... better understand the mechanism of action of HRSV neutralizing antibodies and the impact of resistance to these antibodies upon the fusion activity ofthe F protein A summary of these results is ... high degree of conservation, it was somewhat surprising that the functional analysis ofthe fusion activity ofthe panel of mutations described here revealed that the fusion activity ofthe F protein ... mutagenesis ofthe HRSV F protein AD and RS participated in the design, oversight ofthe conduct ofthe experiments, and interpretation ofthe results All authors have read and approved the final...
... better understand the mechanism of action of HRSV neutralizing antibodies and the impact of resistance to these antibodies upon the fusion activity ofthe F protein A summary of these results is ... high degree of conservation, it was somewhat surprising that the functional analysis ofthe fusion activity ofthe panel of mutations described here revealed that the fusion activity ofthe F protein ... mutagenesis ofthe HRSV F protein AD and RS participated in the design, oversight ofthe conduct ofthe experiments, and interpretation ofthe results All authors have read and approved the final...
... directly to thelossof disc collagen and GAGs The lack of effect on GAG synthesis further validates the importance ofthe degradative component ofthe remodeling cycle in relaxin's modulation of matrix ... relaxin's induction of collagenase but also by the comparable lossof collagen on the exposure of these tissues to the hormone [4,9] Thus, the extent of collagen loss in fibrocartilaginous disc explants ... similar diseases of other joints, TMJ disorders occur primarily in women of reproductive age [14] Given the gender and age distribution of these disorders and the relaxin-induced lossof matrix macromolecules...
... topographical lossof cartilage in the different subregions ofthe knee and the associated risk factors Moreover, the impact ofthe location and rate of cartilage loss on the evolution of OA symptoms ... width data The analyses focused first on MRI data from the central areas ofthe medial compartment as they presented the greatest lossof cartilage volume and were therefore the areas ofthe most ... time as the disease progressed The relationship between the worsening in the WOMAC scores with thelossof cartilage on the central portion ofthe tibial plateau is intriguing The level of significance...
... for the exclusion of inappropriate mates for the conceiving of descendants and their additional care The preand post-delivery care ofthe mother, which is important for females, but also the ... similar as in animals, i.e., the ability to register the presence of pheromones [18] Presentation ofthe hypothesis We hypothesize that the VNO might be unilaterally, or more often bilaterally removed ... including personal criteria for the choice of a mate Evaluation ofthe hypothesis Why the VNO exists in adult humans Although some authors dismiss the existence of a true VNO, there are many observations...
... for the Swedish arm ofthe EXACTLE study She has reviewed and approved the manuscript JS was an investigator in the Dutch part ofthe Danish-Dutch study and was involved in the design ofthe ... even more difficult to deliver The current analysis, however, provides evidence of augmentation therapy reducing the rate of progression of lung tissue lossThe data, therefore, permit future studies ... without statistical adjustment ofthe alpha level Integrating the data from the studies increased the numbers and hence the power ofthe observations By using the most sensitive method for assessing...
... Arthritis Research & Therapy 2010, 12:R35 http://arthritis-research.com/content/12/2/R35 One ofthe other main findings of this study was the nature of and the rate of progression oflossof health status ... cost? To assess the effect of biologic therapy, we determined annual rates of progression up to the time of receipt of biologic therapy and the rates following administration of such therapy in patients ... on average 84% ofthe HAQ score at 10 years and >95% ofthe PCS score change occurs immediately around the onset of RA (Table 1) These findings comport with the slow rate oflossof health status...
... in the Tonle Sap Lake Region Despite ofthe abundant natural resources, livelihoods in the Tonle Sap Lake region is known as the poorest part ofthe country due to the strong dependences on the ... particulates settle to the bottom ofthe container The clear water is then decanted off the top into a second container The benefit of settling and decanting is not requiring equipment other than buckets ... restrict the flow through the filter; larger holes will result in disturbance of sand media The primary functions ofthe diffuser plate are protecting the surface zoogleal biofilm and top layer of...
... Another major factor was the reduction of water use in the factory through the utilization of WWR and water conservation efforts mainly due to their cost consciousness after the introduction of ... proposed the necessity of city-wide recycling system and other measures The fluctuation of water consumption in this period reflects the people’s consideration on the WCP introduced The people ... where the water usage of 700 households was monitored for a period of time to review the consumption pattern However, according to TMG, the amount of reduction is not clear yet but they believe the...
... arrays the factors into several levels in decreasing order in terms of their subordinate relationship, establishes the relationship ofthe factors of different levels, compares the importance ofthe ... Table We applied the index system, index weight and the evaluation formula proposed above to evaluate the household biogas resourcesof each ofthe six areas The evaluation value ofthe indices was ... increase the temperature ofthe biogas digester due to the presence of abundant solar energy in these two areas But the construction of a solar greenhouse enlarges the capital input Therefore,...
... onethird of all mutations in the BTK gene are missense and some of these reduce the stability ofthe protein This is exemplified by mutations in the BTK motif ofthe Tec homology (TH) domain [18] ... identify individuals with mild disease, thereby providing the missing data The phenotype of XLA and the potential of BTK and ITK inhibitors The outcome of defective BTK signaling in humans has ... the expression of ITK is extremely low and often undetectable in immunoblot analysis The activation of CD4+ cells, however, dramatically induces transcription ofthe ITK gene and is key for the...
... Office ofthe Auditor The missions ofthe Office ofthe Auditor are assigned by the Hawai`i State Constitution (Article VII, Section 10) The primary mission is to conduct post audits ofthe ... Board of Land and Natural Resources For Admin Purposes Commission on Water Resource Management Kaho‘olawe Island Reserve Commission Office ofthe Chairperson Office ofthe Chairperson Office ofthe ... Objectives ofthe Audit Assess the effectiveness and efficiency of conservation and resources enforcement operations achieved by the leaders ofthe Department of Land and Natural Resources and the Division...
... feature is the log ofthe “figure of merit” used to guide search in the noisy channel model when it is producing the 25-best list for the reranker The log figure of merit is the sum ofthe log language ... ProceedFinally we investigate the effect of different loss ings ofthe 2nd Meeting ofthe North American Chapfunctions We observe that using a loss function diter ofthe Association for Computational ... when it is part ofthe reparandum or I when it is part ofthe interregnum CopyFlags X Y: When there is an exact copy in the input text of length X (1 ≤ X ≤ 3) and the gap between the copies is...
... in inuseofthe resource base in in the various state of freshwater resources, trends use various on the state ofof freshwater resources, trendsinuse ofof theresource base in the various on the state ... States and reports on the outcomes and impacts ofthe management of water resources inUN Member StatesThe report assesses the status and impacts ofof improved water resourcesresources UN for UNCSD ... While the main purpose ofthe UN-Water report to the 16th session ofthe CSD in 2008 was to take stock ofthe development and implementation of IWRM and Water Efficiency Plans, from the JPOI, the...
... whether each requirement is fulfilled or not The quality ofthe tools is not altered as they are deployed as WSs without any modification According to the evaluation ofthe current version ofthe ... continue processing the rest ofthe input data if the workflow is robust (i.e makes use of retry and parallelisation) and the error is confined to a WS (i.e it does not affect the rest ofthe workflow) ... aspects ofthe interface (layout, colours, names, logos, etc.) The categories that make up the classification system used in the Registry have been adapted to the NLP field At the time of writing there...
... some ofthe problems, neither of them allows the archivist to avoid the reach of copyright law The a priori opt-out requires the rightsholder to make an indication as to the copyability of their ... Liability There are various other types of potential content liability that may cause the web-archivist problems Not the least of these is the issue of material of objectionable content, whether pornographic, ... necessarily been the case in other EU countries The issue ofthe impact ofthe DPA 1998 on archives in general has been addressed in guidelines by both the Public Records Office58 and the Society of Archivists.59...
... review ofthe existing theory and evaluation ofthe results of existing models This establishes the “reference modes” (Sterman, 2000) or a summary ofthe fundamentals of what is known The review ... stage, such that the value ofthe state variable in the next period depends only on the value ofthe state variable in the current period and the decision in the current period If the objective ... the final stage or period ofthe program, T The method of solution is to first express the problem in the form ofthe functional recurrence equation for the final stage or time period (T in the...
... The BL could be seen as the complementary set ofthe FL with respect to the generic language, i.e it contains all the words ofthe language that not belong to the FL In general the quantity of ... If the final experiments will confirm the usefulness ofthe approach, we will extend the integration to the rest ofthe WordNet hierarchy The final evaluation will include a comparison ofthe ... to the use of generic dictionaries with respect to the IE needs First there is no clear way of extracting from them the mapping between the FL and the ontology; this is mainly due to a lack of...
... introduction, the document sets out the standards in two sections The document begins with a short introduction and statement ofthe purpose ofthe standards The main body ofthe document then sets out the ... grades A*-C The level of functional English – as with the other functional skills – is determined by a combination of: • the complexity ofthe situation • the familiarity to the learner ofthe situation ... situation or problem the learner is tackling • the familiarity to the learner ofthe situation or problem • the technical demand ofthe skill required • the independence ofthe learner in identifying...
... costs and the expenses ofthe social and health services are increasing The report analyses the factors influencing the use of social and health services by the elderly On the basis ofthe analysis, ... to the form of care is easiest seen by comparing their contributions at the sample means (the last column ofthe parameter table) The size of FSMAGRANT tells that the average grants from the ... Simulations The actual coverage ofthe domicile services at target year depends on the number of elderly living home, their dependency and the expected usage ofthe care The numbers of users are...