... decrease in the
intrinsic fluorescence of GST–HIPPI protein, indica-
ting binding ofthe protein with this mutated motif
(Fig. 1B, panel II). The apparent dissociation constant
(K
d
) of this binding ... protein; GST, glutathione S-transferase;
HD, Huntington’s disease; HIP1, Huntingtin interacting protein 1; HIPPI, Huntingtin interacting protein 1 protein interactor; Htt, Huntingtin;
IOD, integrated ... further confirmed thein vitro result
that mutation ofthe motif abolished the binding of
HIPPI to the specific sequence ofthe caspase-1 gene
upstream sequence, and the increased expression of
caspase-1...
... the information obtained about the 3D struc-
ture of CDase I-5, the quaternary state of CDase I-5
was likely to be maintained by the intrinsic capability
of the N- and C-terminal regions ofthe ... data indicated that the
effect of pH on dissociation ofthe oligomer was mainly
due to the protonation of a single residue rather than a
global effect of pH on the protein. In agreement with
the ... inthe C-terminal
domain at low pHs. Thus, H539 that is inthe center
of the C-terminal region plays an important role
in determining the quaternary structure ofthe dode-
camer. Four histidine...
... about the role of these factors in vivo and their role in
furunculosis. The A-layer is believed t o play a crucial role
in the bacterial protection against c omplement-mediated
killing in vitro ... pectrometer. The extent of
amidation could be determined by the intensity ratio of
fragments at m/z 662.2 D a (GalNAcAN-containing trisac-
charide repeating unit) and m/z 663.2 Da (GalNAcA-
containing ... sample of A. salmonicida (data not shown).
The proposed structure of CPS and O-chain polysaccharide
of A. salmonicida strain 80204-1 is depicted in Fig. 5.
The biological significance of these findings...
... sauvagine could be observed
in the presence of any of these inhibitors. These findings
indicate that neither the activation of PKA nor the
activation of PKC is necessary for agonist-induced CRFR1
internalization.
Involvement ... internalization of radioligand was
observed during the initial 10 min and the maximal extent
of internalization was reduced to 39% following 40 min of
incubation (Fig. 2). This result indicate s the involvement ... receptor
activation even inthe absence ofthe C-terminal tail of the
receptor and the cluster of serine/threonine inthe third
intracellular loop. This could be due to heterologous
recruitment to other endogenously...
... including limp
(5 points), support (5 points), locking (15 points), insta-
bility (25 points), pain (25 points), swelling (10 points),
stair climbing (10 points) and squatting (5 points).
Instrumented ... increase in osteoar-
thritis of 1 grade in 52% ofthe patients, 35% of the
patients had an increase of 2 grades and 3% ofthe patients
had an increase of 3 grades. (Table 4, 5 and 6) 10 % of the
patients ... OA. The major factor with the potential to
diminish this risk is improvement and maintenance of
joint stability, resulting in a lower frequency of repeat
injuries, especially ofthe meniscus. In...
... Einstein College
of Medicine of Yeshiva University, Bronx, New York, USA.
Authors’ contributions
BAM assisted inthe organization/administration ofthe study, gathering of
the data, analysis of ... (FACT-
Bl). These instruments were administered at different
time points after surgery, usually in a single mailing or a
single session inthe clinic after radical cystectomy. Only
one ofthe studies included ... incl uded examination of patien t character-
istics and quality of life, thematic content coding of
responses to the Brief Quality of Life Appraisal Profile,
examination ofthe relationship of...
... but
may also influence the rate of cooking and optimum boiling time.
One approach in determining optimum boiling time is to judge
the time when the uncooked central core ofthe noodle strands ... thickness of noodles after boiling varies according to
boiling time and the degree of starch swelling (Crosbie 1992).
Accurate measurement ofthe color of boiled noodles necessitates
the use of a ... descriptor of lightness.
The official Japanese method for the assessment of udon noodles
incorporates visual sensory testing ofthe boiled noodles for color
(including brightness, glossiness,...
... operating surgeons inthe whole series and critically
reviewed the paper. Dr RS, Dr KB and Dr AKM maintained all the records of
the patients and followed them. All the authors read and approved the ... reconstruction was the index surgery in 10
of the 12 cases and rest 2 were cases of recurrent GCT
initially treated with extended curettage and bone
cementing for these grade II tumors. Ofthe 10 primary
cases, ... radually
Figure 2 Clinical picture showing the biopsy scar and incision
outline highlighting how the biopsy tract has to be carefully
excised in this patient.
Figure 3 Intraoperati ve picture showing the fixation...
... operating surgeons inthe whole series and critically
reviewed the paper. Dr RS, Dr KB and Dr AKM maintained all the records of
the patients and followed them. All the authors read and approved the ... radually
Figure 2 Clinical picture showing the biopsy scar and incision
outline highlighting how the biopsy tract has to be carefully
excised in this patient.
Figure 3 Intraoperati ve picture showing the fixation ... reconstruction was the index surgery in 10
of the 12 cases and rest 2 were cases of recurrent GCT
initially treated with extended curettage and bone
cementing for these grade II tumors. Ofthe 10 primary
cases,...