... the ter-tiary structureof ApeSOD has not been elucidated.In the present study, for the first time, we describe the crystal structureof ApeSOD. In particular, we focuson the coordination of ... ligand,NE2 of His31, bound to the metal, in the company of a water oxygen, from the apical positions. The manga-nese was only 0.06 A˚out ofthe equatorial plane(Table 3). The angles around the metal ... metal cofactor.Figure 3D shows the superimposition ofthe activesite structures of apo, Mn-bound and Fe-bound Ape-SODs. The most significant difference among themwas related to the OH of Tyr39,...
... especiallythosewhoholdgeneralbachelor’sdegrees,theirqualificationsserveonlyasasignal of theirpotentialtoemployers.Inmanycases,theytakelongertorealiseemploymentandwhentheydotheirentryleveljobsdonotnecessarilyrequire the years of schoolingtheypossess.Theystartat the bottom ofthe jobladderandhavetoprovethemselvesin the labourmarkettoreachhigherincomelevels.Acombination of theirpotentialandtrainingwilldeterminetheirprogressionup the ladder.Aswillbeseenin the nextsection, the field of study,whichsignals the type of skillsacquiredthrougheducation,playsasignificantroleinemployability of universitygraduatesinthiscase.PercyMolekeFree ... www.hsrcpress.ac.za4PercyMoleke5InequalitiesinHigherEducationand theStructureofthe LabourMarketDespite the observedsignificantincreasesin the number of seniorcertificateholdersin the pastdecade, the proportion of learnerswhoactuallysitfor the examremainslow. The quality ofthe seniorcertificateexamalsocontinuestobe of concern. The largemajority of learnersstillopttowrite the seniorcertificateexamon the standardgraderatherthanon the highergrade.Consequently, the proportion of thosepassingwith ... www.hsrcpress.ac.za14PercyMoleke15InequalitiesinHigherEducationand theStructureofthe LabourMarketineducationorin the labourmarket,havedonelittletoaddress the inequalities of the past. The lack of labour marketinformation...
... express εABRA43Bin the form curl/π(2)+ E(2).5. Strategy ofthe proof ofthe Asymptotics TheoremIn this section we describe the main ideas in the proof ofthe AsymptoticsTheorem.(1) Section ... given a detailed proof ofthe theorem by relying heav-ily on a result, which we have called the Asymptotics Theorem, concerning the geometric properties ofthe causal structureof appropriately ... I+0is the future domain ofthe originon Σ0.Remark 9.3. The proof of Corollary 9.2 requires an extension argument. The estimates ofthe Asymptotics Theorem, which are uniform with respectto the...
... to the intensification ofthe sovereign debt crisis in the euro area. The pricing of risk in the repo market has become more dependent on the geographic origin of both the counterparty and the ... maintaining the integrity ofthe single market. Finally, Chapter 5 draws together the analysis ofthe previous chapters. It reiterates the importance of banks in the EU economy, summarises the key ... mandate, the Group also expects the on-going fundamental review of the trading book by the Basel Committee to improve the control of market risk within the banking system. The Group sees the Commission's...
... present for the last four residues at the C-terminus. The stereochemistry ofthe model hasbeen assessed using the program procheck [23]. Ninetyper cent ofthe residues fall in the most favouredregions ... Asp291(2.2 A˚) and the water molecule w1 (2.1 A˚) (Fig. 3A). The DHAP binding site protrudes from the metalN-terC-terFig. 2. Ribbon representation ofthe overall structureof hACMSD. The (a ⁄ b)8barrel ... building using the program o [42].Approximately 7% ofthe randomly chosen reflectionswere excluded from refinement ofthestructure andused for the free R-factor calculation [43]. The pro-gram...
... of SAILFig. 3. Secondary structureof At3g16450.1. (A) Ribbon representa-tion ofthe NMR structureof At3g16450.1. These figures were pre-pared usingMOLMOL [25]. Due to the lack of NOEs, the ... constraints.Solution structureof SAIL At3g16450.1Assignment ofthe NOE peaks of At3g16450.1 and the structure determination were accomplished by use of the cyana program [17,18]. The structural statistics ... Three-dimensional NMR structureof At3g16450.1. (A)Superposition ofthe 20 energy-minimized conformers that repre-sent the 3D solution structureofthe N-terminal domain. (B) Super-position of conformers...
... dispersion in the HN region as well asin the methyl region (data not shown) is an indicator of the lack of globular structure, and of little, if any,secondary structure [15]. The presence of strong ... e.g. the case ofthe association between the N-terminalregion ofthe membrane-bound tyrosine kinase Lckwith the cytoplasmic tail ofthe T-cell coreceptors CD4or CD8 [37].In solution, on the ... typical of disor-dered proteins. The content of secondary structure wasestimated through deconvolution ofthe CD spectrumin the range 190–240 nm using several methods [13]. The best fit between the...
... revealsthat the most similar regions of these proteinases medi-ate interaction ofthe two b-barrels, formation of the catalytic machinery and structures required for binding of the main chain ofthe ... Asp189 at the bottom ofthe pocket determines the specificity ofthe S1 pocket for basic residues Argand Lys at position P1 ofthe substrate. Consequently,in the DESC1 complex structurethe bound ... below). The southern boundary of the active site cleft of DESC1 is formed by the 145autolysis loop. The backbone of this loop differs mark-edly from the other serine proteinases, making the act-ive...
... determines the shape of the active site entry. (e) Thestructureofthe active site isessentially identical with the active sites ofthe MshBand LpxC proteins. The conservation of catalyticallyimportant ... studying the correspondingproteins of B. anthracis because it lacks infectiousness of the latter. The objective ofthe present study is toshed light on the structure, function and thestructure function ... diagram.BAFig. 1. Structureofthe BcZBP dimer. (A) Topology diagram of the dimer drawn with the programTOPDRAW [34]. The relative orienta-tion ofthe secondary structure elements is illustrated. The shadedareas...
... information on the heme pocket structure. As shown in Table 2, the hyperfine splittingconstants of the 15N nucleus ofthe distal NO and of the 14N nucleus ofthe proximal His ofthe GmHO-1complex ... against the concentration of azide of each solution. The intersectionpoint corresponding to the mole fraction of 0.5 of the respective forms gives the amount of azide necessary toattain the equilibrium, ... either stabilize the azide coordinated toheme or facilitate the access of anionic azide to the heme, and conversely, the steric effect ofthe distalresidues might reduce the accessibility of...
... the large P6extension and the last three nucleotides (AU XG) ofthe intron. The sizes ofthe intron (InDGb) and 5¢ exon (5E) are indicated. The arrowindicates cleavage ofthe pre-RNA at the ... Because of theseand other properties of Cr.LSU, the tertiary structureofthe intron from23S.5DGbwas examined using Fe2+-EDTA cleavage. The ground-state structure shows evidence of an unusually ... 23S.5DGbpre-RNA, and the binding of a minimum of n Mg2+ions leads to formation of the active complex, whereas binding of a minimum of mMn2+ions forms the inactive complex. The sizes of the active and inactive...
... confirming that the mutation of Tyr186 to Phe186 does not grossly perturb the overall framework ofthe enzyme or the active site. The active sites of the enzymes are shown in stick format with the sigmaA ... productive binding of steroid substrates:in the first, a (small) sub population of enzyme bindsdirectly the steroid in the reactive conformation, with the remainder ofthe enzyme binding the unreactiveconformation. ... bond inclose proximity ofthe N5 atom. A putative flippingmotion ofthe progesterone molecule along an axisparallel to the FMN plane aligns the C1-C2 with the plane ofthe isoalloxazine ring...
... bestIM:Type full timeIM:Title the godfatherOther the, in, that Other the, in, that Other the, in, thatTable 3: Label sets and their respective query segment examples for the intent class Movie, Job ... goal of this work is to identify the semantic labels of IMs,i.e., the attribute names they implicitly refer to. Weuse Acto denote the set of IM semantic labels for the intent class c.OtherAdditionally, ... se-mantic understanding of noun phrase queries. As-suming that the intent class c ∈ C of a query isknown, we cast the problem of extracting the se-mantic structureofthe query into a joint...
... [18]. Thestructureofthe helicalcoil a2/a3allows us to interpret the consequences of the six mutations. As P153(152) and G162(161) are buried in the protein core, replacement of each of these ... cluster in these two regions. Know-ledge ofthestructureof a larger portion of MeCP2including the transcriptional repression domain wouldresolve these speculations and clarify the role of the helical ... subsequent structure calculations. These newly calculated structureswere then used for the next step in the iteration process. Thisprocedure was continued until the quality ofthe structure could...