... at the last base, G to A, abolished
the interaction of HIPPI, so the last motif would not
interact with HIPPI. The other two motifs might be
the target of HIPPI. In the upstream sequence of the
Table ... positions ofthe motifs are indicated
by distance from the transcription start site (TSS). The
position upstream ofthe TSS of any gene is denoted
by ‘–’ followed by the distance from the TSS. In the
caspase-8 ... confirmed the in vitro result
that mutation ofthe motif abolished the binding of
HIPPI to the specific sequence ofthe caspase-1 gene
upstream sequence, and the increased expression of
caspase-1...
... in the presence of KCl.
Considering also the 3D structure of CDase I-5, the
analysis ofthe quaternary state of CDase I-5 revealed
Fig. 8. Fluorescence spectra of CDase I-5. (A) - - - -, the ... the adjacent
monomer, of which G538 forms a hydrogen bond to
the carbonyl oxygen of M51. Two residues at the
N-terminus (H49 and H89) of a subunit were located
close to the C-domain ofthe other ... either in the secondary
structure ofthe protein according to far-UV CD
data or in the size ofthe protein determined by size-
exclusion HPLC. They suggested that the change
might occur either...
... than
the wild-type both in the absence a nd in the p resence of
Fig. 3. Normalized zinc-dependent ATPase activity ofthe wild-type and
mutated enzymes. TheATPaseactivity(percentageoftheactivityofthe
wild-type) ... correspond-
ingtoH475QinZntA)hasbeenshowntoresultin
mislocalization of t he WD ATPase in the endoplasmic
reticulum [24]. This trafficking defect as well the difficulty of
producing enough of mutant protein has complicated the
attempts to study the roles ofthe ... The effect of 30 l
M
Zn
2+
on the P
i
-phosphorylation ofthe wild-type and the P401L
enzymes (gray columns). Note that the maximal phosphorylation of
the P401L mutant is only 8% ofthe wild-type...
... with the Substance P receptor [25]. Detachment
of the cells from the surface ofthe culture dish could r eflect
disassembly ofthe actin cytoskeleton in the me mbrane
regions as a consequence of ... both the
cAMP and the PLC pathway [22], the second messenger
product of either or both of these pathways could
be invo lved in agonist-stimulated internalization of this
receptor.
The effect of ... f
125
I-labelled sauvagine could be observed
in the presence of any of these inhibitors. These findings
indicate that neither the activation of PKA nor the
activation of PKC is necessary for agonist-induced...
... % ofthe patients B (3–5 mm) and in
16% ofthe patients C (6–10 mm) stability.
Looking at the osteoarthritis rate ofthe operated knee, 55
% ofthe patients decreased one grade according to the
Kellgren ... osteoar-
thritis of 1 grade in 52% ofthe patients, 35% of the
patients had an increase of 2 grades and 3% ofthe patients
had an increase of 3 grades. (Table 4, 5 and 6) 10 % of the
patients had ... test). These
patients were considered at high risk of further knee injury
due to the degree of laxity and the desired level of activity
[27]. In order to minimise the development of arthrofi-
brosis,...
... major motivat ional theme as it demon-
strates yet another dimension ofthe QOL Appraisal
Profile and further helps e lucidate the nuances o f
the profile. The major theme of reaching an event/
milestone ... examination of patien t character-
istics and quality of life, thematic content coding of
responses to the Brief Quality of Life Appraisal Profile,
examination ofthe relationship of goal attainment ... needed. Other patients c om-
pleted the Quality of Life Appraisal Profile and other
measures during the time that they were receiving neo-
adjuvant chemotherapy. In order to see whether these
confounders...
... between Theorems 2 and 8;thatis,
in Theorem 2,thedifferentiability of a function φ is not emphasized which is used in the
proof. Also, the proof of Theorem 2 is completely analogous to the proof of ... 6,page37. Therefore, w e will
look back only on case i of Theorem 1.
By applying Theorem 3 to the function Fx, yx/y, we obtain the following result.
Theorem 7. Suppo se that all the conditions of ... a discrete version of Theorem 8. It is obvious that the main results presented in 2
are special cases of results given in 3, Theorem 1, Corollary 1, Remark 2.
Note that there is a difference...
... υ
zdx
.
3.26
Since the restriction operator is continuous, then u
n
,
n
u, in W
1,px
0
B
r
ì W
1,qx
0
B
r
.
Because ofthe compactness of F
r
, the first expression on the right-hand side ofthe equation
tends ... they apply the mountain
pass theorem to get the nontrivial solutions ofthethe system.
In 30, the author obtains the existence and multiplicity of solutions for the following
problem:
− div|∇u|
px−2
∇u
∂F
∂u
x, ... and Mathematical Theory, vol. 1748 of Lecture Notes in
Mathematics, Springer, Berlin, Germany, 2000.
13 V. V. Zhikov, “Averaging of functionals ofthe calculus of variations and elasticity theory,”...
... 2,700 acres, from the
preponderance of arable, the chief source of income to thelord was from the grain
crops; other sources may be seen from the following table ofthe lord& apos;s receipts ... 3d. The rector ofthe parish had part of a furrow, i.e. one of
the divisions ofthe common arable field, and paid 2d. a year for it. Another tenant
held a cottage in the demesne under the obligation ... of keeping two lamps lighted in
the church. Another person was tenant-at-will ofthe parish mill, at a rent of 40s. a
year. The rest ofthe tenants were villeins or cottagers, thirteen of the...
...
boiling time and the degree of starch swelling (Crosbie 1992).
Accurate measurement ofthe color of boiled noodles necessitates
the use of a method that minimizes the effect of variation on ... but expected to be largely
independent of noodle thickness. These were considerations in the
development of methods in the present study. The aims ofthe study
were to develop new and improved ...
Tests in Experiment 1
The distance along the visual analogue scales (VAS) for each of
the six samples was measured, the results ofthe 32 panelists were
combined, and the mean scores were compared...
... Thus they conceal their identi-
ties, though the beneficiaries are free to reveal the nature ofthe gifts as
long as they do not expose the identities ofthe givers.
Type III returns us to the ... invisible forms of energy.
4
The appeal of these collages lies in their claim to provide holistic and
comprehensive pictures ofthe world. The variety of their elements im-
plies that the belief system ... conspiracy
theories do not claim for their beliefs the status of revelation, nor do
they ask that their beliefs be taken on faith. Yet the version of empiri-
cism that operates in the domain of stigmatized...
... maintained all the records of
the patients and followed them. All the authors read and approved the final
manuscript
Conflict of Interests
The authors declare that they have no competing interests.
Received: ... ulnar translocation in the treatment of giant-cell
tumors ofthe distal end ofthe radius. J Bone Joint Surg Am 1982,
64(1):67-73.
14. Smith RJ, Mankin HJ: Allograft replacement of distal radius for ... bloc
excision ofthe distal radius and fibular autograft replacement. J Bone
Joint Surg Br 1983, 65(5):618-20.
26. Vander Griend RA, Funderburk CH: The treatment of giant-cell tumors of
the distal part of...