the corporate governance role of the media
Báo cáo Y học: The role of the second binding loop of the cysteine protease inhibitor, cystatin A (stefin A), in stabilizing complexes with target proteases is exerted predominantly by Leu73 pdf
... interactions with the enzyme and therefore to considerably decrease the contribution of the second binding loop of cystatin A to the inhibition of target proteases. However, the flexibility of the second ... within the Leu73–Asn77 segment in the second binding loop of cystatin A. After each of these steps, the conformation of the second binding loop in the complex was refined byenergy minimization of the ... in the inhibition of papainand most likely also of cathepsin L. The side chains of Leu73 and Pro74 jointly contribute 45% of the totalunitary free energy of binding of cystatin A to cathepsin...
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Báo cáo khoa học: Structural characterization of the large soluble oligomers of the GTPase effector domain of dynamin potx
... for formation of short helices, transiently,and the chain as such is highly dynamic.Structure of the core of the oligomersBecause of the large size of the core of the oligomer, the NMR spectra ... domain at the extreme carboxy-terminal end. The GTPase domain is the most highly conserved domain within the members of the dynamin family. The functional roles of the various domains of dynamin ... assembles in the form of ringsaround the necks of budding vesicles, and then a con-formational change in the dynamin collar aids the scis-sion of the vesicle from the parent membrane. The coiled-coil...
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Báo cáo khoa học: Revisiting the 13C-label distribution of the non-oxidative branch of the pentose phosphate pathway based upon kinetic and genetic evidence doc
... formedbetween the carbonyl group of the ketose substrate(f6p, s7p) and the e-amino group of a lysine residue of the active site of the enzyme, leading to the formation of either g3p or e4p ... pools gener-ated by the half-reactions.Genetic organization of the nonoxidative branch of the PPPIn recent years, the genes encoding the enzymes of the nonoxidative branch of the PPP have been ... those of the traditionalmodel. The similarity of the flux estimates indicatesthat the presence of isoenzymes reduces the differencein13C-label distribution between the two models andimpedes their...
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A Compilation of the Messages and Papers of the Presidents Section 3 (of 3) of Volume 8: Grover Cleveland, First Term. pptx
... Compilation of the Messages and Papers of the Presidents 12 A Compilation of the Messages and Papers of the Presidents The Project Gutenberg EBook of A Compilation of the Messages and Papers of the ... the date of the exchange of ratifications of the same the provisions of Article VIII of the convention of July 29, 1882, between the United States and Mexico, inregard to the resurvey of the boundary ... the Senate of the United States_:In the matter of the removal of Horatio C. } Burchard as Director of the Mint. }In conformity to section 343 of the Revised Statutes of the United States, the...
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Báo cáo khoa học: The role of the Fe-S cluster in the sensory domain of nitrogenase transcriptional activator VnfA from Azotobacter vinelandii potx
... level of the lacZ gene immediately after the addition of o-phen to minimize the effect of the growthinhibition by o-phen on the transcriptional activity of VnfA. Figure 5 shows the time course of ... upstream of the GAF domain are the potential ligands of the Fe-S cluster. Consequently, the binding of the ATPanalog and the subsequent rearrangement of the inter-domain interaction affects the ... electronic condition of the Fe-S cluster through the protein scaffold, resultingin an alteration of the signal rhombicity of the EPRspectrum. The divergence of the g-value from that of the whole cell...
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The Corporate Governance Lessons from the Financial Crisis docx
... and then considers the responsibility of the board and why its oversight appears to have failed in a number of cases. Other aspects of the corporate governance framework that contributed to the ... dealt in much depth with the role and performance of the boards The available reports have not so far dealt in much depth with the role and performance of the boards, the focus being on documenting ... re-emphasise the respective roles of the CEO and the board in the risk management process in many firms. The report goes on to make suggestions for strengthening Board oversight of risk issues; the...
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Center for Audit Quality Observations on the Evolving Role of the Auditor: A Summary of Stakeholder Discussions doc
... appropriate, the CAQ formed a task force on the role of the auditor and moved to convene investors and other financial reporting stakeholders to examine the role of the auditor and the value of the ... evolve the role of the auditor to meet the needs of investors in the near and longer term. In the near term, the CAQ and its member firms have developed model reports for the PCAOB and other stakeholders ... CENTER FOR AUDIT QUALITY OBSERVATIONS ON THE EVOLVING ROLE OF THE AUDITOR—A SUMMARY OF STAKEHOLDER DISCUSSIONS1IntroductionOver the years, the role of the public company auditor has been examined...
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Báo cáo khoa học: Carbohydrate binding sites in Candida albicans exo-b-1,3-glucanase and the role of the Phe-Phe ‘clamp’ at the active site entrance ppt
... implementedto help explain their importance to the specificity andcatalytic efficiency of the enzyme. The role of the Phe-Phe entranceway The fortuitous discovery of an unreacted molecule of the mechanism-based ... seen for the Phe triad in the structure of the mutant Exg:L3 complex. Neither of the two sugar residues interacting with the Trp triadoverlaps with the sugar seen in the Phe-Phe clamp of Exg.Structural ... solved the crystal structure of this GH5enzyme in the presence of two different mechanism-based inhibitors, thereby revealing the close network of interactions that hold the terminal glucose of the...
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Báo cáo khoa học: Zinc-binding property of the major yolk protein in the sea urchin ) implications of its role as a zinc transporter for gametogenesis ppt
... Indeed, 33% of the total zinc in the ovary at stage 1 and 13% of the total zinc in the testis at stage 1 is still bound to MYP.On the basis of the results of the present study andothers, we propose ... measured the protein content of the CFMYP and EGMYP bands by densitometry of the SDS ⁄ PAGE gel of the purified MYP, and the ratio of CFMYP to total MYP (CFMYP + EGMYP) wascalculated (Fig. 3B). In the ... detected in the ovaries of noninjected animals (Fig. 5F). The results of this experiment suggest that CFMYP in the coelomicfluid is selectively incorporated into the nutritivephagocytes of the ovary...
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Báo cáo khoa học: Isothermal unfolding studies on the apo and holo forms of Plasmodium falciparum acyl carrier protein Role of the 4¢-phosphopantetheine group in the stability of the holo form of Plasmodium falciparum acyl carrier protein docx
... iden-tified as the major and the minor forms of the holo-ACP structure, on the basis of their percentage contri-butions (65% and 35%, respectively) to the overallstructure of the protein. The structures ... estimated on the basis of the linear regression of the fraction number of the molecular mass markers cytochrome c (CyC), carbonic anhydrase (CA), andBSA. From the calibration curve of the sucrose ... with the LEM of protein unfolding [29].It is apparent from the solution denaturation studiesthat the holo form of the protein has greater stabilitythan the apo form. The differences in the...
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INVESTIGATING DIVERSITY IN THE BANKING SECTOR IN EUROPE: THE PERFORMANCE AND ROLE OF SAVINGS BANKS pdf
... is the isolated or direct sale of the reserves if they have been created in the first place. The other possibility is the sale of the entire bank at a price that includes the value of the ... by the controversy concerning their legal status and the role of politics in these banks. Generally speaking, the arguments used by the opponents of the cajas largely resemble those used at the ... quality of the government bonds in the 19th century. As a consequence, the Spanish savings banks soon turned to using deposits to finance the activities of the ‘Mount of Piety’. By the end of the...
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RESPONSIBLE REFORM OF THE WORLD BANK - THE ROLE OF THE UNITED STATES IN IMPROVING THE DEVELOPMENT EFFECTIVENESS OF WORLD BANK OPERATIONS pptx
... response, the institutions often claim that the issue of democracy is outside of their purview. But the very least that should be expected of institutions that receive the support of U.S. taxpayers ... in the countries to these measures. The Fund has supported tariff or excise tax reductions in Uganda, among several other nations. Whatever the merits of privatization of other sectors of the ... process. The U.S. government should also make adoption of the above recommendations a priority. Role of the United States in Achieving Reform As the largest voting member of the World Bank and the...
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