the interaction of lipophilic drugs with the lipid digestion absorption cascade
Investigation of the interaction of antimicrobial peptides with lipids and lipid membranes 1
... help to insert into the membrane core The hydrophobic part of the antimicrobial peptides interacts with the hydrophobic alkyl chains of the lipids and the hydrophilic part of the antimicrobial ... role in the activity of antimicrobial peptides The one cysteine of the S3 peptide which is derived from the Sushi domain of Factor C allows the formation of S3 dimers The S3 dimer is capable of disrupting ... is also related to the L- or D- enantiomer However the effect of enantiomer of the amino acid is dependent on whether the replacement affects the structure of the peptide and the amphipathicity...
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Investigation of the interaction of antimicrobial peptides with lipids and lipid membranes 3
... value The presence of V4 further increased the compressibility of the monolayer, indicative of the increased molecular area, which was consistent with the result of excess surface pressure 154 The ... effect on both lipid monolayers One of the possible reasons might be the conformational change due to the interaction between V4 and lipid When there was no V4, the alkyl chains of the lipid molecules ... upward to the air phase and the headgroup contacted with water phase The hydrophobic interaction between the hydrophobic part of V4 and alkyl chains of the lipid made the alkyl chains tilt to the interface...
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Investigation of the interaction of antimicrobial peptides with lipids and lipid membranes 2
... efficiency of V4-TMR with lipid A was lower than that of LPS despite the fact that lipid A is considered to be the bioactive part of LPS 99 5.4.4 Saturation of lipids affects the binding with V4-TMR The ... interacting with the phosphate groups of the lipid A moiety of LPS and lipids with negative charge, such as POPG and DPPG The importance of electrostatic interactions in comparison to hydrophobic interactions ... similar to the expected diffusion time of lipid SUVs However, F2 and N2 differed markedly depending on the lipid used In the group of lipids with unsaturated lipid tails, the highest values for these...
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Báo cáo Y học: Molecular interaction of neutral trehalase with other enzymes of trehalose metabolism in the fission yeast Schizosaccharomyces pombe pdf
... Taken together, these results support the idea that in S pombe the regulation of Ntp1p activity under stress relies on the existence of some kind of interaction between Ntp1p and Tps1p, or other elements, ... allow the construction of vectors with Ha6H tag fusions at the C-terminus The resulting plasmids were digested at the unique SfiI site within the ntp1+ coding region (at position 1665) and the linear ... than the osmotically induced activation [17,23] In the latter case, the Pka/Sck1p-mediated activation of Ntp1p appears to occur at the level of the enzyme synthesized de novo [17] Finally, the...
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Báo cáo khoa học: Interaction of caspase-3 with the cyclic GMP binding cyclic GMP specific phosphodiesterase (PDE5a1) potx
... treatment of the cells with the caspase-3/7 inhibitor, Ac-DEVD-CHO (added at the time of transfection with caspase-3 plasmid construct) Overexpression of PDE5A1 did not inhibit the auto-activation of ... agreement with studies by Turko et al [14], who reported identical changes in the kinetic constants of the D781A mutant The DQGD site is within the boundary of the catalytic domain of PDE5A1 ... role in the binding of competitive PDE4 inhibitors [36] The side chain of this residue may conceivably p-stack with the purine base of the bound substrate and form hydrophobic interactions with...
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Báo cáo khoa học: A spectroscopic study of the interaction of isoflavones with human serum albumin pdf
... energetics The effect of temperature on the interaction of genistein with HSA has been followed in the range 17–47 °C The binding constant, K, exhibits a recipro- Fig Quantitation of the interaction of ... overlap of the emission spectrum of the donor with the absorption spectrum of the acceptor The energy transfer efficiency E is related to the distance (r0) between acceptor and donor, and also to the ... constant decreased with increasing ionic strength (Fig 5B), establishing the role of ionic interaction in the binding The Stokes radius of HSA in the presence of increasing concentrations of potassium...
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Báo cáo Y học: Tryptophan fluorescence study of the interaction of penetratin peptides with model membranes pdf
... [12] The aim of this study was to gain better insight into the mode of interaction of the penetratin peptide with lipid bilayers and to investigate the role of the Trp residues and the lipids ... as the percentage of the uorescence of the lipid- free peptide was plotted vs the added lipid concentration The data were analyzed using SIGMAPLOT (SPSS Inc.) The change in the uorescence of the ... titration, F1 the uorescence intensity at the end of the titration, [PF] the concentration of free peptide and [PL] the concentration of the peptidelipid complex The concentration of PL can be...
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Báo cáo y học: "Highly specific inhibition of leukaemia virus membrane fusion by interaction of peptide antagonists with a conserved region of the coiled coil of envelope" potx
... alignment of the adjacent peptide sequences relative to the target-binding site on the coiled coil A recurring theme in the interaction of the C-terminal helix of the trimer -of- hairpins with the coiled ... conserved amino acids of the LHR are located on the face of the LHR that interacts with the grooves on the coiled coil By examining the location of substituted residues on the HTLV-1 TM it becomes ... unfavourable charge interaction would improve the binding of the peptide to the BLV coiled coil and thereby improve the inhibitory activity of the peptide We therefore synthesized a peptide,...
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Interaction of burkholderia pseudomallei with cells of the immune system
... production The flagellae of many motile bacteria e.g Salmonella, are comprised of the basal body, the hook, and the filament that is composed mainly of the protein FliC (Macnab, 2004) The secretion of ... with the light microscope under high magnification to check for the absence of bacteria swimming among the cells in the medium Infection of T cells with live B pseudomallei in the absence of a ... facilitate therapeutic developments Our objective is to gain insights into the pathogenesis of the bacteria by employing the use of in vitro culture systems to study the interactions of B pseudomallei...
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Báo cáo khoa học: Interaction of gymnemic acid with cyclodextrins analyzed by isothermal titration calorimetry, NMR and dynamic light scattering doc
... thermodynamic parameters obtained are in the range of those of other interactions with c-CD [15] The interaction of GA with c-CD is accompanied by favorable DS values together with favorable DH values (Tables ... the tongue nor the binding affinity of GA to the receptor has been determined, the need for c-CD in the mm range would correlate with the binding affinity between GA and the receptor 6158 The thermodynamic ... held in the mouth [13] The specific binding of c-CD would cause dissociation of GA from the sweet taste receptor, resulting in recovery of the sweet taste Although neither the concentration of sweet...
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Báo cáo khoa học: Interaction of selenium compounds with zinc finger proteins involved in DNA repair pdf
... with the mutational analysis of Fpg, which revealed that substitution of any of the cysteines in the zinc finger destroys DNA-binding capacity and enzyme function, while substitution of the other ... elucidate interactions with the zinc finger domain of XPA more directly, the effects of selenium compounds on a synthetic 37 amino acid peptide, representing the zinc finger domain of the human ... molecule of PM2, I ¼ the percentage of supercoiled PM2 DNA, and II ¼ the percentage of open circular PM2 DNA The overall number of strand breaks per 10 000 bp represents the sum of single-strand...
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báo cáo khoa học: "Interaction of silver nanoparticles with HIV-1" pdf
... clear that the characteristic absorption of these nanoparticles arises from the contribution of different shapes and sizes, which agrees with the TEM observations On the other hand, the PVP-coated ... from the supernatant of each of the tested wells was divided by the number of bluestained cells obtained from the culture supernatant in the well of the positive control f) Cytotoxicity of silver ... relationships are also found on the surface of the untreated virus, as seen in the inset of Figure 1b The observed darker contrast at these sites could indicate the locations of the glycoprotein knobs...
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báo cáo khoa học: " Interaction of silver nanoparticles with Tacaribe virus" pot
... by the Ag-NPs alone As with the aggregation of Ag-NPs in solution, the largest aggregates formed with the virus are with the 10 nm uncoated AgNPs The Ag-NP-TCRV aggregate size is between the ... Page of Ag-NP interactions with TCRV Prior to determining the effect of Ag-NPs on TCRV infection, we wanted to conclude whether or not there are direct interactions between the Ag-NPs and the ... stronger than that of the NPs with each other TCRV neutralization by Ag-NPs When incubated with the virus hour prior to infection of the Vero cells, the 10 nm uncoated Ag-NP resulted in the most dramatic...
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báo cáo khoa học: " A compatible interaction of Alternaria brassicicola with Arabidopsis thaliana ecotype DiG: evidence for a specific transcriptional signature" pdf
... AKM conceived of the study together with the other authors, and carried out the major part of the experiments SL brought the compatible interaction phenotype of DiG to the attention of AKM and BAH, ... transcript levels of these genes varied with the amount of RNA and efficiency of the reactions, rather than with the treatment All data for the reference genes were therefore combined, and the entire ... that the DiG and Col-0 interactions with A brassicicola differ merely in the extent of sensitivity of the plant to the pathogen, the transcriptional profiles should be very similar in the two interactions...
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Interaction of polymeric nanoparticles with a model cell membrane a langmuir film balance technique
... in the subphase into the lipid monolayer can be correlated to their interaction with biomembranes [16] The influence of the physicochemical properties of Introduction nanoparticles on their interaction ... about the oral absorption of the particles, in particularly the distribution of the particles [14] It is the only means to determine the actual rate of uptake of ingested particles [14] The pit-fall ... are those with amphipathic properties as they can orient themselves at the interface between the droplets and the continuous phase i.e the lipophilic part of the molecule in the oil, the hydrophilic...
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Báo cáo khoa học: The influence of cholesterol on the interaction of HIV gp41 membrane proximal region-derived peptides with lipid bilayers potx
... all the peptide is in the water or lipidic phase, respectively; cL is the lipidic molar volume [26] and [L] is the concentration of the lipid accessible to the peptide (the outer leaflet of the ... by the particular disposition of key residues in the context of long peptides or even in the context of the full protein Bearing this in mind, a MPRP-S role in the interaction of the MPR with ... Castanho The membrane interaction behaviour of MPRP-C and MPRP-I is independent of the membrane phase but not of the presence of charged lipids Cholesterol does not reduce the extent of or potentiate...
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Báo cáo khoa học: Interaction of ostreolysin, a cytolytic protein from the edible mushroom Pleurotus ostreatus, with lipid membranes and modulation by lysophospholipids pptx
... insertion into the lipid lm, and an increase in a-helix at the expense of b-structure Such effects are independent of the presence of antioxidants The other is the effect of lysophospholipids, and ... lipid- bound protein, the spectrum of the protein was obtained by subtracting the contribution of the lipid alone, with a weight that minimized the band remaining at 1738 cm)1 (stretching of the carbonyl ... is the absorption with the 90 polarizer, and S are order parameters calculated from the ratio of the parallel and perpendicular absorption bands SL is for the lipid chains, derived from the...
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Tài liệu The Acquisition of Drugs and Biologics for Chemical and Biological Warfare Defense - Department of Defense Interactions with the Food and Drug Administration doc
... represented by the Office of the Assistant to the Secretary of Defense for Nuclear, Chemical, and Biological Warfare; the The Challenges of Acquisition 27 DATSD(CBD); the ASD(HA); the Office of the General ... justify the use of INDs in actual conflict on the grounds that the benefits of IND use (or the The Challenges of Acquisition 23 costs of nonuse) exceed the risks, such a decision runs the risk of ... inventory of IND drugs and vaccines for CBW defense? There are three problems First, the ease of use of licensed drugs is substantially greater than the ease of use of not-yet-approved drugs The decision...
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Tài liệu Báo cáo khoa học: Insights into the interaction of human arginase II with substrate and manganese ions by site-directed mutagenesis and kinetic studies Alteration of substrate specificity by replacement of Asn149 with Asp docx
... as a consequence of the mutagenic replacements Effects of the His120Asn and His145Asn mutations on the affinity of metal binding to arginase II To further examine the effects of the His120fiAsn and ... the interactions of arginase II with l-arginine and agmatine are greatly altered by replacement of this residue with aspartate To the best of our knowledge, this is the first report in which the ... being involved in the stabilization of the transition state [27], but not in the stabilization of the substrate in the Michaelis–Menten complex [24] Also in agreement with this, the Km value was...
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Tài liệu Báo cáo khoa học: Interaction of the small heat shock protein with molecular mass 25 kDa (hsp25) with actin doc
... electrophoresis The quantity of actin in the pellet was plotted against the total quantity of actin in the sample Results Heat denaturation of actin Before starting the investigation of the HSP25–actin interaction ... polymerization of intact actin and aggregation of heated actin Interaction of HSP25 with intact actin Fig Effect of heating on the kinetics of polymerization (A) and saltinduced increase of the light ... whereas the 3D mutant of HSP25 increased the rate of polymerization without affecting the maximal extent of polymerization (data not presented) We suppose that this effect of the 3D mutant of HSP25...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25