the management of rheumatoid arthritis in adults
Rheumatoid arthritis - The management of rheumatoid arthritis in adults doc
... certain subgroups, on the grounds of clinical and cost effectiveness Other versions of this guideline 6.1 Full guideline The full guideline, Rheumatoid arthritis: the management of rheumatoid arthritis ... NICE clinical guideline 79 Rheumatoid arthritis: The management of rheumatoid arthritis in adults Ordering information You can download the following documents from www.nice.org.uk/CG79 • The NICE ... to inform decision-making about starting combination therapy (see 1.4.1.1) 1.1.2.3 X-ray the hands and feet early in the course of the disease in people with persistent synovitis in these joints...
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Báo cáo khoa học: FLIP and MAPK play crucial roles in the MLN51-mediated hyperproliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis pdf
... increment in the protein level of GM-CSF-induced MLN51 (Fig 2E) These data indicate that GM-CSF not only induces the expression of MLN51, but also blocks the proteasome-mediated degradation of ... of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthritis ... of RA FLSs, thus indicating that other factors must be involved in this proliferation In our previous studies, we have determined that GM-CSF in the synovial fluid plays an important role in the...
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Neuropathic pain - The pharmacological management of neuropathic pain in adults in non-specialist settings pot
... Desipramine Dosulepin (dothiepin) Doxepin Imipramine Lofepramine Nortriptyline Trimipramine Citalopram Fluoxetine Paroxetine Sertraline Duloxetine Venlafaxine Carbamazepine Gabapentin Lamotrigine ... and whether the different types of drugs are used in the NICE clinical guideline 96 – Neuropathic pain correct sequence Furthermore, guidelines on the management of neuropathic pain rarely include ... multi-modal management of all types of pain, including neuropathic pain NICE clinical guideline 96 – Neuropathic pain 11 1.1 List of all recommendations Key principles of care 1.1.1 Consider referring the...
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Báo cáo y học: " Chemokine blockade: a new era in the treatment of rheumatoid arthritis" ppsx
... during infection in light of the short half-life (the drug could be discontinued during infection, allowing inflammatory cells to migrate to the site of infection), and the potential of inhibiting ... inhibiting the migration of cells that are able to produce an array of proinflammatory cytokines at the site of inflammation The identification of the best targets will be the subject of future ... ankle swelling, in association with decreased macrophage numbers in the joints [21] Paw swelling of the hindfeet in the antirat MCP-1 treated rats was decreased to about 70% of that in untreated...
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Báo cáo y học: "Inhibition of antithrombin by hyaluronic acid may be involved in the pathogenesis of rheumatoid arthritis" potx
... dylarginine deiminase of involvement of hyaluronic of rheumatoid Proposed mechanism (PADI4) in the pathogenesis acid (HA) and peptidylarginine deiminase (PADI4) in the pathogenesis of rheumatoid arthritis ... antithrombin However, such binding did not stimulate the activity of antithrombin as did heparin and heparan; in fact, it blocked the ability of antithrombin to inhibit thrombin In the present study, the ... proteinase binding loop on the protein surface [19,20] Because the molecular structure of HA is analogous to that of heparin, HA might exert its effect by binding to the heparin-binding region of...
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Báo cáo y học: "Direct interaction of immunoglobulins with synovial fibroblasts: a missing link in the pathogenesis of rheumatoid arthritis" potx
... demonstrating that in addition to these cytokines, growth factor signals trigger the release of IL-16 in RASFs, the present research from Smith and Cruikshank extends the panel of signals involved in the ... determines the disease specific immune response Given the variety of signaling pathways initiated by IGF-1 in fibroblasts, it may be speculated, as the authors mention briefly, that binding of antibodies ... positively with the degree of joint destruction over a 2-year period [16] These data extend the aforementioned observations and link IL-16 to the disease process of RA In this context it is of interest,...
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Báo cáo y học: "Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes" ppt
... participated in the molecular genetic studies and analysis EK procured the samples and helped in the analysis of data GW participated in the design of the study, analysis of data, and writing of the manuscript ... helping to sustain the synovial inflammation characteristic of RA Competing interests The author(s) declare that they have no competing interests Authors' contributions TD participated in the ... Accumulation of these cells within the inflamed joint and the subsequent increase in ROS may be partially responsible for the increased mtDNA R849 mutational burden of RA patients There are two...
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Báo cáo y học: "Dipeptidyl peptidase IV activity and/or structure homologs: Contributing factors in the pathogenesis of rheumatoid arthritis" doc
... extravasate into the extracellular space Once in the vicinity of the synovium, the DPPIV activity would be able to initiate amino-terminal degradation of the increased levels of proinflammatory ... levels in SF may represent an increase in the presence of attractin Certainly, analysis of serum reveals an increase in attractin in RA patients with erosive disease, which is not observed in individuals ... presence of systemic activated T cells will lead to their continuous influx into the inflamed synovium, maintaining the inflammatory state This will lead to a continuous activation of synovial...
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Báo cáo y học: "MLN51 and GM-CSF involvement in the proliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis" pps
... next investigated whether SFs have an effect on the growth rate of RA FLSs, what kinds of factors in the SFs are involved in the proliferation of RA FLSs, and whether the factors have a role in the ... together with GM-CSF in the SF may be involved in RA pathogenesis in vivo To address the effects of GM-CSF in SF on the growth of RA FLSs, we cultured the RA FLSs in culture media containing ... biology Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis Arthritis Res 2000, 2:361-367 29 Yamanishi Y, Firestein GS: Pathogenesis of rheumatoid arthritis: the role of synoviocytes...
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Báo cáo y học: "Recent developments in the immunobiology of rheumatoid arthritis" potx
... blood of RA patients, there is still persistent inflammation in the joint [66-70], suggesting that the Treg cells are ineffective in controlling inflammatory responses There is increasing evidence ... that the proapoptotic protein Bid, an intermediary for the extrinsic and intrinsic apoptotic pathways, is important in the development of inflammatory arthritis Mice lacking Bid display increased ... Over the past couple of years advances have been made in the understanding of the involvement of T cells in the immunopathology of autoimmune diseases, with a focus on proinflammatory cytokine...
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Báo cáo y học: " Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets" pps
... chain These residues are part of an α-helical domain forming one side of the antigen-presenting binding site The SE hypothesis postulates that the SE motif itself is directly involved in the ... damage in RA is therefore required The increasing comprehension of the role of genetics in disease outcome in RA may promote the development of personalized medicine Although the prospects of RA ... determining the severity of RA [46], the heritability of the level of joint destruction (the variance of joint destruction that can be ascribed to genetic factors) is still unknown Joint damage in...
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Báo cáo y học: "Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis" ppt
... expressed in the RA synovium [22-29] Therefore, interactions between the chemokines and the chemokine receptors might contribute to B cell migration into the synovial tissue in patients with RA In the ... of the synovium in rheumatoid arthritis Dendritic cells Arthritis Res Ther 2007, 9:219 Mauri C, Ehrenstein MR: Cells of the synovium in rheumatoid arthritis B cells Arthritis Res Ther 2007, 9:205 ... the four chemokines induced migration of both CD27- and CD27+ B cells (Figure 3a) However, the migration induced by CCL21 was most prominent Comparison of the migratory effects of the chemokines...
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Báo cáo y học: "Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor" ppsx
... of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor Arthritis Research & Therapy 2010, 12:R62 ... studied the effect of the presence of HLA-DR3 or DERAA-encoding alleles in combination with the SE on susceptibility to RA In the presence of one SE allele, an HLA-DR3 or DERAA-encoding allele ... 42:1071-1079 Helm-van Mil AH van der, Huizinga TW: Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets Arthritis Res Ther 2008, 10:205 Zendman AJ, Vossenaar...
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Báo cáo y học: " Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus" potx
... ζ chain in SLE T cells [64], which may explain the enhanced T-cell-activation-induced Ca2+ fluxing The potential role of NO in the regulation of FcR gamma expression clearly needs further investigation ... synthesis, suggesting that overproduction of NO may be important in the pathogenesis of RA The in amed joint in RA is the predominant source of NO [45,46] Several investigators found correlations between ... therapeutic approach in the treatment of chronic autoimmune diseases Abbreviations eNOS = endothelial NOS; GSH = glutathione; IFN = interferon; IL = interleukin; iNOS = inducible NOS; IP3 = inositol-1,4,5-triphosphate;...
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Báo cáo y học: "Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis" pps
... cells in vivo [38] The upregulation of IL-10 is in line with the induction of Tregs in vitro and in vivo in our study Moreover, in our experiments we did not find UC-MSCs in the joint of the CIA ... damage [31] The MMPs are key mediators of the invasive phenotype of FLSs [32] Therefore, we further investigated the effect of UC-MSCs on the invasive behavior of FLSs by the Cell Migration/Invasion ... differentiation of UC-MSCs staining for alkaline phosphatase Arrows indicate the accumulation of intracytoplasmic alkaline phosphatase of osteoblast Original magnification × 40 involved in the suppression of...
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Báo cáo y học: " A polymorphism in the interleukin-4 receptor affects the ability of interleukin-4 to regulate Th17 cells: a possible immunoregulatory mechanism for genetic control of the severity of rheumatoid arthritis" doc
... the Th2 cytokine IL-4 and its receptor may be of particular interest in the control of Th17-induced inflammation In mice, the genetic absence of IL-4 leads to more severe arthritis in the CIA model ... percentage of IL-17+ cells in the I/I genotype culture, as shown in the top row of Figure 3A, compared to the suppression of IL-17+ cells in the V/V genotype culture, shown in the bottom row In these ... Baseline characteristics of study patients Figure S1 Regulation of interleukin-17 production in vitro Figure S2 Inhibition of interleukin (IL)17 production by IL-4: effect of IL-4R genotype in rheumatoid...
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Báo cáo y học: "Soluble IL-18 receptor complex: a new star in the firmament of rheumatoid arthritis diagnosis" pptx
... half-life and the complexity of the cytokine network, it remains to be determined whether they can be used as biomarkers in a clinical setting IL-18 is a member of the IL-1 cytokine superfamily ... capture the complexity of the in ammatory process: the shedding of membrane IL-18Rα as a marker of enhanced proteolytic activity; the activation and release of IL-18 by the in ammasome as a marker of ... did Interestingly, IL-18 protein expression in synovial tissue did correlate with serum CRP and disease activity in inflammatory arthritis [12], indicating a local role in the pathophysiology of...
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Tài liệu Hypertension - Clinical management of primary hypertension in adults pdf
... be overcome Other versions of this guideline 5.1 Full guideline The full guideline, ‘Hypertension: the clinical management of primary hypertension in adults contains details of the methods and ... Target the intervention to the need Interventions might include: suggesting that patients record their medicine-taking encouraging patients to monitor their condition simplifying the dosing regimen ... hypertension offer to: test for the presence of protein in the urine by sending a urine sample for estimation of the albumin:creatinine ratio and test for haematuria using a reagent strip take a blood...
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INTERNET ADDRESS SPACE: ECONOMIC CONSIDERATIONS IN THE MANAGEMENT OF IPv4 AND IN THE DEPLOYMENT OF IPv6 pptx
... for the future of the Internet economy is the deployment of IPv6 DSTI/ICCP(2007)20/FINAL In terms of public policy, IPv6 plays an important role in innovation and scalability of the Internet In ... IPv6 In other words, once the cost of deploying IPv4 infrastructure – determined by the cost of obtaining the addresses themselves and the cost of designing and operating networks that use fewer ... environment, including greater use and all forms of access In the future, vast numbers of objects may be connected to the Internet Growth in the use of the Internet has meant greater demand for Internet...
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Báo cáo y học: "The prevalence of mental disorders in adults in different level general medical facilities in Kenya: a cross-sectional study" pot
... However, in Kenya, there are only 68 psychiatrists serving a population of approximately 34 million Less than half of them are involved in active clinical work, and they mainly practice in the major ... was involved in interpretation of data VNM participated in acquisition, analysis and interpretation of data and was involved in drafting the manuscript FAO-O participated in acquisition of data ... of data and was involved in drafting the manuscript DAK was involved in acquisition of data and assisted in interpretation of data All the authors have read and approved the final manuscript...
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