... which specify the curvature ofthe line and are determined by themechanicalpropertiesofthe muscle as well as the structural features ofthe ventricle. This curve is called the "end-diastolic ... contraction there is a period of time during which themechanical properties ofthe heart are characterized by the EDPVR; knowledge ofthe EDPVR allows one to specify, for the end of diastole, ... interaction between the ongoing contraction process ofthe cardiac muscles and thepropertiesofthe arterial system and is beyond the scope of this lecture. As the contraction process ofthe cardiac...
... gaps of Ge-core/Si-shell and Si-core/Ge-shell nanowires at the level of density functional theory, where the composition is definedas the ratio ofthe number of atoms ofthe core to the number of ... with each other,and thus the Young’s modulus of either core or shell is not the same as that ofthe isolated nanowire or the isolatednanotube. On the other hand, the Young’s modulus of acore–shell ... the existence ofthe region around the interface between the core and the shell of a core–shell nanowire.Basically, it is unreasonable for the core or the shell toinclude the volume ofthe whole...
... Inc.ÆÀ1¼1=5boundaryisoneinwhich1in5ofthegrainboundaryatomsmatch,asshowninFig.2.8(c).Twinboundariesmayformwithincrystals.Suchboundarieslieacrossdeformationtwinplanes,asshowninFig.2.8(d).Notethattheatomsoneithersideofthetwinplanesaremirrorimages.Stackingfaultsmayalsobeformedwhentheperfectstackinginthecrystallinestackingsequenceisdisturbed,Figs2.8(e)and2.8(f).Thesemaybethoughtofastheabsenceofaplaneofatoms(intrinsicstackingfaults)ortheinsertionofrowsofatomsthatdisturbthearrangementofatoms(extrinsicstackingfaults).IntrinsicandextrinsicstackingfaultsareillustratedschematicallyinFigs2.8(e)and2.8(f),respectively.NotehowtheperfectABCABCstackingofatomsisdisturbedbytheinsertionorabsenceofrowsofatoms.2.3.4VolumeDefectsVolumedefectsareimperfectionssuchasvoids,bubble/gasentrapments,porosity,inclusions,precipitates,andcracks.Theymaybeintroducedintoasolidduringprocessingorfabricationprocesses.AnexampleofvolumedefectsispresentedinFig.2.9.ThisshowsMnSinclusionsinanA707steel.AnotherexampleofavolumedefectispresentedinFig.1.16(d).This ... Inc.whichisgivensimplybyÀðCAÀCBÞ=r0,thediffusionflux,J,maythenbeexpressedasJ¼D0expÀqkTdCdxð2:9ÞIfwescalethequantityqbytheAvogadronumber,thentheenergytermbecomesQ¼NAqandR¼kNA.Equation(2.9)maythusbeexpressedasJ¼ÀD0expÀQRTdCdxð2:10ÞIfwenowsubstituteD¼ÀD0expÀQRTintoEq.(2.10),weobtaintheusualexpressionforJ,i.e.,JisgivenbyJ¼ÀDdCdxð2:11ÞTheaboveexpressionisFick’sfirstlawofdiffusion.Itwasfirstpro-posedbyAdolfHicksin1855.Itisimportanttonoteherethatthediffusioncoefficientforself-diffusion,D,canhaveastrongeffectonthecreepproper-ties,i.e.,thetime-dependentflowofmaterialsattemperaturesgreaterthan$0.3–0.5ofthemeltingtemperatureindegreesKelvin.Also,theactivationenergy,Q,inEq.(2.10)isindicativeoftheactualmechanismofdiffusion,whichmayinvolvethemovementofinterstitialatoms[Fig.2.11(a)]andvacancies[Fig.2.11(b)].Diffusionmayalsooccuralongfastdiffusionpathssuchasdislocationpipesalongdislocationcores[Fig.2.12(a)]orgrainboundaries[Fig.2.12(b)].This ... associated with the disappearance of smal-ler grains and the enhanced growth of larger grains. Due to the combinedeffects of these factors, a limiting grain size is soon reached. The rate atwhich...
... enter into the problem. The engineermust appreciate the relevant aspects ofmechanical behavior at the differentlength scales. Furthermore, the size scale ofthe structure can affect the mechanical ... understanding ofthemechanicalpropertiesof mate-rials. It is not intended to be a comprehensive review of all the differentaspects ofmechanical properties; such a task would be beyond the capabil-ities ... treatment ofthe fundamen-tals ofthemechanical behavior of materials. The text provides a rigorousreview ofthe fundamental mechanics aspects ofthemechanical behavior of materials.Shackleford,...
... roles ofthe cell membrane. • The extracellular space and the components ofthe extracellular matrix (ECM) connect to the cytoskeleton ofthe cells: The electronic functions of the cells and the ... improve the electrical functions ofthe ECM. Therefore the composition and degree of toxicity ofthe ECM-glycocalyx interface will affect the electrical field and the flow of biocurrents in the ... between the inside ofthe cell and the outside ofthe cell. The difference is known as the membrane potential. • Because the membrane potential is created by the difference in the concentration of...
... resonanceswithout the concomitant appearance of other signalsin other parts ofthe spectrum. This result could be aconsequence ofthe paramagnetic propertiesof Fe(II),or it might arise from the presence of ... Fe3+Addition of Fe2+induced the displacement of severalresonances in the [1H,15N]-HSQC NMR spectrum of CyaY, but the most striking consequence ofthe addi-tion was the total disappearance of specific ... Details ofthe superimposition of the hydrophobic core of CyaY (blue) andCyaY–Eu complex (red). The side chains of the CyaY C-terminus rearrange as a long-range effect of binding. The figure...
... in the apparent Kmvalues for these substrates. The interpretation of these results is complicated because the levels of uncoupling will be variable depending on the mutant and the nature ofthe ... cosubstratebinding. In the case ofthe R258K mutant this may beallowed because of disordering ofthe lysine side-chain, aswas previously observed for the R258Q mutant (Fig. 1) [17].InthecaseoftheR258HmutantitismorelikelythattheFig. ... 2-OGconversion in the absence of a penicillin substrate) in the wild-type enzyme. Functional analysis of R160 and R162 bysite-directed mutagenesis suggests that these two residuesbind the nucleus of the...
... materials in the cell walls [Sjostrom 1981]. Alpha-cellulose is the main source ofthemechanicalpropertiesof bamboo and wood [Janssen 1981]. Figure 2-5 presents the holocellulose content of bamboo ... the level ofthe solution in the flask remained below that ofthe boiling water. Samples were then removed from the water bath and filtered by vacuum suction into a fritted glass crucible of ... 13separate the fibers. The diluted mixture was then spread evenly on to a transparent glass of 20× 20 cm and another piece of glass was placed on top. The glasses with the fibers were then dried...
... absorbed in the intestinal tract, and reach the colon mainly intact [27]. They are therefore bio-available to the epithelial cells in the intestinal wall,where procyanidins and other phenolics ... investigated the relationship of different structural factors of procyanidins, such as the mean degree of polymerization and percentage of galloylation, with their antiproliferative potential andtheir ... Department of Health Risk Analysis and Toxicology, Maastricht University, the NetherlandsColorectal cancer is the third most commonly diagnosedcancer in the world and is one ofthe major causes of cancer-associated...
... alanines are likely. The manner in which the number of alanines determines the atomic structure ofthe fibril and the b-strandarrangements remains to be determined.Yet, knowledge ofthe structure and ... using the nanoscope analysis software.Chemical stability of fibrils The chemical stability of fibrils was tested after the fibrilla-tion process was completed (no further rise of ANS sig-nals). The ... 2006 The Authors Journal compilation ª 2006 FEBSEffect of oculopharyngeal muscular dystrophy-associatedextension of seven alanines on the fibrillation properties ofthe N-terminal domain of PABPN1Grit...
... taken to be the subject ofthe clause. This ap- plies to about half of all the instances where the function ofthe relative pronoun is ambiguous. 2. On the other hand, if the form ofthe sub- ... be made by the position ofthe verb because ofthe rule that in a subordinate clause the verb must normally come at the end. How, then, are we to deter- mine the function ofthe relative ... shall write the equations in the form which they assume when these units are used.) If, on the other hand, the number ofthe rela- tive pronoun proves to be identical with that of the following...
... Values of a15(σ) obtained from the construction ofthe master curve in Fig-ure 2.7(b). The second part ofthe experimental verification of time-stress superposition consists of fitting the shift ... change(s) ofthe main chain. The rate of conformational changes, i.e. the molecular mobility, is determined to-tally by the thermal energy available in the system. Increasing the thermal energyincreases ... Molecular backgroundIndependent ofthe stress level or amount of deformation involved, the origin of the deformation of polymer materials lies in their ability to adjust their chain confor-mation...
... enter into the problem. The engineermust appreciate the relevant aspects ofmechanical behavior at the differentlength scales. Furthermore, the size scale ofthe structure can affect the mechanical ... 1/3½1120. The diagonal axis of Type I,therefore, enables us to find the Miller–Bravais indices for any ofthe direc-tions along the axes on the basal plane. The other common type of diagonal ... in all ofthe electronicpackages that are used in modern electronic devices. Since the reliability of these packages is often determined by the thermal and mechanical prop-erties ofthe individual...
... FXR1P and FXR2P. The regions predicted as fibrillo-genic by the WALTZ software [40] are indicated as red crosses.Fig. 2. Summary ofthe modular structure of FXR proteins (A) and of the constructs ... average diameter of 10 nm (Fig. 6D).They also clustered together and were often found tobe decorated with the uranyl acetate stain. Takentogether these results confirm a marked tendency of FXR constructs ... inhumans. In a previous study, we described the biochemical and biophysicalaggregation propertiesof constructs spanning the conserved region of FMRP and of two other human fragile X related (FXR) proteins,...
... the affinity ofthe PLRP2 for micellar sub-strates, and probably allows the interaction of the enzyme with the substrate structure. Whether the motion ofthe lid promotes the recognition ofthe ... worksand resulting in the unmasking ofthe catalytic triad of the enzyme induced by the motion ofthe flap. The accessibility ofthe active site can be tested using the ability of an organophosphate, ... domain and bile salt only in the presence ofthe C2 domain. The inhibition ofthe activesite serine by E600 needs both the motion ofthe flapand the recognition ofthe vehicle in which E600 wassolubilized....