the occasional susceptibility of patients to adverse effects of otherwise mild drugs means there is no intuitive consensus as to how idiosyncrasy occurs
Expression dynamics of the hepatic mitochondrial proteome of the sod2+ mouse in response to troglitazone administration
Ngày tải lên :
12/09/2015, 11:08
... describe the mechanisms or hypotheses that underlie idiosyncratic DILI The occasional susceptibility of patients to adverse effects of otherwise mild drugs means there is no intuitive consensus as to ... mechanism has yet been associated with the cause for idiosyncratic DILI Another hypothesis that has been put forward is the inflammagen hypothesis (Uetrecht, 2008) This is based on a combination of ... Figure shows that from 1976 to 2005, hepatotoxicity formed the single most common toxicity as to why drugs were removed from the market As such, there has been immense attention to address the challenges...
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benkel et al - 2006 - the assassination between corporate governance and earning management
Ngày tải lên :
02/01/2015, 17:34
... Nicolas Couderc The aim of this paper is to document the driving factors of the financial policy choice and to evaluate the relevance of two alternative theories, the trade-off theory and the ... Powers of the Board of Directors The primary function of the board of directors is the selection of the CEO and concurrence with the CEO’s selection of the company’s top management team This includes ... governance has been a topic of increased interest in the boardrooms due to structural backwardness, the crisis of the Athens Stock Exchange and the international pressures toward a more market-based...
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lee et al - 2006 - auditor conservatism and audit quality - evidence from ipo earnings forecasts
Ngày tải lên :
06/01/2015, 19:43
... significance’ of these forecast errors, relative to the funds raised through the IPO However, earnings are for the firm as a whole, but the use of issue size as a deflator reflects only the interest of the ... operations, otherwise Unit offer = if the IPO was a unit offer consisting of a package of shares and options, otherwise SEO = if the firm had a seasoned equity offering in the two years following the ... forecast accuracy, but this influence is not robust to the method of measuring forecast error In contrast, the results in Panel B show both measures of forecast bias are significantly negatively associated...
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jennings et al - 2006 - strong corporate governance and audit firm rotation- effects on judges' independence perceptions and litigation judgments
Ngày tải lên :
06/01/2015, 19:43
... corporate CEO The proportion of independent directors on the Board may vary The level of financial expertise of members of the Board may vary The level of financial expertise of members of the audit ... further analysis is needed to determine the benefits of mandatory rotation, because the benefits are harder to predict and quantify than the additional costs However, the combination of no regulatory ... of impropriety of other audit firms increased public skepticism as to the independence of the auditors In the context of a failed audit, judges will more likely reconstruct a scenario of auditor...
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nasser et al - 2006 - auditor‐client relationship- the case of audit tenure and auditor switching in malaysia
Ngày tải lên :
06/01/2015, 19:43
... way or another regardless of the number of years in of ce, there is little the profession can with regard to this matter (Dunn, 1996) In other words, the profession does not object to auditors serving ... with the same client has been cited as one of the threats to auditor independence Given the importance of this issue, this research attempts to shed some light on the effect of audit tenure and ... can be related to the size of the auditee and the type of services needed It has been argued that larger auditees, due to the complexity of their operations and the increase in the separation...
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raiborn et al - 2006 - should auditor rotation be mandatory
Ngày tải lên :
06/01/2015, 19:44
... allegiance to the corporation’s creditors and stockholders, as well as to the investing public’” (Goodkind, 2000) Second, in the primary sense of the term, the audit firm is not a customer of the audit ... “auditors never noticed” (Norris, 2003) At the time the Parmalat fraud was discovered, Grant Thornton SpA was auditing “Parmalat’s offshore assets, where investigators say the fraud appears to ... believe that the costs of mandatory audit firm rotation are likely to exceed the benefits Thus, the GAO decided the most practical strategy at the time of the report’s issuance was to let the Securities...
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![[cg-sr] aguilera et al - 2006 - corporate governance and social responsibility - uk and us](https://media.store123doc.com/images/document/2015_01/06/medium_xvi1420548465.jpg)
[cg-sr] aguilera et al - 2006 - corporate governance and social responsibility - uk and us
Ngày tải lên :
06/01/2015, 19:47
... level, the relative robustness of the British economy is consistent with the validity of the theory US companies may well gravitate toward British CSR disclosure norms as a positive side effect of ... judge the consequences of Higgs, this change seems likely to spread the power at the top of the firm (Aguilera, 2005, 48) by enhancing the power of the board of directors to operate independent of ... directors to assess the professional dynamics of the relationship between management and directors, and to assess the quality of management (Holland, 1998) In a common theme, a number of the financial...
- 12
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conte r., et al. (eds.) direct and inverse methods in nonlinear evolution equations (lnp632, springer, 2003)(283s)
Ngày tải lên :
24/04/2014, 16:50
... namely: to be a solution of some PDE, (if an auto-BT is desired) the PDE satisfied by U is identical to (53), the vanishing of the commutator [L1 , L2 ] is equivalent to the vanishing of the PDE satisfied ... Similarly, if u satisfies an ODE or a PDE, the structure of singularities of the general solution characterizes the level of integrability of the equation This is the basis of the theory of the (explicit) ... 1-dimensional case a4 = 0, the parameter λ can be set to by the change ψ → ψeλy This is the reason of the precision at the end of item in definition 2.4 This pair has the order four in the generic case...
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transmission line matrix (tlm) in computational mechanics - d. de cogan, et al., (crc, 2006) ww
Ngày tải lên :
05/05/2014, 17:21
... added to the outgoing wave, there is a doubling of the displacement One way of thinking of the action of such boundaries is that there is a virtual wave beyond the boundary that comes in to the ... MATLAB® The tone of the chapters then changes from the application of general principles to the description of the latest research in a range of areas (modeling of heat and mass transfer is of particular ... speed, c, is c= T ρ (2.2) T is the tension of the string in Newtons, and ρ is the linear mass density in kg/m In this equation, x is distance along the string, and y is the departure of the string...
- 275
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color atlas of histopathology of the cervix uteri 2nd ed - c. dallenbach - hellweg, et al., (springer, 2006)
Ngày tải lên :
12/05/2014, 16:59
... differential diagnostic aspects and describes in detail how to reach the correct diagnosis The atlas is also meant for the clinician, to guide him in his often difficult decision of how to provide ... neoplastic-transformed cells to their histogenetic origins The resultant refined classification of cervical neoplasias has helped to predict clinical outcome and to choose type of therapy This atlas is intended ... application of excisional methods is the predictive value of histologically clear margins for the recurrence of disease and the general interpretability of the resection margins, especially if there is...
- 206
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color atlas of immunology - g. burmester, et al., (thieme, 2003)
Ngày tải lên :
12/05/2014, 17:00
... Allergies 202 Atopic Dermatitis and Leukocytoclastic Vasculitis 204 Psoriasis and Bullous Skin Diseases 206 Gastrointestinal Diseases Atrophic Gastritis, Whipple's Disease and Sprue ... Musculoskeletal Diseases Clinical Features of Rheumatoid Arthritis 166 Synovial Changes in Rheumatoid Arthritis 168 Pathogenesis of Rheumatoid Arthritis (I) 170 Pathogenesis of Rheumatoid Arthritis (II) ... appearance of a name without designation as proprietary is not to be construed as a representation by the publisher that it is in the public domain This book, including all parts thereof, is legally...
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contact dermatitis 4th ed - p. frosch, et al., (springer, 2006)
Ngày tải lên :
12/05/2014, 17:10
... constitutes the idiosyncrasy? The history of contact dermatitis in the twentieth century is indistinguishable from the history of patch testing, which is considered the main tool for unmasking the causative ... cause of a recurring, disabling disease With the assistance of the information that is so prolifically available in this text, physicians will be able to bring help to many of these patients The ... testing as the lack of knowledge in selecting the correct allergen and the difficulty encountered in interpreting the results It is works such as this that bring together the knowledge of the past,...
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colonoscopy - principles and practice - j. waye, et al., (blackwell, 2003)
Ngày tải lên :
12/05/2014, 17:35
... the center of the monitor It is also important for the assistant to be able to view the endoscopic image along with the endoscopist If the assistant stands opposite the physician, as is common ... building as well Based on the achievement of these experiments, Bozzini published a book on his light conductor in 1807 However, the Faculty of Medicine of the University of Chapter 1: History of Endoscopy ... III) The instrument was inserted into the proximal colon under fluoroscopic guidance The mechanism of picture-taking was the same as with the gastrocamera; however, the colonocamera was not always...
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stuber et al., das allgemeine gleichbehandlungsgesetz in der betrieblichen praxis (2006)
Ngày tải lên :
05/06/2014, 13:01
... Organisation zu erkennen (siehe Kapitel 4, 7, 11) Wer muss die Benachteiligung beweisen? Das AGG sieht eine Beweislasterleichterung vor, jedoch keine Beweislastumkehr Das bedeutet, dass Betroffene ... Betroffene muss beweisen Das Gesetz bestimmt in § 22, dass der/die Betroffene die ungünstige Behandlung beweisen und Indizien beweisen muss, die eine Benachteiligung oder Belästigung vermuten lassen ... Risiko? Bislang existierten nur wenige Antidiskriminierungsregelungen im deutschen Arbeitsrecht Deshalb ist es kaum möglich abzuschätzen, wie groß das Potenzial für Vorwürfe auf Basis des AGG...
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benston et al - following the money; the enron failure and the state of the corporate disclosure (2003)
Ngày tải lên :
01/11/2014, 11:15
... public companies as part of U.S GAAP (although it need not specify the precise way in which the stock options must be valued) Another reason for the FASB to move on this issue is to keep pace with ... from his management of the SPEs that did business with Enron, and that other employees who reported to Fastow received at least another $11 million Furthermore, a detailed analysis of the Fastow-related ... disclosure issues are now at the top of the public policy agenda and very much on investors’ minds The authors hope that the book will help contribute to better understanding of these issues The...
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barton et al - dangerous markets; managing in financial crises (2003)
Ngày tải lên :
04/11/2014, 05:04
... Minister Lee Hsieng Long, the head of the MAS, had the vision to seize the opportunities that the surrounding crisis in Asia offered to the city-state to become a leading financial center in the ... change as well; it is not uncommon for a list of the top ten companies in a given industry to shift dramatically after a crisis The behavior of customers changes, too, as they get the opportunity to ... judgment, therefore, executives have at least three basic options to consider as they manage a crisis Default to the pre-crisis status quo First, executives can default to the pre-crisis status...
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![gompers et al - 2003 - corporate governance and equity prices [cgi-g-index]](https://media.store123doc.com/images/document/2015_01/02/medium_qgt1420194792.jpg)
gompers et al - 2003 - corporate governance and equity prices [cgi-g-index]
Ngày tải lên :
02/01/2015, 17:33
... investors to review governance provisions Thus, these listings are a noisy measure of a firm’s governance provisions, but there is no reason to suspect any systematic bias Also, all of our analysis ... to the book value of assets: the market value is calculated as the sum of the book value of assets and the market value of common stock less the book value of common stock and deferred taxes The ... is not approved and the bidder proceeds, the pill is triggered Typical poison pills give the holders of the target’s stock other than the bidder the right to purchase stock in the target or the...
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xie et al - 2003 - earnings management and corporate governance - the role of the board and the audit committee
Ngày tải lên :
02/01/2015, 17:34
... mergers inflate their earnings prior to the merger in order to inflate their stock price and thereby reduce the cost of the merger Other studies have examined the incentives of managers to manipulate ... extent to which increased levels of outside director representation on the board of directors benefit shareholders is the subject of much debate The empirical evidence on the efficacy of the monitoring ... directors directors directors directors B Xie et al / Journal of Corporate Finance (2003) 295–316 307 Finally, we show that the log of book value to total assets, the log of sales, and the log of...
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daily et al - 2003 - corporate governance decades of dialogue and data
Ngày tải lên :
02/01/2015, 17:34
... either immediately prior to or at the point of crisis (Daily, 1994) There remains much to learn about governance mechanisms that enable firms to avoid a crisis such as financial decline There is ... shareholders (e.g., Davis et al., 1997) This is not to say that stewardship theorists adopt a view of executives and directors as altruistic; rather, they recognize that there are many situations ... given the assumption that managers are self-interested, and context in which those managers not bear the full wealth effects of their decisions This was the first satisfactory explanation of the public...
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engel et al - 2003 - ceo turnover and properties of accounting information
Ngày tải lên :
02/01/2015, 17:34
... measure of managerial performance That is, the ‘‘signal-strength effect’’ dominates as long as there is enough noise to make the firm’s inference problem difficult 28 To see this, consider the effects ... if the variance of earnings falls, then the association between the two measures increases This will lead to an increase in the weight on earnings, but this arises because of a reduction in noise, ... variance of returns Note that our variance measures are playing two key roles in the analysis First, as discussed here, these measures allow us to test hypotheses relating to how the noise in a measure...
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