/02/2014, 09:20

... promoters, mutation of the CHR leads to a more pronounced deregulation than the alteration of the CDE [40] Another gene tested for its cell cycle regulation is the cellular inhibitor of apoptosis protein ... However, as in most other CDE ⁄ CHR promoters, mutation of the CHR results in a smaller remaining cell cycle -regulation than alteration of the CDE [37] Interestingly, the core of the human Tome-1 ... Moreover, orientation of the CDE ⁄ CHR in the general context of a promoter appears to be relevant because inversion of the site in the human Cdc25C promoter resulted in a deregulation of cell cycle-dependent...

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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc

Ngày tải lên : 16/02/2014, 09:20

... treatment of the chick face with RA, and this is accompanied by an increase in apoptosis [73] The authors of this study ascribe the regulation of outgrowth of limb buds and patterning of the digits ... regulation of AP-2 and the interactions of the transcription factor with binding partners, as well as of the regulation of target gene expression, have been performed for AP-2a Up to now, there have been ... further analyze their interactions with AP-2 and the functional role of these in chondrocytes Furthermore, it is speculated that in melanoma, where AP-2a acts as a tumor suppressor, the loss of...

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Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt

Ngày tải lên : 18/02/2014, 08:20

... into the potential biologically relevant role of miR-27 in the regulation of adipose tissue functions in vivo, we examined the expression of miR-27 in the genetically obese ob ⁄ ob mice The 2352 ... differentiation Taken together, these results illustrate a critical and speciﬁc role of miR-27 in the regulation of adipogenic differentiation miR-27 prevents the induction of PPARc and C ⁄ EBPa ... involved in the regulation of miR-27 expression Our data suggest that the miR-27 gene family is potentially an important class of negative regulators of adipogenesis and may play a role in the regulation...

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Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx

Ngày tải lên : 18/02/2014, 16:20

... trafﬁcking of the CD95 from inside the hepatocyte to the plasma membrane [39], which depends on a ROS-mediated tyrosine phosphorylation of the epidermal growth factor (EGF)-receptor, the association of ... apoptosis include activation of the protein kinase B survival pathway [31], p53 activation [32], induction of the serum- and glucocorticoidinducible kinase Sgk [33], expression of the heat shock protein ... association of CD95 with the EGF-receptor, and phosphorylation of CD95 on Tyr232 and Tyr291 by the EGF-receptor tyrosine kinase activity [15] Although the appearance of CD95 at the plasma membrane...

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Báo cáo khoa học: Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions pptx

Ngày tải lên : 06/03/2014, 01:20

... by application of SH2 domain binding peptides, which results in blocking of the binding of the SH2 domain to the substrate and thereby preventing interaction of the substrate with the kinase domain ... auto-phosphorylation by modulating the kinase activity of the enzyme To determine the roles of the SH3 and ⁄ or SH2 domains in Src regulation of NMDAR phosphorylation, the protein fragment corresponding ... blocking the enzyme activity of Src [3,18] The peak amplitudes of NMDAR currents during PP2 application were 96 ± 4% (n = 7) of those of controls before PP2 application (Fig 1D) Taken together, these...

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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx

Ngày tải lên : 07/03/2014, 01:20

... polymerases, and the solution of the crystal structure of Pol II shows that these two subunits are located close to each other at the surface of the polymerase [29,124] and participate in the transcription ... domain and then to the nascent RNP, where actin in complex with the hnRNP U can facilitate recruitment of PCAF or P2D10 to the active gene Formation of actin ﬁlaments in the proximity of the Pol ... components of the yeast Nu4A HAT complex [38,42] In the yeast Nu4A HAT complex, actin and Act3 ⁄ ARP4 are essential for the structural integity and activity of the complex [38] The presence of actin...

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Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf

Ngày tải lên : 08/03/2014, 08:20

... establish the importance of GSK3 in the acute regulation of glucose transport in terms of its regulatory control of GS in muscle and fat cells we have investigated the effects of Li and the anilinomaleimide, ... regulators the activation status of GSK3 is likely to be a key determinant of GS activity Whilst there is considerable evidence implicating GSK3 in the regulation of glycogen metabolism there are ... 1B shows that whilst preadipocytes express both GSK3 isoforms, the abundance of the b isoform declines by 85%, whereas that of the a isoform is virtually undetectable in differentiated adipocytes...

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Báo cáo khoa học: MicroRNAs and the regulation of ﬁbrosis potx

Ngày tải lên : 15/03/2014, 11:20

... to the development of multiple diseases Fibrosis is characterized by the excess deposition of extracellular matrix (ECM) components, which is the end result of an imbalance of metabolism of the ... and the development of diabetic nephropathy through the down -regulation of PTEN and the subsequent activation of Akt (Fig 1) [43] Increased expression of miR-377 is also thought to regulate the ... failure of a number 2016 of organs Although current treatments typically target the inﬂammatory response, the mechanism of ﬁbrosis is poorly understood and there are few effective therapies For these...

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Báo cáo khoa học: Calcium-induced contraction of sarcomeres changes the regulation of mitochondrial respiration in permeabilized cardiac cells doc

Ngày tải lên : 16/03/2014, 22:20

... Reversibility of the effects of calcium-induced contraction of cardiomyocytes on the kinetics of regulation of mitochondrial respiration by exogenous ADP The kinetics of respiratory regulation was ... alteration of the regular arrangement of mitochondria in the cells, in the changes in the kinetics of regulation of mitochondrial respiration by exogenous ADP and ATP, and in the direct channelling of ... under the conditions of our experiments Figure 3A shows that the addition of ADP activated the respiration of permeabilized bers in the presence of lm free calcium, and that the addition of exogenous...

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Báo cáo Y học: Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice usingin vivo 13 C NMR measurements of hepatic carbohydrate metabolism docx

Ngày tải lên : 17/03/2014, 17:20

... (right) images of the liver of a control mouse acquired using the FLASH sequence (TR ¼ 10 ms, TE ¼ ms) The rectangles indicate the location of the volume of interest, % 400 lL (8.5 · · mm3) The 13Clabeled ... net synthesis of glycogen or the combination of both The rates of total glycogen synthesis and 13C label incorporation into glycogen (Fig 5) suggest that the overall rate of glycogen synthesis ... activity of the indirect pathway of glycogen synthesis In addition, this study reports for the ﬁrst time the simultaneous detection of increased signal intensity for the glycogen C2–C5 resonances These...

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Báo cáo Y học: Identiﬁcation of mammalian-type transglutaminase in Physarum polycephalum Evidence from the cDNA sequence and involvement of GTP in the regulation of transamidating activity potx

Ngày tải lên : 17/03/2014, 23:20

... Although the predicted aminoacid sequence had similarity with the sequences of mammalian TGase, the length of the cDNA was smaller than the length deduced from the molecular size of the puriﬁed ... Although the overall identity with the mammalian TGase primary sequence is low in the deduced sequence of the Physarum TGase, the middle region of the sequence is signiﬁcantly conserved The sequences ... shown that the enzymatic activity of TGase was inhibited by the presence of GTP or ATP, as in the case of PpTGase [51] These results suggest that the mechanism by which nucleotides inhibit the enzymatic...

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Báo cáo khoa học: The regulation of the endosomal compartment by p53 the tumor suppressor gene docx

Ngày tải lên : 23/03/2014, 04:21

... or they are in the same pathway, but each raises the rate of production of exosomes (two distinct rate-limiting steps) p53 regulates the internalization of EGFR from the plasma membrane into the ... whether a p53 response could accelerate removal of the EGFR from the plasma membrane In H460 cells, the localization of the EGFR was determined by ﬂuorescent immunostaining In the absence of ... activity The results conﬁrmed the conclusions presented in Fig 5D, activation of p53 increased the removal of both EGFR and caveolin-1 proteins from the surface and they colocalized within the cell These...

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The Constitution of Private Governance Product Standards in the Regulation of Integrating Markets pptx

Ngày tải lên : 23/03/2014, 05:23

... WIDESPREAD SCHOLARLY neglect of the phenomenon of the use of standards in modern market regulation seems all the more striking in the light of the preoccupation of modern theorising in sociology, ... 3.5 The State of the Art Defence: the European Community 3.6 The State of the Art Defence: the United States 3.6.1 Between Custom and the Frontiers of Science 3.6.2 Standards Bodies and the Constitution ... the EUI, I spent the remainder of the implausible number of years it has taken to write the thesis at the Zentrum für Europäische Rechtspolitik in Bremen, the Centre de Théorie Politique at the...

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Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx

Ngày tải lên : 23/03/2014, 07:20

... HD These processes may not be independent of each other Detailed descriptions of these processes are beyond the scope of this review In the present review, we speciﬁcally focus on the role of ... only on the amount of the interacting proteins but also on the afﬁnities of interacting proteins The uncreased expression of caspase-1 observed in HD may be mediated through HIPPI The role of HIP-1 ... might also be involved in the regulation of apoptosis Even though the exact function of HIPPI remains unknown, knockout mice for Hippi (HIPPI) ⁄ )) exhibit downregulation of the Sonic hedgehog (Shh)...

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Report on the Regulation of Reproductive Cell Donation in the European Union potx

Ngày tải lên : 28/03/2014, 16:20

... Subsection (1); b) the donor offers the cells exclusively for the use of the recipient specified in the declaration of donation; c) the declaration of donation includes – beyond the provisions set ... in Subsection (3) – the written declaration of consent of the donor and the unanimous statement of the donor and the recipient made with both of them present confirming that the donation occurs ... to the use of their gametes for the treatment of others They must be given an opportunity to receive proper counselling about the implications of donation The donor can withdraw consent up to the...

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AN INCREASING ROLE FOR COMPETITION IN THE REGULATION OF BANKS doc

Ngày tải lên : 29/03/2014, 08:20

... Consequent failure 23 The failure of a bank, like the failure of any other firm in the economy, may, of course, lead to the failure of other firms exposed towards the failing bank The loss of value associated ... 1/12 of 1% of the assessable deposits and was the same for all insured institutions regardless of the riskiness of their assets or the size of their equity capital or the capability of their management ... failure of one bank could lead to the failure of other banks or other non-bank firms: (a) the failure of one bank leading to a decline in the value of the assets sufficient to induce the failure of...

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Báo cáo khoa học: A new pathway encompassing calpain 3 and its newly identiﬁed substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-jB pathway in skeletal muscle pdf

Ngày tải lên : 29/03/2014, 21:20

... and 71 Considering the location of the N-terminal extremity of DNter2 on the structure of CARP and the presence of the potential cleavage sites, we identiﬁed the localization of the cleavage site ... analysis of CARP expression in the subcellular compartments Regulation of CARP by calpain obtained from the muscle of the mice injected with pYFP-CARP-CFP-HIS conﬁrms the presence of the protein in the ... observed inside the nucleus However, it is possible that the loss of one NLS in the C-terminal fragment affects the nuclear transport of this form of CARP, although the sensitivity of the methods...

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Báo cáo khoa học: Galanin-like peptide and the regulation of feeding behavior and energy metabolism pptx

Ngày tải lên : 29/03/2014, 21:20

... known about the role of alarin, which was discovered as an alternate transcript of the GALP gene Further elucidation of the function of GALP and alarin will provide the necessary basis for the treatment ... various regions of the rat brain Injection of GALP into the third ventricle induces c-Fos expression, a marker of cell activation, in the horizontal limb of the diagonal band of Broca, POA, ARC ... neurons project from the ARC to the PVN, and the other in which they project to the MPA, bed nucleus of the stria terminalis and lateral septal nucleus Central administration of GALP activates neurons...

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Báo cáo Y học: Molecular characterization of MRG19 of Saccharomyces cerevisiae Implication in the regulation of galactose and nonfermentable carbon source utilization pdf

Ngày tải lên : 31/03/2014, 08:20

... that the energy status of the cell is an important determinant of GAL gene induction [15,25–27] This suggests that the availability of metabolic energy is a rate-limiting step in the synthesis of ... density Both of these promoters are under the control of the Adr1p transcriptional activator [44] b-galactosidase activity was the same in wild-type and the MRG19 disruptant regardless of the cell ... with the wild-type control Growth of an MRG19 disruptant bearing the CYC1::GAL1 construct was lower than that of the wildtype transformed with same construct (Fig 4) Moreover, growth of the MRG19...

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báo cáo hóa học: " Aging and selective sensorimotor strategies in the regulation of upright balance" docx

Ngày tải lên : 19/06/2014, 10:20

... segmental reflexes organized at the level of the spinal cord, but rather depend on the integration of proprioceptive, visual and vestibular information at many levels of the neuraxis [5-7] Head-based ... in vestibular rehabilitation [21] Thus, the aim of the present study was to determine the effects of aging and repeated exposures on the capability of the CNS to select pertinent sensory information ... measures to calculate the displacement of the body's center of mass (COM) Resultant center of pressure (COP) in the horizontal plane was calculated as the weighted sums from the vertical force and...

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