the environment in the pathogenesis of systemic lupus erythematosus 1
Báo cáo y học: "Effect of dsDNA binding to SmD-derived peptides on clinical accuracy in the diagnosis of systemic lupus erythematosus" potx
... 34249 348 14 0 8 .1 4.6 >200.0 13 .4 5 .1 Positive 35784 494 553 8.9 5.6 >200.0 >10 0.0 8.3 Positive Number/ number positive 19 /19 19 /19 18 /19 16 /19 14 /19 9 /19 19 /19 19 /19 aThe sample value in luminescence ... 1. 6 71. 2 0.7 11 .1 Positive 28746 14 3 16 9 4.3 2.6 18 1.3 1. 1 9.2 Positive 29236 98 16 4 5.9 1. 7 18 2 264 6.8 Positive 29354 450 225 4.0 2 .1 32.4 4.2 12 .1 Positive 29659 16 1 13 2 4.9 2.2 30 .1 3.3 11 .6 ... contain sDMA, and this constitutes a major autoepitope within the C-terminus of SmD1 and SmD3 [14 ,18 ,37] In one of these studies, a synthetic peptide of SmD1 (amino acids 95 11 9) containing sDMA...
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Báo cáo y học: "Autoantibodies predate the onset of systemic lupus erythematosus in northern Sweden" potx
... Talal N, Winchester RJ: The 19 82 revised criteria for the classification of systemic lupus erythematosus Arthritis Rheum 19 82, 25 :12 71- 1277 18 Hochberg MC: Updating the American College of Rheumatology ... (2.5) 8 .1 (2.3) RNP 5.9 (2.5) 7.5 (2.5) Histones 5.0 (1. 5) 6.5 (1. 9) ANA La/SSB 16 4 .1 (0.8) 4.0 (1. 0) 7.5 (1. 2) 7.0 (0.6) dsDNA 3.6 (1. 2) 6.6 (2.0) Jo -1 2.4 (1. 1) 3 .1 (1. 1) Scl-70 1. 4 (0.6) 2 .1 (0.9) ... 2):ii28-ii 31 doi :10 .11 86/ar3258 Cite this article as: Eriksson et al.: Autoantibodies predate the onset of systemic lupus erythematosus in northern Sweden Arthritis Research & Therapy 2 011 13 :R30...
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Báo cáo y học: "Hypoxia in the pathogenesis of systemic sclerosis" ppt
... [16 ,17 ] In contrast, levels of HIF -1 decreased when deacetylation was inhibited Finally, mRNA and protein levels of ARD -1 are diminished under hypoxia, resulting in less acetylated HIF -1 [16 ] ... is inhibited and HIF -1 protein accumulates Binding of HIF -1 to HIF binding sites, formation of the transcriptional complex and regulation of HIF -1 transactivation After translocation into the ... http://arthritis-research.com/series/ar_Hypoxia 16 17 18 hypoxia, blocking of TGF-β signalling might be one approach to target at least in part the hypoxia-induced matrix production in SSc 19 Competing interests The authors declare that they...
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Báo cáo y học: "The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus" ppt
... pathogenic autoantibody-inducing T cells of lupus J Exp Med 19 93, 17 7 :13 67 -13 81 Gardner WD, Hoch SO: Binding specificity of the two major DNA-binding proteins in human serum J Biol Chem 19 79, 254:5238-5242 ... induced in mice by the administration of a single high dose of LPS This induces a pulse of nucleosomes and chromatin in the plasma within the first 12 hours post-injection accompanied by an increase ... Dnase1 and the plasminogen system Arthritis Rheum 2004, 50 :18 73 -18 83 Puccetti A, Madaio MP, Bellese G, Migliorini P: Anti-DNA antibodies bind to DNase I J Exp Med 19 95, 18 1 :17 97 -18 04 Page 11 of 11 ...
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Báo cáo y học: "Association of the diplotype configuration at the N-acetyltransferase 2 gene with adverse events with co-trimoxazole in Japanese patients with systemic lupus erythematosus" pps
... Talal N, Winchester RJ: The 19 82 revised criteria for the classification of systemic lupus erythematosus Arthritis Rheum 19 82, 25 :12 71- 1277 20 Hochberg MC: Updating the American College of Rheumatology ... Society for the Promotion of Science Available online http://arthritis-research.com/content/9/2/R23 References 10 11 12 13 14 15 16 17 18 19 Bozzette SA, Finkelstein DM, Spector SA, Frame P, ... We also investigated the involvement of genetic polymorphisms of the GSTT1 and GSTM1 genes in the occurrence of adverse events with co-trimoxazole (data not shown) Nevertheless, none of the GST...
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Báo cáo y học: "Development and management of systemic lupus erythematosus in an HIV-infected man with hepatitis C and B co-infection following interferon therapy: a case report" doc
... Sánchez-Tapias JM, Ingelmo M: Hepatitis C virus infection mimicking systemic lupus erythematosus: study of hepatitis C virus infection in a series of 13 4 Spanish patients with systemic lupus erythematosus ... problem of increasing clinical significance Interferon (INF) therapy is the mainstay of HCV treatment HCV and HIV have been associated with the development of autoimmune markers and disease; INF therapy ... effect of HIV DCs can be infected by HIV, and TLR9 signalling-changes in pDC function may be reduced indirectly by HIV gp120 [14 ] Loss of pDC in HIV infection usually parallels the loss of CD4 [15 ],...
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Báo cáo y học: " Dissemination of Strongyloides stercoralis in a patient with systemic lupus erythematosus after initiation of albendazole: a case report" docx
... images A copy of the written consent is available for review by the Editor -in- Chief of this journal References 10 11 12 13 Conclusion Clinicians should be aware that the S stercoralis hyperinfection ... corticosteroid administration for this disease [8] Dissemination may involve gut, stomach, lung and/or cerebrospinal fluid [9 ,10 ] Furthermore, larval penetration of the intestinal wall during dissemination ... occur several days into appropriate antihelminth therapy and should remain vigilant for signs of sepsis even during the early days of therapy Our findings are based on a single case report, and...
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Báo cáo y học: "Vitamin D receptor gene BsmI polymorphisms in Thai patients with systemic lupus erythematosus" potx
... gamma-interferon production in patients with systemic lupus erythematosus Arthritis Rheum 19 86, 29 :12 10 -12 15 Kelley VR, Wuthrich RP: Cytokines in the pathogenesis of systemic lupus erythematosus ... important intellectual content and have given final approval of the version to be published All authors read and approved the final manuscript 10 11 12 13 14 15 16 17 18 19 20 21 Acknowledgements The ... (8 /10 1) Renal disorder 50 (1/ 2) 68 .18 (15 /22) 64.93 (50/77) 65.34 (66 /10 1) Neurologic disorder (0/2) 9.09 (2/22) 20.77 (16 /77) 17 .82 (18 /10 1) - Seizure (0/2) 9.09 (2/22) 15 .58 (12 /77) 13 .86 (14 /10 1)...
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Báo cáo y học: "Culture-negative bivalvular endocarditis with myocardial destruction in a patient with systemic lupus erythematosus: a case report." ppsx
... edited the manuscript All authors participated in approving the final manuscript Competing interests The authors declare that they have no competing interests Received: April 2 011 Accepted: 14 September ... Study in 819 New Cases CID 2 010 , 51( 2) :13 1 -14 0 doi :10 .11 86 /17 49-8090-6 -10 9 Cite this article as: Laurence and Suh: Culture-negative bivalvular endocarditis with myocardial destruction in a patient ... Journal of Cardiothoracic Surgery 2 011 , 6 :10 9 http://www.cardiothoracicsurgery.org/content/6 /1/ 109 blood urea nitrogen was at baseline of 53 mg/dL [10 -20 mg/dL] The ferritin level was 2055 ng/mL [10 ...
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Báo cáo y học: " Extragonadal germ cell tumor presenting in a woman with systemic lupus erythematosus: a case report" ppt
... Br J Cancer 19 95, 71( 2): 416 -420 McMurray RW, May W: Sex hormones and systemic lupus erythematosus: review and meta-analysis Arthritis Rheum 2003, 48: 210 0 doi :10 .11 86 /17 52 -19 47-4-97 Cite this ... germ cell tumor presenting in a woman with systemic lupus erythematosus: a case report Journal of Medical Case Reports 2 010 4:97 Figure An image of our patient’s pituitary showing polymorphic cells ... advantage of: Authors’ contributions All the authors contributed to the management of the patient Additionally, MS was the primary author of the manuscript All authors read and approved the final...
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Báo cáo y học: "Correction: Steady-state mycophenolate mofetil pharmacokinetic parameters enable prediction of systemic lupus erythematosus clinical flares: an observational cohort study" potx
... (2-3) 1. 3 (1- 2) 0. 01 C12 h, mg/L 32 .1 (24.3- 41. 9) 34.7 (26.4-49.2) 29.8 (15 .5-40) 0.26 MPAG/MPA AUC0 -12 h ratio 11 .5 (8.3-20.7) 10 .9 (6.2 -14 .8) 18 .7 (14 .1- 22.7) 0.07 MPAG/MPA C12 h ratio 11 .5 (6.8 -17 .3) ... (17 - 61) 0.92 (2-2) (2-2) (2-2) 0.9 Corticosteroids, mg/day 11 (7-35) 10 (5-20) 15 (7-45) 0.37 Months of MMF therapy (1- 3) (1- 3) (1- 3) 0.56 Months of corticosteroids 10 (6 -13 ) 10 (5 -15 ) (5 -14 ) 0 .12 ... & Therapy 2 011 , 13 :4 01 http://arthritis-research.com/content /13 /2/4 01 Page of Table Inclusion characteristics (of the 26 systemic lupus erythematosus patients) and their ability to predict clinical...
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Báo cáo y học: " Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus" potx
... Moncada S: The effect of nitric oxide on cell respiration: a key to undertanding its role in cell survival, or death Proc Natl Acad Sci U S A 2000, 26 :14 602 -14 607 11 12 13 14 15 16 17 18 19 20 21 22 ... for increased endogenous NO synthesis, suggesting that overproduction of NO may be important in the pathogenesis of RA The in amed joint in RA is the predominant source of NO [45,46] Several investigators ... associations of Syk in systemic lupus erythematosus T cells J Immunol 2008, 18 1: 814 5- 815 2 44 Moulton VR, Tsokos GC: Alternative splicing factor/splicing factor regulates the expression of the zeta...
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Báo cáo y học: "The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus" potx
... VH5- 51* 01 2 -15 3-22 6 -13 * 01 5-5* 01 5-24* 01 2-2* 01 6 -13 * 01 6*02 4*02 6*02 4*02 3 1 1 4*02 6*02 5*02 4*02 4*02 4*02 3*02 2 (1) 1 (1) 5(3) 1 11 3 (1) 3*02 6*03 4*02 4*02 4*02 1* 01 4*02 13 (10 ) 3 (1) 1 ... 5*02 4*02 2 -15 * 01 3 -10 6*02 4*02 1- 26* 01 VH2-5*02 VH3- 21* 01 VH3-30*03 2-8* 01 VH3-30*03 2-8* 01 VH3-30.3* 01 3-3* 01 VH4-30 .1 2-2* 01 5* 01 VH2-5*02 VH3 -15 * 01 VH3- 21* 01 VH3-23* 01 VH3-23* 01 3 -10 *02 VH3-30*03 ... VH3-33* 01 5-24* 01 VH3-74* 01 VH4-4*03 VH4-30.4* 01 2-2* 01 VH4-34* 01 VH4-59 1- 26* 01 VH5- 51* 01 2-2* 01 VH5- 51* 01 2-2* 01 VH5- 51* 01 4-4* 01 5*02 B C D VH3-07 VH3-23 VH3-33 VH3-72* 01 VH4-59*02 VH5- 51* 01 VH5- 51* 01...
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Báo cáo y học: "Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" potx
... number CD40 Hs 010 02 913 _m1 CD1C Hs00233509_m1 CD14 Hs0 016 912 2_g1 Chemokine (C-C motif) receptor (CCR7) Hs0 017 1054_m1 IL12B Hs00233688_m1 IL-4 receptor (IL4R) Hs0 016 6237_m1 Prostaglandin E synthase ... 2',5'-oligoadenylate synthetase-like (OASL) Hs00388 714 _m1 Guanylate binding protein (GBP1) Hs00266 717 _m1 Guanylate binding protein (GBP2) Hs00269759_m1 IL8RA Hs0 017 414 6_m1 C-type lectin domain family 4, ... Interferon-induced protein with tetratricopeptide repeats (IFIT5) Hs002027 21_ m1 Interferon, alpha-inducible protein (IFI6) Hs002425 71_ m1 Interferon, gamma-inducible protein 16 (IFI16) Hs0 019 42 61_ m1 Interferon,...
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Báo cáo y học: "Practical and theoretical barriers to the prevention of accelerated atherosclerosis in systemic lupus erythematosus" docx
... Haserick JR: Clinical diagnosis of cardiac involvement in systemic lupus erythematosus: a correlation of clinical and autopsy findings in thirty patients Circulation 19 62, 26:7 -11 Hosenpud JD, ... D’Agostino RB, Kuller LH: Age-specific incidence rates of myocardial infarction and angina in women with systemic lupus erythematosus: comparison with the Framingham Study Am J Epidemiol 19 97, 14 5:408- 415 ... and risk factors of carotid plaque in women with systemic lupus erythematosus Arthritis Rheum 19 99, 42: 51- 60 Salmon JE, Roman MJ: Accelerated atherosclerosis in systemic lupus erythematosus: implications...
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Báo cáo y học: "Analysis of HLA DR, HLA DQ, C4A, FcγRIIa, FcγRIIIa, MBL, and IL-1Ra allelic variants in Caucasian systemic lupus erythematosus patients suggests an effect of the combined FcγRIIa R/R and IL-1Ra 2/2 genotypes on disease susceptibility" pptx
... may act in concert in the pathogenesis of SLE, a concept that may be instrumental in the analysis of the genetics of SLE as well as providing hypotheses for pathways in the pathogenesis of lupus ... polymorphisms of the mannose-binding lectin gene Arthritis Rheum 19 98, 41: 1663 -16 68 11 Minchinton RM, Dean MM, Clark TR, Heatley S, Mullighan CG: Analysis of the relationship between mannose-binding lectin ... classification of systemic lupus erythematosus Arthritis Rheum 19 82, 25 :12 71- 1277 16 Jonsson H, Nived O, Sturfelt G: Outcome in systemic lupus erythematosus: a prospective study of patients from a defined...
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Báo cáo y học: "Screening of an endothelial cDNA library identifies the C-terminal region of Nedd5 as a novel autoantigen in systemic lupus erythematosus with psychiatric manifestations" ppt
... iodide staining, according to the method of Nicoletti and colleagues [19 ], and by the binding of FITCconjugated Annexin V, using the Apoptest binding kit, containing annexin V-FITC and binding buffer ... (28–48) 37.2 (14 –70) 1/ 7 2/7 1/ 5 3/25 11 .2 (7– 21) 6.8 (0.5 19 ) (5 15 ) 12 .1 (0.5–24) (62.5) (10 0) (83.3) 18 (64.2) (25) (44.4) (33.3) 11 (39.2) Renal involvement, no (%) (37.5) (50) (32 .1) Cytopenia, ... has 10 0% identity with the Cterminal subunit of Nedd5, a protein of the septin family (Fig 1a,b) The search for possible coiled-coil domains in the database disclosed a coiled-coil domain in this...
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Báo cáo y học: " Replication of the genetic effects of IFN regulatory factor 5 (IRF5) on systemic lupus erythematosus in a Korean population" doc
... × 10 -23 0.44 3,835 3,577 0.47 4,093 0.0002 0.52 Controls Combined analysis 10 9 3.6 × 10 -9 1. 51 (1. 21 1. 87) 1. 44 (1. 34 1. 55) 0.48 Cases 0.04268 1. 47 (1. 29 1. 67) 7 .1 × 10 -7 0.49 Cases 1. 31 (1. 01 1. 71) ... 724 0. 615 1. 32 (1. 14 1. 54) 0.0003 950 610 0.3 21 1290 0.679 Cases 284 309 0.54 259 0.46 1. 52 (1. 20 1. 93) 0.00035 279 245 0.44 313 0.56 Cases 444 559 0.63 329 0.37 1. 42 (1. 18 1. 71) 0.00 016 5 41 589 ... (0.84 1. 13) 0 .15 0.69 71 Haplotypeb AGTC 0.355 0.368 0.95 (0.82 1. 11) 0.49 0.4840 ATCT 0.352 0.295 1. 28 (0 .10 1. 50) 10 .85 0.0 01 CGTT 0 .15 8 0.205 0.74 (0. 61 0.89) 10 . 21 0.0 014 CGCT 0.066 0.0 71 0.96...
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Báo cáo y học: "The role of tumor necrosis factor-alpha in systemic lupus erythematosus" pdf
... in systemic lupus erythematosus Clin Rheumatol 19 99, 18 :17 -22 44 Aringer M, Stummvoll GH, Steiner G, Koller M, Steiner CW, Hofler E, Hiesberger H, Smolen JS, Graninger WB: Serum interleukin -15 ... with the degree of inflammatory organ disease [13 ,14 ] Moreover, even in NZB/W mice, there is an increase in renal TNF expression in conjunction with renal inflammation [15 ] The induction of lupus- like ... blockade in patients with systemic lupus erythematosus While dampening inflammation, TNF blockade with infliximab induced an increase of autoantibodies in five out of seven patients and increases in...
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