the function of dna and rna
Báo cáo khoa học: Human telomeric G-quadruplex: structures of DNA and RNA sequences ppt
Ngày tải lên :
06/03/2014, 09:22
... G-tracts of one strand and only the 3¢-end G-tract of the other strand [30] (Fig 3D) The core of this structure, called the (3 + 1) core, has three strands oriented in one direction and one strand ... G-quadruplexes, there remain many challenges associated with the structure and molecular recognition in the human telomeres These include: (a) the structure and dynamics of all possible DNA, RNA and DNA ⁄ RNA ... to the situation for human telomeric DNA A Long human telomeric DNA and RNA sequences The next step toward understanding the structure of the ‘real’ telomeres is to address the question on the...
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Báo cáo sinh học: "Hierarchical folding of multiple sequence alignments for the prediction of structures and RNA-RNA interactions" doc
Ngày tải lên :
12/08/2014, 17:20
... amount of the RNA- RNA interactions contain compensatory base changes across the binding sites The algorithm presented herein is an extension of the PETfold algorithm [25] and makes further use of the ... description of the scoring of single-stranded positions However, they are scored the same way as in the original PETfold approach; for more details, see [25] The PETfold score is the sum of the evolutionary ... s1 and s … s , where s1 is a ncRNA and s is its target sequence For convenience, we adopt the convenk tion of RNAcofold and assume that the positions in s1 k k are numbered ≤ i ≤ | s1 | and the...
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Báo cáo y học: "Comparative modeling of DNA and RNA polymerases from Moniliophthora perniciosa mitochondrial plasmid" doc
Ngày tải lên :
13/08/2014, 16:20
... years [2] The aim of this work to carry out homology modeling of both DNA and RNA polymerases from the linear mitochondrial plasmid of M perniciosa With the accomplishment of this work, these models ... observed in the whole structure As well as other polymerases from that family, this polymerase showed the three standard domains of the group: Palm, Fingers, and Thumb The active site of the DNA polymerase ... structure of the DNA ciosa mitochondrial plasmid polymerase from the M perniThe 3D The 3D structure of the DNA polymerase from the M perniciosa mitochondrial plasmid Magenta: helices; yellow: strands;...
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The mammalian transcriptome and the function of non-coding DNA sequences pdf
Ngày tải lên :
09/08/2014, 20:20
... hand and the developmental complexity of organisms on the other, although the reasons for the abundance of intron sequences and their functions in higher organisms are not fully understood The ... microRNAs and small temporary RNAs (stRNAs) that inhibit translation of target mRNAs, small nuclear RNAs (snRNAs) that function as components of spliceosomes, and small nucleolar RNAs (snoRNAs) ... function of ncRNAs has expanded far beyond the initial notion of their being intermediates and accessories in protein biosynthesis The size of ncRNA molecules ranges from 20 nucleotides (microRNAs)...
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Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
Ngày tải lên :
14/02/2014, 18:20
... onethird of all mutations in the BTK gene are missense and some of these reduce the stability of the protein This is exemplified by mutations in the BTK motif of the Tec homology (TH) domain [18] ... identify individuals with mild disease, thereby providing the missing data The phenotype of XLA and the potential of BTK and ITK inhibitors The outcome of defective BTK signaling in humans has ... low and often undetectable in immunoblot analysis The activation of CD4+ cells, however, dramatically induces transcription of the ITK gene and is key for the productive infection of HIV in these...
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Tài liệu Báo cáo khoa học: Regulation of DNA fragmentation: the role of caspases and phosphorylation doc
Ngày tải lên :
14/02/2014, 22:20
... emphasis on the induction of DNA fragmentation, which is one of the most typical characteristics of apoptosis Regulators of DNA fragmentation One of the terminal processes of apoptosis is DNA degradation ... They induce the permeabilization of the mitochondrial membrane with the release of cytochrome c and the formation of the apoptosome [38] The major pro-apoptotic protein Bax exists mainly in the ... signal on and off Caspase activation is under the direct control of kinases and phosphatases, and the indirect control of phosphorylation through the regulation of other apoptotic proteins Furthermore,...
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Tài liệu Báo cáo khoa học: Identification of Ewing’s sarcoma protein as a G-quadruplex DNA- and RNA-binding protein ppt
Ngày tải lên :
15/02/2014, 01:20
... 589 and 597 within RGG3 are important for the binding of RGG3 to G-quadruplex DNA and RNA In ssDNA and ssRNA RGG3 (nM) Fraction of RNA bound Fig Binding affinity of RGG3 to Htelo or rHtelo The DNA ... poly G and poly U RNA in vitro [8] On the other hand, Hume et al [15] suggested that EWS binds to the proximal-element DNA of the macrophage-specific promoter of the CSF-1 receptor gene The RGG ... identify the role of EWS and the possible function of such G-quadruplex structures in genomic DNA Materials and methods Preparation, expression and purification of GST fusion proteins The EWS cDNA...
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Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc
Ngày tải lên :
19/02/2014, 12:20
... domain of each subunit contributes to the formation of the hydrophilic pore ACh binding protein has structural and functional homology to the extracellular ligand binding domain of the nAChR, and ... genomic DNA from other cone snail tissues The analysis of the DNA of different Conus species has already revealed a large number of a-conotoxin sequences [45] and the identification of further specific ... because of the impossibility of direct electrophysiological recordings and their incomplete pharmacological characterization Furthermore, the distance of the projection areas from the cell bodies and...
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Tài liệu Báo cáo Y học: Temperature dependence of thermodynamic properties for DNA/DNA and RNA/DNA duplex formation pdf
Ngày tải lên :
22/02/2014, 07:20
... and mss are the intercepts and slopes of the lower and upper baselines of the melting curves, respectively; T is the temperature of interest in Kelvin, a is the molar fraction of strands in the ... sets of the temperature-dependent thermodynamics for the DNA/ DNA and RNA /DNA oligonucleotide duplexes In the present study, we determined the temperatureindependent and temperature-dependent thermodynamic ... As the enthalpy and entropy changes are state functions, their values, in nature, are dependent on the temperature of interest Table summarizes the thermodynamic parameters of the 24 DNA/ DNA and...
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Báo cáo khoa học: The oxidative effect of bacterial lipopolysaccharide on native and cross-linked human hemoglobin as a function of the structure of the lipopolysaccharide A comparison of the effects of smooth and rough lipopolysaccharide ppt
Ngày tải lên :
08/03/2014, 10:20
... comparison of the effects of rough and smooth LPSs of E coli, both in the presence and absence of EDTA (Fig 1) The rate of oxidation was increased in the presence of the LPSs of both the smooth and rough ... measure of the rate of oxidation of oxyHb RESULTS The effect of pH on the auto-oxidation of cross-linked Hb was studied The rate of decrease of the concentration of oxyHb increased as the pH was ... effects of the LPSs of rough and smooth E coli on the oxidation of Hb A0, both in the presence and absence of EDTA, is provided in Fig The rate of oxidation was increased in the presence of the LPSs...
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Báo cáo khoa học: The structural basis for catalytic function of GMD and RMD, two closely related enzymes from the GDP-D-rhamnose biosynthesis pathway pdf
Ngày tải lên :
16/03/2014, 01:20
... disease and reduced lung function [20] An eight-gene cluster encodes functions for synthesis and export of A-band O polysaccharide [21,22], and contains genes for the expression of GMD and RMD ... both the P aeruginosa and A thermoaerophilus RMD sequences have gaps in the region of the RR loop, and in the His6-RMDAt structure, the b2–b3 loop is notably shorter than in GMD The truncation of ... The cofactor-binding domain and the substratebinding domain are shown in aqua and light sand, respectively; the APPR portion of the cofactor (dark gray) and the ligand analog GDP-DMan (light gray)...
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Báo cáo khoa học: Protein engineering of pyruvate carboxylase Investigation on the function of acetyl-CoA and the quaternary structure doc
Ngày tải lên :
16/03/2014, 16:20
... PC-(BC) and PC-(CT + BCCP) The boundary of the BC and CT domains of B thermodenitricans PC was estimated to reside at residue 462 on the basis of the reasoning described in the Results section The ... regulator in the interaction between the active site of the BC domain and the biotin moiety of the BCCP domain Based on these arguments, it is tempting to propose the following hypothesis: in the absence ... upon addition of acetylCoA and the activity in the absence of acetyl-CoA was approximately 0.3% of the maximum (Table 1) PC is known to catalyze the cleavage of ATP in the absence of pyruvate [21]...
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Báo cáo Y học: The function of methyl-menaquinone-6 and polysul®de reductase membrane anchor (PsrC) in polysul®de respiration ofWolinella succinogenes doc
Ngày tải lên :
24/03/2014, 03:21
... phospholipids from the membrane fraction and from the liposomes The activity of polysulđde respiration with H2 increased hyperbolically with the amount of MM The activity was 50 and 80% of the maximum ... reductaseế NrfA of E coli is known to be the catalytic subunit of this enzyme [37] The gene product of nrfD was proposed to encode the membrane anchor of the enzyme and to carry the site of quinol ... codons into the genome of the DpsrC mutant All the mutants so obtained had PsrA bound to the membrane, and the speciđc activities of Psr were similar to those of the wild-type strain Hence, the integration...
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Báo cáo Y học: Thermodynamics and kinetics of the cleavage of DNA catalyzed by bleomycin A5 A microcalorimetric study pdf
Ngày tải lên :
24/03/2014, 04:21
... Eqns (19) and (20), respectively m Thermodynamics of the binding of ADM and (1,10-phenanthroline)-copper to DNA Fig A comparison of the UV and visible spectrum of BLM-A5 after the cleavage of calf ... curves The molar ratio, r, of DNA to L is defined as r ¼ nDNA;0 =nL;0 ¼ DNA 0 =½L0 ð17Þ where nDNA,0 and nL,0 are the initial amounts of DNA and L, respectively Substituting Eqns (15) and (17) ... binds to DNA and DNA L the complex between DNA and L The intrinsic binding constant, KB, is defined by the equation [24,28,29]: KB ¼ y ð1 À yÞð DNA 0 À ny½L0 Þ ð14Þ Here, [DNA] 0 and [L]0 are the initial...
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Chapter 2Communicating Over the Network Quangkien@gmail.com.OverviewDescribe the structure of a network, including the devices and media that are necessary for successful communications. Explain the function of protocols in network communications. Ex potx
Ngày tải lên :
01/04/2014, 12:20
... particular software implementation of a computer networking protocol suite The terms are often used interchangeably Strictly speaking, the suite is the definition of the protocols, and the stack is the ... advantages of using a layered model to describe network functionality Describe the role of each layer in two recognized network models: The TCP/IP model and the OSI model Describe the importance of addressing ... and benefits Criteria for choosing a network media are: – The distance the media can successfully carry a signal – The environment in which the media is to be installed – The amount of data and...
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CURRENT BASIC AND PATHOLOGICAL APPROACHES TO THE FUNCTION OF MUSCLE CELLS AND TISSUES – FROM MOLECULES TO HUMANS pdf
Ngày tải lên :
28/06/2014, 15:20
... sparks, but provides the necessary amount of Ca2+ to charge up the ER and sensitize the RyR [52] Another way of internal store reloading is achieved by the various isoforms of the transient receptor ... representing the position of the particle, were also taken to represent the position of the myosin head The position of the myosin head, determined by the above method, was compared between the two ... Figure Alternative splicing of the human ATP2A2 genes, protein sizes of the SERCA2 isoforms A Representation of the 3'-end of the human ATP2A2 gene Broken lines with letters represent alternative...
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Báo cáo khoa học: "Comparison of RBE values of high- LET a-particles for the induction of DNA-DSBs, chromosome aberrations and cell reproductive death" potx
Ngày tải lên :
09/08/2014, 09:20
... distance of 50 mm underneath the dishes and the particles passed through 50 mm of helium and the thin mylar bottom of the culture dishes before entering the cells through the bottom of the dishes ... fraction of the DSB (about 1% of DSB induced by g-rays and about 10% by a-particles) are causing cell death On the other hand, the values of a for formation of chromosome fragments and colour ... problem The RBE value of 14.6 for cell reproductive death is similar to values in the range of to 15 published for many other lines of cultured cells [45] The RBE of derived for the induction of DNA- DSB...
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báo cáo khoa học: "Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251" pdf
Ngày tải lên :
10/08/2014, 10:21
... pathway to further our current understanding of the underlying mechanisms of AdbFGF-siRNA-induced growth suppression and apoptosis of glioma cells Materials and methods 2.1 Cell Culture and Adenovirus ... Interestingly, the expression of pSTAT3 Ser727 moderately decreased at 24 and 48 h and then restored to the control level at 72 h Furthermore, compared with the levels under the control and Ad-GFP ... http://www.jeccr.com/content/30/1/80 Page of Figure Ad-bFGF-siRNA reduces the activation of upstream molecules and the expression of downstream molecules of STAT3 in U251 cells (A) Ad-bFGF-siRNA (MOI = 100) reduces the phosphorylation/activation...
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Saladin Anatomy and Physiology The Unity of Form and Function Episode 3 pps
Ngày tải lên :
12/08/2014, 16:21
... (b) DNA directs the synthesis of proteins by means of its smaller cousins, the ribonucleic acids (RNAs) There are three types of RNA: messenger RNA (mRNA), ribosomal RNA (rRNA), and transfer RNA ... from the replication fork on one strand and toward it on the other strand (b) The result is two DNA double helices, each composed of one strand of the original DNA and one newly synthesized strand ... in RNA (see fig 4.2) The essential function of RNA is to interpret the code in DNA and direct the synthesis of proteins RNA works mainly in the cytoplasm, while DNA remains safely behind in the...
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Saladin Anatomy and Physiology The Unity of Form and Function Episode 5 ppt
Ngày tải lên :
12/08/2014, 16:21
... on the other The head of the humerus fits into the glenoid cavity of the scapula, and the head of the femur fits into the acetabulum of the os coxae These are the only multiaxial joints of the ... Movements of the Scapulae and Mandible (a) Elevation of the scapulae; (b) depression of the scapulae; (c) protraction of the mandible; (d) retraction of the mandible; (e) lateral excursion of the mandible; ... example is the atlantooccipital joint of the neck, where the muscles of the back of the neck pull down on the nuchal lines of the skull and oppose the tendency of the head to tip forward Loss of muscle...
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