the mechanism of fatigue failure of steels in the ultralong life regime of n 107 cycles
Báo cáo y học: "Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action"
... Shulman GI: Prevention of fat-induced insulin resistance by salicylate J Clin Invest 2001; 108:437–446 52 Evans L Antioxidants: they have a role in the management of insulin resistance Indian J ... antioxidants improve insulin sensitivity and help in wound healing (16,17) Along with others, the investigators have used microcurrent for treatment of chronic wounds and ulcers (18-20) In an ... and the decline of antioxidant defense mechanisms lead to damage of cellular organelles and enzymes, increased lipid peroxidation, and development of insulin resistance (7) The vascular and systemic...
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Tài liệu Báo cáo khoa học: On the mechanism of action of the antifungal agent propionate Propionyl-CoA inhibits glucose metabolism in Aspergillus nidulans doc
... mutants [5] Determination of maintenance Maintenance is the energy that is used for survival of cells without any biomass formation Determination of maintenance was based on the inhibition of ... cells), even in the mutant strain Determination of the intracellular volume In order to obtain the intracellular concentration of accumulated acyl-CoA esters, it was necessary to know the internal volume ... protein biosynthesis by the action of cycloheximide Cycloheximide binds to the 80S-subunit of eukaryotic ribosomes and prevents the initiation and elongation reaction of protein biosynthesis The...
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Tài liệu Báo cáo khoa học: The mechanism of a-proton isotope exchange in amino acids catalysed by tyrosine phenol-lyase doc
... a number of amino acid inhibitors bearing nonbranched substituents without functional groups, the hydrophobicity of the side chain is the main factor controlling Ki Amino acids that contain nucleophilic ... above The interaction of L-phenylalanine, L-methionine, and their a-deuterated analogs with TPL in D2O was characterized by the appearance of quinonoid intermediates, absorbing at % 500 nm The kinetic ... a-carbon atom of the quinonoid intermediate should go faster than the isotopic exchange of the proton in the active site For the reaction of L-methionine, where no internal return is observed, on the...
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Tài liệu Báo cáo khoa học: A role for the intersubunit disulfides of seminal RNase in the mechanism of its antitumor action docx
... reveal a new, signicant event in the mechanism of cytotoxic action of BS-RNase on malignant cells The event consists in the interactions, through sulfhydryldisulde interchange reactions, between surface ... was incubated in binding buffer in the absence of cells no dimerization occurred (data not shown) These results indicate that a monomeric derivative of BSRNase in which disulde bonds are conserved ... Cys32, the cysteine residues originally involved in the intersubunit disulde bonding of BS-RNase, are irreversibly blocked through S-alkylation In the active MSSAE and MSSG monomers, instead, the...
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Báo cáo khoa học: Conservation of the egg envelope digestion mechanism of hatching enzyme in euteleostean fishes pot
... sub-domains, and the two sub-domains are connected by an intervening sequence This intervening sequence is proposed to be protease-sensitive [21] Applying this information to the results obtained in the ... hardening in medaka has been suggested to be a result of the formation of e-(c-glutamyl) lysine cross-links between subunit proteins of the envelope, mainly between inner layer subunit proteins ... expressed in terms of DA280 min)1Æmg protein)1 Cloning of choriogenin cDNAs First-strand cDNAs were synthesized from RNA extracted from the liver of spawning female Fundulus using the SMART RACE cDNA...
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Báo cáo khoa học: Transthyretin and familial amyloidotic polyneuropathy Recent progress in understanding the molecular mechanism of neurodegeneration pdf
... of one monomer and the ˚ H strand of the opposite dimer, creating a 50 A central channel that contains the two binding sites for thyroxine [81] The four binding sites for RBP are located on the ... residues in this region that are normally buried on the inside of the protein [98] Dislocation of the C and D strands from their native edge region may result in the formation of a new interface involving ... Thyroxine-induced conformational changes in prealbumin Biochemistry 17, 5729–5733 Kanai M, Raz A & Goodman DS (1968) Retinol-binding protein: the transport protein for vitamin A in human plasma...
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Báo cáo khoa học: A steady-state modeling approach to validate an in vivo mechanism of the GAL regulatory network in Saccharomyces cerevisiae ppt
... experimental observation given the constraints of total component concentrations and binding constants Discussion Studies in molecular biology have enumerated various interactions resulting in a ... controls the protein expression in the wild-type is the shuttling of Gal80p Increasing the amount of Gal80p in the cytoplasm by increasing the distribution coefficient (K) causes the switch to turn on ... connection between these elements The response is also in uenced by the relative dominance of these individual elements, which are captured by parameters such as the binding constants and the extent of...
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Báo cáo Y học: The mechanism of nitrogen monoxide (NO)-mediated iron mobilization from cells NO intercepts iron before incorporation into ferritin and indirectly mobilizes iron from ferritin in a glutathione-dependent manner pot
... 8) In these studies examining the direct effect of the chelators and NO on the lysate, no significant effect was observed on ferritin-59Fe levels In addition, in the presence of both GSH and GSNO ... within this protein NO reduces ferritin-59Fe levels in a variety of cell types The effect of NO at reducing ferritin-59Fe levels was found in a number of cell types including SK -N- MC neuroepithelioma ... effect of NO at decreasing ferritin-59Fe levels It is of interest that incubation of BSO-treated LMTK– and SK -N- MC cells with GSNO resulted in an increase in the amount of ferritin-59Fe (Fig 4B) These...
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Báo cáo Y học: Role of conserved residues within helices IV and VIII of the oxaloacetate decarboxylase b subunit in the energy coupling mechanism of the Na+ pump ppt
... and an eightfold increase of the Na+ concentration required for half maximal inhibition Upon further increasing the pH, the Na+ affinity of the mutant decarboxylase increases and the Na+ concentration ... Na+-ion again, initiating the decarboxylation of the newly bound carboxybiotin This interpretation can explain why in the S382A mutant decarboxylation requires very high Na+ concentrations and ... binding ligand Sodium ions may still bind to the N3 73L mutant through coordination to the other ligands of the binding site (center I), but the binding becomes much weaker as emphasized by the...
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Báo cáo khoa học: Catalytic mechanism of the primary human prostaglandin F2asynthase, aldo-keto reductase 1B1 – prostaglandin D2 synthase activity in the absence of NADP(H) pptx
... fluorescence quenching curves of wild-type AKR1B1 and its mutants The binding of NADP+ to these proteins was determined by measuring the decrease in fluorescence emission at 338 nm (excitation at 282 nm) ... fluorescence quenching of intrinsic Trp residues after incubation with NADP+ in a concentration-dependent manner The Kd values of NADP+ for AKR1B1 and AKR1B3 are summarized in Tables and S1, respectively, ... Penning TM (1996) Characterization of the substrate binding site in rat liver 3alphahydroxysteroid ⁄ dihydrodiol dehydrogenase The roles of tryptophans in ligand binding and protein fluorescence...
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Báo cáo khoa học: The role of Tyr71 in Streptomyces trypsin on the recognition mechanism of structural protein substrates ppt
... tyrosine, phenylalanine, tryptophan, alanine, glycine, arginine, histidine, aspartic acid, asparagine, serine and proline, respectively The amplified DNA fragments were then cloned, sequenced and ... residue 71 in collagen binding The elucidation of the mechanism of structural protein substrate recognition in serine proteases should help advance therapeutic research into the prevention and 5642 ... specificity of aminoacyl-tRNA synthetase and adenylate kinase has been reported recently [34,35] Moreover, the 60loop of thrombin lining the upper rim of the active site entrance is rearranged by binding...
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A study in the growth mechanism of silicon nanowires with or without metal catalyst
... distribution can be well-organized by using a nano-channel-alumina (NCA) technique [11] Otherwise, the pressure of reaction channel and temperature are also important for the growth of SiNWs In the ... one, leading to an intercrossing structure Fig 3B clearly shows the original growth stage of SiNWs As can be seen from the figure, if Si atoms cannot be added continuously into the droplet, the ... direction and the final extending direction of SiNW (Fig 3A) In particular, when the nanowire becomes longer, the droplet at the tip will be pushed randomly and thus sometimes two or more will combine...
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Báo cáo khoa học: Identification and characterization of important residues in the catalytic mechanism of CMP-Neu5Ac synthetase from Neisseria meningitidis potx
... of Mg2+ concentration The effect of an increase in the concentration of Mg2+ was determined by measuring the rate of the reaction in triplicate at 154 lm CTP and 615 lm Neu5Ac in the reaction ... backbone of Gln163 is shown in pink with the distance given in angstroms the negative charge of the carboxylate group of the second substrate, sialic acid, resulting in the incorrect alignment of ... despite the lack of agreement in the sequence alignment of the CNS and CKS enzymes for these residues (Fig 1) [13] Recently, in the enzyme L-CKS, Gln98 (equivalent to Gln104 in the N meningitidis enzyme)...
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Báo cáo khoa học: Mechanism of the ring contraction process in vitamin B12 biosynthesis by the anaerobe Propionibacterium shermanii under aerobic conditions docx
... al Ring contraction mechanism of vitamin B12 Fig The highlights of previously postulated mechanisms of the ring contraction process in the biosynthesis of vitamin B12 in the anaerobe P shermanii ... C18O-carbonyl oxygen Mechanism of the ring contraction process in the biosynthesis of vitamin B12 by P shermanii Two mechanisms of the ring contraction process in the anaerobe P shermanii have been suggested ... oxygen in the ring A show that the mechanism of the ring contraction process in P shermanii is the same irrespective of the presence or absence of oxygen In other words, although we did not confirm...
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Báo cáo hóa học: " Experimental investigation on the bi-directional growing mechanism of the foils laminate approach in AAO fabrication" pptx
... examining on the interpore distance on both the front and back sides may provide further evidence to the above inference There is a relatively linear relationship between the interpore distance ... structure confirms the non-uniformed anodization inference Conclusion A bi-directional porous array in an alumina membrane can be produces by the laminate foils approach It was intuitively inferred that ... blocking and triplex laminate foils experiments being conducted in this research It is further inferred that the nonuniformity of the thickness or material properties of the aluminum foil induces...
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Báo cáo y học: "Outcome of crisis intervention for borderline personality disorder and post traumatic stress disorder: a model for modification of the mechanism of disorder in complex post traumatic syndromes" ppsx
... breakdown syndrome From the beginning of therapy, clinicians join patients in seizing opportunities for increments of intimacy in life- defining relationships The patients' goal is to test others' ... interventions of different kinds must work either by enhancing the natural course or by making patients' behavior effective in a different way The theory guiding the experimental intervention ... [24,47,58,61,62] There is no significant improvement for a residual cluster of symptoms, a 'subsyndrome' [62] of hopelessness, emptiness and fear of intimacy With these concerns in mind, Benjamin and Linehan...
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Báo cáo y học: "The molecular mechanism of osteoclastogenesis in rheumatoid arthritis" pptx
... (OA) [13] These cytokines may play important roles not only in immune responses and in development of inflammation, but also in joint destruction The role of T cells in the pathogenesis of RA at ... giant cell tumor of bone The concentrations of both IL-6 and sIL-6R were significantly higher in the synovial fluids of patients with RA than in those of patients with OA The concentrations of ... measured the level of a soluble form of RANKL in the synovial fluids Concentrations of soluble RANKL in the synovial fluids were significantly higher in patients with RA than in patients with other...
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báo cáo khoa học: " The function and mechanism of COX-2 in angiogenesis of gastric cancer cells" pdf
... antiproliferative and antiangiogenic activity in several types of human cancer However, the mechanism of COX-2 in angiogenesis remains unclear In this study, the data showed that down-regulation of ... statistical analysis Shuhui Liang and Kaichun Wu have been involved in revising it critically for important intellectual content Daiming Fan participated in its design and gave final approval of the version ... significantly inhibit the in vitro and in vivo growth of gastric cancer cell line SGC7901, and suppress the migration and tube formation of human umbilical vein endothelial cells, which was consistent...
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Báo cáo y học: "Proposed protective mechanism of the pancreas in the ra" pot
... HS can act as an endogenous inducer of an inflammatory response of the pancreatic epithelial cells This phenomenon of HS-induced inflammation was actually identified following intra-ductal infusion ... infusion of HS in the pancreas [4] However, the underlying mechanisms of the inflammation and what effectorcells that actually are involved are still unknown [4] To study the underlying mechanisms of ... double-staining using ED-1 Ab (a clone recognizing an epitope on rat monocytes and macrophages) and Ab against MPO Details concerning the antibodies are summarized in table The single stained slides...
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Báo cáo y học: "Proposed protective mechanism of the pancreas in the rat." ppt
... HS can act as an endogenous inducer of an inflammatory response of the pancreatic epithelial cells This phenomenon of HS-induced inflammation was actually identified following intra-ductal infusion ... infusion of HS in the pancreas [4] However, the underlying mechanisms of the inflammation and what effectorcells that actually are involved are still unknown [4] To study the underlying mechanisms of ... double-staining using ED-1 Ab (a clone recognizing an epitope on rat monocytes and macrophages) and Ab against MPO Details concerning the antibodies are summarized in table The single stained slides...
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Tìm thêm: khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008