the function of protocols
Tài liệu Báo cáo khoa học: Chemical approaches to mapping the function of post-translational modifications ppt
... [11,12]. The study of these events istaxing, as the biosynthesis of glycoproteins is not tem-plate driven. This results in the formation of so-called‘glycoforms’ [11,12], proteins with the same ... 1957catalyze enhanced hydrolytic degradation of the targetprotein.More recently, the glycoMTS method has allowed the synthesis of the first examples of a homogeneousprotein bearing symmetrically ... scaf-fold. These terms reflect not only the linearity orconvergence of the chemical steps that may lead to agiven synthetic protein, but also the structural strategythat links the (linear) segments of...
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Báo cáo khoa học: The influence of heterodimer partner ultraspiracle/retinoid X receptor on the function of ecdysone receptor pot
... amount of RXR pulled down byEcR in the presence of ligand was maximum in the case of HsRXR and minimum in the case of the Hs–LmRXR chimera, and LmRXR was betweenthese two (Fig. 9). These data ... concentrations of ligandsfor the transactivation of genes and functions wellin vivo. The RXR chimeras containing most of HsRXR and helix 9 and the loops on either side of helix 9 from HsRXR or mutants of ... beenused in the place of USP in all EcR gene switchesdeveloped to date. One of the major limitations of cur-rent versions of EcR gene switches is the requirement of micromolar concentrations of ligand...
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Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
... posi-tioned in the connecting loops. Approximately one-third of all mutations in the BTK gene are missenseand some of these reduce the stability of the protein.This is exemplified by mutations in the ... identify individualswith mild disease, thereby providing the missing data. The phenotype of XLA and the potential of BTK and ITK inhibitors The outcome of defective BTK signaling in humanshas ... regarding their potential function, itwas the identification of BTK, as the kinase affected inXLA [9,10], which immediately made TFKs known to the wider scientific community. In the same year, the xid...
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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
... [9]. The KIND domain in theseproteins is localized to the N-terminal region, and theirspecific functional domains are located in the C-termi-nal region. The C-lobe of protein kinases mediates the interaction ... under-stood, the data obtained in the present study indicatethat the 43 residues (amino acids 702–744 in mice) thatreside in the middle region of the CD act as the v-KIND binding core. The v-KIND-binding ... between the Leu residues from v-KIND and MAP2 contributes to the interaction between the two proteins.In conclusion, the present study has clarified the structural and functional importance of the...
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf
... in all of these conditions [22]. In the trau-matically injured brain, however, the synthesis of MT1and MT2, as well as the synthesis of GIF, are up-regu-lated by reactive astrocytes in the vicinity ... lossin the AD brain. Further investigation of the increasedneurotrophic activity of the AD brain revealed that itcorrelated with the loss of a specific neuroinhibitoryfactor, rather than the presence ... inhibit neurite outgrowth (as described above). The functional role of GIF synthesis and secretionin the brainTaken together, the regulation of GIF synthesis byreactive astrocytes, and its subsequent...
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Tài liệu Body Size: The Structure and Function of Aquatic Ecosystems pptx
... W,issimply the sum ofthe body mass of all individuals. For organisms ofsimilar size, itcan be estimated by taking the product of the population, N,andthebodymass,M. Similarly, the store of each ... obvious.We asked the author(s) of each paper to examine the importance and role of body size in the systems in which they work. Essentially the book builds from the level of the individual and ... linksbetween the processing of energy and elements at the individual level to the flux, storage and turnover of these elements at the level of ecosystems.Our second example concerns the role of metabolism...
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Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx
... dif-ferent apoptotic stimuli. Thus, the apoptotic volumedecrease may further disarrange the balance betweensurvival and death signals, thereby promoting execu-tion of the apoptotic program.Concluding ... changes trigger signals involved in the regulation of metabolism, gene expression and the susceptibilityto different kinds of stress [6]. For example, the inhibi-tion of autophagic proteolysis by ... a functional outcome.This minireview summarizes recent progress in the understanding of howosmosensing and osmosignaling integrate into the overall context of growthfactor signaling and the...
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Tài liệu Báo cáo khoa học: Helix mobility and recognition function of the rat thyroid transcription factor 1 homeodomain – hints from 15N-NMR relaxation studies pdf
... interruption of the geometry of the recognition helix for either Antp or the TTF-1HD, the anomalous amide exchange pattern and the NOE connectivity data of the C-terminal portion of helix III ... respec-tively. The proximity to one of the intercepts between the theoretical and fitting curves reflects the relativecontribution of each component Lorentzian function to the specific spectral density of ... conflict with the global interpretation of the data. With the exclusion of the N-terminal octapeptidyl and C-terminal nonapept-idyl fragments of Glu17, Leu34 and Lys46, the average of the {1H}–15N...
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Tài liệu Global Change and the Function and Distribution of Wetlands ppt
... greater than the rate of decomposition. Therefore, the nature of the accumulated organic matter can then be used as a proxy to represent the composition of the former wetland communities at the site. ... Stratigraphic Commission, the beginning of the Pleistocene now coincides with the base of the Quaternary ( Gibbard et al. 2009 ) . The Holocene begins at the end of the Pleistocene (Walker et ... environmental information at the regional, rather than at the local scale. Nevertheless, the spatial resolution of the pollen fl ora is strongly in fl uenced by the size and nature of the depositional setting...
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Tài liệu Báo cáo khoa học: Expression and function of Noxo1c, an alternative splicing form of the NADPH oxidase organizer 1 doc
... inregulation of Nox3, the role of the PX domain in Nox3activity remains unknown.In the process of cloning of human Noxo1, somespliced transcripts of the NOXO1 gene have beenidentified [15,17–19]. They ... between the pair of primers(Fig. 2A). The lengths of the PCR products of Noxo1band Noxo1c were 225 and 240 bp, respectively. Todelineate the difference in the two products, we subjec-ted the ... activity of the PXdomains of Noxo1b and Noxo1c The membrane localization of Noxo1b is mediated inpart by binding of the PX domain to membrane phos-pholipids [19]. Less association of Noxo1c with the membrane...
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Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc
... studies. The highselectivity of the a-conotoxins, together with the possibility of obtaining detailed information on their three dimen-sional structures and the relative ease of synthesis, makesthem ... identified in acloning approach making use of the high conservation of the 3¢ untranslated region and the intron preceding the sequence of the a-prepropeptide [39]. The peptide wascharacterized on oocyte-expressed ... and the deter-mination of their precise subunit composition andphysiological function( s). Compared to the musclenAChR, relatively little is known about the function andcomposition of the...
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Tài liệu Báo cáo khoa học: Cold survival in freeze-intolerant insects The structure and function of b-helical antifreeze proteins pdf
... attributed to the lack of a hydrophobic core typically found in globular proteins.Instead, there is a rung of disulphides down the middle of the protein. The addition of dithiothreitol destroys the THactivity ... activity.Examination of the crystal structure of sbwAFP did notFig. 6. Bound water molecules extend the ice-binding face of insectAFPs. The position of the water oxygen atoms along the TXT f acefound in any of ... determine the handedness of the proteins, ormay prevent the unfolding of the protein at cold temper-atures. The b-helix as an AFP structural motif? The sbwAFP and TmAFP structures represent the firstAFPs...
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THE EFFECTS OF MEGAMERGERS ON EFFICIENCY AND PRICES: EVIDENCE FROM A BANK PROFIT FUNCTION docx
... to change the size of their asset portfolio because of the size of their markets and/or because of regulatory restrictions ontheir expansion.In this event, the efficiency of smaller firms ... data set.IV. The Profit Efficiency Effects of Megamer~ers The Level of Profit Efficiency.We begin discussing the results with some information on the levels of profit efficiency of merging and ... ‘standard profit efficiency model in equations (1) andparameters of the model. The level of profit efficiency the ratio of predicted profits to maximum or optimal profits on the frontier...
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- micrornas mirnas are noncoding regulatory rnas that function via the degradation of target mrnas and inhibition of translation they are found widely in higher eukaryotic organisms
- the social function of law
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- the function of data link layer
- the function of energy in the human body
- the function of public international law
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