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Báo cáo khoa học: Interactions of HIPPI, a molecular partner of Huntingtin interacting protein HIP1, with the specific motif present at the putative promoter sequence of the caspase-1, caspase-8 and caspase-10 genes pdf
... decrease in the intrinsic fluorescence of GST–HIPPI protein, indica-ting binding of the protein with this mutated motif(Fig. 1B, panel II). The apparent dissociation constant(Kd) of this binding ... protein; GST, glutathione S-transferase;HD, Huntington’s disease; HIP1, Huntingtin interacting protein 1; HIPPI, Huntingtin interacting protein 1 protein interactor; Htt, Huntingtin;IOD, integrated ... further confirmed the in vitro resultthat mutation of the motif abolished the binding of HIPPI to the specific sequence of the caspase-1 geneupstream sequence, and the increased expression of caspase-1...
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Báo cáo khoa học: Dissociation/association properties of a dodecameric cyclomaltodextrinase Effects of pH and salt concentration on the oligomeric state pot
... the information obtained about the 3D struc-ture of CDase I-5, the quaternary state of CDase I-5was likely to be maintained by the intrinsic capability of the N- and C-terminal regions of the ... data indicated that the effect of pH on dissociation of the oligomer was mainlydue to the protonation of a single residue rather than aglobal effect of pH on the protein. In agreement with the ... in the C-terminaldomain at low pHs. Thus, H539 that is in the center of the C-terminal region plays an important role in determining the quaternary structure of the dode-camer. Four histidine...
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Báo cáo khoa học: Structural studies of the capsular polysaccharide and lipopolysaccharide O-antigen of Aeromonas salmonicida strain 80204-1 produced under in vitro and in vivo growth conditions docx
... about the role of these factors in vivo and their role in furunculosis. The A-layer is believed t o play a crucial role in the bacterial protection against c omplement-mediatedkilling in vitro ... pectrometer. The extent of amidation could be determined by the intensity ratio of fragments at m/z 662.2 D a (GalNAcAN-containing trisac-charide repeating unit) and m/z 663.2 Da (GalNAcA-containing ... sample of A. salmonicida (data not shown). The proposed structure of CPS and O-chain polysaccharide of A. salmonicida strain 80204-1 is depicted in Fig. 5. The biological significance of these findings...
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Báo cáo khoa học: Internalization of the human CRF receptor 1 is independent of classical phosphorylation sites and of b-arrestin 1 recruitment potx
... sauvagine could be observed in the presence of any of these inhibitors. These findingsindicate that neither the activation of PKA nor the activation of PKC is necessary for agonist-induced CRFR1internalization.Involvement ... internalization of radioligand wasobserved during the initial 10 min and the maximal extent of internalization was reduced to 39% following 40 min of incubation (Fig. 2). This result indicate s the involvement ... receptoractivation even in the absence of the C-terminal tail of the receptor and the cluster of serine/threonine in the thirdintracellular loop. This could be due to heterologousrecruitment to other endogenously...
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báo cáo hóa học:" The occurrence of osteoarthritis at a minimum of ten years after reconstruction of the anterior cruciate ligament" pdf
... including limp(5 points), support (5 points), locking (15 points), insta-bility (25 points), pain (25 points), swelling (10 points),stair climbing (10 points) and squatting (5 points).Instrumented ... increase in osteoar-thritis of 1 grade in 52% of the patients, 35% of the patients had an increase of 2 grades and 3% of the patientshad an increase of 3 grades. (Table 4, 5 and 6) 10 % of the patients ... OA. The major factor with the potential todiminish this risk is improvement and maintenance of joint stability, resulting in a lower frequency of repeatinjuries, especially of the meniscus. In...
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báo cáo hóa học:" The psychological context of quality of life: a psychometric analysis of a novel idiographic measure of bladder cancer patients’ personal goals and concerns prior to surgery" pot
... Einstein College of Medicine of Yeshiva University, Bronx, New York, USA.Authors’ contributionsBAM assisted in the organization/administration of the study, gathering of the data, analysis of ... (FACT-Bl). These instruments were administered at differenttime points after surgery, usually in a single mailing or asingle session in the clinic after radical cystectomy. Onlyone of the studies included ... incl uded examination of patien t character-istics and quality of life, thematic content coding of responses to the Brief Quality of Life Appraisal Profile,examination of the relationship of...
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Measurement of Color, Gloss, and Translucency of White Salted Noodles- Effects of Water Addition and Vacuum Mixing.pdf
... but may also influence the rate of cooking and optimum boiling time. One approach in determining optimum boiling time is to judge the time when the uncooked central core of the noodle strands ... thickness of noodles after boiling varies according to boiling time and the degree of starch swelling (Crosbie 1992). Accurate measurement of the color of boiled noodles necessitates the use of a ... descriptor of lightness. The official Japanese method for the assessment of udon noodles incorporates visual sensory testing of the boiled noodles for color (including brightness, glossiness,...
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báo cáo hóa học:" En bloc excision and autogenous fibular reconstruction for aggressive giant cell tumor of distal radius: a report of 12 cases and review of literature" doc
... raduallyFigure 2 Clinical picture showing the biopsy scar and incisionoutline highlighting how the biopsy tract has to be carefullyexcised in this patient.Figure 3 Intraoperati ve picture showing the fixation ... operating surgeons in the whole series and criticallyreviewed the paper. Dr RS, Dr KB and Dr AKM maintained all the records of the patients and followed them. All the authors read and approved the ... Postgraduate Institute of Medical Education andResearch (PGIMER), Chandigarh, India Full list of author information is available at the end of the articleSaini et al. Journal of Orthopaedic...
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báo cáo hóa học:" En bloc excision and autogenous fibular reconstruction for aggressive giant cell tumor of distal radius: a report of 12 cases and review of literature" ppt
... raduallyFigure 2 Clinical picture showing the biopsy scar and incisionoutline highlighting how the biopsy tract has to be carefullyexcised in this patient.Figure 3 Intraoperati ve picture showing the fixation ... operating surgeons in the whole series and criticallyreviewed the paper. Dr RS, Dr KB and Dr AKM maintained all the records of the patients and followed them. All the authors read and approved the ... Postgraduate Institute of Medical Education andResearch (PGIMER), Chandigarh, India Full list of author information is available at the end of the articleSaini et al. Journal of Orthopaedic...
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