the complement system as part of the cerebral innate immune response

báo cáo hóa học: " Neuronal oxidative damage and dendritic degeneration following activation of CD14-dependent innate immune response in vivo" doc

Ngày tải lên : 19/06/2014, 22:20

... each of which are potent activators of a large family of G protein-coupled receptors [5] The combination of these initial and secondary signaling cascades produces a robust innate immune response ... activate CD14-dependent innate immune response in macrophages While none of these data point to CD14 or innate immune response as etiological in neurodegenerative disorders, these findings from in ... measurement of cerebral F2-IsoPs, like all other measures of oxidative damage, reflects damage to brain tissue but not necessarily to neurons For these reasons, we developed an assay to measure...

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Children security as part of the " living together with floods" strategy in the Mekong river delta, VietNam

Ngày tải lên : 18/10/2013, 12:15

... of child deaths in the total the losses of life in the flood seasons in the MD Save the Children (2003) reported that the vast majority of the drowning deaths in recent years in the region was ... high inundated areas are not attending their schools The beginning and the end of the rainy season are the best time for mosquito reproduction resulting in mosquito-based diseases A recurrent ... 2000, the Mekong River Delta faced a historically high flood, as severe as that of 1961 which was the most destructive flood in past 70 years The flood in 2000 was extreme not only in terms of its...

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Brochure produced as part of the Project: RESTMAC ppsx

Ngày tải lên : 06/07/2014, 18:20

... of the grain to release the starch, it is then diluted into water to adjust the volume of sugar in the mash The mixture is cooked with yeast and all the water soluble starches dissolve into the ... for the production of electricity for either direct use by the plant or to sell to the national grid which can increase their overall profit About 35% of the weight of sugar cane becomes bagasse ... price as the basic petrol model The commercial potential of the car has received a boost by the Avon and Somerset (UK) Police who bought 15 of the fuel flexible Focus’ in March 2006 Further interest...

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Báo cáo y học: " Cyanide intoxication as part of smoke inhalation a review on diagnosis and treatment from the emergency perspective" pps

Ngày tải lên : 13/08/2014, 23:20

... the formation of intracellular adenosine triphosphate (ATP) [10] The result is cytotoxic hypoxia caused by the inhibition of CCO by the high affinity of CN to heme a of the enzyme The effect is ... (CO) and cyanide (CN) Ther Umsch 2009, 66:387-397 11 Smith RP: Toxic Responses of the blood In Casarett and Doull’s Toxicology - The basic science of poisons Edited by: Klaassen CD, Amdur MO, Doull ... oxidase a, a3 (CCO), the terminal enzyme complex of the respiratory chain in complex IV [10] The active (O2-binding) site of CCO is binuclear, consisting of heme a and Cu B [19] CO binds to the...

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Opportunities in the total support service sector as part of oursourcing industry in VietNam a case study of Sodexho

Ngày tải lên : 17/03/2015, 13:22

... presented with the increase for the new server and support of the application, the division will often complain about the increased cost When the service is outsourced and a division asks for the application ... absolute advantage theory in terms of outsourcing from one country to another country Just come back to key points of these theories before considering in aspect of outsourcing The theory of absolute ... company The bottom line of this decision is whether the running of the company will be more efficient or not  Offshoring: In many case, offshoring is refered to one common form of outsourcing Offshoring...

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Evaluation of the effectiveness of Online Learning Program as part of the English course to second-year non-English major students at Hanoi University of Indust

Ngày tải lên : 28/03/2015, 10:31

... the OLP In particular, they were asked about the online materials, the level of difficulty of these exercises to their students, the frequency of giving reports and support, the benefits of the ... suggestions to maximize the effectiveness of Online Learning Program? Scope of the study The study is about the evaluation of the effectiveness of the OLP as part of the English course to second-year ... after the introduction of the OLP Design of the study The study consists of parts: - Part A: Introduction: This part consists of rationale, aims, scope, method, and design of the study - Part...

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Apprenticeships in York - a presentation developed as part of an IAG package raising the profile of the apprenticeship pathway

Ngày tải lên : 05/12/2016, 21:14

... your basic skills, then register on one of the foundation courses Both of the above options are run at various sites in the city and offer support and individual programmes to get you to the next ... about these options please contact the Castlegate centre October 2012 Apprenticeship choices There are three levels of Apprenticeships available:  Intermediate Apprenticeship – this is where the ... range of on and off the job training •Will vary in time to complete depending on your role and need of your employer •Usually include a HNC/HND, NVQ Level and a Higher Education element as part of...

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The Implication of Corporate Social Responsibility in Procurement As Part of Corporate’s Risk Management

Ngày tải lên : 12/12/2016, 20:32

... acceptable The goal of the study is therefore to understand the significance of responsible procurement as part of organization’s risk management The primary research question for the study is: ... from the triple bottom line’s point of view and this has given the basis for the study The study shows that because of varying nature of organizations, which are applicable to CSR, the context of ... of terms used in the research The theoretical framework below ties all the aspects of the study together It shoes the correlation between corporate social responsibility and risk management The...

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Tài liệu Báo cáo khoa học: NirF is a periplasmic protein that binds d1 heme as part of its essential role in d1 heme biogenesis pdf

Ngày tải lên : 15/02/2014, 01:20

... occur; however, when the pH was lowered to neutral pH the uptake of d1 heme proceeded As NirF could have at least two other interacting partners in the periplasm for the d1 heme assembly, 0.21 Absorbance ... was present only in the periplasmic fraction (Fig 3) These results, together with the outcome of the complementation analysis, prove that NirF is a periplasmic protein in P pantotrophus m plas ... reductase activity as seen by the accumulation of large Tota l Inﬂuence of variations of conserved residues on the in vivo activity of NirF te amounts of extracellular nitrite in the DnirF strain complemented...

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Báo cáo khoa học: Proteolytic activation and function of the cytokine Spatzle in the innate immune response of a lepidopteran insect, Manduca sexta ppt

Ngày tải lên : 06/03/2014, 09:22

... prominent feature of the innate immune systems of insects is the activation of serine proteinase cascade pathways in hemolymph, which function to activate plasma proteins that perform immune functions ... positions of the molecular weight markers are indicated on the left of Spatzle-C108 (Fig 8A) Analysis of tryptic peptides ¨ from these bands by MS ⁄ MS and mascot software identiﬁed them as attacin-1, ... in the M sexta splicing isoforms Spatzle 11.15 was as active as ¨ isoform 11.7 in restoring ventrolateral pattern elements [8] How these sequences, which differ in the proregion rather than the...

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Báo cáo sinh học: " Clearance of low levels of HCV viremia in the absence of a strong adaptive immune response" pptx

Ngày tải lên : 18/06/2014, 18:20

... staining in three of the four patients, although the frequencies of tetramer-positive cells were rather low in of them as they did not exceed 0.2% of CD8+ T cells which was much lower as compared to ... method in laboratory of the NLGA (Niedersächsisches Landesgesundheitsamt) which is the central laboraty of public health department of the state of Lower Saxony The frequency of HCV-RNA positive ... respectively) At the second time point, we found also a significant response against NS4 in the proliferation assay as well as a helicase-specific interferon gamma response in the ELISPOT assay detectable...

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Báo cáo hóa học: " Clearance of low levels of HCV viremia in the absence of a strong adaptive immune response" potx

Ngày tải lên : 20/06/2014, 01:20

... staining in three of the four patients, although the frequencies of tetramer-positive cells were rather low in of them as they did not exceed 0.2% of CD8+ T cells which was much lower as compared to ... method in laboratory of the NLGA (Niedersächsisches Landesgesundheitsamt) which is the central laboraty of public health department of the state of Lower Saxony The frequency of HCV-RNA positive ... respectively) At the second time point, we found also a significant response against NS4 in the proliferation assay as well as a helicase-specific interferon gamma response in the ELISPOT assay detectable...

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Báo cáo khoa học: "Ovular secretions as part of pollination mechanisms in conifer" doc

Ngày tải lên : 08/08/2014, 14:20

... continuity between the vascular system and the ovule implies that the phenomenon is regulated by the water relations of the ovule, as separate from the general water relations of the tree This requires ... flaps at the tip of the tube A copious pollination drop gathers the pollen from these flaps The sacci of pollen are unusual as they provide no buoyancy, but absorb the liquid, wetting the pollen ... Sarvas [54] stated that the origin of the liquid was in the tissue below the nucellus, noting that the liquid merely passed through the nucellus on its way in and out of the micropyle In Picea...

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Báo cáo y học: "CD14 mediates the innate immune responses to arthritopathogenic peptidoglycan–polysaccharide complexes of Gram-positive bacterial cell walls" docx

Ngày tải lên : 09/08/2014, 01:23

... soft tissues Extensive deposition of fibrinous exudate in the tibio-tarsal joint and in the bursa of the Achilles' tendon was also observed There was neither pannus formation nor destruction of ... severity of arthritis was assessed as described in the Materials and methods section Data are shown as means ± standard error of the mean (n = 10) The significance of difference between groups was ... secretion of inflammatory cytokines The activation of macrophages by PG-PS represents an example of innate immune response, a defensive reaction based on recognition of conserved pathogen-associated...

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Báo cáo y học: "Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis" pps

Ngày tải lên : 09/08/2014, 10:23

... fibroblasts, in the progression of disease, as they produce large amounts of pro-inflammatory mediators leading to the destruction of the cartilage and bone Given the success of anti-TNFα therapy, there ... Stimulation of TLR3 or TLR4 results in the recruitment of TRIF, and in the case of TLR4 also TRAM [55-57] The dissociation of TRIF activates a complex consisting of the kinases IkappaB kinase (IKK)i ... Given the existing evidence of an involvement of TLRs in the pathogenesis of RA and other inflammatory diseases, a great deal of interest exists in understanding the molecular basis of the signalling...

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Báo cáo y học: "A description of a knowledge broker role implemented as part of a randomized controlled trial evaluating three knowledge translation strategies" potx

Ngày tải lên : 11/08/2014, 05:21

... policies The three main goals of the regional workshops were to: present the results of the systematic reviews disseminated as part of the intervention in the RCT, facilitate discussion concerning the ... quality of an article, report, practice guideline, and/or program evaluation The KB's role was to assist participants in critically appraising the quality of the evidence, and if the evidence was of ... intervention groups of the RCT The KB was responsible for disseminating these summaries electronically as well as in hardcopy to participants in the KB group, along with other relevant evidence as needed...

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Báo cáo y học: "Severe synergistic toxicity from docetaxel in a patient treated concurrently with protease inhibitors as part of HIV post-exposure prophylaxis: a case report" doc

Ngày tải lên : 11/08/2014, 14:20

... administration of PIs as part of PEP The mechanism of this potential novel drugdrug interaction was concluded to be as a result of the inhibition of CYP3A4 causing an increased and prolonged exposure of ... advocated as a method of quantifying the degree of CYP3A4 activity following administration of docetaxel [15] In order to quantify the strength of the association, the authors used the Drug Interaction ... It was previously noted that administration of the PI ritonavir in mice increased the plasma levels of oral docetaxel by up to 50 times The authors thus suggested that the co-administration of...

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báo cáo khoa học: " A description of a knowledge broker role implemented as part of a randomized controlled trial evaluating three knowledge translation strategies" pps

Ngày tải lên : 11/08/2014, 16:20

... policies The three main goals of the regional workshops were to: present the results of the systematic reviews disseminated as part of the intervention in the RCT, facilitate discussion concerning the ... quality of an article, report, practice guideline, and/or program evaluation The KB's role was to assist participants in critically appraising the quality of the evidence, and if the evidence was of ... intervention groups of the RCT The KB was responsible for disseminating these summaries electronically as well as in hardcopy to participants in the KB group, along with other relevant evidence as needed...

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Báo cáo y học: " Differential epithelial expression of the putative innate immune molecule SPLUNC1 in Cystic Fibrosis" pptx

Ngày tải lên : 12/08/2014, 15:21

... is increased in the small airways of the lungs of patients with CF and furthermore suggest the protein is secreted into the luminal contents of the diseased lung The specificity of this was highlighted ... perhaps the severity of the inflammatory disease coupled with the significant pathogenic load overcomes the defensive capability of the innate immune shield One of the major limitations of this ... is the founder member of the PLUNC family of putative innate immune molecules, and is highly expressed in the epithelium of the upper respiratory tract, nasopharynx and submucosal glands [1] The...

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Báo cáo y học: " Characterization of the innate immune response to chronic aspiration in a novel rodent model" ppsx

Ngày tải lên : 12/08/2014, 15:21

... aspiration of either gastric fluid or normal saline are shown The ratio of macrophages in the left to the macrophage in the right lung is shown as a function of time In the inset, the ratio of macrophages ... http://respiratory-research.com/content/8/1/87 Figure Cytokine response as a function of duration of gastric fluid aspiration Cytokine response as a function of duration of gastric fluid aspiration Cytokine levels in bronchoalveolar ... and 16 weeks of gastric fluid aspiration (Figure 3) As early as weeks after the initiation of gastric fluid aspiration, cellular infiltrates were observed in the left lung (Figure 2) These infiltrates...

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