... predeterminations in part to sustain the doctrine that God isthe principal originating source of being and goodness, including moral goodness Suarez is charging in effect that their theory has the ... of his metaphysics, such as his theories of contingency and of individuation His genius isin bringing together in synthesis his own idiosyncratic metaphysical doctrines and the classical themes ... are the preconditions for our mistakes and sins In claiming that the principle of plenitude is ineffective for Descartes's theodicy, Beck is misconstruing the explanatory role the principle is invoked...
... radio-oncologists, respond to a question inthe following way: none choose the "+2", and "+1" ratings, choose the "0" rating, 10 choose the "-1" rating and 30 choose the "-2" rating The modal answer in ... in this example is "-2" An examinee choosing this rating will receive Selecting the "-1" rating will earn 0.33 (10/30) and the "0" rating, 0.06 (2/30) No points are accorded for selecting the ... practitioners in radiation oncology of the province of Quebec (n = 62) The test was administered inthe French language Each examinee received instructions on the particular format of the SCT and on the...
... levels) due to the incidence of (or connectedness of due to the incidence of 0) in a model including 0, and A using the terminology of Foulley et al (1984, 1990) This terminology is also in agreement ... the symbolic notation I dx (Johnsson and Kotz, ¡ 1i The joint and the marginal distributions arising in [3] are as follows: where C isthe variance-covariance matrix of the ML estimators of model ... consisting of what is called disconnectedness or confounding between the factors This suggests the idea of measuring the degree of connectedness by some distance between the current status of the...
... variations inthe radii of the rolls The system starts with a diameter of 0.15 m of material on the unwinder During the nonlinear simulation, the material is wound onto the winder The simulation incorporates ... 1, the set point changes are accurately attained with minimal coupling between the outputs In Figure 2, the evolution of the outputs is shown for the same reference demands, but this time inthe ... great industrial interest Independent control of the velocity and tension of the material inthe face of time-varying parameter changes inthe radius of the material on the winder and unwinder...
... Testing of Homogeneity Hypothesis in Mixed Models 2.1 2.1.1 The Linear Mixed effects model The Log-likelihood functions Recall the model (1.1), under the assumptions in chapter 1, The LME model ... When the assumption is not met in a data analysis, all kinds of conventional hypothesis tests and inference procedures may be misleading Our aim here is to propose tests for checking this homogeneity ... (NR), Fisher scoring (FS) and ExpectationMaximization (EM) The NR algorithm may fail if the starting point is far from the maximum, but it is fast when the starting point is relatively close to the...
... elucidated With the zebrafish gaining popularity as a model organism inthe study of human diseases including cancers, we aim to investigate the role of autophagy in liver cancer using our established ... separated using a divider in a tank the night before Spawning was induced by the removal of the divider and allowing the fish to mate on the following morning Following that, the breeding pair was ... 1992) Inthe early versions of the system, the tetracycline repressor (tetR) from the tetracycline-resistant operon in Escherichia coli was fused to the activating domain of the virion protein 16...
... groups included in this study regarding the folate level Also, there was no correlation between the plasma tHcy and the folate level This finding although surprising, it isin accordance with the ... and the mean values of the two sites were used inthe analysis There is an apparent increase inthe degree of carotid intimal thickness inthe examined patient (0.9mm) compared with 0.6 mm inthe ... degree of insulin resistance inthe studied groups remains to be addressed Furthermore, a recent report [67] stressed on the crucial role played by cytokines inthe evolution of insulin resistance...
... old in their homes by A mowing the lawns, doing shopping and cleaning up their houses B cooking, sewing or washing their clothes C telling them stories, and singing and dancing for them D taking ... marks on the page, the brain receiving signals, from the eyes Secondly, there is cognitive task, that of interpreting the visual information, so the one is not simply “barking at print”” Deriving ... answers T/F exercises Multiple choice exercises Finding the topic sentences Finding synonyms and antonyms Blank filling Reordering exercises Completing exercises Matching exercises Finding equivalents...
... it into account in our regressions 11 Fining can also be achieved with bentonite or gelatine This was the case only once or twice in our sample (8) Bottling the wine In January following the vintage, ... for adding inthe forward procedure (removing inthe backward procedure) a variable to (from) the model is 5% (10%) 18 This is not so inthe Broadbent equation Note, however, that there is only ... completed, the wine is macerated with the skins during one to two weeks The length of this period is crucial for the wine, but since most châteaux proceed inthe same way, we included no control...
... financial indexation There is strong inertia due to the indexation of financial contracts to the overnight interest rate (World Bank, 2006) While this indexation has maintained financial intermediation ... following system of equations: where isthe nominal short-run (90-day paper) interest rate, the neutral nominal interest rate, stands for the rate of inflation, isthe inflation target of the central ... analysis entails estimating a dynamic stochastic general equilibrium model (DSGE), often based on New-Keynesian theory.7 In these models, the NRIR is interpreted as the real interest rate in a model...
... in which the IFN-b gene contained or not the ARE (pIFNHA and pIFNHAAU–) In addition, the sequence encoding the HA epitope was inserted at the end of the IFN-b coding sequence to distinguish the ... synthesis is induced by stimulating agents The fact that the 65-kDa protein binds ARE and CRID in UV-crosslinking experiments, performed with cytosolic extracts from both noninfected and infected ... ARE in this process [10,11] In addition, another destabilizing sequence was identified within the coding region of IFN-b mRNA [12,13] Whereas the independent removal of the ARE or the coding region...
... possibility that disruption of the scaffolding ability of hDlg by caspase cleavage may be one of the major steps in apoptosis, which isthe dismantling of the cell– cell contacts, therefore causing cell–cell ... protein inthe human epithelial cell line HeLa We report a strong decrease in hDlg protein, although this event is independent of its phosphorylation state Moreover, this hDlg proteolysis was ... protein levels by inducing its proteasome-mediated degradation [11] In epithelial cell lines, this degradation is highly dependent on the state of hDlg phosphorylation and the degree of isolation...
... protein in Bombyx brain bound to the MEF2 consensus binding sequence, and its binding was prevented by an antiserum that recognizes the MADS box of BmMEF2 We examined this further using recombinant ... as the MEF2 domain The MADS box is essential for DNA binding and dimerization, and the MEF2 domain plays an important role in DNA binding affinity as well as an indirect role in dimerization The ... cells inthe protocerebrum, and a faint signal was found in many cells throughout the brain lobes and at the midline inthe subesophageal ganglion (SG) (Fig 1A) The axons emanating from the somata...
... macrophage infiltration inthe invasive front (81.0%) than in those with a lower macrophage infiltration (48.6%), which isin agreement with the previous studies [36-39] The mechanisms behind the antitumor ... conceived the study, participated inthe design, and coordinated and helped draft the manuscript All authors read and approved the final manuscript Competing interests The authors declare that they ... macrophage infiltration is involved inthe inhibition of hepatic metastasis These data indicate that colon cancer is an immunogenic tumor Therefore, more Figure Kaplan–Meier analysis of overall...
... DNA-binding of the drug, increased DNA-repair of cisplatin adducts and failure of induction of apoptosis, reviewed in [2,5,7] The RNA binding motif protein 3, RBM3, is a glycine rich protein containing ... reduces cisplatin sensitivity in ovarian cancer cells The relationship between RBM3 and cisplatin response was then examined using siRNA mediated gene silencing, whereby the cisplatin-sensitive ... participated inthe data collection JE participated inthe design of the study and helped draft the manuscript MAK assisted with the data collection and helped draft the manuscript IBJ assisted with the...
... formulate a theory or a model A model is a hypothesis that is sufficiently general and is continually effective in predicting facts yet to be observed A theory is an explanation of the general principles ... electrons) The strength of the force depends on the charges and on the distance between them The greater the charges, the greater the force The closer the charges are to each other, the greater the ... scientists is figuring out why things change and why they stay the same On one hand, many systems seek to establish equilibrium In organisms, this equilibrium is called homeostasis It isthe tendency...
... inthe end he acquired a convincing and sonorous voice as he had wished Theabove saying is quite right if it is applied to the pupils’ lives If we are weak at certain subjects, not be disappointed ... hope and was determined to investigate the causes of his failure: he tried to better his soil, fertilizing his rice-fields with mush nitrogen and finally he succeeded in collecting tons of rice ... to our unflinching determination after bitter failures Demosthenes, the greatest Athenian orator, before reaching the acme of his glory, had to suffer so much despair and failure The audience did...
... guidance, they began to visualize the blossoms inthe sunshine and inthe rain Then they saw petals falling down and the tiny green fruit appear The sunshine and the rain continued, and the tiny tangerine ... unpleasant feeling inthe same way Transforming Feelings The first step in dealing with feelings is to recognize each feeling as it arises The agent that does this is mindfulness Inthe case of ... will tend the feeling of pain A mother holding her baby is one with her baby If the mother is thinking of other things, the baby will not calm down The mother has to put aside other things and...
... surprising, and may dwindle (either in extent or in significance) with the accumulation of more facts There seems no need for the snobbery (it is said) of the highly quantitative founding biologists ... and indeed understanding - at many levels must be fed into the mathematics Nor should the value of facts and understanding on their own be dismissed The case for Darwin's theory of evolution by ... signaling are also implicated, and in which the Hes/her cellintrinsic oscillator may not be the only one Robertson least in so complex a system as a developing embryo, then facts - and indeed...
... significantly elevated inthe joints of the aforementioned rat OA joint instability model, including genes encoding proteins involved in retinoic acid synthesis (Aldh1a3) and retinol transport and ... [33] We were interested in confirming these findings and determining the kinetics of Crabp2 induction during OA Further, we desired to develop and validate murine cartilage-sparing models of OA ... distal femur and extending to the proximal tibia on the medial side of the knee The subcutaneous tissue was dissected throughout the length of the skin incision The deep fascia that connects the...