the public switched telephone network is designed to be available 90 of the time
Báo cáo khoa học: Cellular refractoriness to the heat-stable enterotoxin peptide is associated with alterations in levels of the differentially glycosylated forms of guanylyl cyclase C pdf
... thoughtthey were able to bind the ST peptide (Fig. 2). Therefore,there appeared to be a correlation between the presence of the 145 kDa form of GC-C, which represents the matureglycosylated form of ... proteinsynthesis was not required, and a pool of ER-associatedGC-C is available to replenish the ligand-activable form of the receptor, lost from the cell surface on ST addition. The levels of cGMP ... down-regulation of GC-C activity. This requirement for prolonged treatment of cells to ST to observe desensitization, is in contrast to the rapid inactivation that is seen for other members of the guanylyl...
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Báo cáo khoa học: MR solution structure of the precursor for carnobacteriocin B2, an antimicrobial peptide fromCarnobacterium piscicola Implications of the a-helical leader section for export and inhibition of type IIa bacteriocin activity pdf
... peptide[14]. To help determine the structural basis of the inhibition of the antimicrobial activity of CbnB2 by the leader and to assist future analysis of the interaction of preCbnB2 with its ABC ... bacteria, e.g. Listeria monocyto-genes, but display no toxicity toward humans or othereukaryotes. We reported purification and the primarystructure of the first member of this class, leucocin ... )15 to )5 relative to CbnB2) in the leader section of the peptide. This helix appears to be conserved in related type IIa bacteriocin precursors basedon sequence analysis. It is likely to be...
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Báo cáo khoa học: The C-terminal region of the proprotein convertase 1⁄ 3 (PC1⁄ 3) exerts a bimodal regulation of the enzyme activity in vitro pdf
... needs to be estab-lished. In the case of the propeptide, thought to be essential for protease folding and as an auto-inhibitorduring transit from the endoplasmic reticulum to the secretory granules, ... implication of this in vitro study remains to be firmly established.PC1⁄3 is able to autoregulate its enzymaticactivity The CT-peptide is the least conserved region among allmembers of the convertase ... stimula-ting conversion of the 87 kDa form into the moreactive 66 kDa form via activation. Hence, after the synthesis of proPC1 ⁄ 3, the propeptide is cleaved off in the early secretory compartments...
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báo cáo hóa học:" Reconstruction of the acetabulum in THA using femoral head autografts in developmental dysplasia of the hip" docx
... has to be considered that the hip centre is often located relatively high. A correc-tion of the hip centre by 20.8 mm into the medial and11.4 mm into the distal direction on average could be shown ... acquisition of data, analysis and interpretation of data, revision and finalapproval of manuscriptJS acquisition of data, analysis and interpretation of data, revision and finalapproval of ... incorporation was assessed by the disappearance of the radiolucent line between graft andhost bone and the remodelling of the inner structure of the bone graft. C overage of the socket by bone graft...
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báo cáo hóa học:" Reconstruction of the acetabulum in THA using femoral head autografts in developmental dysplasia of the hip" pot
... has to be considered that the hip centre is often located relatively high. A correc-tion of the hip centre by 20.8 mm into the medial and11.4 mm into the distal direction on average could be shown ... wasmeasured according to the DeLee/Charnley zones [30].Reconstruction of the anato mic hip centre is animportant part of any hip procedure. The centre of rota-tion of the hip joint can be determined ... unilateral dis-ease by mirroring the opposite, non-affected side. In the other cases, a previously described method was used to determine the anatomic rotation centre of the hip [31].Wear of the polyethylene...
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Tài liệu GPON Migration Ensuring my Network is Ready to Migrate to GPON doc
... will the network migrate from one PON flavor to the next as bandwidth demand continues to rise.GPON MigrationEnsuring my Network is Ready to Migrate to GPON Ensuring my Network is Ready to ... characteristics – but they may also be quite different. The spectral attenuation refers to the loss of a signal as a direct correlation between the wavelength and the distance traveled. The lower the ... design. This applies equally to overbuilds, Greenfield applications, or even a migration network. To be profitable, it’s imperative to understand the impact of the decisions made early in the planning...
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Tài liệu Báo cáo khoa học: Novel aggregate formation of a frame-shift mutant protein of tissue-nonspecific alkaline phosphatase is ascribed to three cysteine residues in the C-terminal extension pdf
... processed to the 90 kDa formin the Golgi apparatus before being released into the medium. In support of this, this secretory form wasfound to be sensitive to PNGase F but resistant to Endo H ... longerembedded into the lipid bilayer via GPI, which helpsanchor TNSALP to the plasma membrane, but is secreted out of the cell. To investigate whether thismutant protein is secreted, we labeled the ... was found to be heavily ubiquitinated in the presence of the inhibitor of proteasome function. Furthermore, the extent of ubiquitination of TNSALP (1559delT) was furtheraugmented in the cells...
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Báo cáo khoa học: A characteristic Glu17 residue of pig carnitine palmitoyltransferase 1 is responsible for the low Km for carnitine and the low sensitivity to malonyl-CoA inhibition of the enzyme docx
... expression of the liver and muscleisoforms of ovine carnitine palmitoyltransferase 1: resi-dues within the N-terminus of the muscle isoform influ-ence the kinetic properties of the enzyme. ... that the low sensitivity to malonyl-CoA of the pig enzyme is not related to the presence of anegative determinant between residues 19 and 28 in the N-terminal region of the enzyme.Switching the ... which the N-terminal segment (resi-dues 1–79) has been related to the low IC50 of thisrecombinant enzyme [26].As the pig N-terminal fragment is able to change the malonyl-CoA sensitivity of the...
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Báo cáo khoa học: In vitro gamma-secretase cleavage of the Alzheimer’s amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc potx
... different mechanisms to control the aggregationstates of these substrates and supports our originalhypothesis that mammalian cellular factors enableendogenous proteins to be presented to the c-secretasecomplex ... 5557 strategy for the prevention of AD. An initial step indiscovering c-secretase inhibitors is the development of assays that monitor c -secretase activity. This paperdescribes two novel in ... zinc-bind-ing domain may be present in the Ab sequence of C99,we hypothesized that zinc may affect the oligomeriza-tion state of C101-3FLAG. Therefore, the molecularmass of C101-3FLAG before and after...
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She is going to go on business at the end of June potx
... end of June” – vào cuối tháng 6. “at the end (of something)” – vào lúc cuối, vào phần cuối (của một sự kiện, thời gian). Ví dụ: at the end of the street (cuối con đường), at the end of the ... to be (am, is, are)” – được chia dựa theo chủ ngữ. “going to có thể được viết tắt là “gonna” trong văn nói. Nếu muốn chia ở dạng phủ định, ta thêm “not” vào sau động từ to be . - “She is ... She is going to go on business at the end of June 2. Các bạn hãy di chuột vào từng cụm từ một để biết chức năng của cụm trong câu: She is going to go on business at the end of June....
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báo cáo sinh học:" Empowering health personnel for decentralized health planning in India: The Public Health Resource Network" ppt
... Health Resource Network is an efforttowards this end.Discussion The Public Health Resource Network Started in 2005, the Public Health Resource Network (PHRN) is an innovative distance-learning ... decentral-ized governance of systems of planning and delivery, atleast at the level of the district. In India, a district is the smallest administrative unit. The country has 604 districtsacross its ... managerstowards strengthening the public health system in theirdistricts, and assisting in the emergence of state and dis-trict resource groups for this purpose;ã empowering civil society to create...
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