the confounding factor of apolipoprotein e on response to chemotherapy and hormone regulation al
Effects of apolipoprotein e on n methyl d aspartate receptor signalling the roles of ageing and chicken extract
... from the top of the curve (usually at the peak) down to the horizontal line The area under the curve was measured by clicking inside the shape on left or right side defined by the line and the curve ... much effort has been made to seek for effective therapeutic and preventive strategies as even a 1year delay in the onset of and progression of AD will significantly reduce the global burden of ... 1997) The effect of the ε4 allele on the CNS apoE protein levels has been studied in both AD patient CNS and animal models, reporting controversial results showing either reduced levels (Beffert et...
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Báo cáo lâm nghiệp: "Influence of the moisture content of forest tree its response to different viability tests pollen on" pdf
... had little or even negative effects on other assay responses (Webber, unpublished data) Work must continue to evaluate the effect of hydration on viability responses for all species and, in particular, ... hydration and most severe for 30°C It was less severe for 10°C and not observed at all for 20°C Again, the poorest lot seemed to be more sensitive than the best one Conclusion Correlating the response ... Of particular interest was the differential response by pollen lots (data not shown) Our best lot, determined by assay re- was sponse, remained stable and showed the least deterioration in conductivity...
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The Economic Impact of Cloud Computing on Business Creation, Employment and Output in Europe pdf
... as to contribute to the recovery of the EU economy Most of all, part of these effects are going to be positively related to the speed of adoption of the new technology Our results are only preliminary ... are provided in the Appendix The results of the numerical exercise are presented in the next section For our estimates, we develop a DSGE model calibrated on the EU economy in the traditional ... and the entry/competitive conditions at the level of EU countries and their aggregate sectors A main aspect of our empirical exercise concerns the nature of the shock affecting the economy The...
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báo cáo khoa học: " Transcriptome changes in the phenylpropanoid pathway of Glycine max in response to Pseudomonas syringae infection" ppsx
... levels of the CHS gene family members were measured relative to the endogenous reference PEPC All calculations and statistical analysis were performed as described in the ABI 7700 Sequence Detection ... accumulation during the HR while the second subset showed a decrease (see Table 1) In the case of DFR and CCR, the increasing ratios of one of the subsets (bold type) and the decreasing ratios of the ... downstream of F3H, thus giving preference to the isoflavone/phytoalexin branch of the pathway during the response to infection The critical nature of partitioning the naringenin substrate between...
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Báo cáo khoa học: Haptoglobin binds the antiatherogenic protein apolipoprotein E – impairment of apolipoprotein E stimulation of both lecithin:cholesterol acyltransferase activity and cholesterol uptake by hepatocytes pdf
... as percentage of the value obtained by incubation of Hpt alone, and expressed as mean ± SEM In each panel, a single representative of at least three independent experiments is shown The interassay ... triplicate, and the data are expressed as means ± SEM A single representative of at least three independent experiments is shown The interassay coefficient of variation from three independent experiments ... between the acute phase of inflammation and ApoE function that should be considered when the effects of either protein are investigated Experimental procedures Materials Chemicals of the highest purity,...
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Báo cáo khoa học: The antagonistic effect of hydroxyl radical on the development of a hypersensitive response in tobacco pot
... extents were also assessed by ion leakage measurement (lower panel) Mean values ± standard error of at least three replicates are presented (B) The EPR measurements indicated that the leaves pretreated ... The suppressor role of OH• in HR development is verified by the Fenton reaction and EPR measurements OH• is introduced and generated by a Fenton-type reaction that takes place in the presence of ... coinfiltrated into the same leaves Because Fe2+ ⁄ Fe3+ may interfere with the results of ion leakage measurement, five grades were adopted to assess the severity of the HR induced by ParA1 (Fig 4A) In the...
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Báo cáo khoa học: Mechanisms of obesity and related pathologies: Role of apolipoprotein E in the development of obesity potx
... disease [36,37] Despite the pivotal role of obesity and dyslipidemia in the development of the metabolic syndrome and heart disease, the functional interactions between adipose tissue and the ... lower potential to promote these conditions One study [55] investigated the contribution of the natural human ApoE3 and ApoE4 phenotypes in the development of obesity and other metabolic abnormalities ... surface of adipocytes In summary, the recently acquired knowledge reported in the literature identifies ApoE expression as a key peripheral contributor to the development of obesity and related metabolic...
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Báo cáo hóa học: "TAp73 is one of the genes responsible for the lack of response to chemotherapy depending on B-Raf mutational status" pot
... to be an extremely important aspect of chemotherapy response In this sense, there is evidence that the interaction between p53, p73 and p63 may be involved in the response to this drug Further ... has long been recognized as central to the induction of apoptosis in response to DNA damage, a function thought to be critical for tumor suppression and the response of tumor cells to chemotherapy ... article as: Herreros-Villanueva et al. : TAp73 is one of the genes responsible for the lack of response to chemotherapy depending on BRaf mutational status Journal of Translational Medicine 2010...
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Báo cáo lâm nghiệp: "Frost damage on the terminal shoot as a risk factor of fork incidence on common beech (Fagus sylvatica L.)" docx
... 1981 We were not able to measure the characteristics of the late frost in the plot, or in the experimental site, or even at the individual tree scale On the other hand, we were able to describe accurately ... open experimental beech plantation whose genetic origin, site conditions and environment in the vicinity of the trees were known factors, and the trees were at a stage of development when the ... tested due to the strong correspondence observed between height and damage level The estimates and the P-value Chi-2 test of nullity of the parameters intercept, Bfrost−nipped , Bred−spots and...
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Báo cáo lâm nghiệp: "The effects of thinning treatments on density, MOE, MOR and maximum crushing strength of Pinus brutia Ten. wood" ppt
... and other wood properties Bendtsen reported that the e ect of accelerated growth on wood properties is minor compared to the differences between juvenile and mature wood properties of the same ... Turkey, only a few plantation areas are being and have been managed for research purposes and thus the studied plantations are unique and valuable Therefore, it is essential to preserve these areas ... beginning, mechanical tests were conducted with the same sample size and the results were analyzed to determine if the sample size was large enough to obtain low experimental error The results showed...
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báo cáo khoa học: "The grapevine guard cell-related VvMYB60 transcription factor is involved in the regulation of stomatal activity and is differentially expressed in response to ABA and osmotic stress" ppt
... change in expression after exposure to the hormone under these conditions (Figure 2E) To further investigate the expression of VvMYB60 and VvMYB30 in response to osmotic stresses, we designed an ... the VvMYB60 gene model, was misannotated in terms of exon number Indeed, our results indicate the presence of three exons, as opposed to the five exons predicted by the gene model, thus revealing ... Arabidopsis and grape The R2 and R3 repeats lie between the three alpha helices of each repeat Boxes represent the Cterminal motifs CtM1, CtM2 and CtM3 (red boxes) conserved in members of subgroup and the...
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Báo cáo y học: " The effects of IQPLUS Focus on cognitive function, mood and endocrine response before and following acute exercise" pps
... Endocrine data are presented in table There were no significant differences between treatment groups or treatment × time interactions for serum cortisol, total testosterone, or the testosterone to ... repetitions at 70% of their pre-determined 1RM for SQ, LP, and LE Participants were allowed a 90 second rest between sets and a 180 second rest between exercises This exercise protocol was determined ... with the microplate reader Subject samples were compared to the standard curve to determine concentrations of cortisol and testosterone present Statistical Analyses SST data were analyzed using...
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Age related effects of apolipoprotein e genotypes on cholesterol metabolism and insulin signaling
... neurodegeneration Alternatively, the increment in the expression of ApoE may have been triggered to accelerate the removal of excess cholesterol 32 | P a g e present in the cells Nevertheless, ... soluble portions of the lysates were harvested while the insoluble portions were stored at -80̊C freezer The soluble lysates were further distributed into aliquots to minimize freeze-thaw over the ... approaches to accurately determine the severity or progression of the illness Existing cognitive performance tests are only able to determine the severity of the cognitive impairment To date, confirmed...
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Báo cáo y học: "HLA-DR regulation and the influence of GM-CSF on transcription, surface expression and shedding
... HLA-DR therefore seemed to represent a small fraction of the total HLA-DR of the cell, however the function of these shed HLA-DR molecules remains to be investigated with respect to any potential ... product and one reverse transcriptase negative product This allowed identification of DNA contamination The sequence of the amplified primer product revealed homology to the primer target sequence The ... Discussion A lowered expression of both the percentage of monocytes expressing HLA-DR and the density of HLA-DR expression have been observed as a feature of sepsis [4;5;7;8;22-25] Only recently have...
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Tài liệu Framing the Issues— the Positive Impacts of Affordable Housing on Health pdf
... making their mortgage payments experienced lower levels of psychological well-being and were more likely to see a doctor (Nettleton and Burrows 1998) Indeed, even the very presence of a mortgage, ... further evidence of the relationship between crowding and infectious diseases, see Baker et al 2000; Fonseca et al 1996; Victora et al 1994.) Lack of sleep and proper rest has also been presented ... town.9 Even without considering the impact of personal vehicles on the environment, the residential sector generated 18 percent of United States greenhouse gas emissions, primarily as a result of energy...
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Tài liệu The Bitter Chain of Slavery'''': Reflections on Slavery in Ancient Rome pdf
... speaking of the age of the Antonines: Everyone learned to speak and think in Latin, even the slaves, who in the second century raised their standard of living to the level of the 'ingenui' Legislation ... Both the grief caused by death and the sense of intimacy in life between master and slave conveyed by these poems seem to me genuine, and it is difficult not to take them as evidence of the close ... altogether free from the presence or influence of slavery Across the vast chronological interval from the Mycenaeans to the Roman Empire of the fifth century and beyond, and in all the regions where...
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Tài liệu Báo cáo khoa học: Coordination chemistry of iron(III)±porphyrin±antibody complexes In¯uence on the peroxidase activity of the axial coordination of an imidazole on the iron atom ppt
... in the same buffer) were then added in both cuvettes and difference spectra were recorded between 350 and 650 nm In most cases, the spectral evolution observed involved the formation of well de®ned ... then added and the reaction was started by the addition of H2O2 at concentrations ranging between and 10 mM The initial rates of oxidation were then measured as above mentioned and the kcat and ... ligands on the iron atom, and the only one that enters the active site bind on the less hindered face of the porphyrin which bears only one ortho-COOH substituent (Fig 7C) The inhibition of the...
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Tài liệu Báo cáo khoa học: "Selecting the “Right” Number of Senses Based on Clustering Criterion Functions" pdf
... curvature in the criterion function graph, by fitting a pair of lines to the curve (where the intersection of these lines represents the selected k) Experimental Results We conducted experiments ... and In these tables, the actual numbers of senses are in the columns, and the predicted number of senses are in the rows We see that the predicted value of P K1 agreed 113 Table 1: k Predicted ... single name to create pseudo or false ambiguities For example, we replaced all mentions of Bill Clinton and Tony Blair with a single name that can refer to either of them In general the names we...
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JUDGMENTS OF THE COURT OF APPEAL OF NEW ZEALAND ON PROCEEDINGS TO REVIEW ASPECTS OF THE REPORT OF THE ROYAL COMMISSION OF INQUIRY INTO THE MOUNT EREBUS AIRCRAFT DISASTER potx
... not even be admissible in evidence in legal proceedings as to the cause of a disaster In themselves they not alter the legal rights of the persons to whom they refer Nevertheless they may greatly ... was expressed to be issued under the authority of the Letters Patent of 1917 constituting the office of Governor-General One of the powers delegated by the Letters Patent to the Governor-General ... deliberately set out to conceal the change from the American personnel there The motive for the 1979 change ascribed by the Commissioner to the navigation section appears to be that they considered...
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