the nature of strength enhancement and weakening by
Báo cáo khoa học: Netropsin interactions in the minor groove of d(GGCCAATTGG) studied by a combination of resolution enhancement and ab initio calculations pot
Ngày tải lên :
16/03/2014, 22:20
... evaluating the interaction energies and
hydrogen positions of the end fragment and the bases
of base pair T8-A25 and base G9 (Table 2, Fig. 4).
For the bases of the A25-T8 base pair, the interac-
tion ... complex. The NH amide atoms of the
drug in particular form H-bonds with thymine O2 and
adenine N3 atoms in the AATT-rich sequence of the
decamer. Part of the spine of hydration is substituted
by the ... Waals’
interactions between the drug and the floor and walls
of the minor groove [21,22]. Electrostatic interactions
between the negatively charged minor groove and the
positively charged end groups of the drug...
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Báo cáo khoa học: Monitoring the prevention of amyloid fibril formation by a-crystallin Temperature dependence and the nature of the aggregating species pdf
Ngày tải lên :
30/03/2014, 04:20
... decreased by 0.0167 gÆcm
)3
, from the start
of the experiment. By the end of the measurement, the
thickness had increased by 0.342 nm, the mass had
increased by 0.10 ngÆmm
)2
and the density ... channel 3, the mass increased by
0.02 ngÆmm
)2
and the density decreased
by 0.0072 gÆcm
)3
. After 2.5 h, the thickness increased
by 0.212 nm, the mass increased by 0.05 ngÆmm
)2
and
the density ... during the entire experiment (Fig. 5), i.e. the
thickness of the layer decreased by 0.014 nm, the layer
density decreased by only 0.0086 gÆcm
)3
, and the mass
decreased by 0.03 ngÆmm
)2
. The process...
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Báo cáo y học: "The association of meat intake and the risk of type 2 diabetes may be modified by body weight"
Ngày tải lên :
31/10/2012, 16:49
... assessment of dietary intake, physical
activity, and measurement of anthropometrics and
other lifestyle factors. Protocols for the SWHS were
approved by the Institutional Review Boards of all ... followed by a
question on the amount consumed in lians (50g/lian)
per unit of time. A lian is the unit of weight in China
equivalent to 50 g.
The reproducibility and validity of the FFQ was ... of type 2 DM in four prospective
studies [3;5-7]. The available data on the association
between meat intake and the risk of type 2 DM are
limited to four health professionals cohorts and the...
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Tài liệu Báo cáo khoa học: Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3 pdf
Ngày tải lên :
20/02/2014, 11:20
... indicate the 5¢-ter-
minus of 33 clones isolated after 5¢-RACE. (B)
Primer extension analysis of fgl2 mRNA. The
left side of the figure is the sequence ladder
using the same primer and the pM166 ... indicates the nucleotide that
is matched to the band present in the primer
extension reaction on the right. The sequence
of the primer is 5¢-CCTCCACCGCTCGG
CAGGCAGCGAGGACGG-3¢. The lanes
on the right ... these
probes. All the lanes have labelled probes. The adding of extracts and
cold probe are indicated in the top of the panel. Supershift, ss-Sp1
and ss-Sp3, were shown in presence of anti-Sp1 and anti-Sp3...
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Open Cultures and The Nature of Networks doc
Ngày tải lên :
05/03/2014, 22:20
... made audible the resonances between
the blast of Dada at the end of WWI in Zurich and Berlin, the gust of the Situationists on the
Rive Gauche in Paris in the 1960s, and the explosion of Punk Rock ... reduce the imbalances of power between
the developer and the user, and between the rich and the comparatively poor.
However, what the effects of this leveling of the playing field will be on other ...
supporters of FOSS.
For the time being, the low costs which increase its accessibility are offset by the still rather
high barrier of technical expertise necessary to make use of the much of the software....
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Báo cáo khoa học: Versatile regulation of multisite protein phosphorylation by the order of phosphate processing and protein–protein interactions pptx
Ngày tải lên :
07/03/2014, 10:20
... the shape of the response curve is
strongly affected by the two groups of parameters that
determine the protein–protein interactions: the concen-
trations of the enzymes relative to the target ... to kinase or phospha-
tase; the respective concentrations of the target will be
denoted by X
n,0
, X
n,K
and X
n,P
, respectively. They are
determined by the rates of the reversible enzyme–target
associations ... for the kinase and
phosphatase. Moreover, Eqn (3) shows that the phos-
phorylation can be directly inhibited by the phosphatase
(and dephosphorylation by the kinase) due to competi-
tion of the...
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THE FACTORS AFFECTING THE USE OF ELDERLY CARE AND THE NEED FOR RESOURCES BY 2030 IN FINLAND pot
Ngày tải lên :
14/03/2014, 17:20
... 0
Simulations30
The growth in operating costs is of the same order of magnitude as the rise in the
number of care personnel. The € 508 million operating cost of the domicile
elderly care in the year ... services they need either from the keeper
Simulations26
The actual coverage of the domicile services at target year depends on the
number of elderly living home, their dependency and the expected ... usage and shifts in it. In most of the cases the distribution is
not monotone, therefore we have smoothened the distributions by linear discrete
models. An example of smoothing the distribution of...
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- 0
Changing Nature Of Financial Intermediation And The Financial Crisis Of 2007-09 pptx
Ngày tải lên :
14/03/2014, 23:20
... held by banks with the assets of securitization pools and
those held by institutions that fund themselves mainly by issuing securities. By the end of the
second quarter of 2007 (just before the ... 2007).
The fluctuations of credit in the context of secured lending expose the fallacy of the lump
of liquidity in the financial system. The language of liquidity suggests a stock of available ...
The increased importance of the market-based banking system has been mirrored by the growth
(and subsequent collapse) of the broker-dealer sector of the economy, the sector that includes the...
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Báo cáo khoa học: A region within the C-terminal domain of Ure2p is shown to interact with the molecular chaperone Ssa1p by the use of cross-linkers and mass spectrometry doc
Ngày tải lên :
15/03/2014, 00:20
... observed in the presence of ATP.
No change in the mobility of the Ure2p–Ssa1p com-
plexes was detected in the presence of ATP.
The stoichiometry of Ure2p and Ssa1p within the 120
and 160 kDa ... built from the X-ray structure of the C-terminal domain of Ure2p and integrates the finding that the N-terminal domain of
Ure2p is flexible. An enlargement of the region of Ure2p involved in the interaction ... (MH+exp) and the calculated mass difference (p.p.m.) with the theoretical monoisotopic mass of the identified peptide are given. The presence of the modified peptides in the
Ure2p, Ssa1p and Ure2p–Ssa1p...
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The Duration of Bank Retail Interest Rates BY Ben R. Craig and Valeriya Dinger ppt
Ngày tải lên :
22/03/2014, 23:20
... of deviating from and optimal price (which is a function of
the costs and the demand function faced by the firm) and the costs of adjusting the price.
Under the assumption of a state-dependent ... advantage of an extraordinarily rich
dataset, we extend the scope of this strand of the literature by exploring the effects of
4
Hofmann and Mizen (2004) and De Graeve et al. (2007) relax the ...
extend the analysis to study the determinants of the hazard of changing the retail rates. The
exploration of these determinants contains, on the one hand, information on the effect of
observed...
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Báo cáo khoa học: A strategy for the generation of specific human antibodies by directed evolution and phage display An example of a single-chain antibody fragment that neutralizes a major component of scorpion venom docx
Ngày tải lên :
23/03/2014, 13:20
... of these changes occurred at frame-
work 3 of the heavy chain (Asp74Asn) and 3 of the light
chain. Two of the changes (Thr152Ile and Ser197Gly)
occurred at frameworks 1 and 3, respectively, and ... for
the selection of human antibodies through the creation
of large repertoires in vitro [10]. This process begins
with the cloning and expression of cDNAs encoding
the variable regions of the ... venom
obtained by electric stimulation of scorpions of the species
Centruroides noxius Hoffmann. The venom was purified by
Sephadex G-50 gel filtration and cation-exchange chroma-
tography [37]. The other...
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