the involvement of serotonin receptor function stress resistance and neurogenesis
báo cáo khoa học: " The Arabidopsis pop2-1 mutant reveals the involvement of GABA transaminase in salt stress tolerance" pps
Ngày tải lên :
12/08/2014, 03:21
... identified the GABA-T step as a key point of regulation of GABA metabolism and further performed a functional analysis of the POP2 gene that encodes GABA-T Results GABA-T is the most responsive step of ... the control of its expression [46] Analysis of GAD4 expression pattern under stressful conditions may bring precious information on functions of the gene In spite of the enhancement of two GAD ... (GAD1-5), the GABA transaminase (POP2), the succinate semialdehyde dehydrogenase (SSADH) and the well-known stress- induced 1-pyrroline-5-carboxylate synthetase (P5CS1) Results are the mean S.E of independent...
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báo cáo khoa học: " Transcriptional responses to polycyclic aromatic hydrocarbon-induced stress in Arabidopsis thaliana reveal the involvement of hormone and defense signaling pathways" pdf
Ngày tải lên :
12/08/2014, 03:21
... performed the mutant growth and histochemistry experiments DW and MA contributed equally to this work ACC conceived of the studies and contributed to the planning and oversight of the experiments ... between the phenanthrene microarray and other experimental conditions The heatmap in Figure shows the results from clustering genes and experimental conditions The complete dataset of the heatmap ... microarray profiles of 1031 phenanthrene-responsive genes under phenanthrene treatment and 27 other stress and hormone treatments Plant age in weeks and duration of treatment are given in parenthesis;...
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Tài liệu Báo cáo khoa học: MicroRNA-23a promotes the growth of gastric adenocarcinoma cell line MGC803 and downregulates interleukin-6 receptor pdf
Ngày tải lên :
18/02/2014, 04:20
... and colony formation assays confirmed the active role of miR-23a in the growth promotion of malignant cells The fundamental function of miRNAs is to regulate their targets by direct cleavage of ... Institute and Hospital and the National Foundation of Cancer Research All of the tumor types were confirmed by pathologic analysis The experiments were undertaken with the understanding and written ... on the expression of IL6R by RT-PCR and western blot, and found an inverse correlation between miR-23a and IL6R expression at both the mRNA and protein levels To confirm the direct regulation of...
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Tài liệu Báo cáo khoa học: ¨ Induction of Kruppel-like factor 4 by high-density lipoproteins promotes the expression of scavenger receptor class B type I pptx
Ngày tải lên :
18/02/2014, 04:20
... enhancement of the expression of the tumour suppressor gene p53 [5] Because of the important roles of KLF4 on the above three cell types, we postulated the novel effect of KLF4 in atherogenesis ... role in the activation of endothelial cells and macrophages, as well as the differentiation and proliferation of VSMCs Overexpression of KLF4 induced expression of multiple anti-inflammatory and antithrombotic ... (PBMCs) and human THP-1 monocytes In addition, the effects of KLF4 on the expression of SR-BI and the primary mechanism were also investigated Results HDL induces the expression of KLF4 and SR-BI...
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Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx
Ngày tải lên :
18/02/2014, 16:20
... association of CD95 with the EGF -receptor, and phosphorylation of CD95 on Tyr232 and Tyr291 by the EGF -receptor tyrosine kinase activity [15] Although the appearance of CD95 at the plasma membrane ... trafficking of the CD95 from inside the hepatocyte to the plasma membrane [39], which depends on a ROS-mediated tyrosine phosphorylation of the epidermal growth factor (EGF) -receptor, the association of ... activation of the protein kinase B survival pathway [31], p53 activation [32], induction of the serum- and glucocorticoidinducible kinase Sgk [33], expression of the heat shock protein Hsp70 [34] and...
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Tài liệu Báo cáo khoa học: Characterization of human deoxyribonuclease I gene (DNASE1) promoters reveals the utilization of two transcription-starting exons and the involvement of Sp1 in its transcriptional regulation ppt
Ngày tải lên :
19/02/2014, 06:20
... and quantitative real-time RT-PCR, the locations of the primers DN)105 and DN)9 used in ChIP assays, the locations of the primers DN+232 and DN+254 utilized in 5¢-RACE, and the locations of the ... in fragments F and I The number at the right of each RT-PCR product represents the length of the product The scheme also shows the location of the reverse primer DN+89 used in another starting ... numbers over the diagrams indicate the position of the corresponding nucleotides relative to the translation start site, and the numbers in parentheses below the diagram show the position of the corresponding...
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Báo cáo khoa học: Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response potx
Ngày tải lên :
07/03/2014, 21:20
... including the gene encoding arginase II (ArgII) ArgII is the extrahepatic isoform of the arginase type enzymes, and ArgI is the hepatic-specific counterpart [16] The two isoforms possess the same ... l-ornithine and urea, a critical step in the polyamine biosynthesis pathway Subcellular localization of the two isoforms differs, with ArgI located in the cytoplasm and ArgII in the mitochondria ... response to virus infection As the two isoforms of arginase, I (hepatic isoform) and II (extrahepatic isoform), may contribute to the arginase activity measured in the previous experiment, ArgII...
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Báo cáo khoa học: The involvement of human ribonucleases H1 and H2 in the variation of response of cells to antisense phosphorothioate oligonucleotides pot
Ngày tải lên :
08/03/2014, 10:20
... center of the input target RNA The asterisk indicates the input target RNA; the arrow indicates the digested product bands The amount of digested product obtained is indicated at the bottom of the ... top of the lanes The lanes depicted 0.5 + 0.5 and + are assayed with a mixture of both cell extracts Digested product is detected as a single band on these gels, as the ODN hybridizes to the ... (three of which are shown in Fig 6) had the same low level of antisense inhibition as the parental and vector control cells ( 10% reduction of target mRNA) The high level of activity in vitro, and...
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Báo cáo khoa học: Control of nuclear receptor function by local chromatin structure doc
Ngày tải lên :
28/03/2014, 22:21
... expression of receptors (and receptors’ isoforms) and other co-factors, metabolism of ligands, and expression of selective modulators [17,18] In addition, chromatin structure can play a role in the ... phosphate backbone and lysine and arginine residues on the surface of the octamer, while the unstructured N-terminal histone tails protrude outside the nucleosome core and are the subjects of numerous ... the primary ⁄ ancestral function of these prototype proteins is regulatory rather than structural and the function of DNA compaction evolved much later either as a result of or as a necessary precondition...
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Báo cáo sinh học: " The involvement of survival signaling pathways in rubella-virus induced apoptosis" ppt
Ngày tải lên :
18/06/2014, 22:20
... increase in the speed and magnitude of RV-induced apoptosis To evaluate the role of PI3K-dependent signaling during RV infection, the effects of PI3K inhibitor LY294002 on the development of RV-induced ... RV-infected cells and RV in the presence of U0126 (Fig 3C), although the presence of the drug also appeared to result in smearing of high molecular weight DNA, characteristic of necrosis [26,27] The detrimental ... phosphorylation profiles during RV infection demonstrated that the presence of the virus stimulated an increase in the phosphorylation of ERK1/2, Akt, and Akt target GSK-3β over time The presence of phosphorylated...
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báo cáo hóa học: " Effects of betaine on lipopolysaccharide-induced memory impairment in mice and the involvement of GABA transporter 2" doc
Ngày tải lên :
19/06/2014, 22:20
... then returned to the apparatus and participated in a 5-min retention session in the presence -8- of the familiar object and the novel object The time spent exploring the familiar and novel objects ... Immediately after the familiarization session, the mice were removed from the apparatus, and one of the familiar objects was randomly replaced with a novel object (triangle pole) The mice were then returned ... Pharmacol Japon, 1992, 99: 35A); the Interministerial Decree of May 25th, 1987 (Ministry of Education, Japan); and the National Institutes of Health Guide for the Care and Use of Laboratory Animals (NIH...
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báo cáo hóa học:" Confronting TB/HIV in the era of increasing anti-TB drug resistance" pdf
Ngày tải lên :
20/06/2014, 08:20
... outbreaks of MDR and XDR TB have reinforced the fear of expansion of isoniazid resistance Expansion of Isoniazid resistance could lead to the emergence of MDR and XDR TB in places where these forms of ... recording and reporting tools to allow for the routine collection, collation and analysis of data related to the provision of IPT We are hoping that these will form part of the pre-ART care register and ... and the first draft of this manuscript with the assistance of Haileyesus Getahun Reuben Granich and Diane Havlir reviewed the presentation and this manuscript and provided further inputs Page of...
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báo cáo khoa học: "Is the involvement of opinion leaders in the implementation of research findings a feasible strategy?" doc
Ngày tải lên :
11/08/2014, 05:21
... practice The recognition of the failure of this model has led to greater awareness of the role of other factors in the practice environment influencing behaviour [1] and the importance of identifying ... working in and employed by general practices), and practice managers in two regions of Scotland, one Health Board in the West of Scotland (PC1), and one in the North East of Scotland (PC2) In ... used as a source of advice by their peers Please read each of the paragraphs and write in the names of up to three colleagues that best fit the description of each characteristic The same person...
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Báo cáo y học: " The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations" doc
Ngày tải lên :
12/08/2014, 16:20
... Position(red) ofgenotyped polymorphisms (SNPs) in the ADAM33 gene in respect to the 22 exons (blue) and untranslated Figure of regions the the gene Position of the genotyped polymorphisms (SNPs) in the ... evaluation of the independent and combined roles of genotype and exposure on disease risk [19] All statistical analyses were carried out using the SAS statistical software package (Version 9.1) and the ... because of different techniques of BHR assessment in the case-control study and in the cohort study analysis in the cohort study because of low number of cases while FEV1 was increased in carriers of...
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Báo cáo y học: " Cysteinyl-leukotrienes in the regulation of β2-adrenoceptor function: an in vitro model of asthma" ppsx
Ngày tải lên :
12/08/2014, 16:20
... messenger (i.e cAMP) production, and certainly involve the activation of other components downstream of the receptor, while the β2-AR may perform functions other than adenylyl cyclase activation ... adenylyl cyclase dysfunction The PKA inhibitor H89 also failed to prevent the LTD4-induced β2-AR desensitization in HASMC, thus ruling out the possibility of the involvement of this protein kinase ... in HASMC Note the weaker effect of salbutamol compare to isoproterenol (10-5 M) and the similarity with the effects of LTD4 in Fig.s 1-3 The results are presented as mean ± s.e.m of two experiments...
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Báo cáo y học: "Improving the prediction of yeast protein function using weighted protein-protein interactions" pps
Ngày tải lên :
13/08/2014, 16:20
... to infer the functions of an un-annotated protein from the PPI This method locates the neighbour proteins and predicts their assigned functions and the frequency of these functions; the functions ... pairs where one has the function and the other does not; (4) number of protein pairs without this function A weighted sum of these numbers is calculated according to the random Markov field algorithm, ... was the best weight for the cellular role function category when the number of interactions was two, and W3 (weights of IG2) were the best weights for the cellular role function category when the...
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Báo cáo y học: "Mechanisms of leukocyte distribution during sepsis: an experimental study on the interdependence of cell activation, shear stress and endothelial injury" potx
Ngày tải lên :
13/08/2014, 21:21
... AP and BN conceived of the study, participated in its design and coordination, and drafted the manuscript VS and AH carried out the adhesion assays JR and HAH participated in the design of the ... [12,13] Far exceeding the effects of shear stress is the plateletcovered endothelial lesion, which proved to be the strongest determinant of PMN-adhesion at all levels of shear stress In maximally ... examined the adhesion of activated PMN to platelet-covered endothelial lesions The presence of platelets was the strongest variable for adhesion of activated PMN At all levels of shear stress PMN...
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Báo cáo y học: "Endothelial Cardiac filling volumes versus pressures for predicting fluid responsiveness after cardiovascular surgery: the role of systolic cardiac function" pptx
Ngày tải lên :
14/08/2014, 07:21
... analyzed and interpreted the data, and drafted and revised the article ID, MR and AG conceived the protocol of the study, and analyzed and interpreted the data RB facilitated the accomplishment of the ... analysis The groups to be analyzed were divided into low GEF (
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The study of GRIM 19 function in mitochondria
Ngày tải lên :
11/09/2015, 16:07
... contains the ribosomes and other enzyme systems responsible for the synthesis of mitochondrial DNA (mtDNA), RNA and proteins Because of the folds of the cristae, no part of the matrix is far from the ... Crofts Figure 1.3 A schematic picture of the morphology and function of the RC (1) NADH: ubiquinone oxidoreductase (Complex I) The mitochondrial Complex I, which carries out the first step of the ... stands for outside (intermembrane space ), and H+ refers to proton The NADH: ubiquinone oxidoreductase (Complex I) of the RC catalyzes the oxidation of NADH, the reduction of ubiquinone, and the...
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