... disorders, cancer and atherosclerosis [5,6], as a result of its antiproliferative, anti-inflammatory and anti-oxidant effects [7–9] DHEA is a powerful inhibitor of carcinogenesis, in the early- and late-progression ... 25 and 55 years old, and it is the second most common cause ofdeath from cancer among Mexican women [21] Therefore, the aim of this work was to evaluate the effect of pharmacological doses of ... and late apoptosis than C33A cells (Table 2) These results indicate that DHEA can induce early and late apoptosis and also necrosis Discussion DHEA is an intermediate in the biosynthesis of androgen...
... monomers and acidic organelles When the extrameiotic products (Fig 2A) andthe parental macronucleus (Fig 2C and D) began to degenerate, they were stained in yellow (merged colour of green and orange), ... (lanes 6, 7, and 8, respectively), and 0.1, 1, and mM ZnCl2 (lanes 9, 10, and 11, respectively) were assayed at 30 °C for 120 A standard reaction (S) was performed with 50 mM Mops (pH 6.5) and ... requirement ofthe mitochondrial nuclease activity Reaction mixtures that contained 50 mM Mops (pH 6.5) and 10 mM KCl, together with 1, 5, and 10 mM MgCl2 (lanes 3, 4, and 5, respectively), 1, 5, and...
... upstream of, the apoptotic cascade and loss of membrane integrity Thus, it has been shown that the stimulation of inflammatory-related enzymes and caspases is involved in the cytotoxicity of CSE, and ... to play an important role in the toxicity and in the effects on inflammatory-immune processes of cigarette smoke There are many ROS inducers among these toxic components, and they cause the oxidative ... significantly the CSE-evoked activation of both MMPs and caspase-3 Furthermore, it has been suggested that the deactivation of CSE-stimulated MMPs and caspase-3 was one ofthe possible mechanisms...
... CD69NG70 (lanes and 5), CD69NV82 (lanes and 7) CD69NS84 (lanes and 9), rat CD69 (lanes 10 and 11) and mouse CD69 (lanes 12 and 13) was performed under nonreducing (even lanes) and reducing (odd lanes) ... in the solubility and stability among these proteins and allow us to select the human protein containing amino acids Gly70 to Lys199 (and the rat and mouse orthologs) as the most physically and ... Moreover, the exclusion ofthe protein in urine and faeces, and uptake by the liver, was relatively low On the other hand, the least stable human CD69NS84 protein displayed a rapid plasma clearance...
... course of humanity, the rabble who could never understand his feelings and who projected their own prejudices on others, because they could not understand the glory ofthe human soul andthe majesty ... ghosts of men, and all they cared about was food, wine, women, and gold The emperor’s army attacked Rome from the west, between the walls ofthe Vatican andthe Janiculum hill, just south ofthe ... all the news He stayed in the house of Gianfrancesco Aldrovandi, a lover of Florentine culture Aldrovandi made Michelangelo read from Petrarch and Dante every night before he fell asleep, and the...
... important political themes and performance techniques to both entertain and inform his audience Accidental Deathofan Anarchist creatively uses a comic, grotesque and satirical style to avoid any ... By breaking down the fourth wall, the audience becomes co-conspirators, and part ofthe political conspiracy Through the Maniac's exaggerated and comic view ofthe court system, the responder also ... slaps and kicks the police officers This is an unexpected thing for the audience to see and so it adds to the humour Fo also uses satire in real situations and characters to present his view of the...
... Aleksandr Serafimovich (the future author ofThe Iron Flood) and Maiakovsky tried their hand at working for movies, but they had little experience and understanding ofthe special needs ofthe ... on the basis ofthe work of a few outstanding directors but on the basis ofthe films of dozens of others, many of whom were talented and able people, but less ambitious and innovative that the ... sorcerer The child dies andthe unhappy couple break up By contrast, the other family, which observes the advice ofthe doctor and appreciates the importance of cleanliness have a healthy child and the...
... Debian, the real heart and soul behind Debian is the community These men and women spend their free time working on the code with an understanding that the software is shared freely around the ... MATERIALS THE ACCURACY AND COMPLETENESS OFTHE INFORMATION PROVIDED HEREIN ANDTHE OPINIONS STATED HEREIN ARE NOT GUARANTEED OR WARRANTED TO PRODUCE ANY PARTICULAR RESULTS, ANDTHE ADVICE AND STRATEGIES ... Stopping the System Using the reboot, halt, and poweroff commands Using the shutdown command Working with the Filesystem and Related Commands Mounting drives...
... research? The brand andthe snake-oil salesmen Problem 1: brand gets in the way ofthe real problems Problem 2: the claims made for the importance ofthe brand are overblown Problem 3: the brand ties ... and ‘strategy’; endless incantation ofthe mantra of brands, branding and brand values Hours are spent dissecting the nuances of focus groups and tracking studies6 – looking for indications of ... for the offer and its acceptance and how the acceptance becomes another offer and so on Exhilarating! Sit in your next meeting and listen for the offers And watch what happens when you take them...
... contributed to the design ofthe study VJ performed conception and design ofthe study and substantially contributed to interpretation of data, drafting and critical revision ofthe manuscript and final ... chemotherapy and radiotherapy, these lipophilic drugs target cellular membranes and interfere with membrane lipid composition andthe formation of lipid second messengers, thereby affecting the ... the results from the WST-1 test and flow cytometry may be due to the high standard deviations in the WST-1 test that would preclude the detection of a small combination effect On the other hand,...
... Cheng for their helpful discussions and advice The authors thank Ms Wun-Hsiang Yu for her maintenance ofthe fish room We thank the Core Facility ofthe Institute of Cellular and Organismic Biology, ... treatment induces thedeathof erythrocytes and endocardium Embryos at 24 hpf were treated with either DMSO or blapachone for h and then fixed at 30 and 48 hpf to analyze the presence of erythrocytes ... system Materials and methods Fish maintenance and collection of embryos Adult zebrafish (Danio rerio) were raised at the zebrafish facility ofthe Institute of Cellular and Organismic Biology,...
... 0.1 ml ofthe chitosan granules (contain 0.5 mg) and 0.1 ml of O/ CHN/99 strain at the same time, and other ten suckling mice were only injected 0.1 ml of O/CHN/99 strain as the control Thedeath ... immunostimulants 20 years ago due to its harmless, biodegradable, biocompatible, abundant and anti- antimicrobial And now, chitosan is widely used in human and veterinary medicine [4] The data showed ... particles of chitin and chitosan (but not their soluble analogues) increase the generation of active oxygen species in mouse (Mus musculus L.) alveolar macrophages and induce the synthesis of γ-interferon...
... conception ofthe study andthe data interpretation, and revised the manuscript critically MO has made substantial contribution to the conception and design ofthe study; organized, performed and supervised ... the analysis and interpretation ofthe data WB contributed to the conception and design ofthe study, performed the animal experiments and revised the manuscript carefully RRW contributed to the ... calculated the data and made substantial contribution to the analysis and interpretation ofthe data LK performed the histological analysis, calculated the data and made substantial contribution to the...
... fractures ofthe pelvic ring andthe acetabulum, fractures and dislocations ofthe face, head, neck, complex fractures ofthe hand and some ofthe fractures ofthe thoracic and lumbar spine) The primary ... accuracy ofthe register and contributed to data extraction and writing KH made the operation planning program; ORPlan and contributed to the data extraction AJA contributed in the planning and participated ... to the implementation ofan inhospital fracture and dislocation registry using the AO/OTA classification: compliance, completeness and commitment Scandinavian Journal of Trauma, Resuscitation and...
... Prohibition andthe Ku Klux Klan In 1912, he and a prominent Houston oilman, Joseph Cullinan, formed the American Anti-Klan Association in an effort to force the KKK to disband It was a remarkable stand ... huge sums of money and did investment banking for the company, but their executives invested in Enron's off -the- balance-sheet partnerships Andthe same bankers employed a gaggle of analysts who, ... and Calhoun borrowed from a series of New York and Baltimore banks The two men used most ofthe money to acquire 800,000 acres of forestland, which Kirby and Calhoun believed might hold oil The...
... please the gods He made all the laws, and was also commander-inchief ofthe army Above all, the pharaoh had to maintain ma’at (harmony and order) and hold the regions of Upper and Lower Egypt together ... represented both the rebirth ofthe land through the Nile floods, andthe rebirth ofthe body in the afterlife BOOK OFTHE DEAD This Hall of Judgement picture comes from the tomb of Hunefer, a scribe ... linen, first the head, then each toe and finger, then the arms and legs, and finally the trunk were painstakingly wrapped The bandages were kept tight and coated with resin to stiffen them was covered...
... results from the analytical model and simulation 51 3.6 The best sampling plans of cases and 54 3.7 The best sampling plans of Cases 19 and 20 56 4.1 Balance equation ... business environment, thereby pressurizing manufacturers to enhance manufacturing performance for financial survival (Anand and Kodali, 2009) In the past decades, manufacturers of many industries have ... critical to manufacturing industries, and losses of quality may significantly undermine profit and competitiveness of manufacturers (Colledani and Tolio, 2006) For instance, the number of automobile...
... the theory ofthe steering ofthe possible planning and arrangement of human labour Cybernetics transforms language into an exchange of news The arts become regulated-regulating instruments of ... unified the field of control and communication theory, and defined it with the same title as his book: as the study of control and communication in the animal andthe machine The study of messages, ... through these quantifiable objectives, that the goals ofthe organization can be fulfilled, for every employee understands the vision of these goals and objectives and thus the end goal of a smoothly...
... and ADAIR, Lieutenant ROTELY ofthe Marines, and some ofthe Midshipman on the Victory's poop, for some time afterwards At length one of them was killed by a musket-ball: and on the other's then ... suffer, and now and then a Commander be picked off: but it never can decide the fate of a general engagement; and a circumstance in many respects similar to that ofthe Victory's running on board of ... chosen for the reception ofthe Body; which, after the hair had been cut off, was stripped ofthe clothes except the shirt, and put into it, andthe Cask was then filled with brandy.[23] In the evening...