the heart and systemic lupus erythematosus
Báo cáo y học: " Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus" potx
... abnormalities in systemic lupus erythematosus Curr Immunol Rev 2005, 1:61-67 Perl A: Emerging new pathways of pathogenesis and targets for treatment in systemic lupus erythematosus and Sjogren’s syndrome ... activity and damage in systemic lupus erythematosus and lupus nephritis Arthritis Rheum 2008, 58:263-272 Nagy G, Koncz A, Philips PE, Perl A: Mitochondrial signal transduction abnormalities in systemic ... IL-12Rβ2 via cGMP Together, these data indicate that NO has a crucial role in the regulation of Th1/Th2 polarization Nitric oxide regulates T lymphocyte activation in systemic lupus erythematosus Considerable...
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Báo cáo y học: "Differential expression of chemokine receptors on peripheral blood B cells from patients with rheumatoid arthritis and systemic lupus erythematosus" ppsx
... osteoarthritis (OA), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) Box plots show the median values, 25th and 75th quartile and the range of values Significant differences from ... factor-α therapy The percentage of CXCR3hi and CXCR5+ B cells is shown for total B cells and the subpopulation of naive B cells Box plots show the median values, 25th and 75th quartile and the range ... SLE, systemic lupus erythematosus blood B cells supports their accumulation in the inflamed synovial tissue for RF A correlation of chemokine receptor expression and the level of RF was therefore...
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Báo cáo y học: "Effect of dsDNA binding to SmD-derived peptides on clinical accuracy in the diagnosis of systemic lupus erythematosus" potx
... A, Schoessler W, Werle E: Reactivities to the Sm autoantigenic complex and the synthetic SmD1-aa83-119 peptide in systemic lupus erythematosus and other autoimmune diseases J Autoimmun 2001, ... observed with PM1-α and Ribosomal P (b) The inhibitory effect of the SmD1 and SmD3 peptides was analysed by testing an antidsDNA-positive sample from a systemic lupus erythematosus patient on ... script AW performed the ELISAexperiments and helped with data analysis FH consulted in the evaluation of the data and helped to write the manuscript All authors read and approved the final manuscript...
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báo cáo khoa học: "Pigmented villonodular synovitis of the hip in systemic lupus erythematosus: a case report" pptx
... and the key words lupus , autoimmunity”, “kidney” or “proteinuria”, rendering a causal relationship between the underlying SLE or lupus nephritis and PVNS to be unlikely It is of note that the ... villonodular synovitis of the hip in systemic lupus erythematosus: a case report Journal of Medical Case Reports 2011 5:443 Conclusion This is the first reported association between PVNS and SLE which might ... persistent high fever and rashes, fatigue, diffuse arthralgia, leucopenia and hypocomplementemia A lupus flare-up was suspected ANAs and anti-dsDNA were 1:7680 and 2713 U/mL, respectively The prednisolone...
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Báo cáo y học: "Autoantibodies predate the onset of systemic lupus erythematosus in northern Sweden" potx
... study design and analysed and interpreted the data GH and GW contributed to the design of the study and were involved with the supply of the blood samples SRD designed the study, analysed and interpreted ... AfricanAmerican men with systemic lupus erythematosus Lupus 2003, 12:99-106 Borchers AT, Naguwa SM, Shoenfeld Y, Gershwin ME: The geoepidemiology of systemic lupus erythematosus Autoimmun Rev ... patients with systemic lupus erythematosus Arthritis Rheum 2001, 44:2367-2370 24 Lau CS, Yin G, Mok MY: Ethnic and geographical differences in systemic lupus erythematosus: an overview Lupus 2006,...
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Báo cáo y học: "Systemic lupus erythematosus and the type I interferon system" docx
... KL, Harley JB: The genetics of systemic lupus erythematosus: putting the pieces together Genes Immun 2002, (Suppl):S71-S85 Tsao BP: An update on genetic studies of systemic lupus erythematosus Curr ... occurring SLE The type I IFN system The type I IFN system comprises the inducers of type I IFN synthesis, the type I IFN genes and proteins, the cells producing type I IFNs, and the target cells ... healthy individuals and persons with systemic lupus erythematosus Arthritis Rheum 2002, 46:1417-1429 Casciola-Rosen LA, Anhalt G, Rosen A: Autoantigens targeted in systemic lupus erythematosus are...
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Báo cáo y học: "The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus" potx
... spleen, and to determine whether there are abnormalities in the pattern of somatic hypermutation and antigen selection To our knowledge, this is the first detailed study of the repertoire of the ... compared using the DNA plot 1.4 programme (W Müller, Institut für Genetik, Köln, Germany) The nomenclature for the V, D and J gene segments adopted here and the definitions of the CDRs were previously ... 0.0066), and VH5 was observed in 16.6% of the VH sequences in the present study as compared with the 3.92% that is theoretically expected (P = 0.046) The D gene family use was skewed towards D2 but the...
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Báo cáo y học: "Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" potx
... lupus erythematosus patients systemic TNF stimulation on gene expression in healthy individuals Effect of TNF stimulation on gene expression in healthy individuals and and systemic lupus erythematosus ... Winchester RJ: The 1982 revised criteria for the classification of systemic lupus erythematosus Arthritis Rheum 1982, 25:1271-1277 Gladman DD, Ibanez D, Urowitz MB: Systemic lupus erythematosus disease ... interleukin-12 and other Th1-type cytokines in patients with recent-onset systemic lupus erythematosus Arthritis Rheum 1998, 41:838-844 Liu TF, Jones BM: Impaired production of IL-12 in system lupus erythematosus...
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Báo cáo y học: "Practical and theoretical barriers to the prevention of accelerated atherosclerosis in systemic lupus erythematosus" docx
... Prevalence and risk factors of carotid plaque in women with systemic lupus erythematosus Arthritis Rheum 1999, 42:51-60 Salmon JE, Roman MJ: Accelerated atherosclerosis in systemic lupus erythematosus: ... asymptomatic patients with systemic lupus erythematosus Am J Med 1984, 77:286-292 Shome GP, Sakauchi M, Yamane K, Takemura H, Kashiwagi H: Ischemic heart disease in systemic lupus erythematosus A retrospective ... Rheum 1997, 40 (suppl):S219 Bulkley BH, Roberts WC: The heart in systemic lupus erythematosus and the changes induced in it by corticosteroid therapy A study of 36 necropsy patients Am J Med 1975,...
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Báo cáo y học: "Analysis of HLA DR, HLA DQ, C4A, FcγRIIa, FcγRIIIa, MBL, and IL-1Ra allelic variants in Caucasian systemic lupus erythematosus patients suggests an effect of the combined FcγRIIa R/R and IL-1Ra 2/2 genotypes on disease susceptibility" pptx
... for data analysis and interpretation and wrote the report AAB contributed to the data analysis and interpretation GS and LT were both responsible for the planning of the work and contributed to ... Hay E, et al.: The development and initial validation of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index for systemic lupus erythematosus Arthritis ... rates for the R allele and the allele (i.e the patient should have at least one R allele and one allele) was also performed, but no significant difference was detected between the SLE and the control...
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Báo cáo y học: "The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus" ppt
... and sequenced (data not shown) to confirm the presence of the wt.DNase I or ash.DNase I construct To confirm the expression and secretion of DNase I from the T cells in the transgenic mice, the ... of the analysis and compiled the manuscript FC performed part of the immunoassays HTK carried out the renal histological analysis RAL contributed to the development of some of the assays, to the ... from the circulation is responsible for the development of the lupus- like disease observed in Apcs-/- mice [35,36] These observations made Apcs-/- mice an ideal model to test whether increasing the...
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Báo cáo y học: "Autoantibodies against the replication protein A complex in systemic lupus erythematosus and other autoimmune diseases" pps
... technical help and advice for immunoassays, took immunofluorescent ANA pictures, and also helped edit the manuscript MS designed and coordinated the study, performed the immunoassays and the data analysis, ... with all three components of RPA; of the remainder, one reacted with RPA70 and RPA32, one reacted with RPA14 only, and one was negTable Systemic lupus erythematosus criteria of cases with anti-RPA ... coexist and thus about 80% of SSc has one of these autoantibodies [30] In PM/DM, patients with antiaminoacyl tRNA synthetase antibodies have antibodies against only one of the synthetases, and other...
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Báo cáo y học: " Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" pptx
... lupus erythematosus patients systemic TNF stimulation on gene expression in healthy individuals Effect of TNF stimulation on gene expression in healthy individuals and and systemic lupus erythematosus ... Winchester RJ: The 1982 revised criteria for the classification of systemic lupus erythematosus Arthritis Rheum 1982, 25:1271-1277 Gladman DD, Ibanez D, Urowitz MB: Systemic lupus erythematosus disease ... interleukin-12 and other Th1-type cytokines in patients with recent-onset systemic lupus erythematosus Arthritis Rheum 1998, 41:838-844 Liu TF, Jones BM: Impaired production of IL-12 in system lupus erythematosus...
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Báo cáo y học: " Systemic lupus erythematosus associated with type 4 renal tubular acidosis: a case report and review of the literatur" pps
... contributions HP and NM collected the data and drafted the manuscript HP and JL contributed to the treatment of the patient LY and OL participated in critical revision of the report and helped draft the manuscript ... report and any accompanying images A copy of the written consent is available for review by the Editor-inChief of this journal Abbreviations RTA: renal tubular acidosis; SLE: systemic lupus erythematosus; ... in systemic lupus: clinical and laboratory findings Am J Kidney Dis 1985, 6:59-63 Li SL, Liou LB, Fang FT, Tsai WP: Symptomatic renal tubular acidosis (RTA) in patients with systemic lupus erythematosus: ...
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Báo cáo y học: "A GA microsatellite in the Fli1 promoter modulates gene expression and is associated with systemic lupus erythematosus patients without nephritis" potx
... SLE: Systemic Lupus Erythematosus; SLEIGH: Systemic Lupus Erythematosus in Gullah Health Acknowledgements This work was supported by a grant from the Alliance for Lupus Research awarded to TKN and ... 10-70 (39) The number of patients and controls and the median age ranges for the Carolina Lupus (CLU) study, Medical University of South Carolina (MUSC) clinic, and System Lupus Erythematosus ... 241 (p < 0.05) 241 Summary of results for the Carolina Lupus (CLU) study African American (AA) and Caucasian participants and for the Systemic Lupus Erythematosus in Gullah Health (SLEIGH) participants...
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Báo cáo y học: " The interplay of inflammation and cardiovascular disease in systemic lupus erythematosus" doc
... damage and plaque formation in systemic lupus erythematosus IFN-α contributes to endothelial dysfunction and decreased repair of endothelial damage by decreasing numbers and function of endothelial ... resistance and coronary atherosclerosis Lupus 2009, 18:799-806 53 Clancy R, Ginzler E: Endothelial function and its implications for cardiovascular and renal disease in systemic lupus erythematosus ... in endothelial function and vascular repair may contribute to the survival benefit More research into the vascular effects of antimalarials is needed to understand their benefits and whether they...
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Báo cáo y học: "TLR7 single-nucleotide polymorphisms in the 3’ untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study" ppsx
... not of the other haplotypes All of these results support the possibility that the possession of both the 3’UTR and intronic risk alleles may confer further risk for SLE Although rs179019 and rs179010 ... between the two (Table and Figure 1) In agreement with these findings, when only the patients and controls carrying the risk genotypes of the 3’ UTR SNP were analyzed, possession of both of the intronic ... controls and collected clinical information NT designed and coordinated the study and helped in the manuscript preparation All authors read and approved the final manuscript Competing interests The...
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Báo cáo y học: "Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis" pot
... in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) even though both Gas6 and sAxl in most of the patients were within the normal range [13] Systemic lupus erythematosus (SLE) and ... and TS participated in the design of the study, in the analysis of the patient cohorts, in the statistical analysis and in the writing of the manuscript BD initiated, planned and supervised the ... Pascual V: Type I interferon in systemic lupus erythematosus and other autoimmune diseases Immunity 2006, 25:383-392 37 Pascual V, Farkas L, Banchereau J: Systemic lupus erythematosus: all roads lead...
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Identification and characterization of a novel heart reactive autoantibody in systemic lupus erythematosus possible serological marker for early myocardial dysfunction
... less obvious The lowest overall incidence was found in Iceland and Japan and highest in USA and France The overall prevalence was the lowest in Northern Ireland, UK and Finland, and the highest ... 1: The role of environment in SLE Adapted from “Environment and systemic lupus erythematosus: an overview.” (Sarzi-Puttini et al 2005) 1.1.2.3 Hormones The prevalence of systemic lupus erythematosus ... Introduction 1.1 Systemic lupus erythematosus Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disease characterized by a wide array of clinical manifestations, from mild skin and mucosal...
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Báo cáo y học: "Decreased levels of soluble amyloid β-protein precursor and β-amyloid protein in cerebrospinal fluid of patients with systemic lupus erythematosus" ppsx
... neuropsychiatric systemic lupus erythematosus logical status, served as controls in the present study CSF-tau levels and CSF-Aβ42 levels from the 53 patients, and CSF-APP levels from 35 of these 53 healthy ... manifestations of the CNS involvement NPSLE, neuropsychiatric systemic lupus erythematosus used was multiplanar MRI The MRI examinations (Philips Gyroscan NT5, Einhoven, The Netherlands) were performed ... patients with CNS lupus [9,10] Elevated concentrations of IgG in the cerebrospinal fluid (CSF), of the IgG–albumin ratio and of the IgG index, and the presence of oligoclonal bands have all been...
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