the neurologic and cognitive consequences of hiv 1 infection
báo cáo hóa học:" Substitutions in the Reverse Transcriptase and Protease Genes of HIV-1 Subtype B in Untreated Individuals and Patients Treated With Antiretroviral Drugs" potx
... M41L ( 21. 5) Q151M (3.9) L74V (3.9) E44A/D (5.8) T 215 Y (33.3) V75I (0) L 210 W (25.4) K 219 E (11 .7) E44D (0) K 219 Q (7.8) Q151M (3.9) T 215 F (11 .7) T 215 Y (33.3) RT (NNRTI) (n = 12 ) V108I (25) Y181C ... absence of Vif, the synthesis of the negative strand of DNA can result in the insertion of a uracil as a result of the deamination of a cytosine, leading to the inclusion of an adenosine instead of ... (1. 9) M41L ( 21. 5) F77G (1. 9) I54L (2.9) A71T (8.8) G73S (11 .7) V77I (8.8) V82T (5.8) RT (NRTI) (n = 51) D67N (19 .6) K65R (0) A62V (0) V75I (5.9) K70R ( 31. 3) T 215 F (11 .7) V 118 I (25) M184V (76.4)...
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Báo cáo y học: " Peptide P5 (residues 628–683), comprising the entire membrane proximal region of HIV-1 gp41 and its calcium-binding site, is a potent inhibitor of HIV-1 infection" pptx
... http://www.retrovirology.com/content/5 /1/ 93 Table 1: The α-helical content of P1 & P5 alone or in the presence of N36 & LZ [θ]222 (10 -3deg cm2dmol -1) [θ]222 (10 -3deg cm2dmol -1) N36 P1 P1+N36 P5+N36 aT20 -6 -11 -17 - 21 -2 LZ P5 P1+LZ ... properties of peptides P5, P1 and T20 were tested against infection of PBMC by X4- (HIV- 1Lai) and R5-tropic (HIV- 1JRCSF) strains of HIV- 1 As shown in Figure 3b, and 3c, at μM the P5 and T20 peptides had ... Yahi N, Andre-Barres C, RicoLattes I, Lattes A: Synthetic soluble analogs of galactosylceramide (GalCer) bind to the V3 domain of HIV- 1 gp120 and 19 20 21 22 inhibit HIV- 1- induced fusion and entry...
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Báo cáo y học: "Genetic and phylogenetic evolution of HIV-1 in a low subtype heterogeneity epidemic: the Italian example" pdf
... E: HIV1 group N among HIV- 1- seropositive individuals in Cameroon AIDS 2000, 14 :2623-2625 Page of (page number not for citation purposes) Retrovirology 2007, 4:34 10 11 12 13 14 15 16 17 18 19 ... tree of HIV- 1 env gene C2-V3 region from ItalPhylogenetic tree of HIV- 1 env gene C2-V3 region from Italian B-clade isolates The C2-V3 env region (position 70 01 to 719 6 of HIV- 1HXB2) of 14 3 Italian ... tree of HIV- 1 gag p17 region from Italian isoPhylogenetic tree of HIV- 1 gag p17 region from Italian isolates The gag p17 region of B as well as non-B clade HIV- 1 isolates, identified in the whole...
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Báo cáo y học: "Mutation in the loop C-terminal to the cyclophilin A binding site of HIV-1 capsid protein disrupts proper virus assembly and infectivity" ppt
... E98A and 373 wild-type HIV- 1 particle morphology Click here for file [http://www.biomedcentral.com/content/supplementary /17 424690-4 -19 -S3.doc] 10 11 12 13 14 15 16 17 18 Acknowledgements We would ... of the HIV- 1 gag was amplified with the forward primer SK-38 5'-ATC CAC CTA TCC CAG TAG GAG AAA T-3' (10 90 11 17) and the reverse primer SK-39 5'TTT GGT CCT TGT CTT ATG TCC AGA ATG C-3' (11 77 12 04) ... analysis of capsid mutants Structural view and Western blot analysis of capsid mutants A close view of the structure of the cyclophilin A binding loop in the N-terminal (A) and the position of E187...
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Báo cáo khoa học: Retrocyclin RC-101 overcomes cationic mutations on the heptad repeat 2 region of HIV-1 gp41 ppt
... cationic mutations in the presence of sublethal concentrations of RC -10 1 [14 ] Of the three mutations, one was found in gp120 and one each in the HR1 and HR2 regions of gp 41, and all three mutations ... of HR1 and HR2, formation of the 6HB, and subsequent fusion of the host and viral membranes (Fig 4C), as supported by recent in vitro studies [12 ,14 ] RC -10 1 binds to the HR1-binding regions of ... Conformational changes in HIV- 1 gp 41 in the course of HIV- 1 envelope glycoprotein- RC -10 1 overcomes cationic mutations in HIV- 1 gp 41 mediated fusion and inactivation Biochemistry 44, 12 4 71 12 479 42 Buffy...
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The Causes and Behavioral Consequences of Disasters pot
... 11 1 11 5 11 5 11 6 11 7 11 9 12 0 18 Stage Five: Renormalization 12 3 References 12 4 19 Stage Five: Renormalization South Africa Traffic Accidents – December 23, 19 98 and September ... 11 11 12 14 15 Part II Causes of Disasters The Missing Role of Context: A Conceptual Model Understanding the Causes and Consequences of Disasters References 19 19 22 The ... References 13 3 13 3 13 3 13 6 13 6 13 7 13 7 13 7 13 8 13 9 14 2 14 4 14 5 Disasters from a Public Health Perspective How Can We Use the Models? Implications of the Models for Public...
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Báo cáo hóa học: " Sargassum fusiforme fraction is a potent and specific inhibitor of HIV-1 fusion and reverse transcriptase" pot
... inhibition of HIV- 1 Further purification of SP4-2 to its individual components is currently in progress Cells 1G5 [11 ], SupT1 [12 ], and GHOST X4/R5 [13 ] cells were obtained from the HIV AIDS Research and ... precipitation [19 ], with 10 µg of HIV- 1 clone DNA and 15 µg of VSV-G envelope expression plasmid DNA, a ratio of DNAs found to yield the highest HIV- 1 infectious titers in our hands For native HIV- 1 production, ... infected with HIV- 1 (NL4-3) at multiplicity of infection (moi) of 0. 01 for 1. 5 h, washed times, and returned to culture with the same concentration of each treatment, for the duration of the experiment...
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Báo cáo hóa học: " Closing two doors of viral entry: Intramolecular combination of a coreceptor- and fusion inhibitor of HIV-1" docx
... gp 41 R5 HIV gp120 CD4 Cell Membrane CCR5 C D X4 HIV X4 HIV CXCR4 Figure Proposed model of the mechanism of action of BFFI Proposed model of the mechanism of action of BFFI The fusion process of ... help with the manuscript http://www.virologyj.com/content/5 /1/ 56 17 References 10 11 12 13 14 15 16 Alkhatib G, Berger EA: HIV coreceptors: from discovery and designation to new paradigms and promise ... compared to IGF-R1mAb-FI, where the two molecules differ only in the variable regions of the antibody, one recognizing IGF-1R and the other the HIV co-receptor CCR5 (Table 1) Several lines of evidence...
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Báo cáo y học: " Genetic and functional analysis of HIV-1 Rev Responsive Element (RRE) sequences from North-India" pdf
... Research and Therapy 2 010 , 7:28 http://www.aidsrestherapy.com/content/7 /1/ 28 10 11 12 13 14 15 16 17 18 19 Page of inhibition by the transdominant negative RevM10 protein J Virol 19 99, 73:57 41- 5747 ... Rev monomers to the viral RRE: Implications for HIV1 latency Cell 19 91, 65:2 41- 248 Sood V, Ranjan R, Banerjea AC: Functional analysis of HIV- 1 subtypes B and C HIV- 1 Tat exons and RGD/QGD motifs ... RRE-S1 RRE-S2 RRE-S3 RRE-S4 RRE-S5 RRE-S6 RRE VT1 RRE-VT1 RRE-VT2 RRE-VT3 RRE-VT5 RRE-VT6 RRE-D1 RRE-E3 CONSENSUS_B Clustal Co | | | | | | | | | | | | | | | | 90 10 0 11 0 12 0 13 0 14 0 15 0 16 0 GACGGTACAG...
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Retrovirology Commentary BioMed Central Open Access The co-receptor signaling model of HIV-1 ppt
... both HIV- 1 infection of humans [6 ,12 ] and in the pathogenic and nonpathogenic SIV infection of monkeys [11 ], and can result in lasting pathogenic insults [13 ] to or non-pathogenic effects [14 ,15 ] ... value of plasma HIV RNA level on rate of CD4 T-cell decline in untreated HIV infection Jama 2006, 296 :14 98 -15 06 Page of (page number not for citation purposes) Retrovirology 2009, 6: 41 10 11 12 13 ... http://www.retrovirology.com/content/6 /1/ 41 and signal through CXCR4 Therefore, the direct correlation of CD4 depletion with the X4 genotypes in the absence of the X4 phenotype is a strong indication of the possible existence of the...
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Báo cáo y học: "sCD4-17b bifunctional protein: Extremely broad and potent neutralization of HIV-1 Env pseudotyped viruses from genetically diverse primary isolates" doc
... Comparison of the potencies of sCD4-35 -17 b and sCD4-40 -17 b against the 91US054 pseudotype and infectious virus In the TZM-bl system, the IC50 values against the pseudotype were 11 nM for both sCD4-35 -17 b ... Retrovirology 2 010 , 7 :11 http://www.retrovirology.com/content/7 /1/ 11 Page 10 of 13 Figure HIV- 1 sensitivity to sCD4-40 -17 b: independence from cellular source of virions IMCs from strains BL 01 and 89.6 ... Retrovirology 2 010 , 7 :11 http://www.retrovirology.com/content/7 /1/ 11 Page of 13 Figure Design and purification of sCD4 -17 b constructs and related proteins A) Schematic representation of three sCD4 -17 b constructs...
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Báo cáo y học: "Association of chemokine receptor gene (CCR2CCR5) haplotypes with acquisition and control of HIV-1 infection in Zambians" pdf
... 203 1. 1 0.85 -1. 46 0. 417 10 4 1. 1 0.77 -1. 56 0. 61 99 1. 2 0.75 -1. 75 0.5 31 HHD 16 7 1. 0 0.74 -1. 32 0.983 94 0.9 0.59 -1. 23 0.385 73 1. 2 0.75 -1. 92 0.442 HHE HHD/HHE 15 8 31 1 .1 1.9 0.82 -1. 51 1 .14 -3 .16 0.495 ... (15 .9) 75 (15 .6) 10 5 (16 .1) HHE 310 (13 .7) 13 8 (12 .2) 17 2 (15 .2) 61 (12 .7) 11 1 (17 .0) HHF *1 128 (5.6) 76 (6.7) 52 (4.6) 24 (5.0) 28 (4.3) HHF*2 480 ( 21. 2) 259 (22.8) 2 21 (19 .5) 99 (20.6) 12 2 (18 .7) ... < 00 01 162 3.0 2.04-4. 51 < 00 01 137 4.6 2.79-7.65 < 00 01 Donor VL (per 1. 0 log10 unit) 523 1. 6 1. 32 -1. 91 < 00 01 263 1. 3 1. 03 -1. 74 0.028 260 1. 8 1. 35-2.47 < 00 01 *N represents the number of HESNs...
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Báo cáo y học: "Decidual soluble factors participate in the control of HIV-1 infection at the" docx
... activation J Allergy Clin Immunol 19 97, 10 0:838-845 Marlin et al Retrovirology 2 011 , 8:58 http://www.retrovirology.com/content/8 /1/ 58 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 Makrigiannakis ... of IL -10 , IL -12 , IL -15 , TNF-a, IFN-a, IFN-g and CXCL -12 (SDF -1) , and large amounts of CCL-2 (MCP1), CCL-3 (MIP-1a), CCL-4 (MIP-1b), CCL-5 (Rantes), CXCL -10 (IP -10 ), IL-6 and IL-8 CCL-3 and CCL-4 ... the viral entry step, we used HIV- 1 pseudotypes Decidual soluble factors inhibited the entry of HIV- 1 pseudotypes bearing the HIV- 1 (R5 or X4) envelope but not the entry of the VSV-Gbearing HIV- 1...
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Báo cáo y học: " Interactions between Nef and AIP1 proliferate multivesicular bodies and facilitate egress of HIV-1" potx
... infection and replication in primary lymphocytes and macrophages J Exp Med 19 94, 17 9 (1) :10 1 -11 3 Page of 11 (page number not for citation purposes) Retrovirology 2006, 3:33 13 14 15 16 17 18 19 ... HIV1 by a mechanism other than the removal of CD4 from HIV- 1 Env and emphasizes the importance of Nef during late stages of the viral replicative cycle in these cells Nef can substitute for the ... of the L domain of Gag The budding of HIV- 1 is dependent on the consensus Tsg1 01- binding motif (PTAP), which is located in p6 of Gag [33] To confirm that Nef could contribute to the release of...
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Báo cáo y học: " Transactivation and signaling functions of Tat are not correlated: biological and immunological characterization of HIV-1 subtype-C Tat protein" docx
... 3A) and the purity of the protein confirmed using MALDI-TOF (Figure 3B) The mass spectrum of C-Tat revealed a single major peak with a mass of 12 513 . 317 as compared to the calculated mass of 12 274.67 ... J Biol Chem 19 97, 272 :11 313 -11 320 Frankel AD, Pabo CO: Cellular uptake of the tat protein from human immunodeficiency virus Cell 19 88, 55 :11 89 -11 93 Hunt G, Tiemessen CT: Occurrence of additional ... 200 15 0 0.335 0 .13 1 0.895 0.074 Figure Seroreactivity of the Tat antigen Seroreactivity of the Tat antigen Determination of Tat and gp 41- reactive IgG antibody titers in HIV- 1 seropositive and...
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Báo cáo y học: " Conservation of functional domains and limited heterogeneity of HIV-1 reverse transcriptase gene following vertical transmission" pdf
... mh .13 mh.5 mh .11 mh .12 10 0 10 0 mh .10 mh.3 mh.4 mh.6 mh.7 ih1 .1 ih1.2 ih1.3 ih1 .11 ih1.4 ih1.5 ih1.9 ih1.6 ih1.7 ih1.8 ih1 .10 ih2 .1 ih2.2 ih2.9 ih2.3 ih2.6 ih2.4 ih2.5 ih2.7 ih2.8 ih2 .10 ih2 .11 ... 0.0 0.0 0.80 1. 76 1. 37 1. 21 2.90 2 .10 3.46 2. 21 1.54 2.60 2.05 3.26 4.48 2.08 3.30 3.46 1. 30 2 .17 2. 21 2.93 1. 34 1. 75 2. 21 1.05 1. 70 1. 74 1. 22 1. 45 1. 34 0.80 1. 49 1. 37 1. 31 0.64 1. 24 1. 48 0.0 0.0 ... 66.5 15 .1 18.4 4.50 N Infant B Infant C Infant D Infant F Infant H1 Infant H2 P1 P2 P3 dN/dS 12 13 10 12 11 11 69 41 74.8 47 56 36.5 42 81. 2 19 .2 10 0 50 42 55.7 16 18 .8 5.9 2.8 0.6 7.8 3. 31 0.01...
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Báo cáo y học: " Human embryonic stem cell (hES) derived dendritic cells are functionally normal and are susceptible to HIV-1 infection" pot
... 364 :16 3 -17 1 Page of (page number not for citation purposes) AIDS Research and Therapy 2008, 5 :1 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 Martin CH, Kaufman DS: Synergistic use of adult ... cells and their Page of (page number not for citation purposes) AIDS Research and Therapy 2008, 5 :1 http://www.aidsrestherapy.com/content/5 /1/ 1 Figure HIV- 1 infection of hES and FL DCs HIV- 1 infection ... B7 .1, and B7.2 surface expression (Figure 3) The expression levels are comparable between hES-DCs and FL-DCs: CD1a+HLA-DR+ (10 .5% and 9.6%), CD1a+B7 .1+ (14 % and 15 .4%), and CD1a+B7.2+ (11 .4% and...
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Báo cáo y học: " Differential activity of candidate microbicides against early steps of HIV-1 infection upon complement virus opsonizatio" pdf
... RPMI -16 40 were used: Lectines HHA and GNA (1, 10 and 10 0 μg/ml), Lf (200 μg/ml), PVAS (1, 10 and 10 0 μg/ ml), CADA (0.2 and μg/ml), T20 (0.5 and μg/ml), IgG2G12 (1 and 10 μg/ml), IgG2F5 (7.5 and ... μg/ml), IgG12G5 (2.5 and 12 .5 μg/ml), and IgG1B12 (1 and 10 μg/ ml) and polyclonal anti-gp160 antibodies (10 μg/ml) as positive control for HIV inhibition Complement opsonization of HIV- 1 The activation ... IgG1B12 NI NI NI IgG1B12 I (28%) I (14 %) NI [S] IgG12G5 NI NI NI IgG12G5 I (26%) I (16 %) NI [S] IgG2G12 NI NI NI IgG2G12 I (19 %) I (16 %) NI [S] IgG2F5 NI NI NI IgG2F5 I (17 %) I (17 %) I (11 %)...
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Báo cáo y học: "Chemokine control of HIV-1 infection: Beyond a binding competition" pot
... Lewin SR: CCR7 ligands CCL19 and CCL 21 increase permissiveness of resting memory CD4+ T cells to HIV- 1 infection: a novel model of HIV- 1 latency Blood 2007, 11 0: 416 1- 416 4 Cameron PU, Saleh S, ... Establishment of a functional human immunodeficiency virus type (HIV- 1) reverse transcription complex involves the cytoskeleton J Exp Med 19 98, 18 8: 211 3- 212 5 10 Harmon B, Ratner L: Induction of the Galpha(q) ... cascade by the human immunodeficiency virus envelope is required for virus entry J Virol 2008, 82: 919 1-9205 doi :10 .11 86 /17 42-4690-7-86 Cite this article as: Wu: Chemokine control of HIV- 1 infection: ...
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Báo cáo Y học: Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules pptx
... HIV- 1 PROTEASE Structure and function of HIV- 1 PR HIV- 1 PR catalyzes the hydrolysis of specific peptide bonds within the HIV- 1 Gag and Gag-Pol polyproteins to generate the various structural and ... likened to that of a Ôright-handÕ [35] The major subdomains of the polymerase domain of p66 are termed fingers (residues 1 85, 11 8 15 5), palm (86 11 7, 15 6–237) and thumb (238– 318 ) The DNA polymerase ... 3984–3989 61 Engelman, A., Mizuuchi, K & Craigie, R (19 91) HIV- 1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer Cell 67, 12 11 12 21 62 Asante-Appiah, E & Skalka, A.M (19 99) HIV- 1...
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Tìm thêm: xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008