the multiple cellular functions of tfiiia
Báo cáo khóa học: Genetic approaches to the cellular functions of polyamines in mammals potx
... as DFMO retards the growth of the pancreas [101], but does not inhibit the secretory function of the exocrine part of the organ [102] The cellular functions of the polyamines in the pancreas were ... SSAT The apparent synergism between the polymorphism of the ODC gene and the use of aspirin was proposed to be a combined result of an inhibition of polyamine biosynthesis and an activation of their ... in the absence of the polyamines – or, in the case of ODC deficiency, an excessive accumulation of decarboxylated AdoMet – inhibiting DNA methylation and thus disruption of the programming of the...
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báo cáo hóa học:" Research Article On Multiple Interpolation Functions of the q-Genocchi Polynomials" pptx
... 4.8 By comparing the coefficients of both sides of tm /m! in the above, we have the following theorem 12 Journal of Inequalities and Applications Theorem 4.3 Let r, y ∈ Z Then one has k r y ... In 14 , Kim defined new generating functions of q-Genocchi, q-Euler polynomials and their interpolation functions In this paper, we give another definition of the multiple Hurwitz type q-zeta function ... note that Genocchi zeta functions are entire functions in the whole complex s-plane see 14–16 Journal of Inequalities and Applications Various kinds of the q-analogue of the Genocchi numbers and...
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Molecular and cellular functions of the alternatively spliced isoforms of GDNF receptor complex in neuronal differentiation
... Franklin Neither this thesis, nor the man I am today, would be possible without the heroic effort of Professor Too Heng-Phon, whose philosophy of mentoring is a true embodiment of the quote Professor ... interactions of the multi-component ligand receptor system with multiple receptor isoforms, provide a molecular basis for the pleiotropic functions of GFLs Using multiple cell models, we investigated the ... distinct sequences in multiple isoforms of GFRα, may play an important modulatory role in the interactions of GFRα with the different components of the receptor complexes In the nervous system,...
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Tài liệu Báo cáo khoa học: Aldehydes release zinc from proteins. A pathway from oxidative stress⁄lipid peroxidation to cellular functions of zinc pptx
... the exception of formaldehyde, none of the aldehydes affects the absorbance of PAR The data for the reaction of MT with formaldehyde were corrected for the absorbance changes in the absence of ... MT protect the liver and the heart against the toxic effects of ethanol [45–47] The above results suggest that a critical aspect of the protective function of MT is the scavenging of the acetaldehyde ... injury [51] The reaction of acetaldehyde with the Zn–SCys bonds in ADH and concomitant zinc release underscores the significance of these reactions for compromising the functions of other proteins...
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The Practices and Functions of Customer Reference Marketing − Leveraging Customer References as Marketing Assets pptx
... However, the contextual effects that determine the relevance of the different functions of customer reference marketing are beyond the scope of this study Theoretical implications The results of the ... and coded with the help of NVivo software, a program designed for qualitative data analysis Nvivo software was used to code the interview data in the first phase of the analysis The open coding ... further developed, the focus being on the ways in which the case companies leveraged their customer references as marketing assets In order to demonstrate the consistency of the findings and the...
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báo cáo hóa học:" Multiple functions of the von Willebrand Factor A domain in matrilins: secretion, assembly, and proteolysis" ppt
... site of matn-1 To further test this hypothesis, we determined whether the presence of the inhibitors of matrix proteases affected the proteolytic processing of matn-1 The presence of mM EDTA in the ... shown that the number of the EGF repeats does not affect the assembly of matrilins [4] In this study, we investigate whether the presence or absence of the vWF A domain adjacent to the coiled-coil ... Interestingly, all of these MED-causing mutations are located in the β strands in the center of the vWF A domain, which are important for the folding of the protein structure [13] It suggests that the secretion...
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Investigations on the cellular and neuroprotective functions of nogo AReticulon 4a
... encoding the C-terminus with the ER retention signal and the 3‟ UTR An illustration of the domain structures of Nogo-A, -B and -C is shown in Fig 1.2A Nogo-A is the longest of the three major isoforms, ... prediction has the N-terminus facing the extracellular/lumenal region, as a result of the putative TM1 flip-flopping in the membrane without transversing the lipid bilayer The looping back of the putative ... N-terminus of Nogo facing extracellularly came from the study of the topology of Nogo-B on the surface of endothelial cells (Acevedo et al., 2004) Nogo-A has also been postulated to adopt other topologies...
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The Natural Functions of Secondary Metabolites
... intracellularly and replace partially the middle lamellae between the cortical cells of the feeder roots The endomycorrhizae, which form on the roots of 90% of the plant species, enter the root ... Production of the antibiotics is the primary factor in the competitive fitness of P aureofaciens in the rhizosphere and the relationships between it, the plant, and the fungal pathogens The antibiotic, ... intermediates of the shikimic acid pathway, the tricarboxylic acid cycle, and from amino acids The regulation of the biosynthesis of secondary metabolites is similar to that of the primary processes,...
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Tài liệu Báo cáo khoa học:Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau ppt
... disruption of the association of these proteins could represent a potential therapeutic strategy for the treatment of AD Here, we used GST fusion proteins of Fyn-SH2 and FynSH3 to further investigate the ... whether the tyrosine phosphorylation status of tau also affects the binding of tau to Fyn-SH3, CHO cells were cotransfected with Fyn together with either wild-type or the YF mutant forms of tau ... The SH3 domain of Fyn binds to proline-rich motifs within the sequence PXXP in interacting proteins Seven such motifs are present in the proline-rich domain of the longest isoform of tau in the...
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Tài liệu Báo cáo khoa học: Seeking the determinants of the elusive functions of Sco proteins pptx
... function of the CXXXC motif of human Sco proteins could therefore be implicated not only in the maturation of the CuA site of Cox2 but also in the maintenance of cellular copper homeostasis The involvement ... Sco2 proteins (Fig 5), but the molecular details of the role of Sco proteins in the copper insertion into the CuA site needs to be further investigated Other functions of eukaryotic Sco proteins ... detected in the redox state of the cysteines of Sco1 in both Sco1 and Sco2 patient backgrounds, and these correlate well with the severity of the observed cellular copper deficiency [17] The thiol-disulfide...
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Tài liệu Đề tài " On the K2 of degenerations of surfaces and the multiple point formula " pptx
... components of double curves in X; • fn : the number of n-faces of G, i.e the number of En -points of X, for n 3; • f := n fn , the number of faces of G, i.e the total number of En -points of X, for ... rn : the number of open n-faces of G, i.e the number of Rn -points of X, for n 3; • r:= n rn , the total number of Rn -points of X, for all n 3; • sn : the number of n-angles of G, i.e the number ... even clearer in the second part of the proof, when we will enter into the details of the proof of formula (7.3) Following the blowing-up process at the Rn - and Sn -points of the central fibre...
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Tài liệu Effect modification of air pollution on Urinary 8-Hydroxy-2’-Deoxyguanosine by genotypes: an application of the multiple testing procedure to identify significant SNP interactions ppt
... averages of OC, O3, respectively SO42- and maximal 1-hour more strongly associated with OC among those carrying the wild type of CAT (rs2284367), the non-deletion of GSTM1 and the non-wild type of the ... None of these studies found the GSTP1 is significantly associated with the outcomes of interest although some studies found positive trends Therefore, the functions of the polymorphisms have not ... significance of interaction terms of individual SNP and pollutant The current version of MTP allows one to identify the significance of a group of candidate variables to reduce the false discovery rate...
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Tài liệu Báo cáo khoa học: Branched N-glycans regulate the biological functions of integrins and cadherins doc
... N-glycans located on either the b-propeller of a5 [55] or the I-like domain of b1 or b3 [68] contribute to the regulation of integrin function Therefore, we speculate that modification of particular sites, ... Downregulation of the alpha-Gal epitope expression in N-glycans of swine endothelial cells by transfection with the N-acetylglucosaminyltransferase III gene Modulation of the biosynthesis of terminal ... b4) The N-terminal domains of the a- and b-subunits associate to form the integrin headpiece, which contains the extracellular matrix (ECM) binding site The C-terminal segments traverse the plasma...
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Tài liệu Báo cáo khoa học: Different mechanisms for cellular internalization of the HIV-1 Tat-derived cell penetrating peptide and recombinant proteins fused to Tat docx
... abolished the internalization of the GFP-fused Tat protein but did not alter the uptake of the Tat CPP These biochemical evidences con®rmed a pathway for the entry of the Tat peptide unrelated to the ... concentration of lgámL)1 in the presence of 100 lM chloroquine in the cell culture medium For FACS analysis, the concentration of the recombinant protein was increased to lgámL)1 The internalization of the ... rightward shift of the signal was observed signifying a reduction of the uptake of the Tat peptide at low temperature Likewise, a threefold reduction of the uptake at °C has been reported for the Antennapedia...
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Báo cáo khoa học: Analysis of Lsm1p and Lsm8p domains in the cellular localization of Lsm complexes in budding yeast ppt
... investigated the cellular localization of GFPtagged versions of these proteins, as well as their ability to support growth Besides clarifying the relative importance of different regions of the Lsm1 ... (Fig 1B) [32] The Lsm1 and Lsm8 polypeptides are most similar in the regions of the Sm1 and Sm2 motifs These motifs form the Sm-fold, the hallmark of the Sm-like proteins, consisting of a five-stranded ... for the localization and function of these complexes In budding yeast, only one form of the homologous Sm complex exists; it forms the core of non-U6 spliceosomal snRNPs and accumulates in the...
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Báo cáo khoa học: Unravelling the functional interaction structure of a cellular network from temporal slope information of experimental data docx
... particular, if fij > then we interpret that the node j activates the node i by increasing the net rate of xi and if fij < then the node j inhibits the node i We note that the dynamics of the system in ... is the ith network node, denoting the biochemical quantity of an element, and the corresponding function fi describes how the rate of change of xi with respect to (w.r.t.) time depends on all the ... interaction’) for the unknown sign of fij We can then obtain the feasible network signs (FNS) at xi by excluding the INS from the all network signs (ANS) as a complementary set of the INS in ANS...
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Báo cáo khoa học: Cellular refractoriness to the heat-stable enterotoxin peptide is associated with alterations in levels of the differentially glycosylated forms of guanylyl cyclase C pdf
... level over the time period of the experiments as conducted here As shown below, alterations in the levels of the differentially glycosylated forms of GC-C regulate the cellular response to the ST-peptide, ... thought they were able to bind the ST peptide (Fig 2) Therefore, there appeared to be a correlation between the presence of the 145 kDa form of GC-C, which represents the mature glycosylated form of ... representing the amount of GC-C detected by ST binding (Fig 2C) Therefore, the fraction of GC-C present in the membranes of desensitized cells possessed guanylyl cyclase activity, but this form of the...
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Đề tài " Prescribing symmetric functions of the eigenvalues of the Ricci tensor " pdf
... give the proof of the second inequality of (6.1): Theorem 6.5 Near xk ∈ Σ0 , the function w satisfies w(x) ≤ log ρ(x) + C (6.12) Proof As in the preceding proofs, the argument is complicated by the ... obtain a global bound: max wi ≤ C n M The next result summarizes the properties of the limit w = limi wi Recall from the proof of Theorem 3.5 the definition of the tensor: Sg = Ric − 2δσ1 (Ag )g ... of the σk -Yamabe problem Moreover, the set of all such solutions is compact 478 MATTHEW J GURSKY AND JEFF A VIACLOVSKY We note that the proof of Theorem 1.1 does not rely on the Liouville theorem...
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Báo cáo khoa học: Proteoglycans in health and disease: the multiple roles of syndecan shedding ppt
... extracellular ligands in the pericellular environment [15] (Fig 2) The remaining portion of the membranebound receptor loses its ability to bind ligands, and can be further processed by the presenilin ... (mainly between Leu403 and Val404) of the phospholipid bilayer of the membrane [17] In turn, there is decreased plasma membrane targeting of the transcriptional cofactor calcium ⁄ calmodulin-associated ... effect [22] Tissue inhibitor of metalloproteinases The catalytic activity of MMPs can be inhibited by the family of tissue inhibitor of metalloproteinases (TIMP), of which there are four members (TIMP1-4)...
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Báo cáo khoa học: Tumour necrosis factor-a attenuates insulin action on phosphoenolpyruvate carboxykinase gene expression and gluconeogenesis by altering the cellular localization of Foxa2 in HepG2 cells pptx
... including the synthesis of albumin, lipoprotein and several other liver-specific functions, and, most importantly, these functions are stable through passages They are therefore valuable in the study of ... by TNFa, there is a relatively increased nuclear translocation of Foxa2, we studied the resulting effects of TNFa pretreatment on the effect of insulin on the expression of PEPCK and another gluconeogenic ... for the respective indicated times Cells in the absence of any of these were taken as the control (Con) Two micrograms of total RNA were reverse transcribed with random primers and the levels of...
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